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1. 发明申请

WO03031063A3 DEVICE FOR HOLDING A SUBSTANCE LIBRARY CARRIER 审中-公开
标题翻译：用于安装物质库支持的装置
公开(公告)号：WO03031063A3
公开(公告)日：2003-09-12
申请号：PCT/EP0211313
申请日：2002-10-09
申请人： CLONDIAG CHIP TECH GMBH , SCHULZ TORSTEN , ERMANTRAUT EUGEN , ULLRICH THOMAS , ELLINGER THOMAS , FISCHER JOACHIM , KAISER THOMAS , MOEBIUS KLAUS-PETER , POSER SIEGFRIED , TUCHSCHEERER JENS , ZEIREN MARTIN
发明人： SCHULZ TORSTEN , ERMANTRAUT EUGEN , ULLRICH THOMAS , ELLINGER THOMAS , FISCHER JOACHIM , KAISER THOMAS , MOEBIUS KLAUS-PETER , POSER SIEGFRIED , TUCHSCHEERER JENS , ZEIREN MARTIN
IPC分类号： G01N33/53 , B01J19/00 , B01L3/00 , B01L7/00 , C12M1/00 , C12N15/09 , C12Q1/68 , G01N33/566 , G01N37/00
CPC分类号： B01L7/52 , B01J2219/00527 , B01J2219/00531 , B01J2219/00596 , B01J2219/00605 , B01J2219/00659 , B01J2219/00722 , B01J2219/00725 , B01L3/502715 , B01L2200/025 , B01L2200/027 , B01L2200/10 , B01L2200/141 , B01L2200/147 , B01L2300/044 , B01L2300/0636 , B01L2300/0877 , B01L2300/1805
摘要： The invention relates to a modularly structured device for holding substance library carriers and the use of said device for qualitative and quantitative detection of given molecular target molecules. The invention more particularly relates to a device (1) for holding a substance library carrier, which is characterized in that two holder elements that can be fixed to one another (101 and 102) form a layer composite consisting of: (i) a cover element (200) that has a detection surface with a substance library (201) on its lower surface and that is optically transparent at least in the area of the detection surface; (ii) an intermediate sealing element (300) having an enclosed groove and (iii) an optically transparent bottom element in the area of the detection surface of the cover element (400), whereby an optically transparent chamber area is obtained.
摘要翻译：本发明涉及一种用于容纳物质库载体的模块化装置及其用于定性和定量检测某些分子靶分子的用途。特别地，本发明涉及一种装置（1），用于保持一个物质文库的载体，其特征在于，两个可固定到彼此保持元件（101和102）的层的复合由在其下侧（I）的盖元件（200）的，检测表面与一种物质库（201），并且是光学透明的，至少在检测表面的面积，（ⅱ）密封并且具有中间元件（300）和一个封闭的凹口（iii）至少在盖部件底部构件的检测面的面积的光学透明（400）形式，由此光学地通过腔室空间出现。

2. 发明申请

WO2006056466A3 METHOD FOR SPECIFICALLY LOCATED SYNTHESIS OF BIOPOLYMERS ON SOLID CARRIERS 审中-公开
标题翻译：在固体支持物上特定位点合成生物聚合物的方法
公开(公告)号：WO2006056466A3
公开(公告)日：2006-08-03
申请号：PCT/EP2005012648
申请日：2005-11-25
申请人： CLONDIAG CHIP TECH GMBH , ELLINGER THOMAS , ERMANTRAUT EUGEN , HOLZHEY NANCY , PLENZ FRANK , SCHULZ TORSTEN , TUCHSCHEERER JENS , WEICHERDING DANIEL
发明人： ELLINGER THOMAS , ERMANTRAUT EUGEN , HOLZHEY NANCY , PLENZ FRANK , SCHULZ TORSTEN , TUCHSCHEERER JENS , WEICHERDING DANIEL
IPC分类号： B01J19/00 , C40B40/06 , C40B50/14
CPC分类号： B82Y30/00 , B01J19/0046 , B01J2219/0043 , B01J2219/00659 , B01J2219/00662 , B01J2219/00675 , B01J2219/00722 , B01J2219/00725 , C40B40/06 , C40B40/10 , C40B50/14 , C40B60/14
摘要： The invention relates to a method for specifically located synthesis of biopolymers such as nucleic acids or peptides and the respective derivatives thereof on solid carriers, wherein local discrimination of synthesis is carried out particularly with the aid of masks, directing aqueous activation reagents for the cleavage of protective groups to predetermined areas on the carrier.
摘要翻译：本发明涉及一种用于生物聚合物的位点特异性的合成方法，如核酸或肽和在固体载体上，其中所述合成的本地鉴别特别是通过使用掩模的情况下进行其各自的衍生物，例如，使得所述水性活化试剂用于除去保护基团，以预定区域在载体上。

