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1. 发明申请

WO2008099081A3 NOVEL TRIAZABENZO[?]NAPHTHO[2,L,8-CDE]AZULENE DERIVATIVES, METHOD FOR PREPARING THE SAME AND PHARMACEUTICAL COMPOSITIONS CONTAINING THE SAME 审中-公开
标题翻译：新型三唑并[α]萘基[2，L，8-CDE]亚苄基衍生物，其制备方法和含有该衍生物的药物组合物
公开(公告)号：WO2008099081A3
公开(公告)日：2008-10-23
申请号：PCT/FR2008000012
申请日：2008-01-04
申请人： SERVIER LAB , CENTRE NAT RECH SCIENT , UNIV PARIS SUD , BRION JEAN-DANIEL , HERVE MAUD , MOREAU ANNE , RENKO ZAFIARISOA DOLOR , LE RIDANT ALAIN , HARPEY CATHERINE
发明人： BRION JEAN-DANIEL , HERVE MAUD , MOREAU ANNE , RENKO ZAFIARISOA DOLOR , LE RIDANT ALAIN , HARPEY CATHERINE
IPC分类号： C07D471/22 , A61K31/551 , A61P25/00
CPC分类号： C07D471/22
摘要： The invention relates to compounds of formula (I), to their enantiomers, diastereoisomers, and N-oxides, as well as to their addition salts to a pharmaceutically acceptable acid or base. The compounds according to the invention are powerful tyrosine hydroxylase inducers.
摘要翻译：本发明涉及式（I）化合物，其对映异构体，非对映异构体和N-氧化物，以及它们与药学上可接受的酸或碱的加成盐。根据本发明的化合物是强大的酪氨酸羟化酶诱导剂。

2. 发明专利

AR064747A1 DERIVADOS DE TRIAZABENZO[(ALFA)]NAFTO[2,1,8-CDE]AZULENO SU PORCEDIMIENTO DE PREPARACION Y LAS COMPOSICIONES FARMACEUTICAS QUE LOS CONTIENEN 未知
公开(公告)号：AR064747A1
公开(公告)日：2009-04-22
申请号：ARP080100029
申请日：2008-01-04
申请人： SERVIER LAB , UNIV PARIS SUD , CENTRE NAT RECH SCIENT
发明人： HERVET MAUD , MOREAU ANNE , RENKO ZAFIARISOA DOLOR , LE RIDANT ALAIN , HARPEY CATHERINE , BRION JEAN-DANIEL
IPC分类号： C07D471/22 , C07D487/12 , A61K31/551 , A61P25/00
摘要： Reivindicacion 1: Compuesto de formula (1), en la que R1 representa un átomo de hidrogeno o un grupo alquilo C1-6 lineal o ramificado, aminoalquilo C1-6 lineal o ramificado, o hidroxialquilo C1-6 lineal o ramificado, R2 representa un átomo de hidrogeno, o R1 y R2 junto con los átomos de carbono a los que están unidos forman un enlace carbono-carbono, R3 representa un átomo de hidrogeno, R4 representa un átomo de hidrogeno o un grupo metilo o alquilo C3-6 lineal o ramificado, aminoalquilo C1-6 lineal o ramificado, hidroxialquilo C1-6 lineal o ramificado, arilalquilo C1-6 lineal o ramificado, heterocicloalquilalquilo C1-6 lineal o ramificado, o R3 y R4 junto con los átomos de carbono a los que están unidos forman un enlace carbono- carbono, R5, R6, R7, R8, idénticos o diferentes, independientemente el uno del otro, representan un átomo de hidrogeno, o dos sustituyentes geminados (R5 y R6 y/o R7 y R8) forman un grupo oxo, tioxo o imino, R9 representa un átomo de hidrogeno o de halogeno o un grupo alquilo C1-6 lineal o ramificado sustituido opcionalmente, alcoxi C1-6 lineal o ramificado, hidroxi, ciano, nitro, polihalogenoalquilo C1-6 lineal o ramificado, amino (sustituido opcionalmente con uno o dos alquilo C1-6 lineal o ramificado, alquenilo C2-6 lineal o ramificado, pudiendo ser alquilo y alquenilo idénticos o diferentes), R10, R11, idénticos o diferentes, independientemente el uno del otro, representan un átomo de hidrogeno o de halogeno o un grupo alquilo C1-6 lineal o ramificado, alcoxi C1-6 lineal o ramificado, hidroxi, ciano, nitro, polihalogenoalquilo C1-6 lineal o ramificado, amino (sustituido opcionalmente con uno o dos alquilo C1-6 lineal o ramificado, alquenilo C2-6 lineal o ramificado, pudiendo ser alquilo y alquenilo idénticos o diferentes), n representa un numero entero comprendido entre 0 y 4 (0, 1, 2, 3, 4), m representa un numero entero comprendido entre 0 y 2 (0, 1, 2), p representa un numero entero comprendido entre 0 y 3 (0, 1, 2, 3), X representa un grupo NR12, R12 representa un átomo de hidrogeno o un grupo alquilo C1-6 lineal o ramificado sustituido opcionalmente, alquenilo C2-6 lineal o ramificado sustituido opcionalmente, arilalquilo C1-6 lineal o ramificado, polihalogenoalquilo C1-6 lineal o ramificado, sus enantiomeros, diastereoisomeros, N-oxidos, así como sus sales de adicion a un ácido o a una base aceptable farmacéuticamente, entendiéndose que: por arilalquilo, se entiende el grupo arilo-alquilo en el que el grupo alquilo designa una cadena de 1 a 6 átomos de carbono, lineal o ramificado y el grupo arilo designa un grupo fenilo o naftilo sustituido opcionalmente, la expresion ôsustituido opcionalmenteö cuando se refiere a los grupos alquilo C1- 6 lineal, ramificado o alquenilo C2-6 lineal o ramificado o arilalquilo significa que estos grupos pueden estar sustituidos con uno o varios átomos de halogeno, uno o varios grupos hidroxi, alcoxi C1-6 lineal o ramificado o amino sustituido opcionalmente con uno o dos grupos, idénticos o diferentes, alquilo C1-6 lineal o ramificado, por a, b, c y d se entiende los centros quirales presentes opcionalmente en los compuestos de formula (1).

