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1. 发明申请

WO2006113038A1 METHOD FOR IMAGING MICROSPHERES USING SPECULAR ILLUMINATION 审中-公开
标题翻译：使用光学照明成像微球的方法
公开(公告)号：WO2006113038A1
公开(公告)日：2006-10-26
申请号：PCT/US2006/010490
申请日：2006-03-21
申请人： EASTMAN KODAK COMPANY , KAPLAN, Martin, C. , CHARI, Krishnan , CHEN, Samuel , VIZARD, Douglas, L.
发明人： KAPLAN, Martin, C. , CHARI, Krishnan , CHEN, Samuel , VIZARD, Douglas, L.
IPC分类号： G01N15/14
CPC分类号： G01N21/31 , G01N15/1463
摘要： A specular light source and camera for detecting and quantifying the presence of biological probes, which contain a colorant with spectral properties that depend upon the angle of illumination and angle of imaging, that indicate the presence of specific chemical moieties within a biological system.
摘要翻译：用于检测和定量生物探针的存在的镜面光源和相机，其包含着色剂，其具有取决于照射角度和成像角度的光谱性质，其指示生物系统内特定化学部分的存在。

2. 发明申请

WO2009099526A2 APPARATUS AND METHOD FOR IMAGING IONIZING RADIATION 审中-公开
标题翻译：用于成像电离辐射的装置和方法
公开(公告)号：WO2009099526A2
公开(公告)日：2009-08-13
申请号：PCT/US2009/000457
申请日：2009-01-23
申请人： CARESTREAM HEALTH, INC. , FEKE, Gilbert , WOOD, Douglas O. , VIZARD, Douglas L.
发明人： FEKE, Gilbert , WOOD, Douglas O. , VIZARD, Douglas L.
IPC分类号： G03B42/02 , G03C5/17
CPC分类号： A61B5/0059 , A61B6/00 , A61B6/4216 , A61B6/5241 , A61B6/583 , G03B42/023 , G21K2004/06
摘要： A system and method are disclosed for capturing a radiographic or autoradiographic image of an object, in which a support member is provided to receive the object in an immobilized state; a phosphor screen is provided to transduce ionizing radiation from the source to visible light; film or a digital capture device is provided for capturing an image using the visible light; and the phosphor screen is moved incrementally to facilitate reduction of phosphor screen mottle.
摘要翻译：公开了一种用于捕获物体的放射线照相或放射自显影图像的系统和方法，其中提供支撑构件以在固定状态下接收物体; 提供荧光屏以将来自光源的电离辐射转换成可见光; 提供胶片或数字捕获设备用于使用可见光捕获图像; 并且荧光屏逐渐移动以促进荧光屏斑点的减少。

3. 发明申请

WO2009032236A1 FLUORESCENCE RESONANCE ENERGY TRANSFER DETECTION WITH NANOPARTICLES 审中-公开
标题翻译：荧光共振能量转移与纳米颗粒的检测
公开(公告)号：WO2009032236A1
公开(公告)日：2009-03-12
申请号：PCT/US2008/010305
申请日：2008-09-02
申请人： CARESTREAM HEALTH, INC. , PAPINENI, Rao , HARDER, John, W. , MCLAUGHLIN, William, E. , VIZARD, Douglas, L.
发明人： PAPINENI, Rao , HARDER, John, W. , MCLAUGHLIN, William, E. , VIZARD, Douglas, L.
IPC分类号： G01N33/58
CPC分类号： G01N33/542 , C08G65/3322 , C08G65/33306 , C08G65/3342 , C08G65/3348 , G01N33/54346
摘要： A combination of nanoparticles is disclosed comprised of amine functionalized polyethylene glycol in which one particle with a fluorescent donor dye having one wavelength excitation maximum and at least one additional particle with a second fluorescent dye having a second, higher wavelength excitation maximum, the particles having the same or different biomolecule targeting moieties bound to their external surfaces.
摘要翻译：公开了纳米颗粒的组合，其中胺官能化聚乙二醇其中一个具有一个波长激发最大值的荧光供体染料的颗粒和至少一个另外的颗粒与具有第二较高波长激发最大值的第二荧光染料，所述颗粒具有与其外表面结合的相同或不同的生物分子靶向部分。