3. 发明申请

WO2008135564A3 ASSAYS 审中-公开
公开(公告)号：WO2008135564A3
公开(公告)日：2009-05-22
申请号：PCT/EP2008055508
申请日：2008-05-05
申请人： CLONDIAG GMBH , KAISER THOMAS , MOEBIUS KLAUS-PETER , SCHULZ TORSTEN , UHLIG THOMAS , VON SCHENK ZU SCHWEINSBERG ALE , ERMANTRAUT EUGEN , TUCHSCHEERER JENS
发明人： KAISER THOMAS , MOEBIUS KLAUS-PETER , SCHULZ TORSTEN , UHLIG THOMAS , VON SCHENK ZU SCHWEINSBERG ALEXANDER , ERMANTRAUT EUGEN , TUCHSCHEERER JENS
IPC分类号： B01L3/00
CPC分类号： B01L3/50273 , B01L3/502715 , B01L3/502738 , B01L2300/0636 , B01L2300/0816 , B01L2300/123 , B01L2400/0481
摘要： A method for assaying a sample for each of multiple analytes is described. The method includes contacting an array of spaced-apart test zones with a liquid sample (e.g., whole blood). The test zones disposed within a channel of a microfluidic device. The channel is defined by at least one flexible wall and a second wall which may or may not be flexible. Each test zone comprising a probe compound specific for a respective target analyte. The microfluidic device is compressed to reduce the thickness of the channel, which is the distance between the inner surfaces of the walls within the channel. The presence ofeach analyte is determined by optically detecting an interaction at each of multiple test zones for which the distance between the inner surfaces at the corresponding location is reduced. The interaction ateach test zone is indicative of the presence in the sample of a target analyte.
摘要翻译：描述了用于分析多种分析物中的每一种的样品的方法。该方法包括使间隔开的测试区域的阵列与液体样品（例如全血）接触。测试区域设置在微流体装置的通道内。通道由至少一个柔性壁和可以是柔性的第二壁限定。每个测试区域包含对各个目标分析物特异的探针化合物。微流体装置被压缩以减小通道的厚度，其是通道内的壁的内表面之间的距离。每个分析物的存在通过光学检测在相应位置处的内表面之间的距离减小的多个测试区域中的每一个处的相互作用来确定。每个测试区的相互作用表明在样品中存在目标分析物。

4. 发明申请

WO2010105802A3 ASSAY METHODS USING ARRAY OF TEST ZONES 审中-公开
标题翻译：使用测试区域的测定方法
公开(公告)号：WO2010105802A3
公开(公告)日：2011-03-10
申请号：PCT/EP2010001650
申请日：2010-03-16
申请人： CLONDIAG GMBH , ERMANTRAUT EUGEN , KAISER THOMAS , TUCHSCHEERER JENS , BEIER VICO , SCHULZ TORSTEN , WOESTEMEYER ANKE
发明人： ERMANTRAUT EUGEN , KAISER THOMAS , TUCHSCHEERER JENS , BEIER VICO , SCHULZ TORSTEN , WOESTEMEYER ANKE
IPC分类号： G01N21/64 , G01N21/27
CPC分类号： G01N21/6452 , B01L3/502715 , B01L3/502723 , B01L2200/027 , B01L2200/0684 , B01L2300/0816 , B01L2300/0864 , B01L2300/088 , B01L2400/0481 , B01L2400/0694 , G01N21/274 , G01N2021/6441
摘要： A method for assaying a sample for each of multiple analytes is described. The method includes contacting an array of spaced-apart test zones with a liquid sample (e.g., whole blood). The test zones disposed within a channel of a microfluidic device. The channel is defined by at least one flexible wall and a second wall which may or may not be flexible. Each test zone comprising a probe compound specific for a respective target analyte. The microfluidic device is compressed to reduce the thickness of the channel, which is the distance between the inner surfaces of the walls within the channel. The presence of each analyte is determined by optically detecting an interaction at each of multiple test zones for which the distance between the inner surfaces at the corresponding location is reduced. The interaction at each test zone is indicative of the presence in the sample of a target analyte. Capillary structures of the devices or used in the methods may comprise a matrix and the devices may comprise control elements and methods for assaying of sample may use corresponding controlling activities.
摘要翻译：描述了用于分析多种分析物中的每一种的样品的方法。该方法包括使间隔开的测试区域的阵列与液体样品（例如全血）接触。测试区域设置在微流体设备的通道内。通道由至少一个柔性壁和可以是柔性的第二壁限定。每个测试区域包含对各个目标分析物特异的探针化合物。微流体装置被压缩以减小通道的厚度，其是通道内的壁的内表面之间的距离。每个分析物的存在通过光学检测在相应位置处的内表面之间的距离减小的多个测试区域中的每一个处的相互作用来确定。每个测试区的相互作用表明样品中存在目标分析物。装置的毛细管结构或方法中使用的毛细管结构可以包括基质，并且装置可以包括控制元件和用于测定样品的方法可以使用相应的控制活动。