3. 发明专利

CA2674097A1 NOUVEAUX DERIVES AMINOPYRROLO[1,2-A]INDOLE ET AMINOPYRIDAZINO[1,6-A]INDOLE, LEUR PROCEDE DE PREPARATION ET LES COMPOSITIONS PHARMACEUTIQUES QUI LES CONTIENNENT 未知
公开(公告)号：CA2674097A1
公开(公告)日：2008-08-21
申请号：CA2674097
申请日：2008-01-04
申请人： CENTRE NAT RECH SCIENT , UNIV PARIS SUD , SERVIER LAB
发明人： GALTIER CHRISTOPHE , LE RIDANT ALAIN , HARPEY CATHERINE , RENKO ZAFIARISOA DOLOR , HERVET MAUD , LE STRAT FREDERIC , MOREAU ANNE , BRION JEAN-DANIEL
IPC分类号： C07D471/04 , A61K31/4375 , A61K31/5025 , A61P25/22 , A61P25/24 , C07D471/14 , C07D471/16
摘要： L'invention concerne les composés de formule (I); Formule (I) leurs énant iomères, diastcréoisomcres, N-oxydes, ainsi que leurs sels d'addition à un a cide ou à une base pharmaceutiquement acceptable. Les composés de formule (I ) sont des inducteurs de tyrosine hydroxylase.

