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1. 发明申请

WO2009099526A2 APPARATUS AND METHOD FOR IMAGING IONIZING RADIATION 审中-公开
标题翻译：用于成像电离辐射的装置和方法
公开(公告)号：WO2009099526A2
公开(公告)日：2009-08-13
申请号：PCT/US2009/000457
申请日：2009-01-23
申请人： CARESTREAM HEALTH, INC. , FEKE, Gilbert , WOOD, Douglas O. , VIZARD, Douglas L.
发明人： FEKE, Gilbert , WOOD, Douglas O. , VIZARD, Douglas L.
IPC分类号： G03B42/02 , G03C5/17
CPC分类号： A61B5/0059 , A61B6/00 , A61B6/4216 , A61B6/5241 , A61B6/583 , G03B42/023 , G21K2004/06
摘要： A system and method are disclosed for capturing a radiographic or autoradiographic image of an object, in which a support member is provided to receive the object in an immobilized state; a phosphor screen is provided to transduce ionizing radiation from the source to visible light; film or a digital capture device is provided for capturing an image using the visible light; and the phosphor screen is moved incrementally to facilitate reduction of phosphor screen mottle.
摘要翻译：公开了一种用于捕获物体的放射线照相或放射自显影图像的系统和方法，其中提供支撑构件以在固定状态下接收物体; 提供荧光屏以将来自光源的电离辐射转换成可见光; 提供胶片或数字捕获设备用于使用可见光捕获图像; 并且荧光屏逐渐移动以促进荧光屏斑点的减少。

2. 发明申请

WO2010042139A1 TUNABLE SPECTRAL FILTRATION DEVICE 审中-公开
标题翻译：可调光谱过滤装置
公开(公告)号：WO2010042139A1
公开(公告)日：2010-04-15
申请号：PCT/US2009/002610
申请日：2009-04-29
申请人： CARESTREAM HEALTH, INC. , FEKE, Gilbert , VIZARD, Douglas, L.
发明人： FEKE, Gilbert , VIZARD, Douglas, L.
IPC分类号： G02B5/28 , G02B5/02
CPC分类号： G02B5/285 , G02B26/002 , G02B26/008 , G02B26/023
摘要： A tunable spectral filtration device includes one or more pairs of interference filters in series, each element of each pair is independently selected, independently positioned to intersect a path of converging or diverging light, and independently tilted with respect to the light path. Each filter may be a bandpass type, a shortpass type, a longpass type, a notch type, or combinations thereof. Each filter may be independently selected and tilted to tune the net spectral output of the series. The elements in a pair of filters may be tilted in opposite directions to cancel angle-of incidence dependent broadening of the spectral output of the individual filters for noncollimated light, or cancel translational shift of the transmitted light rays. The elements in a pair of filters may be tilted through orthogonal tilt axes to cancel polarization dependent broadening of the spectral output of the individual filters.
摘要翻译：可调谐光谱过滤装置包括一对或多对串联的干涉滤光片，每对中的每个元件被独立地选择，独立地定位成与会聚光或发散光相交并相对于光路独立地倾斜。每个滤波器可以是带通型，短路型，长通型，陷波型或其组合。可以独立地选择和倾斜每个滤光片以调节该系列的净光谱输出。一对滤波器中的元件可以在相反的方向上倾斜以消除入射角依赖于对于非准直光的各个滤光器的光谱输出的加宽，或者消除透射光线的平移移动。一对滤波器中的元件可以通过正交倾斜轴倾斜以消除各个滤波器的频谱输出的偏振相关的加宽。

