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1. 发明申请

WO03031063A3 DEVICE FOR HOLDING A SUBSTANCE LIBRARY CARRIER 审中-公开
标题翻译：用于安装物质库支持的装置
公开(公告)号：WO03031063A3
公开(公告)日：2003-09-12
申请号：PCT/EP0211313
申请日：2002-10-09
申请人： CLONDIAG CHIP TECH GMBH , SCHULZ TORSTEN , ERMANTRAUT EUGEN , ULLRICH THOMAS , ELLINGER THOMAS , FISCHER JOACHIM , KAISER THOMAS , MOEBIUS KLAUS-PETER , POSER SIEGFRIED , TUCHSCHEERER JENS , ZEIREN MARTIN
发明人： SCHULZ TORSTEN , ERMANTRAUT EUGEN , ULLRICH THOMAS , ELLINGER THOMAS , FISCHER JOACHIM , KAISER THOMAS , MOEBIUS KLAUS-PETER , POSER SIEGFRIED , TUCHSCHEERER JENS , ZEIREN MARTIN
IPC分类号： G01N33/53 , B01J19/00 , B01L3/00 , B01L7/00 , C12M1/00 , C12N15/09 , C12Q1/68 , G01N33/566 , G01N37/00
CPC分类号： B01L7/52 , B01J2219/00527 , B01J2219/00531 , B01J2219/00596 , B01J2219/00605 , B01J2219/00659 , B01J2219/00722 , B01J2219/00725 , B01L3/502715 , B01L2200/025 , B01L2200/027 , B01L2200/10 , B01L2200/141 , B01L2200/147 , B01L2300/044 , B01L2300/0636 , B01L2300/0877 , B01L2300/1805
摘要： The invention relates to a modularly structured device for holding substance library carriers and the use of said device for qualitative and quantitative detection of given molecular target molecules. The invention more particularly relates to a device (1) for holding a substance library carrier, which is characterized in that two holder elements that can be fixed to one another (101 and 102) form a layer composite consisting of: (i) a cover element (200) that has a detection surface with a substance library (201) on its lower surface and that is optically transparent at least in the area of the detection surface; (ii) an intermediate sealing element (300) having an enclosed groove and (iii) an optically transparent bottom element in the area of the detection surface of the cover element (400), whereby an optically transparent chamber area is obtained.
摘要翻译：本发明涉及一种用于容纳物质库载体的模块化装置及其用于定性和定量检测某些分子靶分子的用途。特别地，本发明涉及一种装置（1），用于保持一个物质文库的载体，其特征在于，两个可固定到彼此保持元件（101和102）的层的复合由在其下侧（I）的盖元件（200）的，检测表面与一种物质库（201），并且是光学透明的，至少在检测表面的面积，（ⅱ）密封并且具有中间元件（300）和一个封闭的凹口（iii）至少在盖部件底部构件的检测面的面积的光学透明（400）形式，由此光学地通过腔室空间出现。

2. 发明申请

WO03004699A3 METHOD FOR IDENTIFYING NUCLEIC ACID MOLECULES AMPLIFIED IN A POLYMERASE CHAIN REACTION 审中-公开
标题翻译：方法用于检测在聚合酶链式反应扩增的核酸分子
公开(公告)号：WO03004699A3
公开(公告)日：2003-04-24
申请号：PCT/EP0207539
申请日：2002-07-05
申请人： CLONDIAG CHIP TECH GMBH , SCHULZ TORSTEN , ERMANTRAUT EUGEN , POSER SIEGFRIED , KAISER THOMAS , MOEBIUS KLAUS-PETER , ULLRICH THOMAS , ADELHELM KARIN
发明人： SCHULZ TORSTEN , ERMANTRAUT EUGEN , POSER SIEGFRIED , KAISER THOMAS , MOEBIUS KLAUS-PETER , ULLRICH THOMAS , ADELHELM KARIN
IPC分类号： G01N33/483 , C12M1/00 , C12N15/09 , C12Q1/68 , B01J19/00
CPC分类号： C12Q1/6851 , C12Q2563/173
摘要： Die Erfindung betrifft eine Vorrichtung sowie ein Verfahren zum qualitativen und/oder quantitativen Nachweis von in einer Polymerase-Kettenreaktion amplifizierten Nukleinsäuremolekülen.
摘要翻译：本发明涉及一种装置和方法，用于定性和/或核酸分子定量识别并在聚合酶链反应扩增。