4. 发明专利

BRPI0806290A2 未知
公开(公告)号：BRPI0806290A2
公开(公告)日：2011-09-06
申请号：BRPI0806290
申请日：2008-01-04
申请人： SERVIER LAB , CENTRE NAT RECH SCIENT , UNIV PARIS SUD
发明人： BRION JEAN-DANIEL , HERVET MAUD , MOREAU ANNE , RENKO ZAFIARISOA DOLOR , LE RIDANT ALAIN , HARPEY CATHERINE
IPC分类号： A61K31/551 , A61P25/00 , C07D471/22
摘要： Triazabenzo[a]naphtho[2,1,8-cde]azulene derivatives (I) are new. Triazabenzo[a]naphtho[2,1,8-cde]azulene derivatives of formula (I) are new. R 1H, 1-6C alkyl, 1-6C aminoalkyl or 1-6C hydroxyalkyl; R 2H; R 1+R 2 = a bond; R 3H; R 4H, Me, 3-6C alkyl, 1-6C aminoalkyl, 1-6C hydroxyalkyl, aryl(1-6C)alkyl or heterocycloalkyl(1-6C)alkyl; R 3+R 4a bond; R 5-R 8H, or R 5+R 6 and/or R 7+R 8 = O, S or NH; R 9H, halo, 1-6C alkyl (optionally substituted with Q), 1-6C alkoxy, OH, CN, NO 2, 1-6C polyhaloalkyl or NRR"; R, R" : H, 1-6C alkyl or 2-6C alkenyl; R 10, R 11H, halo, 1-6C alkyl, 1-6C alkoxy, OH, CN, NO 2, 1-6C polyhaloalkyl or NRR"; n : 0-4; m : 0-2; p : 0-3; X : NR 12; R 12H, 1-6C alkyl (optionally substituted with Q), 2-6C alkenyl (optionally substituted with Q), aryl(1-6C)alkyl, 1-6C polyhaloalkyl; aryl : optionally substituted phenyl or naphthyl; Q : halo, OH, 1-6C alkyl, 1-6C alkoxy, NH 2 or mono- or di(1-6C alkyl)amino. An independent claim is also included for a process for preparing (I). [Image] ACTIVITY : Antidepressant; Tranquilizer; Nootropic; Neuroprotective; Antiparkinsonian. MECHANISM OF ACTION : Tyrosine hydroxylase inducer. Administering (5aRS,12aSR,12bSR,12cSR)-7-chloro-2,3,5a,10,12a,12b,12c-hexahydro-1H,4H-3a,9b,11-triazabenzo[a]naphtho[2,1,8-cde]azulene-10,12(5H,11H)-dione to mice by intraperitoneal injection (20 mg/kg) gave a 53% increase in tyrosine hydroxylase level in an anterior section of the locus coeruleus.

5. 发明专利

BRPI0806274A2 未知
公开(公告)号：BRPI0806274A2
公开(公告)日：2011-09-06
申请号：BRPI0806274
申请日：2008-01-04
申请人： SERVIER LAB , CENTRE NAT RECH SCIENT , UNIV PARIS SUD
发明人： BRION JEAN-DANIEL , GALTIER CHRISTOPHE , HERVET MAUD , LE STRAT FREDERIC , MOREAU ANNE , RENKO ZAFIARISOA DOLOR , LE RIDANT ALAIN , HARPEY CATHERINE
IPC分类号： C07D471/04 , A61K31/4375 , A61K31/5025 , A61P25/22 , A61P25/24 , C07D471/14 , C07D471/16
摘要： Amino-pyrrolo(1,2-a)indole and amino-pyridazino(1,6-a)indole derivatives (I) are new. Fused indole derivatives of formula (I) (including enantiomers and diastereomers) and their N-oxides and acid or base addition salts are new. X : CO or -N(R 10)-CO- (bonded to N at the left-hand terminal); R 1H, alkyl, aminoalkyl, hydroxyalkyl or arylalkyl; R 2 - R 4H, alkyl, aminoalkyl or hydroxyalkyl; or R 1 + R 2 or R 3 + R 4additional C-C bond; R 5, R 6H or alkyl; R 7, R 8H; or alkyl, alkenyl or alkynyl (all optionally substituted (os) by one or more of OH, CN, alkoxy and NR 13R 14); or R 5 + R 8 or R 7 + R 8group completing a 5-7 membered heterocycle (os by R 11), provided that at least one heterocycle-completing group as R 5 + R 8 or R 7 + R 8 must be present; R 9H, halo, alkyl (os by one or more of halo, OH, alkoxy or NR 15R 16), alkoxy, OH, CN, NO 2, polyhaloalkyl or NR 15R 16; n : 0-4; R 10H, alkyl (os by one or more of halo, OH, alkoxy or NR 15R 16), alkenyl, arylalkyl or polyhaloalkyl; R 11COOT or CH 2OU'; T, U' : H or alkyl; R 13, R 14H or alkyl; or NR 13R 14os 4-8 membered heterocycle, optionally containing a double bond or a second O or N heteroatom; R 15, R 16H, alkyl or alkenyl; aryl moieties : phenyl or naphthyl (both os by one or more of halo, NO 2, NH 2, alkyl or alkoxy); 5-7 membered heterocycle : e.g. pyrrolidine, piperidine or azepane; 4-8 membered heterocycle : e.g. pyrrolidine, piperidine, azepane, piperazine or morpholine (all os by one or more of alkyl, hydroxyalkyl, alkoxyalkyl, aminoalkyl or mono- or dialkylaminoalkyl; alkyl moieties have 1-6C and alkenyl or alkynyl moieties 2-6C; the compound (3aSR,RSR)-3-benzyl-4-ethyl-2,3,3a,4-tetrahydro-benzo(b)pyrido(2,3,4-gh)pyrrolizin-5(1H)-one is excluded. Independent claims are included for the preparation of (I). [Image] ACTIVITY : Tranquilizer; Antidepressant; Nootropic; Neuroprotective; Antiparkinsonian. MECHANISM OF ACTION : Tyrosine hydroxylase (TH) inducer. (4aSR,11aSR,11bRS)-1-Methyl-1,2,3,4,4a,11,11a,11b-octahydro-pyrido(2',3':3,4)pyrrolo(1,2-a)indol-5-one (Ia) induced an increase in the TH levels in the locus coeruleus of the brain in mice after intravenous injection at a dose of 20 mg/kg.