3. 发明申请

WO2009120281A2 SPATIAL ORIENTATION METHOD OF AN IMMOBILIZED SUBJECT 审中-公开
标题翻译：固定主体的空间定位方法
公开(公告)号：WO2009120281A2
公开(公告)日：2009-10-01
申请号：PCT/US2009/001694
申请日：2009-03-18
申请人： CARESTREAM HEALTH, INC. , FEKE, Gilbert , PAPINENI, Rao , CHEN, Shoupu , WOOD, Douglas , MCLAUGHLIN, William
发明人： FEKE, Gilbert , PAPINENI, Rao , CHEN, Shoupu , WOOD, Douglas , MCLAUGHLIN, William
IPC分类号： A61B6/00
CPC分类号： A61B5/0073 , A01K1/031 , A61B5/0035 , A61B6/04 , A61B6/4417 , A61B6/508 , A61B6/5235 , A61B6/5247 , A61B2503/40
摘要： Methods are disclosed for (A) adjusting the physical, spatial orientation of an immobilized subject in a multi-modal imaging system so as substantially to reproduce or match the physical, spatial orientation of a reference subject, wherein the reference subject is either (a) the same or (b) a different subject, either (1) during a prior imaging session for a later imaging session, or, in the case where a plurality of subjects is imaged in one imaging session, (2) during a contemporaneous imaging session; and (B) adjusting the virtual, spatial orientation of an immobilized subject in a set of multi-modal images.
摘要翻译：公开了用于（A）调整多模式成像系统中的固定对象的物理空间定向以基本上复制或匹配参考对象的物理空间定向的方法，其中参考对象是（a）相同的或（b）不同的对象，（1）在之前的成像会话期间用于稍后的成像会话，或者在多个对象在一个成像会话中成像的情况下，（2）在同期成像期间; 和（B）调整一组多模态图像中固定对象的虚拟空间取向。

4. 发明申请

WO2013036597A2 ANIMAL SPECIMEN POSITIONING SYSTEM 审中-公开
标题翻译：动物标本定位系统
公开(公告)号：WO2013036597A2
公开(公告)日：2013-03-14
申请号：PCT/US2012/053901
申请日：2012-09-06
申请人： CARESTREAM HEALTH, INC. , HURLEY, Rex, D. , FEKE, Gilbert , GELDHOF, Benjamin , PAPINENI, Rao
发明人： HURLEY, Rex, D. , FEKE, Gilbert , GELDHOF, Benjamin , PAPINENI, Rao
IPC分类号： A01K15/04
CPC分类号： A01K1/0613
摘要： An animal specimen positioning system comprises a mount, at least two elongated receptacles sized and shaped to receive and hold an animal specimen, a connection system for securing the at least two elongated receptacles to the mount and an imaging adaptor for securing said animal positioning system to an imaging device. The at least two elongated receptacles may be configurable in a plurality of different orientations on the mount and the connection system may include a plurality of ports and connectors arranged in different positions. Various iterations of the animal specimen positioning system may together form a kit.
摘要翻译：动物样本定位系统包括支架，至少两个长形容器，其尺寸和形状被设计成接收和保持动物样本;连接系统，用于将至少两个细长容器固定到支架;以及成像用于将所述动物定位系统固定到成像装置的适配器。所述至少两个细长容座可以在所述底座上以多个不同方向配置，并且所述连接系统可以包括布置在不同位置的多个端口和连接器。动物样本定位系统的各种迭代可以一起形成套件。

5. 发明申请

WO2009151554A2 TORSIONAL SUPPORT FOR CRANIOCAUDAL ROTATION OF ANIMALS 审中-公开
标题翻译：动物旋转旋转的扭转支持
公开(公告)号：WO2009151554A2
公开(公告)日：2009-12-17
申请号：PCT/US2009/003380
申请日：2009-06-03
申请人： CARESTREAM HEALTH, INC. , FEKE, Gilbert , GELDHOF, Benjamin , LEEVY, Warren, M. , BRIDGES, Mark, E. , MCLAUGHLIN, William, E.
发明人： FEKE, Gilbert , GELDHOF, Benjamin , LEEVY, Warren, M. , BRIDGES, Mark, E. , MCLAUGHLIN, William, E.
IPC分类号： A61B6/02
CPC分类号： A61B5/0059 , A61B5/0035 , A61B5/0095 , A61B6/0428 , A61B6/0471 , A61B6/4417 , A61B6/508 , A61B2503/40
摘要： A torsional support apparatus is disclosed for craniocaudal rotation of test animals to enable multiple-view imaging. The animal is supported in a U-shaped loop of optically transparent material and the loop is moved to apply torsion to the animal to rotate it about its craniocaudal axis. Methods of imaging also are disclosed that use the torsional support technique.
摘要翻译：公开了一种扭转支撑装置，用于测试动物的头颈部旋转，以实现多视图成像。动物被支撑在光学透明材料的U形环中，并且环被移动以向动物施加扭转以围绕其头颅轴旋转。公开了使用扭转支撑技术的成像方法。

