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1. 发明申请

WO2005065771A1 LEAD FOR STIMULATING THE BARORECEPTORS IN THE PULMONARY ARTERY 审中-公开
标题翻译：用于刺激肺动脉中的闭塞器的领导
公开(公告)号：WO2005065771A1
公开(公告)日：2005-07-21
申请号：PCT/US2004/043691
申请日：2004-12-23
申请人： CARDIAC PACEMAKERS, INC. , LIBBUS, Imad , HEIL, Ronald, W., Jr. , SCHEINER, Avram , KELLEY, Peter, T.
发明人： LIBBUS, Imad , HEIL, Ronald, W., Jr. , SCHEINER, Avram , KELLEY, Peter, T.
IPC分类号： A61N1/36
CPC分类号： A61N1/057 , A61N1/36117
摘要： An apparatus includes a flexible lead body, an electrode coupled to the lead body, and an implantable pulse generator electrically coupled to the electrode. The implantable pulse generator is adapted to deliver a baroreflex stimulation signal to a baroreceptor in the pulmonary artery via the electrode. The apparatus includes means for passively fixating the electrode within the pulmonary artery.
摘要翻译：一种装置包括柔性引线体，耦合到引线本体的电极以及电耦合到电极的可植入脉冲发生器。可植入脉冲发生器适于通过电极将压力反射刺激信号传递给肺动脉中的压力感受器。该装置包括用于被动地固定肺动脉内的电极的装置。

2. 发明申请

WO2004067086A2 MEDICAL ELECTRICAL LEAD EMPLOYING LOAD BEARING SLEEVE 审中-公开
标题翻译：医用电气铅负载轴承套管
公开(公告)号：WO2004067086A2
公开(公告)日：2004-08-12
申请号：PCT/US2004/002148
申请日：2004-01-27
申请人： CARDIAC PACEMAKERS, INC.
发明人： WESTLUND, Randy , KRISHNAN, Mohan , SCHEINER, Avram
IPC分类号： A61N1/05
CPC分类号： A61N1/056 , A61N2001/0578 , A61N2001/0585
摘要： A medical electrical lead employs a load bearing sleeve arrangement. A medical electrical lead includes an outer sleeve, having proximal and distal ends, and is formed of a first material. At least one electrical conductor is situated within the outer sleeve and extends between the proximal and distal ends of the outer sleeve. At least one electrode is electrically coupled to the electrical conductor. A load bearing sleeve extends between the proximal and distal ends of the outer sleeve. The load bearing sleeve is formed of a second material different from the first maternal. The load bearing sleeve offers resistance to axial loading forces applied to the lead. The load bearing sleeve can be coextensive with the outer sleeve or extend along at least the majority of the length of the outer sleeve.
摘要翻译：医用电线使用承载套筒装置。医用电线包括具有近端和远端的外套，并由第一材料形成。至少一个电导体位于外套筒内并且在外套筒的近端和远端之间延伸。至少一个电极电耦合到电导体。承载套筒在外套筒的近端和远端之间延伸。承载套筒由不同于第一母亲的第二材料形成。承载套筒提供抵抗施加到引线的轴向载荷力。承载套筒可以与外套筒共同延伸或者沿外套筒的至少大部分长度延伸。

3. 发明申请

WO2006138068A2 VASCULARLY STABILIZED PERIPHERAL NERVE CUFF ASSEMBLY 审中-公开
标题翻译：血管稳定性外周神经钳组件
公开(公告)号：WO2006138068A2
公开(公告)日：2006-12-28
申请号：PCT/US2006/021322
申请日：2006-06-01
申请人： CARDIAC PACEMAKERS, INC. , CAPARSO, Anthony , SCHEINER, Avram
发明人： CAPARSO, Anthony , SCHEINER, Avram
IPC分类号： A61N1/05
CPC分类号： A61N1/0551 , A61N1/0556 , A61N1/0558
摘要： A vascularly stabilized peripheral nerve cuff assembly is provided. One aspect of this disclosure relates to an electrode assembly used in the delivery of neural stimulation therapy. The electrode assembly includes a body adapted to at least partially encompass a blood vessel and a nerve proximate to the blood vessel. The electrode assembly also includes at least one electrode along at least a portion of the body. The at least one electrode is adapted to be electrically connected to a neural stimulator. According to an embodiment, the electrode assembly includes a spacer within the body, the spacer having a first and second end, the first end secured to an inside surface of the body and the second end adapted to pass between the vessel and the nerve and to be secured to the inside surface of the body. Other aspects and embodiments are provided herein.
摘要翻译：提供血管稳定的外周神经袖带组件。本公开的一个方面涉及用于递送神经刺激疗法的电极组件。电极组件包括适于至少部分地包围血管和靠近血管的神经的主体。电极组件还包括沿着身体的至少一部分的至少一个电极。至少一个电极适于电连接到神经刺激器。根据一个实施例，电极组件包括在主体内的间隔件，间隔件具有第一和第二端，第一端固定到主体的内表面，第二端适于在容器和神经之间通过，固定在身体的内表面。本文提供了其它方面和实施例。

