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1. 发明申请

WO2008031095A1 PHYSIOLOGICAL DATA ACQUISITION AND MANAGEMENT SYSTEM FOR USE WITH AN IMPLANTED WIRELESS SENSOR 审中-公开
标题翻译：生理数据采集和管理系统，用于带有无线传感器
公开(公告)号：WO2008031095A1
公开(公告)日：2008-03-13
申请号：PCT/US2007/078027
申请日：2007-09-10
申请人： CARDIOMEMS, INC. , RUTKOWSKI, Kim , MILLER, Donald, J. , KROH, Jason , BROGDON, Shawn, Michael , MOORE, Erik
发明人： RUTKOWSKI, Kim , MILLER, Donald, J. , KROH, Jason , BROGDON, Shawn, Michael , MOORE, Erik
IPC分类号： H04B5/00 , A61B5/00 , G01R33/00 , H04B5/02
CPC分类号： H04B5/02 , A61B5/0031 , A61B2560/0219 , H04B5/0043 , H04B5/0087
摘要： Aspects and embodiments of the present invention provide a system for obtaining, processing and managing data from an implanted sensor. In some embodiments, a patient or other persons can use a flexible antenna to obtain data from the implanted sensor. The flexible antenna includes at least one transmit loop and at least one receive loop. The transmit loop is adapted to propagate energizing signals to the implanted sensor. The receive loop is adapted to detect a response signal from the implanted sensor. The transmit loop includes a capacitor formed by a discontinuous area. The capacitor is adapted to allow the loop to be tuned. The flexible antenna can communicate with a patient device that collects the data from the implanted sensor, creates a data file and transmits the data file to a remote server over a network. A physician or other authorized person may access the remote server using an access device.
摘要翻译：本发明的方面和实施例提供了一种用于从植入的传感器获得，处理和管理数据的系统。在一些实施例中，患者或其他人可以使用柔性天线从植入的传感器获得数据。柔性天线包括至少一个发射环路和至少一个接收环路。发射环路适于将激励信号传播到植入的传感器。接收环路适于检测来自植入传感器的响应信号。发射环路包括由不连续区域形成的电容器。电容器适于允许调谐环路。柔性天线可以与从植入的传感器收集数据的患者设备进行通信，创建数据文件，并通过网络将数据文件发送到远程服务器。医生或其他授权人员可以使用访问设备访问远程服务器。

2. 发明公开

EP2012658A2 IMPLANTABLE WIRELESS SENSOR FOR IN VIVO PRESSURE MEASUREMENT AND CONTINUOUS OUTPUT DETERMINATION 审中-公开
标题翻译：植入无线传感器可连续测定体内压力测量结果
公开(公告)号：EP2012658A2
公开(公告)日：2009-01-14
申请号：EP07776789.5
申请日：2007-05-04
申请人： CardioMems, Inc.
发明人： STERN, David , RALPH, Stephen , WHITE, Jason , KROH, Jason , MOORE, Erik
IPC分类号： A61B5/00 , A61B5/0215
CPC分类号： A61B5/0215 , A61B5/0031
摘要： A method and apparatus for determining cardiac parameters within the body of a patient includes a wireless sensor positioned in the patient's pulmonary artery. An external RF telemetry device communicates wirelessly with the sensor and interrogates the sensor to determine changes in pressure in the pulmonary artery over time. The peak pressure difference is determined. Then, assuming zero blood flow velocity at the time of valve opening and at the time of valve closing, a velocity-time function is determined. The velocity-time function is used to determine a velocity-time integral. The velocity-time integral is then used to determine cardiac stroke volume. The cardiac stroke volume is multiplied times the heartbeat rate to determine cardiac output. The cardiac output can be monitored over time to determine continuous cardiac output.