6. 发明申请

WO2009134363A2 VARIABLE CONDENSER FOR DELIVERY OF ILLUMINATION 审中-公开
标题翻译：用于交付照明的可变冷凝器
公开(公告)号：WO2009134363A2
公开(公告)日：2009-11-05
申请号：PCT/US2009/002597
申请日：2009-04-29
申请人： CARESTREAM HEALTH, INC. , FEKE, Gilbert
发明人： FEKE, Gilbert
IPC分类号： F21V8/00 , F21V5/04
CPC分类号： G02B6/04 , G02B6/0008 , G02B26/103
摘要： A variable condenser for delivery of illumination, including a recursively nested circle-to-line fiber optic shape-converting cable and a focusable input lens system. At the input of the fiber optic cable, sets of individual optical fibers comprise successively smaller annuli recursively nested about a common center. At the output of the fiber optic cable, the sets of individual optical fibers comprise pairs of line segments recursively nested about the line midpoint, whereby the nesting level of the pairs of line segments has an exact or an approximate correspondence to the nesting level of the annuli. The output may be split into a plurality of lines, whereby the sets of individual optical fibers are distributed among the plurality of lines. The input lens system has a single adjustable focus means to vary the radius of an illumination spot incident upon the input of the fiber optic cable circle input.
摘要翻译：用于传输照明的可变电容器，包括递归嵌套的圆形到光纤形状转换电缆和可调焦输入透镜系统。在光纤电缆的输入端，单独的光纤组包括相对较小的环，其相对于公共中心递归地嵌套。在光纤电缆的输出处，各组光纤包括一对线段，其以线中点递归地嵌套，由此线段对的嵌套级别具有与嵌套级别的精确或近似对应关系环带。输出可以被分成多条线，由此各组光纤分布在多条线之间。输入透镜系统具有单个可调节聚焦装置，以改变入射到光纤光缆圆输入端的照明点的半径。

7. 发明申请

WO2007081386A3 MICROFLUIDIC DEVICES AND METHODS OF USE 审中-公开
公开(公告)号：WO2007081386A3
公开(公告)日：2007-07-19
申请号：PCT/US2006/021286
申请日：2006-06-01
申请人： RAINDANCE TECHNOLOGIES, INC. , LINK, Darren, R. , BOITARD, Laurent , BRANCIFORTE, Jeffrey , CHARLES, Yves , FEKE, Gilbert , LU, John, Q. , MARRAN, David , TABATABAI, Ahmadali , WEINER, Michael , HINZ, Wolfgang , ROTHBERG, Jonathan, M.
发明人： LINK, Darren, R. , BOITARD, Laurent , BRANCIFORTE, Jeffrey , CHARLES, Yves , FEKE, Gilbert , LU, John, Q. , MARRAN, David , TABATABAI, Ahmadali , WEINER, Michael , HINZ, Wolfgang , ROTHBERG, Jonathan, M.
IPC分类号： B01L3/00 , B01F13/00 , G01N15/14
摘要： The present invention provides novel microfluidic devices and methods that are useful for performing high-throughput screening assays and combinatorial chemistry. The device can include a plurality of electrically addressable, channel bearing fluidic modules integrally arranged on a microfabricated substrate such that a continuous channel is provided for flow of immiscible fluids.