4. 发明申请

WO2010126643A1 TUNABLE SPECTRAL FILTRATION DEVICE 审中-公开
标题翻译： TUNNABLE光谱过滤器
公开(公告)号：WO2010126643A1
公开(公告)日：2010-11-04
申请号：PCT/US2010/024845
申请日：2010-02-20
申请人： CARESTREAM HEALTH, INC. , FEKE, Gilbert, D. , VIZARD, Douglas, L.
发明人： FEKE, Gilbert, D. , VIZARD, Douglas, L.
IPC分类号： G02B27/00
CPC分类号： G02B27/144 , G02B27/0988 , G02B27/288
摘要： A tunable spectral filtration device comprises at least one optical filter for intersecting a first path of converging or diverging light comprising an axis at a first angle of incidence and at least one device positioned to enable a second path of the converging or diverging light to pass through the at least one optical filter at a second angle of incidence. The optical filter comprises at least one coating and is tillable over a plurality of angles with respect to the axis. The first angle of incidence is opposite in sign to the second angle of incidence, such that the positioning of the at least one optical filter and the at least one device substantially cancels angle-of-incidence dependent spectral broadening and/or polarization dependent spectral broadening of the converging or diverging light.
摘要翻译：可调谐光谱过滤装置包括至少一个光学滤光器，用于与会聚或发散光的第一路径交叉，该第一路径包括以第一入射角的轴线和至少一个装置，所述至少一个装置定位成使得会聚或发散光的第二路径通过所述至少一个滤光器处于第二入射角。光学滤波器包括至少一个涂层并且可相对于轴线在多个角度上被压扁。所述第一入射角与所述第二入射角相反，使得所述至少一个滤光器和所述至少一个器件的定位基本上抵消入射角依赖的光谱展宽和/或偏振相关光谱展宽的会聚光或发散光。

5. 发明申请

WO2006113037A1 METHOD FOR IMAGING AN ARRAY OF MICROSPHERES 审中-公开
标题翻译：用于成像微阵列的方法
公开(公告)号：WO2006113037A1
公开(公告)日：2006-10-26
申请号：PCT/US2006/010487
申请日：2006-03-21
申请人： EASTMAN KODAK COMPANY , KAPLAN, Martin C. , CHARI, Krishnan , CHEN, Samuel , VIZARD, Douglas L.
发明人： KAPLAN, Martin C. , CHARI, Krishnan , CHEN, Samuel , VIZARD, Douglas L.
IPC分类号： G01N15/14
CPC分类号： G01N15/1463 , G01N2015/1465
摘要： A method for imaging an array of microspheres. A light source, filter or combination of filters that isolate wavelength, or wavelength ranges, of light and a camera are used for detecting and quantifying the presence of biological probes that indicate the presence of specific chemical moieties within a biological system.
摘要翻译：一种用于对微球阵列进行成像的方法。用于隔离光和相机的波长或波长范围的光源，滤光器或滤光器的组合用于检测和定量生物探针的存在，所述生物探针指示生物系统内特定化学部分的存在。