5. 发明申请

WO2009112594A3 ASSAYS 审中-公开
公开(公告)号：WO2009112594A3
公开(公告)日：2010-03-04
申请号：PCT/EP2009053106
申请日：2009-03-16
申请人： CLONDIAG GMBH , ERMANTRAUT EUGEN , KAISER THOMAS , TUCHSCHEERER JENS , BEIER VICO , SCHULZ TORSTEN , WOESTEMEYER ANKE
发明人： ERMANTRAUT EUGEN , KAISER THOMAS , TUCHSCHEERER JENS , BEIER VICO , SCHULZ TORSTEN , WOESTEMEYER ANKE
IPC分类号： B01L3/00
CPC分类号： G01N33/58 , B01L3/50273 , B01L2200/025 , B01L2200/0684 , B01L2300/0816 , B01L2300/0887 , B01L2300/123 , B01L2400/0481 , Y10T436/25
摘要： A method for assaying a sample for each of multiple analytes is described. The method includes contacting an array of spaced-apart test zones with a liquid sample (e.g., whole blood). The test zones disposed within a channel of a microfluidic device. The channel is defined by at least one flexible wall and a second wall which may or may not be flexible. Each test zone comprising a probe compound specific for a respective target analyte. The microfluidic device is compressed to reduce the thickness of the channel, which is the distance between the inner surfaces of the walls within the channel. The presence of each analyte is determined by optically detecting an interaction at each of multiple test zones for which the distance between the inner surfaces at the corresponding location is reduced. The interaction at each test zone is indicative of the presence in the sample of a target analyte. Capillary structures of the devices or used in the methods may comprise a matrix and the devices may comprise control elements and methods for assaying of sample may use corresponding controlling activities.
摘要翻译：描述了用于分析多种分析物中的每一种的样品的方法。该方法包括使间隔开的测试区域的阵列与液体样品（例如全血）接触。测试区域设置在微流体装置的通道内。通道由至少一个柔性壁和可以是柔性的第二壁限定。每个测试区域包含对各个目标分析物特异的探针化合物。微流体装置被压缩以减小通道的厚度，其是通道内的壁的内表面之间的距离。每个分析物的存在通过光学检测在相应位置处的内表面之间的距离减小的多个测试区域中的每一个处的相互作用来确定。每个测试区域的相互作用表明样品中目标分析物的存在。装置的毛细结构或方法中使用的毛细管结构可以包括基质，并且装置可以包括控制元件和用于测定样品的方法可以使用相应的控制活动。

6. 发明专利

DE50206263D1 未知
公开(公告)号：DE50206263D1
公开(公告)日：2006-05-18
申请号：DE50206263
申请日：2002-10-09
申请人： CLONDIAG CHIP TECH GMBH
发明人： SCHULZ TORSTEN , ERMANTRAUT EUGEN , ULLRICH THOMAS , ELLINGER THOMAS , FISCHER JOACHIM , KAISER THOMAS , MOEBIUS KLAUS-PETER , POSER SIEGFRIED , TUCHSCHEERER JENS , ZEIREN MARTIN
IPC分类号： B01L3/00 , G01N33/53 , B01J19/00 , B01L7/00 , C12M1/00 , C12N15/09 , C12Q1/68 , G01N33/566 , G01N37/00
摘要： Device (1) for supporting a substance library carrier in which two mutually connectable elements (101; 102) form a layered composite so as to create an optically transparent chamber (500). Device (1) for supporting a substance library carrier in which two mutually connectable elements (101; 102) form a layered composite so as to create an optically transparent chamber (500). The composite comprises: (i) a cover (200) that has on its under side a detection surface with the substance library (201) and is optically transparent, at least in the region of the detection surface; (ii) an intermediate element (300) having a sealable opening; and (iii) an optically transparent base element (400), at least in the region of the detection surface. An independent claim is also included for a device (2000) for filling (1).