8. 发明申请

WO2007081385A3 MICROFLUIDIC DEVICES AND METHODS OF USE IN THE FORMATION AND CONTROL OF NANOREACTORS 审中-公开
公开(公告)号：WO2007081385A3
公开(公告)日：2007-07-19
申请号：PCT/US2006/021280
申请日：2006-06-01
申请人： RAINDANCE TECHNOLOGIES, INC. , LINK, Darren, R. , BOITARD, Laurent , BRANCIFORTE, Jeffrey , CHARLES, Yves , FEKE, Gilbert , LU, John, Q. , MARRAN, David , TABATABAI, Ahmadali , WEINER, Michael , HINZ, Wolfgang , ROTHBERG, Jonathan, M.
发明人： LINK, Darren, R. , BOITARD, Laurent , BRANCIFORTE, Jeffrey , CHARLES, Yves , FEKE, Gilbert , LU, John, Q. , MARRAN, David , TABATABAI, Ahmadali , WEINER, Michael , HINZ, Wolfgang , ROTHBERG, Jonathan, M.
IPC分类号： G01N33/536 , C12Q1/68 , B01J19/00 , C07B61/00 , C07K1/04 , G01N33/68
摘要： The present invention provides novel microfluidic devices and methods that are useful for performing high-throughput screening assays and combinatorial chemistry. Such methods can include labeling a library of compounds by emulsifying aqueous solutions of the compounds and aqueous solutions of unique liquid labels on a microfluidic device, which includes a plurality of electrically addressable, channel bearing fluidic modules integrally arranged on a microfabricated substrate such that a continuous channel is provided for flow of immiscible fluids, whereby each compound is labeled with a unique liquid label, pooling the labeled emulsions, coalescing the labeled emulsions with emulsions containing a specific cell or enzyme, thereby forming a nanoreactor, screening the nanoreactors for a desirable reaction between the contents of the nanoreactor, and decoding the liquid label, thereby identifying a single compound from a library of compounds.