3. 发明申请

WO2004087951A2 DEVICE FOR THE MULTIPLICATION AND DETECTION OF NUCLEIC ACIDS 审中-公开
标题翻译：装置用于生殖和对于核酸的检测
公开(公告)号：WO2004087951A2
公开(公告)日：2004-10-14
申请号：PCT/EP2004003532
申请日：2004-04-02
申请人： CLONDIAG CHIP TECH GMBH , BICKEL RALF , ELLINGER THOMAS , ERMANTRAUT EUGEN , KAISER THOMAS , SCHULZ TORSTEN , ULLRICH THOMAS
发明人： BICKEL RALF , ELLINGER THOMAS , ERMANTRAUT EUGEN , KAISER THOMAS , SCHULZ TORSTEN , ULLRICH THOMAS
IPC分类号： B01L3/00 , B01L7/00 , G01N21/47 , G01N21/59 , C12Q1/68
CPC分类号： B01L7/52 , B01L3/5027 , B01L2200/147 , B01L2300/0636 , B01L2300/0654 , B01L2300/0877 , G01N21/4738 , G01N21/59
摘要： The invention relates to a device for the multiplication and detection of nucleic acids, comprising a temperature controller and/or regulation unit, a reaction chamber, containing a substrate with a detection surface on which a substance library is immobilised and an optical system, by means of which the temporal process of formation of deposit on the detection surface may be detected. The temperature in the reaction chamber may be controlled and/or regulated by means of the temperature controller and/or regulation unit. The invention further relates to a method for the amplification and qualitative and quantitative detection of nucleic acids in a sample, comprising the following steps: a) introduction of the sample into a reaction chamber, formed by a capillary gap between a chamber support and a microarray, whereby the microarray comprises a substrate with nucleic acid probes arranged on array elements thereon, b) amplification of the nucleic acid for detection in the reaction chamber, by means of a cyclical amplification reaction, c) detection of a hybridisation between the nucleic acid for detection and the nucleic acid probes immobilised on the substrate without removal from the reaction chamber of molecules which are not hybridized with the nucleic acids immobilised on the substrate.
摘要翻译：本发明涉及一种用于再现的装置和用于检测的核酸，包括温度控制和/或调节单元; 包含具有检测表面在其上的物质库是一个irrmobilisiert载体，其中在所述反应室中的温度通过温度控制和调节单元和/或调节控制的反应室; 和光学系统与沉淀的时间进程是在检测区域中检测到。本发明还涉及一种用于扩增和核酸的定性和定量检测样品中，包括以下步骤的方法：（a）将所述样品引入反应室中，这是由腔室支撑件和微阵列，其特征在于之间的毛细间隙形成所述微阵列包含用irrmobilisierten上的核酸探针阵列元件的衬底; （B）通过循环扩增反应的扩增方法在反应室中的核酸; （C）检测irrmobilisierten而不分子在基板上的核酸和核酸探针之间的杂交，从该反应室，与所述核酸在基板上irrmobilisierten未杂交去除。

4. 发明申请

WO2005108604A3 DEVICE AND METHOD FOR DETECTING MOLECULAR INTERACTIONS 审中-公开
标题翻译：设备和检测方法的分子间的相互作用
公开(公告)号：WO2005108604A3
公开(公告)日：2006-04-13
申请号：PCT/EP2005004923
申请日：2005-05-06
申请人： CLONDIAG CHIP TECH GMBH , DWORRAK ALEXANDRA , ELLINGER THOMAS , ERMANTRAUT EUGEN , SCHULZ TORSTEN , ULLRICH THOMAS , KAISER THOMAS
发明人： DWORRAK ALEXANDRA , ELLINGER THOMAS , ERMANTRAUT EUGEN , SCHULZ TORSTEN , ULLRICH THOMAS , KAISER THOMAS
IPC分类号： G01N21/03 , B01L3/00 , B01L7/00 , C12Q1/68 , G01N21/64 , G01N33/50
CPC分类号： B01L3/502738 , B01L3/50851 , B01L7/52 , B01L7/525 , B01L2300/0636 , B01L2300/0654 , B01L2300/0816 , B01L2300/0819 , B01L2300/0864 , B01L2300/0877 , B01L2300/1827 , B01L2300/1838 , B01L2400/0481 , G01N21/6428 , G01N21/6452 , G01N2201/024
摘要： The invention relates to devices and methods for detecting specific interactions between probe and target molecules. The invention especially relates to a device for the qualitative and/or quantitative detection of molecular interactions between probe and target molecules, which comprises a) a microarray comprising a substrate on which probe molecules are immobilized on array elements, said microarray being located on a first surface of the device; and b) a reaction chamber that is defined between the first area with the microarray disposed thereon and a second surface, the distance between the microarray and the second surface being modifiable.
摘要翻译：本发明涉及一种装置和方法用于检测探针和目标分子之间的特异性相互作用的。特别地，本发明涉及一种用于探测和目标分子之间的分子相互作用的定性和/或定量检测的装置，其包括：（a）具有一个基片的微阵列在其上的阵列元件的探针分子被固定，其中，在第一表面上的微阵列该装置被设置; 及（b）其与微阵列中的第一面之间所形成的反应室设置在其上和第二表面，其中所述Mikroarrayund第二表面修改的之间的距离。

