专利快速检索-快速检索全球专利，免费商用专利数据库-IPRDB

1. 发明申请

WO2009112594A3 ASSAYS 审中-公开
公开(公告)号：WO2009112594A3
公开(公告)日：2010-03-04
申请号：PCT/EP2009053106
申请日：2009-03-16
申请人： CLONDIAG GMBH , ERMANTRAUT EUGEN , KAISER THOMAS , TUCHSCHEERER JENS , BEIER VICO , SCHULZ TORSTEN , WOESTEMEYER ANKE
发明人： ERMANTRAUT EUGEN , KAISER THOMAS , TUCHSCHEERER JENS , BEIER VICO , SCHULZ TORSTEN , WOESTEMEYER ANKE
IPC分类号： B01L3/00
CPC分类号： G01N33/58 , B01L3/50273 , B01L2200/025 , B01L2200/0684 , B01L2300/0816 , B01L2300/0887 , B01L2300/123 , B01L2400/0481 , Y10T436/25
摘要： A method for assaying a sample for each of multiple analytes is described. The method includes contacting an array of spaced-apart test zones with a liquid sample (e.g., whole blood). The test zones disposed within a channel of a microfluidic device. The channel is defined by at least one flexible wall and a second wall which may or may not be flexible. Each test zone comprising a probe compound specific for a respective target analyte. The microfluidic device is compressed to reduce the thickness of the channel, which is the distance between the inner surfaces of the walls within the channel. The presence of each analyte is determined by optically detecting an interaction at each of multiple test zones for which the distance between the inner surfaces at the corresponding location is reduced. The interaction at each test zone is indicative of the presence in the sample of a target analyte. Capillary structures of the devices or used in the methods may comprise a matrix and the devices may comprise control elements and methods for assaying of sample may use corresponding controlling activities.
摘要翻译：描述了用于分析多种分析物中的每一种的样品的方法。该方法包括使间隔开的测试区域的阵列与液体样品（例如全血）接触。测试区域设置在微流体装置的通道内。通道由至少一个柔性壁和可以是柔性的第二壁限定。每个测试区域包含对各个目标分析物特异的探针化合物。微流体装置被压缩以减小通道的厚度，其是通道内的壁的内表面之间的距离。每个分析物的存在通过光学检测在相应位置处的内表面之间的距离减小的多个测试区域中的每一个处的相互作用来确定。每个测试区域的相互作用表明样品中目标分析物的存在。装置的毛细结构或方法中使用的毛细管结构可以包括基质，并且装置可以包括控制元件和用于测定样品的方法可以使用相应的控制活动。

2. 发明申请

WO2010105802A3 ASSAY METHODS USING ARRAY OF TEST ZONES 审中-公开
标题翻译：使用测试区域的测定方法
公开(公告)号：WO2010105802A3
公开(公告)日：2011-03-10
申请号：PCT/EP2010001650
申请日：2010-03-16
申请人： CLONDIAG GMBH , ERMANTRAUT EUGEN , KAISER THOMAS , TUCHSCHEERER JENS , BEIER VICO , SCHULZ TORSTEN , WOESTEMEYER ANKE
发明人： ERMANTRAUT EUGEN , KAISER THOMAS , TUCHSCHEERER JENS , BEIER VICO , SCHULZ TORSTEN , WOESTEMEYER ANKE
IPC分类号： G01N21/64 , G01N21/27
CPC分类号： G01N21/6452 , B01L3/502715 , B01L3/502723 , B01L2200/027 , B01L2200/0684 , B01L2300/0816 , B01L2300/0864 , B01L2300/088 , B01L2400/0481 , B01L2400/0694 , G01N21/274 , G01N2021/6441
摘要： A method for assaying a sample for each of multiple analytes is described. The method includes contacting an array of spaced-apart test zones with a liquid sample (e.g., whole blood). The test zones disposed within a channel of a microfluidic device. The channel is defined by at least one flexible wall and a second wall which may or may not be flexible. Each test zone comprising a probe compound specific for a respective target analyte. The microfluidic device is compressed to reduce the thickness of the channel, which is the distance between the inner surfaces of the walls within the channel. The presence of each analyte is determined by optically detecting an interaction at each of multiple test zones for which the distance between the inner surfaces at the corresponding location is reduced. The interaction at each test zone is indicative of the presence in the sample of a target analyte. Capillary structures of the devices or used in the methods may comprise a matrix and the devices may comprise control elements and methods for assaying of sample may use corresponding controlling activities.
摘要翻译：描述了用于分析多种分析物中的每一种的样品的方法。该方法包括使间隔开的测试区域的阵列与液体样品（例如全血）接触。测试区域设置在微流体设备的通道内。通道由至少一个柔性壁和可以是柔性的第二壁限定。每个测试区域包含对各个目标分析物特异的探针化合物。微流体装置被压缩以减小通道的厚度，其是通道内的壁的内表面之间的距离。每个分析物的存在通过光学检测在相应位置处的内表面之间的距离减小的多个测试区域中的每一个处的相互作用来确定。每个测试区的相互作用表明样品中存在目标分析物。装置的毛细管结构或方法中使用的毛细管结构可以包括基质，并且装置可以包括控制元件和用于测定样品的方法可以使用相应的控制活动。