4. 发明申请

WO2005118069A1 DRUG ELUTING IMPLANTS TO PREVENT CARDIAC APOPTOSIS 审中-公开
标题翻译：药物涂抹植入物以防止心脏病
公开(公告)号：WO2005118069A1
公开(公告)日：2005-12-15
申请号：PCT/US2005/018805
申请日：2005-05-27
申请人： CARDIAC PACEMAKERS, INC. , SHUROS, Allan , SCHEINER, Avram , SALO, Rodney, W.
发明人： SHUROS, Allan , SCHEINER, Avram , SALO, Rodney, W.
IPC分类号： A61P9/10
CPC分类号： A61L31/16 , A61L2300/40 , D04C1/06 , D10B2509/00
摘要： Implantable devices are configured to be positioned in or near the heart and to carry and deliver an anti-apoptotic drug to a treatment site in or near the heart. The implantable devices include, but are not limited to, leads, stents, heart valves, atrial septal defect devices, cardiac patches and ventricular restraint devices. Depending on the composition of the device, the drug may be carried by the device through a coating applied to the device, or may be included in the device during the device manufacturing process. The drug may also be included in microparticles, such as microspheres, that are delivered locally through a conduit, such as a catheter.
摘要翻译：可植入装置被配置为定位在心脏中或附近，并将抗细胞凋亡药物携带并递送至心脏内或附近的治疗部位。可植入装置包括但不限于引线，支架，心脏瓣膜，心房间隔缺损装置，心脏贴片和心室约束装置。根据装置的组成，药物可以由装置通过施加到装置的涂层携带，或者可以在装置制造过程中包括在装置中。药物也可以包括在通过诸如导管的导管局部递送的微粒中，例如微球。

5. 发明申请

WO2005089643A1 WIRELESS ECG IN IMPLANTABLE DEVICES 审中-公开
标题翻译：无线心电图在可植入设备
公开(公告)号：WO2005089643A1
公开(公告)日：2005-09-29
申请号：PCT/US2005/006984
申请日：2005-03-03
申请人： CARDIAC PACEMAKERS, INC. , MCCABE, Aaron , SCHEINER, Avram , ZHANG, Geng , NI, Quan , DAUM, Douglas, R. , ZHANG, Yi
发明人： MCCABE, Aaron , SCHEINER, Avram , ZHANG, Geng , NI, Quan , DAUM, Douglas, R. , ZHANG, Yi
IPC分类号： A61B5/0402
CPC分类号： A61B5/0402 , A61N1/365 , A61N1/3756
摘要： An implantable medical device (220A) such as an implantable pacemaker or implantable cardioverter/defibrillator includes a programmable sensing circuit (222) providing for sensing of a signal approximating a surface electrocardiogram (ECG) through implanted electrodes (210A, 210B). With various electrode configurations, signals approximating various standard surface ECG signals are acquired without the need for attaching electrodes with cables onto the skin. The various electrode configurations include, but are not limited to various combinations of intracardiac pacing electrodes, portions of the implantable medical device contacting tissue, and electrodes incorporated onto the surface of the implantable medical device.
摘要翻译：诸如可植入起搏器或植入式心律转复/除纤颤器之类的可植入医疗装置（220A）包括可编程感测电路（222），用于通过植入电极（210A，210B）感测接近表面心电图（ECG）的信号。通过各种电极配置，获取近似各种标准表面ECG信号的信号，而不需要将电极与电缆连接在皮肤上。各种电极配置包括但不限于心内起搏电极的各种组合，可植入医疗器件接触组织的部分，以及结合到可植入医疗装置的表面上的电极。

6. 发明申请

WO2008123923A2 UNIDIRECTIONAL NEURAL STIMULATION SYSTEMS, DEVICES AND METHODS 审中-公开
标题翻译：单向神经刺激系统，装置和方法
公开(公告)号：WO2008123923A2
公开(公告)日：2008-10-16
申请号：PCT/US2008/003683
申请日：2008-03-20
申请人： CARDIAC PACEMAKERS, INC. , LIBBUS, Imad , SCHEINER, Avram
发明人： LIBBUS, Imad , SCHEINER, Avram
IPC分类号： A61N1/36
CPC分类号： A61N1/36057 , A61B5/021 , A61B5/024 , A61N1/0551 , A61N1/36114 , A61N1/36135 , A61N1/37217 , A61N1/37282 , A61N1/37288
摘要： An embodiment relates to a method for delivering a unidirectional afferent nerve stimulation treatment. A test neural stimulation is delivered, and a physiologic response to the test neural stimulation is monitored. At least one neural stimulation parameter for the test neural stimulation is adjusted if the test neural stimulation does not elicit a desired physiologic response. If the test neural stimulation does elicit the desired physiologic response, at least one treatment parameter for a unidirectional afferent nerve stimulation is determined using the at least one neural stimulation parameter for the test neural stimulation that provided the desired physiologic response. The unidirectional afferent nerve stimulation is delivered using the at least one treatment parameter.
摘要翻译：一个实施例涉及一种用于递送单向传入神经刺激治疗的方法。递送测试神经刺激，并监测对测试神经刺激的生理反应。如果测试神经刺激不引起期望的生理反应，则调整用于测试神经刺激的至少一个神经刺激参数。如果测试神经刺激引起期望的生理反应，则使用提供所需生理反应的测试神经刺激的至少一个神经刺激参数来确定单向传入神经刺激的至少一个治疗参数。使用至少一个治疗参数传递单向传入神经刺激。