5. 发明申请

WO0102094A8 MICROCHIP MATRIX DEVICE FOR DUPLICATING AND CHARACTERIZING NUCLEIC ACIDS 审中-公开
标题翻译：如需复制MICROCHIP矩阵设备和核酸表征
公开(公告)号：WO0102094A8
公开(公告)日：2001-06-21
申请号：PCT/EP0006103
申请日：2000-06-30
申请人： CLONDIAG CHIP TECH GMBH , EHRICHT RALF , ELLINGER THOMAS , TUCHSCHERER JENS , ERMANTRAUT EUGEN , POSER SIEGFRIED , SCHULZ TORSTEN
发明人： EHRICHT RALF , ELLINGER THOMAS , TUCHSCHERER JENS , ERMANTRAUT EUGEN , POSER SIEGFRIED , SCHULZ TORSTEN
IPC分类号： B01F13/00 , B01L3/00
CPC分类号： B01F13/0076 , B01L3/5027 , B01L3/508 , B01L2200/142 , B01L2300/0636 , B01L2300/0809 , B01L2400/0406 , B01L2400/0418
摘要： The aim of the invention is to provide a device for duplicating and characterizing nucleic acids almost simultaneously and with a high sample throughput rate, hereby avoiding the disadvantages of the prior art. To this end, the inventive device consists of a chamber body (1) with a recess whose edge sealingly holds an optically transparent chip (2). Said chip holds nucleic acids in individual spots (13) on a detection surface (12). The chamber body (1) is placed on an optically transparent chamber support (5) with a bearing surface (4), in such a way that a capillary gap (7), which can be filled with a liquid sample, is formed between the detection surface (12) of the chip (2) facing towards the chamber support (5) and said chamber support (5). The chamber body (1) is provided with an inlet (81) and an outlet (82), which are spatially separate from each other, and has a space, which laterally encompasses the chip (2) and which has a gas reservoir (6). The chamber support (5) is provided with heating elements .
摘要翻译：本发明的目的是提供用于再现和核酸表征其允许几乎同时扩增和表征具有高样品通量的装置，从而避免了现有技术的实现在于该装置包括一腔室主体的缺点（1 密封），其具有凹部，其边界，检测光学透明芯片（2）携带（在检测表面（12），在各个点13）的核酸密封件，其中所述腔室主体（1）进一步包括（在支撑表面4）上的光学透明的腔室支承件（5）被安装成使得所述芯片的腔室支承件之间朝向（5），探测表面（12）（2）和（7）形成所述腔室支撑件（5）可填充有样品液体毛细间隙，其中，所述腔室主体（1）具有在空间上分开的入口（81）和出口（82）verseh s是与容器主体（1）上的含侧空间中的芯片（2），其包围一个气体贮存器（6），并且所述腔室支撑件（5）设置有用于温度加载，组成。

6. 发明申请

WO2006056466A3 METHOD FOR SPECIFICALLY LOCATED SYNTHESIS OF BIOPOLYMERS ON SOLID CARRIERS 审中-公开
标题翻译：在固体支持物上特定位点合成生物聚合物的方法
公开(公告)号：WO2006056466A3
公开(公告)日：2006-08-03
申请号：PCT/EP2005012648
申请日：2005-11-25
申请人： CLONDIAG CHIP TECH GMBH , ELLINGER THOMAS , ERMANTRAUT EUGEN , HOLZHEY NANCY , PLENZ FRANK , SCHULZ TORSTEN , TUCHSCHEERER JENS , WEICHERDING DANIEL
发明人： ELLINGER THOMAS , ERMANTRAUT EUGEN , HOLZHEY NANCY , PLENZ FRANK , SCHULZ TORSTEN , TUCHSCHEERER JENS , WEICHERDING DANIEL
IPC分类号： B01J19/00 , C40B40/06 , C40B50/14
CPC分类号： B82Y30/00 , B01J19/0046 , B01J2219/0043 , B01J2219/00659 , B01J2219/00662 , B01J2219/00675 , B01J2219/00722 , B01J2219/00725 , C40B40/06 , C40B40/10 , C40B50/14 , C40B60/14
摘要： The invention relates to a method for specifically located synthesis of biopolymers such as nucleic acids or peptides and the respective derivatives thereof on solid carriers, wherein local discrimination of synthesis is carried out particularly with the aid of masks, directing aqueous activation reagents for the cleavage of protective groups to predetermined areas on the carrier.
摘要翻译：本发明涉及一种用于生物聚合物的位点特异性的合成方法，如核酸或肽和在固体载体上，其中所述合成的本地鉴别特别是通过使用掩模的情况下进行其各自的衍生物，例如，使得所述水性活化试剂用于除去保护基团，以预定区域在载体上。