3. 发明申请

WO2008135564A3 ASSAYS 审中-公开
公开(公告)号：WO2008135564A3
公开(公告)日：2009-05-22
申请号：PCT/EP2008055508
申请日：2008-05-05
申请人： CLONDIAG GMBH , KAISER THOMAS , MOEBIUS KLAUS-PETER , SCHULZ TORSTEN , UHLIG THOMAS , VON SCHENK ZU SCHWEINSBERG ALE , ERMANTRAUT EUGEN , TUCHSCHEERER JENS
发明人： KAISER THOMAS , MOEBIUS KLAUS-PETER , SCHULZ TORSTEN , UHLIG THOMAS , VON SCHENK ZU SCHWEINSBERG ALEXANDER , ERMANTRAUT EUGEN , TUCHSCHEERER JENS
IPC分类号： B01L3/00
CPC分类号： B01L3/50273 , B01L3/502715 , B01L3/502738 , B01L2300/0636 , B01L2300/0816 , B01L2300/123 , B01L2400/0481
摘要： A method for assaying a sample for each of multiple analytes is described. The method includes contacting an array of spaced-apart test zones with a liquid sample (e.g., whole blood). The test zones disposed within a channel of a microfluidic device. The channel is defined by at least one flexible wall and a second wall which may or may not be flexible. Each test zone comprising a probe compound specific for a respective target analyte. The microfluidic device is compressed to reduce the thickness of the channel, which is the distance between the inner surfaces of the walls within the channel. The presence ofeach analyte is determined by optically detecting an interaction at each of multiple test zones for which the distance between the inner surfaces at the corresponding location is reduced. The interaction ateach test zone is indicative of the presence in the sample of a target analyte.
摘要翻译：描述了用于分析多种分析物中的每一种的样品的方法。该方法包括使间隔开的测试区域的阵列与液体样品（例如全血）接触。测试区域设置在微流体装置的通道内。通道由至少一个柔性壁和可以是柔性的第二壁限定。每个测试区域包含对各个目标分析物特异的探针化合物。微流体装置被压缩以减小通道的厚度，其是通道内的壁的内表面之间的距离。每个分析物的存在通过光学检测在相应位置处的内表面之间的距离减小的多个测试区域中的每一个处的相互作用来确定。每个测试区的相互作用表明在样品中存在目标分析物。