3. 发明申请

WO2014047528A1 METHOD AND SYSTEM FOR TREND-BASED PATIENT MANAGEMENT 审中-公开
标题翻译：基于趋势的患者管理的方法和系统
公开(公告)号：WO2014047528A1
公开(公告)日：2014-03-27
申请号：PCT/US2013/061094
申请日：2013-09-21
申请人： CARDIOMEMS, INC.
发明人： KROH, Jason
IPC分类号： G06Q50/22 , G06Q50/24
CPC分类号： G06F19/345 , G06F19/00 , G16H10/60 , G16H15/00 , G16H50/20
摘要： The present disclosure is directed to a system having a database operable to receive at least one physiological parameter data from at least one of an electronic medical record (EMR) portal configured for receiving EMR data from an electronic medical record; a healthcare provider (HCP) portal configured for receiving HCP data; a patient portal configured for receiving patient data; and a medical device portal configured for receiving medical device data; for calculating secondary parameters from scoring algorithms, trend algorithms, parameter algorithms and treatment algorithms; then displaying the data and secondary parameters in a graphical format in order to for detect, diagnose and treat chronic disease in patients.
摘要翻译：本公开涉及一种具有数据库的系统，其可操作以从电子医疗记录（EMR）门户中的至少一个接收至少一个生理参数数据，所述电子医疗记录门户被配置为从电子病历接收EMR数据; 配置用于接收HCP数据的医疗保健提供者（HCP）门户; 被配置用于接收患者数据的病人门户; 以及被配置用于接收医疗设备数据的医疗设备入口; 用于从计分算法，趋势算法，参数算法和处理算法计算次要参数; 然后以图形格式显示数据和次要参数，以便检测，诊断和治疗患者的慢性病。

4. 发明申请

WO2007008493A1 COUPLING LOOP, CABLE ASSEMBLY AND METHOD FOR POSITIONING COUPLING LOOP 审中-公开
标题翻译：耦合环，电缆组件和定位耦合环路的方法
公开(公告)号：WO2007008493A1
公开(公告)日：2007-01-18
申请号：PCT/US2006/026015
申请日：2006-06-30
申请人： CARDIOMEMS, INC. , KROH, Jason , ELLIS, Michael , MILLER, Donald , REFERMAT, Robert
发明人： KROH, Jason , ELLIS, Michael , MILLER, Donald , REFERMAT, Robert
IPC分类号： H04B5/00 , A61B5/00 , G01R33/00
CPC分类号： A61B5/02014 , A61B5/0031 , A61B5/064 , A61B5/07 , A61B2560/0219 , H01B11/20 , H04B5/0043 , Y10S128/903
摘要： A coupling loop or antenna is provided that can be used with a system that determines the resonant frequency of a sensor by adjusting the phase and frequency of an energizing signal until the frequency of the energizing signal matches the resonant frequency of the sensor. The coupling loop includes multiple loops. Preferably two tuned loops are used for transmitting the energizing signal to the sensor and an un-tuned loop is used for receiving the sensor signal from the sensor. A cable attached to the coupling loop provides maximum isolation between the energizing signal and the sensor signal by maximizing the distance between the coaxial cables that carry the signals and maintaining the relative positions of the coaxial cables throughout the cable assembly. Orientation features on the housing for the coupling loop and the sensor are provided to assist in positioning the coupling loop relative to the sensor to maximize the coupling between the sensor signal and the coupling loop.
摘要翻译：提供耦合环路或天线，其可以与通过调节激励信号的相位和频率来确定传感器的谐振频率的系统一起使用，直到通电信号的频率与传感器的谐振频率匹配。耦合回路包括多个回路。优选地，两个调谐回路用于将激励信号传输到传感器，并且未调谐回路用于从传感器接收传感器信号。连接到耦合回路的电缆通过使承载信号的同轴电缆之间的距离最大化并且保持同轴电缆在整个电缆组件中的相对位置来提供激励信号和传感器信号之间的最大隔离。提供用于耦合回路和传感器的壳体上的定向特征以帮助相对于传感器定位耦合回路，以使传感器信号和耦合回路之间的耦合最大化。

5. 发明授权

EP2268218B1 SYSTEM AND APPARATUS FOR IN-VIVO ASSESSMENT OF RELATIVE POSITION OF AN IMPLANT 失效
标题翻译：系统和设备的体内试验植入物的相对位置
公开(公告)号：EP2268218B1
公开(公告)日：2016-02-10
申请号：EP09755451.3
申请日：2009-04-01
申请人： CardioMems, Inc.
发明人： KROH, Jason , CROS, Florent , COURCIMAULT, Christophe
IPC分类号： A61B17/70 , A61F2/44 , A61B18/18
CPC分类号： G01L9/0073 , A61B5/0031 , A61B5/076 , A61B5/1116 , A61B5/4504 , A61B5/686 , A61B17/7002 , A61B2017/00221 , A61B2560/0219 , A61B2560/0223 , A61B2562/0261 , G01F15/066 , G01L1/14 , H01Q7/00