7. 发明申请

WO0202810A3 METHOD FOR QUALITATIVE AND/OR QUANTITATIVE DETECTING OF MOLECULAR INTERACTIONS ON PROBE ARRAYS 审中-公开
标题翻译：用于定性和/或定量检测探针阵列上分子相互作用的方法
公开(公告)号：WO0202810A3
公开(公告)日：2002-09-19
申请号：PCT/EP0107575
申请日：2001-07-02
申请人： CLONDIAG CHIP TECH GMBH , BICKEL RALF , EHRICHT RALF , ELLINGER THOMAS , ERMANTRAUT EUGEN , KAISER THOMAS , SCHULZ TORSTEN , WAGNER GERD
发明人： BICKEL RALF , EHRICHT RALF , ELLINGER THOMAS , ERMANTRAUT EUGEN , KAISER THOMAS , SCHULZ TORSTEN , WAGNER GERD
IPC分类号： G01N33/53 , C12M1/00 , C12Q1/68 , G01N21/47 , G01N29/06 , G01N33/566 , G01N37/00
CPC分类号： C12Q1/6837
摘要： The invention relates to a method for qualitatively and/or quantitatively detecting certain molecular targets using probe arrays. The inventive detection method comprises a reaction which delivers a product with a particular solubility product, this solubility product causing the precipitation or the formation of a precipitate of the product on an array element of the probe array on which an interaction has taken place between the probe and the target.
摘要翻译：本发明涉及用于通过探针阵列定性和/或定量检测某些分子靶标的装置和方法，其中在本发明方法中通过提供具有某种溶解度产物的反应的检测，所述溶解度产物是沉淀将产品沉淀在探针阵列的阵列元素上，探针和目标之间发生相互作用，产生结果。

8. 发明申请

WO2008135564A3 ASSAYS 审中-公开
公开(公告)号：WO2008135564A3
公开(公告)日：2009-05-22
申请号：PCT/EP2008055508
申请日：2008-05-05
申请人： CLONDIAG GMBH , KAISER THOMAS , MOEBIUS KLAUS-PETER , SCHULZ TORSTEN , UHLIG THOMAS , VON SCHENK ZU SCHWEINSBERG ALE , ERMANTRAUT EUGEN , TUCHSCHEERER JENS
发明人： KAISER THOMAS , MOEBIUS KLAUS-PETER , SCHULZ TORSTEN , UHLIG THOMAS , VON SCHENK ZU SCHWEINSBERG ALEXANDER , ERMANTRAUT EUGEN , TUCHSCHEERER JENS
IPC分类号： B01L3/00
CPC分类号： B01L3/50273 , B01L3/502715 , B01L3/502738 , B01L2300/0636 , B01L2300/0816 , B01L2300/123 , B01L2400/0481
摘要： A method for assaying a sample for each of multiple analytes is described. The method includes contacting an array of spaced-apart test zones with a liquid sample (e.g., whole blood). The test zones disposed within a channel of a microfluidic device. The channel is defined by at least one flexible wall and a second wall which may or may not be flexible. Each test zone comprising a probe compound specific for a respective target analyte. The microfluidic device is compressed to reduce the thickness of the channel, which is the distance between the inner surfaces of the walls within the channel. The presence ofeach analyte is determined by optically detecting an interaction at each of multiple test zones for which the distance between the inner surfaces at the corresponding location is reduced. The interaction ateach test zone is indicative of the presence in the sample of a target analyte.
摘要翻译：描述了用于分析多种分析物中的每一种的样品的方法。该方法包括使间隔开的测试区域的阵列与液体样品（例如全血）接触。测试区域设置在微流体装置的通道内。通道由至少一个柔性壁和可以是柔性的第二壁限定。每个测试区域包含对各个目标分析物特异的探针化合物。微流体装置被压缩以减小通道的厚度，其是通道内的壁的内表面之间的距离。每个分析物的存在通过光学检测在相应位置处的内表面之间的距离减小的多个测试区域中的每一个处的相互作用来确定。每个测试区的相互作用表明在样品中存在目标分析物。