4. 发明申请

WO03031063A3 DEVICE FOR HOLDING A SUBSTANCE LIBRARY CARRIER 审中-公开
标题翻译：用于安装物质库支持的装置
公开(公告)号：WO03031063A3
公开(公告)日：2003-09-12
申请号：PCT/EP0211313
申请日：2002-10-09
申请人： CLONDIAG CHIP TECH GMBH , SCHULZ TORSTEN , ERMANTRAUT EUGEN , ULLRICH THOMAS , ELLINGER THOMAS , FISCHER JOACHIM , KAISER THOMAS , MOEBIUS KLAUS-PETER , POSER SIEGFRIED , TUCHSCHEERER JENS , ZEIREN MARTIN
发明人： SCHULZ TORSTEN , ERMANTRAUT EUGEN , ULLRICH THOMAS , ELLINGER THOMAS , FISCHER JOACHIM , KAISER THOMAS , MOEBIUS KLAUS-PETER , POSER SIEGFRIED , TUCHSCHEERER JENS , ZEIREN MARTIN
IPC分类号： G01N33/53 , B01J19/00 , B01L3/00 , B01L7/00 , C12M1/00 , C12N15/09 , C12Q1/68 , G01N33/566 , G01N37/00
CPC分类号： B01L7/52 , B01J2219/00527 , B01J2219/00531 , B01J2219/00596 , B01J2219/00605 , B01J2219/00659 , B01J2219/00722 , B01J2219/00725 , B01L3/502715 , B01L2200/025 , B01L2200/027 , B01L2200/10 , B01L2200/141 , B01L2200/147 , B01L2300/044 , B01L2300/0636 , B01L2300/0877 , B01L2300/1805
摘要： The invention relates to a modularly structured device for holding substance library carriers and the use of said device for qualitative and quantitative detection of given molecular target molecules. The invention more particularly relates to a device (1) for holding a substance library carrier, which is characterized in that two holder elements that can be fixed to one another (101 and 102) form a layer composite consisting of: (i) a cover element (200) that has a detection surface with a substance library (201) on its lower surface and that is optically transparent at least in the area of the detection surface; (ii) an intermediate sealing element (300) having an enclosed groove and (iii) an optically transparent bottom element in the area of the detection surface of the cover element (400), whereby an optically transparent chamber area is obtained.
摘要翻译：本发明涉及一种用于容纳物质库载体的模块化装置及其用于定性和定量检测某些分子靶分子的用途。特别地，本发明涉及一种装置（1），用于保持一个物质文库的载体，其特征在于，两个可固定到彼此保持元件（101和102）的层的复合由在其下侧（I）的盖元件（200）的，检测表面与一种物质库（201），并且是光学透明的，至少在检测表面的面积，（ⅱ）密封并且具有中间元件（300）和一个封闭的凹口（iii）至少在盖部件底部构件的检测面的面积的光学透明（400）形式，由此光学地通过腔室空间出现。

5. 发明申请

WO2009013321A3 ASSAYS 审中-公开
公开(公告)号：WO2009013321A3
公开(公告)日：2009-10-08
申请号：PCT/EP2008059670
申请日：2008-07-23
申请人： CLONDIAG GMBH , ERMANTRAUT EUGEN , KAISER THOMAS , SCHULZ TORSTEN , STEINMETZER KATRIN , ULLRICH THOMAS
发明人： ERMANTRAUT EUGEN , KAISER THOMAS , SCHULZ TORSTEN , STEINMETZER KATRIN , ULLRICH THOMAS
IPC分类号： B01L3/00
CPC分类号： B01L3/502738 , B01L3/5027 , B01L2300/0816 , B01L2300/0887 , B01L2300/18 , B01L2400/0415 , B01L2400/0481 , B01L2400/0655 , C12Q1/6816 , C12Q1/6848 , C12Q1/703 , C12Q1/708 , C12Q2521/107 , C12Q2531/113 , C12Q2547/101 , C12Q2563/107 , C12Q2563/149 , C12Q2565/601 , C12Q2565/629
摘要： A device comprising a rigid substrate, a flexible cover element at least partially covering the substrate, a first structure formed in the substrate, adapted for accommodating liquids and adapted for releasing contents of one or more cells, spores, or viruses, the contents including the target molecules, a second structure formed in the substrate, adapted for accommodating liquids and comprising at least one binding member adapted for capturing the target molecules and for determining a value indicative for the presence and/or amount of the target molecules, a microfluidic network interconnecting at least the first structure and the second structure, and an actuator member adapted for effecting a fluid flow between the first structure and the second structure by pressing the flexible cover element against the substrate to selectively close a portion of the microfluidic network.
摘要翻译：一种包括刚性基板的装置，至少部分地覆盖基板的柔性盖元件，形成在基板中的适于容纳液体并适于释放一个或多个单元，孢子或病毒内容物的第一结构，所述内容包括目标分子，形成在基底中的第二结构，适于容纳液体，并且包括适于捕获靶分子的至少一个结合成分，以及用于确定指示靶分子的存在和/或量的值;互连的微流体网络至少第一结构和第二结构，以及致动器构件，其适于通过将柔性覆盖元件压靠在衬底上来选择性地关闭微流体网络的一部分来实现第一结构和第二结构之间的流体流动。