6. 发明公开

EP1921983A1 PREVENTING FALSE LOCKS IN A SYSTEM THAT COMMUNICATES WITH AN IMPLANTED WIRELESS SENSOR 有权
标题翻译：防止误锁在一个系统中有一个内置的无线传感器通讯
公开(公告)号：EP1921983A1
公开(公告)日：2008-05-21
申请号：EP06803012.1
申请日：2006-09-06
申请人： CardioMems, Inc.
发明人： POWERS, Richard , ELLIS, Michael, G. , KROH, Jason , MILLER, Donald, J.
IPC分类号： A61B5/00 , G08C17/04 , G01L9/12 , G01D5/241
CPC分类号： A61B5/02014 , A61B5/0031 , A61B5/0215 , A61B5/076 , A61B5/726 , A61B2560/0223 , G01D21/00
摘要： The present invention determines the resonant frequency of a wireless sensor by adjusting the phase and frequency of an energizing signal until the frequency of the energizing signal matches the resonant frequency of the sensor. The system energizes the sensor with a low duty cycle, gated burst of RF energy having a predetermined frequency. The system receives the ring down response of the sensor and determines the resonant frequency of the sensor, which is used to calculate a physical parameter. The system uses a pair of phase locked loops to adjust the phase and the frequency of the energizing signal. The system identifies false locks by detecting an unwanted beat frequency in the coupled signal, as well as determining whether the coupled signal exhibits pulsatile characteristics that correspond to blood pressure.

7. 发明申请

WO2014179739A1 METHOD AND SYSTEM FOR TREATING CARDIOVASCULAR DISEASE 审中-公开
标题翻译：用于治疗心血管疾病的方法和系统
公开(公告)号：WO2014179739A1
公开(公告)日：2014-11-06
申请号：PCT/US2014/036652
申请日：2014-05-02
申请人： CARDIOMEMS, INC.
发明人： KROH, Jason , MOORE, Erik , SCHOLZ, Tamera , DUREY, Adriane , WHITE, Jason , LAY, Khin Khin , BROGDON, Michael
IPC分类号： A61B5/02
CPC分类号： A61B5/0215 , A61B5/0004 , A61B5/002 , A61B5/0022 , A61B5/4836 , A61B5/4839 , A61B5/6876 , G06F19/00 , G16H40/67
摘要： A system and method for treating congestive heart failure in a patient, including: implanting at least one pressure sensor in a desired location within the patient; providing an ex- vivo interrogation system and monitoring system that can be configured to optionally affect at least one of: selectively energizing the at one pressure sensor, receiving a return or output signal from the at one pressure sensor, processing the return signal, and displaying processed data derived from the at least one pressure sensor to a physician. The system and method also includes deriving diagnostic and treatment information from the processed data and sending diagnostic and treatment information to the patient.
摘要翻译：一种用于治疗患者充血性心力衰竭的系统和方法，包括：将至少一个压力传感器植入患者期望的位置; 提供可被配置为可选地影响以下中的至少一个的离散询问系统和监视系统：选择性地激励所述一个压力传感器，从所述一个压力传感器接收返回或输出信号，处理所述返回信号，以及显示将从至少一个压力传感器得到的处理数据传送给医生。该系统和方法还包括从处理的数据中导出诊断和治疗信息，并向患者发送诊断和治疗信息。

8. 发明申请

WO2008031011A1 ANTENNA CABLE 审中-公开
标题翻译：天线
公开(公告)号：WO2008031011A1
公开(公告)日：2008-03-13
申请号：PCT/US2007/077847
申请日：2007-09-07
申请人： CARDIOMEMS, INC. , MILLER, Donald, J. , KROH, Jason
发明人： MILLER, Donald, J. , KROH, Jason
IPC分类号： H01B11/20
CPC分类号： H01B11/203 , H01B7/0861
摘要： Embodiments of the present invention are directed to a cable assembly that is adapted to be connected to an antenna and a base unit. The cable assembly may be relatively flat with shielding and structures to reduce ground currents or other interference. Embodiments of the cable assembly include at least two coaxial cables for transmit and receive signals that are separated to reduce crosstalk or other interference. The cable may also include one or more inner cables, such as differential or switching pairs, between the two coaxial cables to provide cables for control, power, switching, or other functions. The inner cables may be positioned in parallel to each other and to each of the coaxial cables. In some embodiments, the inner cables include a first inner cable located at a first end of the inner cables and a second inner cable located at a second end of the inner cables. One coaxial cable may be positioned adjacent and parallel to the first inner cable, which the other coaxial cable may be positioned adjacent and parallel to the second inner cable.
摘要翻译：本发明的实施例涉及一种适于连接到天线和基座单元的电缆组件。电缆组件可以相对平坦，具有屏蔽和结构以减少接地电流或其它干扰。电缆组件的实施例包括用于发射和接收被分离以减少串扰或其他干扰的信号的至少两根同轴电缆。电缆还可以包括在两个同轴电缆之间的一个或多个内部电缆，例如差分或开关对，以提供用于控制，电力，开关或其他功能的电缆。内部电缆可以彼此平行并且与各个同轴电缆定位。在一些实施例中，内部电缆包括位于内部电缆的第一端的第一内部电缆和位于内部电缆的第二端的第二内部电缆。一个同轴电缆可以被定位成与第一内部电缆相邻并平行，另一个同轴电缆可以被定位成与第二内部电缆相邻并且平行。