9. 发明申请

WO2007081387A1 MICROFLUIDIC DEVICES, METHODS OF USE, AND KITS FOR PERFORMING DIAGNOSTICS 审中-公开
标题翻译：微流体装置，使用方法和用于执行诊断的工具
公开(公告)号：WO2007081387A1
公开(公告)日：2007-07-19
申请号：PCT/US2006/021380
申请日：2006-06-01
申请人： RAINDANCE TECHNOLOGIES, INC. , LINK, Darren, R. , BOITARD, Laurent , BRANCIFORTE, Jeffrey , CHARLES, Yves , FEKE, Gilbert , LU, John, Q. , MARRAN, David , TABATABAI, Ahmadali , WEINER, Michael , HINZ, Wolfgang , ROTHBERG, Jonathan, M.
发明人： LINK, Darren, R. , BOITARD, Laurent , BRANCIFORTE, Jeffrey , CHARLES, Yves , FEKE, Gilbert , LU, John, Q. , MARRAN, David , TABATABAI, Ahmadali , WEINER, Michael , HINZ, Wolfgang , ROTHBERG, Jonathan, M.
IPC分类号： G01N33/536 , C12Q1/68 , B01J19/00 , C07B61/00 , C07K1/04 , G01N33/68
CPC分类号： C12N15/1075 , B01F3/0807 , B01F13/0071 , B01F13/0076 , B01J19/0046 , B01J2219/00286 , B01J2219/00459 , B01J2219/00466 , B01J2219/00468 , B01J2219/00479 , B01J2219/005 , B01J2219/00576 , B01J2219/00599 , B01J2219/00702 , B01J2219/0072 , B01J2219/00743 , B01L3/5027 , B01L3/502715 , B01L3/50273 , B01L3/502746 , B01L3/502761 , B01L3/502784 , B01L3/502792 , B01L3/565 , B01L7/52 , B01L2200/027 , B01L2200/0621 , B01L2200/0647 , B01L2200/0652 , B01L2200/0673 , B01L2300/0816 , B01L2300/0864 , B01L2300/0867 , B01L2300/0896 , B01L2400/0415 , B01L2400/0424 , B01L2400/0487 , B01L2400/084 , B82Y5/00 , B82Y30/00 , C07K1/047 , C12Q1/6804 , C12Q1/6816 , C12Q1/6825 , C12Q1/6834 , C12Q1/686 , C12Q1/6869 , C12Q1/6874 , C12Q1/6876 , C12Q2525/161 , C12Q2561/119 , C12Q2563/103 , C12Q2563/107 , C12Q2563/159 , C12Q2565/537 , C12Q2565/629 , C12Q2600/16 , C40B30/04 , C40B40/04 , C40B50/08 , C40B60/08 , C40B60/12 , C40B70/00 , G01N21/6428 , G01N21/6445 , G01N21/6458 , G01N33/536 , G01N33/542 , G01N33/543 , G01N33/6845 , G01N33/6854 , G01N2500/10
摘要： The present invention provides novel microfluidic devices, kits, and methods that are useful for performing high-throughput screening assays and diagnostics. Such diagnostic methods can include emulsifying an aqueous library of compounds with a set of uniquely dyecoded-labeled droplets in an inert fluorocarbon medium, thereby forming an interactor library, emulsifying an aqueous sample from a subject in an inert fluorocarbon medium, wherein said sample contains a compound that will react with at least one interactor molecule from the interactor library, coalescing the emulsions to form a nanoreactor, and screening the nanoreactors for a desirable reaction between the contents of the nanoreactor, herein one or more steps are performed on a microfluidic device, which can include a plurality of electrically addressable, channel bearing fluidic modules integrally arranged on a microfabricated substrate such that a continuous channel is provided for flow of immiscible fluids.
摘要翻译：本发明提供了用于进行高通量筛选测定和诊断的新型微流体装置，试剂盒和方法。这样的诊断方法可以包括用惰性碳氟介质中的一组独特的经编码标记的液滴乳化化合物的水性文库，从而形成相互作用文库，在惰性碳氟介质中乳化来自受试者的含水样品，其中所述样品含有将与来自相互作用文库的至少一个相互作用分子反应的化合物，聚合乳液以形成纳米反应器，并筛选纳米反应器以获得纳米反应器内容物之间所需的反应，这里，一个或多个步骤在微流体装置上进行，其可以包括整体地布置在微加工基板上的多个可电寻址的通道支承流体模块，从而为不混溶流体的流动提供连续通道。

10. 发明公开

EP2285283A2 TORSIONAL SUPPORT FOR CRANIOCAUDAL ROTATION OF ANIMALS 审中-公开
标题翻译： TORSIONSSTÜTZEZUR KRANIOKAUDALEN DREHUNG VON TIEREN
公开(公告)号：EP2285283A2
公开(公告)日：2011-02-23
申请号：EP09762850.7
申请日：2009-06-03
申请人： Carestream Health, Inc.
发明人： FEKE, Gilbert , GELDHOF, Benjamin , LEEVY, Warren, M. , BRIDGES, Mark, E. , MCLAUGHLIN, William, E. , RAO, Papineni
IPC分类号： A61B6/02
CPC分类号： A61B5/0059 , A61B5/0035 , A61B5/0095 , A61B6/0428 , A61B6/0471 , A61B6/4417 , A61B6/508 , A61B2503/40
摘要： A torsional support apparatus is disclosed for craniocaudal rotation of test animals to enable multiple-view imaging. The animal is supported in a U-shaped loop of optically transparent material and the loop is moved to apply torsion to the animal to rotate it about its craniocaudal axis. Methods of imaging also are disclosed that use the torsional support technique.
摘要翻译：公开了一种扭转支撑装置用于测试动物的头颈部旋转，以实现多视图成像。动物被支撑在光学透明材料的U形环中，并且环被移动以向动物施加扭转以围绕其头颅轴旋转。公开了使用扭转支撑技术的成像方法。

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