6. 发明申请

WO2008055915A3 DEVICE AND PROCESS FOR ASSAYS USING BINDING MEMBERS 审中-公开
标题翻译：使用绑定成员的设备和方法
公开(公告)号：WO2008055915A3
公开(公告)日：2008-07-03
申请号：PCT/EP2007061953
申请日：2007-11-06
申请人： CLONDIAG GMBH , STEINMETZER KATRIN , ERMANTRAUT EUGEN , SCHULZ TORSTEN , KAISER THOMAS
发明人： STEINMETZER KATRIN , ERMANTRAUT EUGEN , SCHULZ TORSTEN , KAISER THOMAS
IPC分类号： B01J19/00 , B01L3/00 , C12Q1/68
CPC分类号： C12Q1/703 , B01J19/0046 , B01J2219/00527 , B01J2219/00576 , B01J2219/00605 , B01J2219/00659 , B01J2219/00695 , B01J2219/00704 , B01J2219/0072 , B01J2219/00722 , B01L3/502738 , B01L3/502746 , B01L3/502753 , B01L3/502761 , B01L7/52 , B01L9/527 , B01L2200/0647 , B01L2200/10 , B01L2300/0636 , B01L2300/0681 , B01L2300/0816 , B01L2400/0481 , B01L2400/0487 , B01L2400/0655 , C12Q1/6813 , C12Q1/6825 , C12Q1/6837 , C12Q1/701 , C12Q2600/158
摘要： A device comprising a rigid substrate, a flexible cover element at least partially covering the substrate, a first structure formed in the substrate, adapted for accommodating liquids and adapted for releasing contents of one or more cells, spores, or viruses, the contents including the target molecules, a second structure formed in the substrate, adapted for accommodating liquids and comprising at least one binding member adapted for capturing the target molecules and for determining a value indicative of the presence and/or amount of the target molecules, a micro fluidic network interconnecting at least the first structure and the second structure, and an actuator member adapted for effecting a fluid flow between the first structure and the second structure by pressing the flexible cover element against the substrate to selectively close a portion of the micro fluidic network.
摘要翻译：一种包括刚性基底的装置，至少部分地覆盖基底的柔性覆盖元件，形成在基底中的适于容纳液体并适于释放一个或多个细胞，孢子或病毒的内容物的第一结构，所述内容物包括目标分子，形成在基底中的第二结构，适于容纳液体，并且包括适于捕获靶分子的至少一个结合成分，并用于确定指示靶分子的存在和/或量的值;微流体网络至少互连第一结构和第二结构，以及致动器构件，其适于通过将柔性覆盖元件压靠在衬底上来选择性地关闭微流体网络的一部分来实现第一结构和第二结构之间的流体流动。