9. 发明申请

WO2007130628A2 IMPLANTABLE WIRELESS SENSOR FOR IN VIVO PRESSURE MEASUREMENT AND CONTINUOUS OUTPUT DETERMINATION 审中-公开
标题翻译：用于输血压力测量和连续输出测量的无侵入式无线传感器
公开(公告)号：WO2007130628A2
公开(公告)日：2007-11-15
申请号：PCT/US2007/010927
申请日：2007-05-04
申请人： CARDIOMEMS, INC. , STERN, David , RALPH, Stephen , WHITE, Jason , KROH, Jason , MOORE, Erik
发明人： STERN, David , RALPH, Stephen , WHITE, Jason , KROH, Jason , MOORE, Erik
IPC分类号： A61B5/00 , A61B5/0215
CPC分类号： A61B5/0215 , A61B5/0031
摘要： A method and apparatus for determining cardiac parameters within the body of a patient includes a wireless sensor positioned in the patient's pulmonary artery. An external RF telemetry device communicates wirelessly with the sensor and interrogates the sensor to determine changes in pressure in the pulmonary artery over time. The peak pressure difference is determined. Then, assuming zero blood flow velocity at the time of valve opening and at the time of valve closing, a velocity-time function is determined. The velocity-time function is used to determine a velocity-time integral. The velocity-time integral is then used to determine cardiac stroke volume. The cardiac stroke volume is multiplied times the heartbeat rate to determine cardiac output. The cardiac output can be monitored over time to determine continuous cardiac output.
摘要翻译：用于确定患者体内的心脏参数的方法和装置包括位于患者肺动脉中的无线传感器。外部RF遥测装置与传感器无线通信，并询问传感器以确定肺动脉随时间变化的变化。确定峰值压力差。然后，假设在阀打开时和阀关闭时的血流速度为零，则确定速度 - 时间函数。速度 - 时间函数用于确定速度 - 时间积分。然后使用速度 - 时间积分来确定心脏搏动量。将心脏搏动量乘以心跳速率以确定心输出量。可以随时间监测心输出量以确定持续的心输出量。

10. 发明申请

WO2006096582A1 COMMUNICATING WITH AN IMPLANTED WIRELESS SENSOR 审中-公开
标题翻译：与植入式无线传感器通信
公开(公告)号：WO2006096582A1
公开(公告)日：2006-09-14
申请号：PCT/US2006/007790
申请日：2006-03-06
申请人： CARDIOMEMS, INC. , ALLEN, Mark , KROH, Jason , MILLER, Donald , ELLIS, Michael
发明人： ALLEN, Mark , KROH, Jason , MILLER, Donald , ELLIS, Michael
IPC分类号： A61B5/00
CPC分类号： G01R23/145 , A61B5/0002 , A61B5/0031 , A61B5/05 , A61B5/076 , A61B2560/0219 , A61B2560/0223 , G01F15/066 , G01R23/12 , H04L2027/0028 , H04L2027/0055 , H04L2027/0067
摘要： The present invention determines the resonant frequency of a sensor by adjusting the phase and frequency of an energizing signal until the frequency of the energizing signal matches the resonant frequency of the sensor. The system energizes the sensor with a low duty cycle, gated burst of RF energy having a predetermined frequency or set of frequencies and a predetermined amplitude. The energizing signal is coupled to the sensor via magnetic coupling and induces a current in the sensor which oscillates at the resonant frequency of the sensor. The system receives the ring down response of the sensor via magnetic coupling and determines the resonant frequency of the sensor, which is used to calculate the measured physical parameter. The system uses a pair of phase locked loops to adjust the phase and the frequency of the energizing signal.
摘要翻译：本发明通过调整激励信号的相位和频率来确定传感器的谐振频率，直到激励信号的频率与传感器的谐振频率匹配为止。系统以低占空比，具有预定频率或一组频率和预定幅度的RF能量的选通脉冲来激励传感器。激励信号通过磁耦合耦合到传感器，并在传感器中感应出电流，该电流以传感器的谐振频率振荡。系统通过磁耦合接收传感器的响铃响应，并确定传感器的谐振频率，用于计算测量的物理参数。该系统使用一对锁相环来调节激励信号的相位和频率。

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