6. 发明申请

WO2010042139A1 TUNABLE SPECTRAL FILTRATION DEVICE 审中-公开
标题翻译：可调光谱过滤装置
公开(公告)号：WO2010042139A1
公开(公告)日：2010-04-15
申请号：PCT/US2009/002610
申请日：2009-04-29
申请人： CARESTREAM HEALTH, INC. , FEKE, Gilbert , VIZARD, Douglas, L.
发明人： FEKE, Gilbert , VIZARD, Douglas, L.
IPC分类号： G02B5/28 , G02B5/02
CPC分类号： G02B5/285 , G02B26/002 , G02B26/008 , G02B26/023
摘要： A tunable spectral filtration device includes one or more pairs of interference filters in series, each element of each pair is independently selected, independently positioned to intersect a path of converging or diverging light, and independently tilted with respect to the light path. Each filter may be a bandpass type, a shortpass type, a longpass type, a notch type, or combinations thereof. Each filter may be independently selected and tilted to tune the net spectral output of the series. The elements in a pair of filters may be tilted in opposite directions to cancel angle-of incidence dependent broadening of the spectral output of the individual filters for noncollimated light, or cancel translational shift of the transmitted light rays. The elements in a pair of filters may be tilted through orthogonal tilt axes to cancel polarization dependent broadening of the spectral output of the individual filters.
摘要翻译：可调谐光谱过滤装置包括一对或多对串联的干涉滤光片，每对中的每个元件被独立地选择，独立地定位成与会聚光或发散光相交并相对于光路独立地倾斜。每个滤波器可以是带通型，短路型，长通型，陷波型或其组合。可以独立地选择和倾斜每个滤光片以调节该系列的净光谱输出。一对滤波器中的元件可以在相反的方向上倾斜以消除入射角依赖于对于非准直光的各个滤光器的光谱输出的加宽，或者消除透射光线的平移移动。一对滤波器中的元件可以通过正交倾斜轴倾斜以消除各个滤波器的频谱输出的偏振相关的加宽。

7. 发明申请

WO2009099526A3 APPARATUS AND METHOD FOR IMAGING IONIZING RADIATION 审中-公开
标题翻译：用于成像离子辐射的装置和方法
公开(公告)号：WO2009099526A3
公开(公告)日：2009-10-15
申请号：PCT/US2009000457
申请日：2009-01-23
申请人： CARESTREAM HEALTH INC , FEKE GILBERT , WOOD DOUGLAS O , VIZARD DOUGLAS L
发明人： FEKE GILBERT , WOOD DOUGLAS O , VIZARD DOUGLAS L
IPC分类号： G03B42/02 , G03C5/17
CPC分类号： A61B5/0059 , A61B6/00 , A61B6/4216 , A61B6/5241 , A61B6/583 , G03B42/023 , G21K2004/06
摘要： A system and method are disclosed for capturing a radiographic or autoradiographic image of an object, in which a support member is provided to receive the object in an immobilized state; a phosphor screen is provided to transduce ionizing radiation from the source to visible light; film or a digital capture device is provided for capturing an image using the visible light; and the phosphor screen is moved incrementally to facilitate reduction of phosphor screen mottle.
摘要翻译：公开了一种用于捕获物体的射线照相或放射自显影图像的系统和方法，其中提供支撑构件以在固定状态下接收物体; 提供荧光屏以将从源的电离辐射转换成可见光; 提供电影或数字捕获装置用于使用可见光捕获图像; 并且荧光屏逐渐移动以便于减少荧光屏斑点。