9. 发明申请

WO2007051863A3 METHOD AND DEVICE FOR THE DETECTION OF MOLECULAR INTERACTIONS 审中-公开
标题翻译：用于检测分子相互作用的方法和装置
公开(公告)号：WO2007051863A3
公开(公告)日：2007-06-28
申请号：PCT/EP2006068155
申请日：2006-11-06
申请人： CLONDIAG CHIP TECH GMBH , ERMANTRAUT EUGEN , BICKEL RALF , SCHULZ TORSTEN , ULLRICH THOMAS
发明人： ERMANTRAUT EUGEN , BICKEL RALF , SCHULZ TORSTEN , ULLRICH THOMAS
IPC分类号： C12Q1/68 , B01L3/00
CPC分类号： C12Q1/6837 , B01F11/0045 , B01L3/5027 , B01L3/502746 , B01L7/52 , B01L7/525 , B01L2200/027 , B01L2300/044 , B01L2300/0636 , B01L2300/0654 , B01L2300/0816 , B01L2300/0819 , B01L2300/0864 , B01L2300/0877 , B01L2300/1827 , B01L2300/1838 , B01L2400/0481 , G01N21/6452 , G01N21/6458
摘要： The present invention relates to devices and methods for the detection of analytes. In particular, the invention relates to methods for the qualitative and/or quantitative detection of analytes, comprising a microarray on a substrate, onto which probe molecules are immobilized on array elements, said microarray being disposed on a first surface of the device; and a detection chamber formed between the first surface including the microarray disposed thereon and a second surface, wherein the distance between the microarray and the second surface is variable, and wherein the second surface has a displacement structure.
摘要翻译：本发明涉及用于检测分析物的装置和方法。特别地，本发明涉及用于定性和/或定量检测分析物的方法，其包括在基底上的微阵列，探针分子固定在阵列元件上，所述微阵列设置在装置的第一表面上; 以及形成在包括设置在其上的微阵列的第一表面和第二表面之间的检测室，其中微阵列和第二表面之间的距离是可变的，并且其中第二表面具有位移结构。

10. 发明申请

WO2008034914A3 A DISPENSER DEVICE FOR AND A METHOD OF DISPENSING A SUBSTANCE ONTO A SUBSTRATE 审中-公开
标题翻译：用于分配物质的分配器装置和分配物质的方法
公开(公告)号：WO2008034914A3
公开(公告)日：2008-07-31
申请号：PCT/EP2007060129
申请日：2007-09-24
申请人： CLONDIAG GMBH , ERMANTRAUT EUGEN , SCHULZ TORSTEN , FISCHER JOACHIM , WEICHERDING DANIEL , POSER SIEGFRIED , KIRST MATTHIAS
发明人： ERMANTRAUT EUGEN , SCHULZ TORSTEN , FISCHER JOACHIM , WEICHERDING DANIEL , POSER SIEGFRIED , KIRST MATTHIAS
IPC分类号： G01N35/10 , G01N35/00 , G01N35/02
CPC分类号： G01N35/1011 , G01N35/028 , G01N35/109 , G01N2001/4027 , G01N2035/00158 , G01N2035/1037 , G01N2035/1039
摘要： A dispenser device (100) for dispensing a substance (101) onto a substrate (102), the dispenser device (100) comprising a gripper unit (103) adapted for gripping a container (104) including the substance (101), a first motion mechanism (116, 117) adapted for moving the gripper unit (103) and the substrate (102) relative to each other within a planar region (106), and a second motion mechanism (115, 201 to 209) adapted for moving the gripper unit (103) and the substrate (102) relative to each other in a direction (108) essentially perpendicular to the planar region (106) to thereby dispense the substance (101) to a surface portion (109) of the substrate (102), wherein the first motion mechanism (115) and the second motion mechanism (116, 117) are decoupled from one another.
摘要翻译：一种用于将物质（101）分配到基底（102）上的分配器装置（100），所述分配器装置（100）包括适于夹持包括所述物质（101）的容器（104）的夹持器单元（103），第一适于在平坦区域（106）内相对于彼此移动所述夹持单元（103）和所述基板（102）的运动机构（116,117）以及适于移动所述夹持单元夹持器单元（103）和基板（102）在基本上垂直于平面区域（106）的方向（108）上相对于彼此分配，从而将物质（101）分配到基板（102）的表面部分（109）），其中所述第一运动机构（115）和所述第二运动机构（116,117）彼此分离。

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