6. 发明专利

FR2911141B1 未知
公开(公告)号：FR2911141B1
公开(公告)日：2009-02-20
申请号：FR0700046
申请日：2007-01-05
申请人： SERVIER LAB , CENTRE NAT RECH SCIENT , UNIV PARIS SUD
发明人： BRION JEAN DANIEL , HERVET MAUD , MOREAU ANNE , RENKO ZAFIARISOA DOLOR , LE RIDANT ALAIN , HARPEY CATHERINE
IPC分类号： C07D471/22 , A61K31/551 , A61P25/00 , A61P25/22 , A61P25/28 , C07D209/14 , C07D211/22 , C07D211/56 , C07D211/70 , C07D243/04
摘要： Triazabenzo[a]naphtho[2,1,8-cde]azulene derivatives (I) are new. Triazabenzo[a]naphtho[2,1,8-cde]azulene derivatives of formula (I) are new. R 1H, 1-6C alkyl, 1-6C aminoalkyl or 1-6C hydroxyalkyl; R 2H; R 1+R 2 = a bond; R 3H; R 4H, Me, 3-6C alkyl, 1-6C aminoalkyl, 1-6C hydroxyalkyl, aryl(1-6C)alkyl or heterocycloalkyl(1-6C)alkyl; R 3+R 4a bond; R 5-R 8H, or R 5+R 6 and/or R 7+R 8 = O, S or NH; R 9H, halo, 1-6C alkyl (optionally substituted with Q), 1-6C alkoxy, OH, CN, NO 2, 1-6C polyhaloalkyl or NRR"; R, R" : H, 1-6C alkyl or 2-6C alkenyl; R 10, R 11H, halo, 1-6C alkyl, 1-6C alkoxy, OH, CN, NO 2, 1-6C polyhaloalkyl or NRR"; n : 0-4; m : 0-2; p : 0-3; X : NR 12; R 12H, 1-6C alkyl (optionally substituted with Q), 2-6C alkenyl (optionally substituted with Q), aryl(1-6C)alkyl, 1-6C polyhaloalkyl; aryl : optionally substituted phenyl or naphthyl; Q : halo, OH, 1-6C alkyl, 1-6C alkoxy, NH 2 or mono- or di(1-6C alkyl)amino. An independent claim is also included for a process for preparing (I). [Image] ACTIVITY : Antidepressant; Tranquilizer; Nootropic; Neuroprotective; Antiparkinsonian. MECHANISM OF ACTION : Tyrosine hydroxylase inducer. Administering (5aRS,12aSR,12bSR,12cSR)-7-chloro-2,3,5a,10,12a,12b,12c-hexahydro-1H,4H-3a,9b,11-triazabenzo[a]naphtho[2,1,8-cde]azulene-10,12(5H,11H)-dione to mice by intraperitoneal injection (20 mg/kg) gave a 53% increase in tyrosine hydroxylase level in an anterior section of the locus coeruleus.