7. 发明专利

DE10149684B4 未知
公开(公告)号：DE10149684B4
公开(公告)日：2005-02-17
申请号：DE10149684
申请日：2001-10-09
申请人： CLONDIAG CHIP TECH GMBH
发明人： SCHULZ TORSTEN , ERMANTRAUT EUGEN , ULLRICH THOMAS , ELLINGER THOMAS , FISCHER JOACHIM , KAISER THOMAS , MOEBIUS KLAUS-PETER , POSER SIEGFRIED , TUCHSCHEERER JENS , ZIEREN MARTIN
IPC分类号： G01N33/53 , B01J19/00 , B01L3/00 , B01L7/00 , C12M1/00 , C12N15/09 , C12Q1/68 , G01N33/566 , G01N37/00 , G01N35/00
摘要： Device (1) for supporting a substance library carrier in which two mutually connectable elements (101; 102) form a layered composite so as to create an optically transparent chamber (500). Device (1) for supporting a substance library carrier in which two mutually connectable elements (101; 102) form a layered composite so as to create an optically transparent chamber (500). The composite comprises: (i) a cover (200) that has on its under side a detection surface with the substance library (201) and is optically transparent, at least in the region of the detection surface; (ii) an intermediate element (300) having a sealable opening; and (iii) an optically transparent base element (400), at least in the region of the detection surface. An independent claim is also included for a device (2000) for filling (1).

8. 发明专利

DE10200865A1 未知
公开(公告)号：DE10200865A1
公开(公告)日：2002-10-10
申请号：DE10200865
申请日：2002-01-11
申请人： CLONDIAG CHIP TECH GMBH
发明人： ERMANTRAUT EUGEN , KAISER THOMAS , TUCHSCHEERER JENS
IPC分类号： G01N21/64 , G01N33/543 , G01N33/52
摘要： The invention relates to a device for referencing fluorescence signals and/or calibration of fluorescence detection systems, whereby the device comprises an essentially non-fluorescing support, on which are applied polymer layers in several defined regions and with partly varying thicknesses and/or compositions. Said polymer layers are applied to the support such as to fluoresce after corresponding irradiation and the device may thus be used as a fluorescence standard. The invention further relates to a method for the production of said fluorescence standards.

9. 发明专利

DE102004056980A1 未知
公开(公告)号：DE102004056980A1
公开(公告)日：2006-06-01
申请号：DE102004056980
申请日：2004-11-25
申请人： CLONDIAG CHIP TECH GMBH
发明人： ELLINGER THOMAS , ERMANTRAUT EUGEN , HOLZHEY NANCY , PLENZ FRANK , SCHULZ TORSTEN , TUCHSCHEERER JENS , WEICHERDING DANIEL
IPC分类号： C07K1/04 , C07B51/00 , C07B61/00 , C07H1/00 , C07H19/207 , C07H21/00 , C07K17/00 , C12M1/34 , C12Q1/68 , G01N33/50
摘要： Type-specific synthesis of bio-polymers of a defined sequence on pre-determined ranges of a solid carrier comprises gradual coupling of monomer and/or oligomer components (I); where, before the coupling step, at least a pre-determined area of the carrier are activated for coupling of (I) to activate the reactive groups; and the temporary group for protection are removed by addition of an activation reagent in aqueous solution, is new. Independent claims are also included for: (1) a procedure for the type-specific synthesis of biopolymers of a defined sequence on pre-determined ranges of solid carrier, comprising: (a) arranging a mask on the carrier (for coupling of (I) of the biopolymer, which is to be synthesized for controlling available reactive groups with protection groups to the carrier); (b) activating the reactive groups by removing the temporary protective groups at the ranges given by the mask, by adding the activation reagent in aqueous solution; (c) coupling (I) with activated reactive groups; and (d) repeating step (a) to (c), until the desired biopolymers is synthesized; (2) a micro array prepared by the process; and (3) a micro array with pre-determined ranges immobilized biopolymer probes, where the proportional portion P at biopolymers, which exhibits the desired number of monomer M, is given by the formula P = S-M (where S is an average step yield with the coupling of (I); and the density at pre-determined ranges is at least 1500 spots per cm 2>and the average step yield is 95 (preferably 98) %).

10. 发明专利

DE50210457D1 未知
公开(公告)号：DE50210457D1
公开(公告)日：2007-08-23
申请号：DE50210457
申请日：2002-03-20
申请人： CLONDIAG CHIP TECH GMBH
发明人： ERMANTRAUT EUGEN , KAISER THOMAS , TUCHSCHEERER JENS
IPC分类号： G01N21/64 , C12M1/00 , C12N15/09 , C12Q1/68 , G01N21/27 , G01N33/483 , G01N33/53 , G01N33/566 , G01N33/68 , G01N37/00
摘要： The invention relates to a device for referencing fluorescence signals and/or calibration of fluorescence detection systems, whereby the device comprises an essentially non-fluorescing support, on which are applied polymer layers in several defined regions and with partly varying thicknesses and/or compositions. Said polymer layers are applied to the support such as to fluoresce after corresponding irradiation and the device may thus be used as a fluorescence standard. The invention further relates to a method for the production of said fluorescence standards.

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