8. 发明申请

WO2009032235A1 APPARATUS AND METHOD FOR MULTI-MODAL IMAGING 审中-公开
标题翻译：多模式成像的装置和方法
公开(公告)号：WO2009032235A1
公开(公告)日：2009-03-12
申请号：PCT/US2008/010304
申请日：2008-09-02
申请人： CARESTREAM HEALTH, INC. , HARDER, John W , ZHENG, Shiying , WANG, Ruizheng , BRINGLEY, Joseph F. , VIZARD, Douglas L. , MCLAUGHLIN, William E. , HALL, Heidi , BRIDGES, Mark E
发明人： HARDER, John W , ZHENG, Shiying , WANG, Ruizheng , BRINGLEY, Joseph F. , VIZARD, Douglas L. , MCLAUGHLIN, William E. , HALL, Heidi , BRIDGES, Mark E
IPC分类号： A61B5/00 , A61B6/00
CPC分类号： A61B6/00 , A61B5/0035 , A61B5/0059 , A61B6/4216 , A61B6/4417 , A61B6/481 , A61B6/508 , A61B2503/40 , A61B2562/0242
摘要： Apparatus for multimodal imaging of an object includes a support stage for receiving an object; an object supported on the stage, the object having been treated with a biocompatible imaging probe comprising nanoparticles carrying targeting moieties and diagnostic components; a light source for producing a beam; a filter positioned to receive and pass the beam toward the object; and a lens and camera system for capturing an image of the object. The apparatus includes a tiltable filter for filtering light from the source. The apparatus includes a mechanism for directing light through a first filter assembly to produce a first beam of light of a first frequency range for illuminating an object in a first imaging mode or through a second filter assembly to produce a second beam of light of a second frequency range for illuminating an object in a second imaging mode.
摘要翻译：用于物体的多模式成像的装置包括用于接收物体的支撑台; 支撑在舞台上的物体，已经用包含携带靶向部分和诊断部件的纳米颗粒的生物相容性成像探针处理该物体; 用于产生光束的光源; 定位成接收并将光束传递到物体的过滤器; 以及用于捕获对象的图像的镜头和相机系统。该装置包括用于过滤来自源的光的可倾斜滤光器。该装置包括用于引导光通过第一过滤器组件以产生第一频率范围的第一光束的机构，用于以第一成像模式照射物体或通过第二过滤器组件产生第二光束的第二光束用于在第二成像模式中照亮对象的频率范围。

9. 发明申请

WO2006113032A1 METHOD FOR IMAGING AN ARRAY OF MICROSPHERES 审中-公开
标题翻译：用于成像微阵列的方法
公开(公告)号：WO2006113032A1
公开(公告)日：2006-10-26
申请号：PCT/US2006/010270
申请日：2006-03-21
申请人： EASTMAN KODAK COMPANY , KAPLAN, Martin, C. , CHARI, Krishnan , CHEN, Samuel , VIZARD, Douglas, L.
发明人： KAPLAN, Martin, C. , CHARI, Krishnan , CHEN, Samuel , VIZARD, Douglas, L.
IPC分类号： G01N21/64 , G01N33/58 , G01N33/533
CPC分类号： G01N33/585 , G01N21/6428 , G01N21/6452 , G01N21/6456 , G01N21/76 , G01N2021/6419
摘要： A method for imaging an array (20) of microspheres. The method employs a wavelength tunable light source (10) and camera (15) for detecting and quantifying the presence of biological probes that indicate the presence of specific chemical moieties within a biological system.
摘要翻译：一种用于对微球阵列（20）进行成像的方法。该方法采用波长可调光源（10）和照相机（15），用于检测和定量生物探针的存在，其指示在生物系统内特定化学部分的存在。

10. 发明申请

WO2005015182A1 IMAGING SYSTEM USING COMBINED DICHROIC/HIGH-PASS FILTERS 审中-公开
标题翻译：使用组合二色/高通滤镜的成像系统
公开(公告)号：WO2005015182A1
公开(公告)日：2005-02-17
申请号：PCT/US2004/018806
申请日：2004-06-14
申请人： EASTMAN KODAK COMPANY , VIZARD, Douglas L. , MCLAUGHLIN, William E.
发明人： VIZARD, Douglas L. , MCLAUGHLIN, William E.
IPC分类号： G01N21/64
CPC分类号： G01N21/6456 , G02B5/20
摘要： An imaging system comprising: a lens; a dichroic filter positioned in front of the lens; and a high pass filter positioned between the lens and the dichroic filter. An appropriate design coordinating the components of such an imaging system to diminish imaging artifacts related to wide-angle imaging of fluorescent objects.
摘要翻译：一种成像系统，包括：透镜; 位于透镜前方的二向色滤光片; 以及位于透镜和二向色滤光片之间的高通滤光器。适当的设计协调这种成像系统的部件，以减少与荧光物体的广角成像相关的成像伪影。

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