7. 发明申请

WO2005108604A3 DEVICE AND METHOD FOR DETECTING MOLECULAR INTERACTIONS 审中-公开
标题翻译：设备和检测方法的分子间的相互作用
公开(公告)号：WO2005108604A3
公开(公告)日：2006-04-13
申请号：PCT/EP2005004923
申请日：2005-05-06
申请人： CLONDIAG CHIP TECH GMBH , DWORRAK ALEXANDRA , ELLINGER THOMAS , ERMANTRAUT EUGEN , SCHULZ TORSTEN , ULLRICH THOMAS , KAISER THOMAS
发明人： DWORRAK ALEXANDRA , ELLINGER THOMAS , ERMANTRAUT EUGEN , SCHULZ TORSTEN , ULLRICH THOMAS , KAISER THOMAS
IPC分类号： G01N21/03 , B01L3/00 , B01L7/00 , C12Q1/68 , G01N21/64 , G01N33/50
CPC分类号： B01L3/502738 , B01L3/50851 , B01L7/52 , B01L7/525 , B01L2300/0636 , B01L2300/0654 , B01L2300/0816 , B01L2300/0819 , B01L2300/0864 , B01L2300/0877 , B01L2300/1827 , B01L2300/1838 , B01L2400/0481 , G01N21/6428 , G01N21/6452 , G01N2201/024
摘要： The invention relates to devices and methods for detecting specific interactions between probe and target molecules. The invention especially relates to a device for the qualitative and/or quantitative detection of molecular interactions between probe and target molecules, which comprises a) a microarray comprising a substrate on which probe molecules are immobilized on array elements, said microarray being located on a first surface of the device; and b) a reaction chamber that is defined between the first area with the microarray disposed thereon and a second surface, the distance between the microarray and the second surface being modifiable.
摘要翻译：本发明涉及一种装置和方法用于检测探针和目标分子之间的特异性相互作用的。特别地，本发明涉及一种用于探测和目标分子之间的分子相互作用的定性和/或定量检测的装置，其包括：（a）具有一个基片的微阵列在其上的阵列元件的探针分子被固定，其中，在第一表面上的微阵列该装置被设置; 及（b）其与微阵列中的第一面之间所形成的反应室设置在其上和第二表面，其中所述Mikroarrayund第二表面修改的之间的距离。

8. 发明申请

WO2004087951A2 DEVICE FOR THE MULTIPLICATION AND DETECTION OF NUCLEIC ACIDS 审中-公开
标题翻译：装置用于生殖和对于核酸的检测
公开(公告)号：WO2004087951A2
公开(公告)日：2004-10-14
申请号：PCT/EP2004003532
申请日：2004-04-02
申请人： CLONDIAG CHIP TECH GMBH , BICKEL RALF , ELLINGER THOMAS , ERMANTRAUT EUGEN , KAISER THOMAS , SCHULZ TORSTEN , ULLRICH THOMAS
发明人： BICKEL RALF , ELLINGER THOMAS , ERMANTRAUT EUGEN , KAISER THOMAS , SCHULZ TORSTEN , ULLRICH THOMAS
IPC分类号： B01L3/00 , B01L7/00 , G01N21/47 , G01N21/59 , C12Q1/68
CPC分类号： B01L7/52 , B01L3/5027 , B01L2200/147 , B01L2300/0636 , B01L2300/0654 , B01L2300/0877 , G01N21/4738 , G01N21/59
摘要： The invention relates to a device for the multiplication and detection of nucleic acids, comprising a temperature controller and/or regulation unit, a reaction chamber, containing a substrate with a detection surface on which a substance library is immobilised and an optical system, by means of which the temporal process of formation of deposit on the detection surface may be detected. The temperature in the reaction chamber may be controlled and/or regulated by means of the temperature controller and/or regulation unit. The invention further relates to a method for the amplification and qualitative and quantitative detection of nucleic acids in a sample, comprising the following steps: a) introduction of the sample into a reaction chamber, formed by a capillary gap between a chamber support and a microarray, whereby the microarray comprises a substrate with nucleic acid probes arranged on array elements thereon, b) amplification of the nucleic acid for detection in the reaction chamber, by means of a cyclical amplification reaction, c) detection of a hybridisation between the nucleic acid for detection and the nucleic acid probes immobilised on the substrate without removal from the reaction chamber of molecules which are not hybridized with the nucleic acids immobilised on the substrate.
摘要翻译：本发明涉及一种用于再现的装置和用于检测的核酸，包括温度控制和/或调节单元; 包含具有检测表面在其上的物质库是一个irrmobilisiert载体，其中在所述反应室中的温度通过温度控制和调节单元和/或调节控制的反应室; 和光学系统与沉淀的时间进程是在检测区域中检测到。本发明还涉及一种用于扩增和核酸的定性和定量检测样品中，包括以下步骤的方法：（a）将所述样品引入反应室中，这是由腔室支撑件和微阵列，其特征在于之间的毛细间隙形成所述微阵列包含用irrmobilisierten上的核酸探针阵列元件的衬底; （B）通过循环扩增反应的扩增方法在反应室中的核酸; （C）检测irrmobilisierten而不分子在基板上的核酸和核酸探针之间的杂交，从该反应室，与所述核酸在基板上irrmobilisierten未杂交去除。