7. 发明专利

AU2008214549A1 New aminopyrrolo[1,2-Alpha]indole et aminopyridazino[1,6-Alpha]indole derivatives, method for preparing the same and pharmaceutical compositions containing the same 未知
公开(公告)号：AU2008214549A1
公开(公告)日：2008-08-21
申请号：AU2008214549
申请日：2008-01-04
申请人： CENTRE NAT RECH SCIENT , SERVIER LAB , UNIV PARIS SUD
发明人： HARPEY CATHERINE , MOREAU ANNE , HERVET MAUD , BRION JEAN-DANIEL , GALTIER CHRISTOPHE , STRAT FREDERIC LE , RENKO ZAFIARISOA DOLOR , RIDANT ALAIN LE
IPC分类号： C07D471/04 , A61K31/4375 , A61K31/5025 , A61P25/22 , A61P25/24 , C07D471/14 , C07D471/16
摘要： Amino-pyrrolo(1,2-a)indole and amino-pyridazino(1,6-a)indole derivatives (I) are new. Fused indole derivatives of formula (I) (including enantiomers and diastereomers) and their N-oxides and acid or base addition salts are new. X : CO or -N(R 10)-CO- (bonded to N at the left-hand terminal); R 1H, alkyl, aminoalkyl, hydroxyalkyl or arylalkyl; R 2 - R 4H, alkyl, aminoalkyl or hydroxyalkyl; or R 1 + R 2 or R 3 + R 4additional C-C bond; R 5, R 6H or alkyl; R 7, R 8H; or alkyl, alkenyl or alkynyl (all optionally substituted (os) by one or more of OH, CN, alkoxy and NR 13R 14); or R 5 + R 8 or R 7 + R 8group completing a 5-7 membered heterocycle (os by R 11), provided that at least one heterocycle-completing group as R 5 + R 8 or R 7 + R 8 must be present; R 9H, halo, alkyl (os by one or more of halo, OH, alkoxy or NR 15R 16), alkoxy, OH, CN, NO 2, polyhaloalkyl or NR 15R 16; n : 0-4; R 10H, alkyl (os by one or more of halo, OH, alkoxy or NR 15R 16), alkenyl, arylalkyl or polyhaloalkyl; R 11COOT or CH 2OU'; T, U' : H or alkyl; R 13, R 14H or alkyl; or NR 13R 14os 4-8 membered heterocycle, optionally containing a double bond or a second O or N heteroatom; R 15, R 16H, alkyl or alkenyl; aryl moieties : phenyl or naphthyl (both os by one or more of halo, NO 2, NH 2, alkyl or alkoxy); 5-7 membered heterocycle : e.g. pyrrolidine, piperidine or azepane; 4-8 membered heterocycle : e.g. pyrrolidine, piperidine, azepane, piperazine or morpholine (all os by one or more of alkyl, hydroxyalkyl, alkoxyalkyl, aminoalkyl or mono- or dialkylaminoalkyl; alkyl moieties have 1-6C and alkenyl or alkynyl moieties 2-6C; the compound (3aSR,RSR)-3-benzyl-4-ethyl-2,3,3a,4-tetrahydro-benzo(b)pyrido(2,3,4-gh)pyrrolizin-5(1H)-one is excluded. Independent claims are included for the preparation of (I). [Image] ACTIVITY : Tranquilizer; Antidepressant; Nootropic; Neuroprotective; Antiparkinsonian. MECHANISM OF ACTION : Tyrosine hydroxylase (TH) inducer. (4aSR,11aSR,11bRS)-1-Methyl-1,2,3,4,4a,11,11a,11b-octahydro-pyrido(2',3':3,4)pyrrolo(1,2-a)indol-5-one (Ia) induced an increase in the TH levels in the locus coeruleus of the brain in mice after intravenous injection at a dose of 20 mg/kg.

