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    • 4. 发明申请
    • MEROCYANINE DERIVATIVES
    • WO2006003094A2
    • 2006-01-12
    • PCT/EP2005/052850
    • 2005-06-20
    • CIBA SPECIALTY CHEMICALS HOLDING INC.WAGNER, BarbaraBIENEWALD, FrankWOLLEB, HeinzWALLQUIST, OlofHERZOG, BerndEHLIS, ThomasHAASE, Jürg
    • WAGNER, BarbaraBIENEWALD, FrankWOLLEB, HeinzWALLQUIST, OlofHERZOG, BerndEHLIS, ThomasHAASE, Jürg
    • A61K7/42
    • A61K8/498A61K8/4913A61K8/494A61Q17/04
    • Disclosed is the use of merocyanine derivatives of formula (I), wherein Q is hydrogen; C 1 -C 22 alkyl; -OH; -OR 7 ; -NR 7 R 8 ; or -N=R 9 ; R 1 is hydrogen; C 1 -C 22 alkyl; -OR 7 , -SR 7 ; -NR 7 R 8 ; C 1 -C 22 alkyl; C 2 -C 12 alkenyl; C 2 -C 12 alkinyl; C 3 -C 12 cycloalkyl; C 3 -C 12 cycloalkenyl; C 7 -C 12 aralkyl; C 1 -C 12 heteroalkyl, C 2 -C 11 heteroaralkyl; C 6 -C 10 aryl; or C 1 -C 9 heteroaryl; R 4 is cyano; COR 7 , COOR 7 ; CONR 7 R 8 ; SO 2 (C 6 -C 12 )aryl; C 2 -C 12 alk-1-enyl; C 3 -C 12 cycloalk-1-enyl; C 2 -C 12 alk-1-inyl; C 2 -C 12 heteroalkyl; C 3 -C 5 heterocycloalkyl; C 6 -C 10 aryl; or C 1 -C 9 heteroaryl; R 5 is -COR 7 ; -COOR 7 ; -OR 7 ; -SR 7 , -NHR 7 , -NR 7 R 8 ; C 1 -C 22 alkyl; C 2 -C 12 alkenyl; C 2 -C 12 alkinyl; C 3 -C 12 cycloalkyl; C 3 -C 12 cycloalkenyl; C 7 -C 12 aralkyl; C 1 -C 12 alkylphenyl; C 1 -C 12 alkoxy-C 6 -C 10 aryl; C 1 -C 12 heteroalkyl; C 2 -C 11 heteroaralkyl; C 3 -C 12 cycloheteroalkyl; C 6 -C 10 aryl; C 1 - C 12 alkoxy-C 6 -C 10 aryl; or C 1 -C 9 heteroaryl; R 6 is hydrogen; C 1 -C 22 alkyl; C 1 -C 22 alkoxy; or COR 7 ; R 7 and R 8 independently from each other are hydrogen; C 1 -C 22 alkyl; C 2 -C 12 alkenyl; C 2 -C 12 alkinyl; C 3 -C 12 cycloalkyl; C 3 -C 12 cycloalkenyl; -(CH 2 ) t COOH; C 7 -C 12 aralkyl; C 1 -C 12 heteroalkyl; C 2 -C 11 heteroaralkyl; C 6 -C 10 aryl; C 1 -C 9 heteroaryl; Si-R 10 R 11 R 12 ; Si(OR 10 )(OR 11 )(OR 12 ); SiR 10 (OR 11 )(OR 12 ); SiR 10 R 11 (OR 12 ); -(CH 2 ) u -O-(CH 2 ) v -SiR 10 R 11 R 12 ; or a radical X-Sil; t, u and v, independently from each other are a number from 1 to 5; R 9 is a (C 1 -C 6 )alkylidene radical; R 10 , R 11 , R 12 independently form each other are C 1 -C 22 alkyl; X is a linker; Sil is a silane-, oligosiloxane- or polysiloxane radical; R 1 and R 2 , R 1 and Q, R 1 and R 6 , R 1 and T, R 2 and R 3 , R 2 and R 4 , R 2 and R 6 , R 2 and Q, R 4 and R 6 , R 4 and T, R 6 and Q, T and Q, each independently, are linked together, so that 1, 2, 3 or 4 carbocyclic or N, O and/or S-heterocyclic rings are formed, wherein each of them, independently from each other, may be condensed with an aromatic or heteroaromatic ring, and/or more N-, O- and/or S-heterocyclic rings, and each N atom in a N-heterocyclic ring may be substituted by C 1 -C 22 alkyl; n is a number from 1 to 4; wherein at least one of the radicals R 1 , R 6 or Q is different from hydrogen; if n = 1 T is -COR 5 ; -CN; C 6 -C 10 aryl; -NHR 5 ; or -SO 2 -(C 6 -C 12 )aryl; R 2 and R 3 independently from each other are C 1 -C 22 alkyl; hydroxy-C 1 -C 22 alkyl; C 2 -C 12 alkenyl; C 2 -C 12 alkinyl; C 3 -C 12 cycloalkyl, C 3 -C 12 cycloalkenyl; C 7 -C 12 aralkyl; C 1 -C 12 heteroalkyl; C 3 -C 12 cycloheteroalkyl; C 6 -C 10 aryl; C 1 -C 9 heteroaryl; or a radical of formula (II); p is a number from 5 to 100; q is a number from 1 to 5; s is a number from 0 to 4; if n = 2 R 2 and R 3 are each C 1 -C 5 alkylene; and simultaneously T is defined as for n = 1; or T is a bivalent radical of formula -NR 7 -V-NR 7 -, wherin V is phenylene; or C 1 -C 5 alkylene; R 7 is hydrogen; or C 1 -C 5 alkyl; and R 2 and R 3 simultaneously are defined as for n = 1; if n = 3 one of R 2 , R 3 or T is a trivalent radical; if n = 4 one of R 2 , R 3 or T is a tetravalent radical; for protecting of human hair and skin against the damaging effect of UV radiation.