9. 发明申请

WO03004699A3 METHOD FOR IDENTIFYING NUCLEIC ACID MOLECULES AMPLIFIED IN A POLYMERASE CHAIN REACTION 审中-公开
标题翻译：方法用于检测在聚合酶链式反应扩增的核酸分子
公开(公告)号：WO03004699A3
公开(公告)日：2003-04-24
申请号：PCT/EP0207539
申请日：2002-07-05
申请人： CLONDIAG CHIP TECH GMBH , SCHULZ TORSTEN , ERMANTRAUT EUGEN , POSER SIEGFRIED , KAISER THOMAS , MOEBIUS KLAUS-PETER , ULLRICH THOMAS , ADELHELM KARIN
发明人： SCHULZ TORSTEN , ERMANTRAUT EUGEN , POSER SIEGFRIED , KAISER THOMAS , MOEBIUS KLAUS-PETER , ULLRICH THOMAS , ADELHELM KARIN
IPC分类号： G01N33/483 , C12M1/00 , C12N15/09 , C12Q1/68 , B01J19/00
CPC分类号： C12Q1/6851 , C12Q2563/173
摘要： Die Erfindung betrifft eine Vorrichtung sowie ein Verfahren zum qualitativen und/oder quantitativen Nachweis von in einer Polymerase-Kettenreaktion amplifizierten Nukleinsäuremolekülen.
摘要翻译：本发明涉及一种装置和方法，用于定性和/或核酸分子定量识别并在聚合酶链反应扩增。

10. 发明申请

WO0202810A3 METHOD FOR QUALITATIVE AND/OR QUANTITATIVE DETECTING OF MOLECULAR INTERACTIONS ON PROBE ARRAYS 审中-公开
标题翻译：用于定性和/或定量检测探针阵列上分子相互作用的方法
公开(公告)号：WO0202810A3
公开(公告)日：2002-09-19
申请号：PCT/EP0107575
申请日：2001-07-02
申请人： CLONDIAG CHIP TECH GMBH , BICKEL RALF , EHRICHT RALF , ELLINGER THOMAS , ERMANTRAUT EUGEN , KAISER THOMAS , SCHULZ TORSTEN , WAGNER GERD
发明人： BICKEL RALF , EHRICHT RALF , ELLINGER THOMAS , ERMANTRAUT EUGEN , KAISER THOMAS , SCHULZ TORSTEN , WAGNER GERD
IPC分类号： G01N33/53 , C12M1/00 , C12Q1/68 , G01N21/47 , G01N29/06 , G01N33/566 , G01N37/00
CPC分类号： C12Q1/6837
摘要： The invention relates to a method for qualitatively and/or quantitatively detecting certain molecular targets using probe arrays. The inventive detection method comprises a reaction which delivers a product with a particular solubility product, this solubility product causing the precipitation or the formation of a precipitate of the product on an array element of the probe array on which an interaction has taken place between the probe and the target.
摘要翻译：本发明涉及用于通过探针阵列定性和/或定量检测某些分子靶标的装置和方法，其中在本发明方法中通过提供具有某种溶解度产物的反应的检测，所述溶解度产物是沉淀将产品沉淀在探针阵列的阵列元素上，探针和目标之间发生相互作用，产生结果。

你已经成功收藏专利！

检索式保存成功!

IPRDB

热门服务

关于我们

友情链接

联系方式