9. 发明专利

AT466863T 未知
公开(公告)号：AT466863T
公开(公告)日：2010-05-15
申请号：AT08761737
申请日：2008-01-04
申请人： SERVIER LAB , CENTRE NAT RECH SCIENT , UNIV PARIS SUD
发明人： BRION JEAN-DANIEL , GALTIER CHRISTOPHE , HERVET MAUD , LE STRAT FREDERIC , MOREAU ANNE , RENKO ZAFIARISOA , LE RIDANT ALAIN , HARPEY CATHERINE
IPC分类号： C07D471/04 , A61K31/4375 , A61K31/5025 , A61P25/22 , A61P25/24 , C07D471/14 , C07D471/16
摘要： Amino-pyrrolo(1,2-a)indole and amino-pyridazino(1,6-a)indole derivatives (I) are new. Fused indole derivatives of formula (I) (including enantiomers and diastereomers) and their N-oxides and acid or base addition salts are new. X : CO or -N(R 10)-CO- (bonded to N at the left-hand terminal); R 1H, alkyl, aminoalkyl, hydroxyalkyl or arylalkyl; R 2 - R 4H, alkyl, aminoalkyl or hydroxyalkyl; or R 1 + R 2 or R 3 + R 4additional C-C bond; R 5, R 6H or alkyl; R 7, R 8H; or alkyl, alkenyl or alkynyl (all optionally substituted (os) by one or more of OH, CN, alkoxy and NR 13R 14); or R 5 + R 8 or R 7 + R 8group completing a 5-7 membered heterocycle (os by R 11), provided that at least one heterocycle-completing group as R 5 + R 8 or R 7 + R 8 must be present; R 9H, halo, alkyl (os by one or more of halo, OH, alkoxy or NR 15R 16), alkoxy, OH, CN, NO 2, polyhaloalkyl or NR 15R 16; n : 0-4; R 10H, alkyl (os by one or more of halo, OH, alkoxy or NR 15R 16), alkenyl, arylalkyl or polyhaloalkyl; R 11COOT or CH 2OU'; T, U' : H or alkyl; R 13, R 14H or alkyl; or NR 13R 14os 4-8 membered heterocycle, optionally containing a double bond or a second O or N heteroatom; R 15, R 16H, alkyl or alkenyl; aryl moieties : phenyl or naphthyl (both os by one or more of halo, NO 2, NH 2, alkyl or alkoxy); 5-7 membered heterocycle : e.g. pyrrolidine, piperidine or azepane; 4-8 membered heterocycle : e.g. pyrrolidine, piperidine, azepane, piperazine or morpholine (all os by one or more of alkyl, hydroxyalkyl, alkoxyalkyl, aminoalkyl or mono- or dialkylaminoalkyl; alkyl moieties have 1-6C and alkenyl or alkynyl moieties 2-6C; the compound (3aSR,RSR)-3-benzyl-4-ethyl-2,3,3a,4-tetrahydro-benzo(b)pyrido(2,3,4-gh)pyrrolizin-5(1H)-one is excluded. Independent claims are included for the preparation of (I). [Image] ACTIVITY : Tranquilizer; Antidepressant; Nootropic; Neuroprotective; Antiparkinsonian. MECHANISM OF ACTION : Tyrosine hydroxylase (TH) inducer. (4aSR,11aSR,11bRS)-1-Methyl-1,2,3,4,4a,11,11a,11b-octahydro-pyrido(2',3':3,4)pyrrolo(1,2-a)indol-5-one (Ia) induced an increase in the TH levels in the locus coeruleus of the brain in mice after intravenous injection at a dose of 20 mg/kg.

10. 发明专利

MA31144B1 NOUVEAUX DÉRIVÉS TRIAZABENZO[A]NAPHTHO[2,L,8-CDE]AZULÈNE, LEUR PROCÉDÉ DE PRÉPARATION ET LES COMPOSITIONS PHARMACEUTIQUES QUI LES CONTIENNENT 未知
公开(公告)号：MA31144B1
公开(公告)日：2010-02-01
申请号：MA32051
申请日：2009-06-29
申请人： SERVIER LAB , CENTRE NAT RECH SCIENT , UNIV PARIS SUD
发明人： HARPEY CATHERINE , BRION JEAN-DANIEL , HERVE MAUD , MOREAU ANNE , RENKO ZAFIARISOA DOLOR , LE RIDANT ALAIN
IPC分类号： C07D471/22 , A61K31/551 , A61P25/00
摘要： Composés de formule (I), leurs énantiomères, diastéréoisomères, N-oxydes, ainsi que leurs sels d'addition à un acide ou à une base pharmaceutiquement acceptable. Les composés de la présente invention se révèlent être de puissants inducteurs de tyrosine hydroxylase.

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