7. 发明申请

WO2005063332A1 BAROREFLEX STIMULATION SYSTEM 审中-公开
标题翻译： BAROREFLEX刺激系统
公开(公告)号：WO2005063332A1
公开(公告)日：2005-07-14
申请号：PCT/US2004/043255
申请日：2004-12-22
申请人： CARDIAC PACEMAKERS, INC. , HEIL, JR., Ronald W. , SCHEINER, Avram , LIBBUS, Imad , ZHU, Qingsheng , GIROUARD, Steven D. , SALO, Rodney W.
发明人： HEIL, JR., Ronald W. , SCHEINER, Avram , LIBBUS, Imad , ZHU, Qingsheng , GIROUARD, Steven D. , SALO, Rodney W.
IPC分类号： A61N1/36
CPC分类号： A61N1/36117 , A61N1/3627 , A61N1/36564
摘要： In various embodiments of an implantable device, the device comprises a pulse generator, a lead, a sensor, and a controller. The pulse generator generates a baroreflex stimulation signal as part of a baroreflex therapy. The lead is adapted to be electrically connected to the pulse generator and to be intravascularly fed into a heart. The lead includes an electrode to be positioned in or proximate to the heart to deliver the baroreflex signal to a baroreceptor region in or proximate to the heart. The sensor senses a physiological parameter regarding an efficacy of the baroreflex therapy and provides a signal indicative of the efficacy. The controller is connected to the pulse generator to control the baroreflex stimulation signal and to the sensor to receive the signal indicative of the efficacy of the baroreflex therapy.
摘要翻译：在可植入装置的各种实施例中，装置包括脉冲发生器，引线，传感器和控制器。脉冲发生器产生压力反射刺激信号作为压力反射治疗的一部分。引线适于电连接到脉冲发生器并且被血管内馈送到心脏中。引线包括位于心脏中或靠近心脏的电极，以将压力反射信号传递到心脏中或心脏附近的压力感受器区域。传感器感测关于压力反射治疗的功效的生理参数，并提供指示功效的信号。控制器连接到脉冲发生器以控制压力反射刺激信号和传感器以接收指示压力反射治疗功效的信号。

8. 发明申请

WO2003047688A1 APPARATUS AND METHOD FOR STABILIZING AN IMPLANTABLE LEAD 审中-公开
标题翻译：用于稳定可植入引线的装置和方法
公开(公告)号：WO2003047688A1
公开(公告)日：2003-06-12
申请号：PCT/US2002/038817
申请日：2002-12-04
申请人： CARDIAC PACEMAKERS, INC.
发明人： KRISHNAN, Mohan , SCHEINER, Avram , WESTLUND, Randy
IPC分类号： A61N1/05
CPC分类号： A61N1/056 , A61N2001/0585
摘要： A method and system for stabilizing an implantable lead system employs a lead having one or more sensing, pacing, or shocking electrodes. A sleeve arrangement of the lead includes one or more first locations comprising a first material that substantially prevents or inhibits tissue ingrowth between the first locations and cardiac tissue contacting the first locations. The sleeve arrangement further includes one or more adhesion sites provided at one or more of the first locations. The adhesion sites promote tisue in-growth or attachment between the adhesion sites and cardiac tissue contacting the adhesion sites. The cardiac tissue may represent tissue of a cardiac structure of the heart or coronary vasculature of the heart.
摘要翻译：用于稳定可植入引线系统的方法和系统采用具有一个或多个感测，起搏或冲击电极的引线。引线的套筒布置包括一个或多个第一位置，其包括基本上防止或抑制第一位置与接触第一位置的心脏组织之间的组织向内生长的第一材料。套筒装置还包括设置在一个或多个第一位置处的一个或多个粘附位置。粘附位点促进附着位点和接触粘附部位的心脏组织之间的生长或附着。心脏组织可以表示心脏的心脏结构的组织或心脏的冠状动脉脉管系统。

9. 发明申请

WO2007109796A3 LEFT VENTRICULAR LEAD SHAPES 审中-公开
公开(公告)号：WO2007109796A3
公开(公告)日：2007-09-27
申请号：PCT/US2007/064820
申请日：2007-03-23
申请人： CARDIAC PACEMAKERS, INC. , BLY, Mark J. , SOLTIS, Brian D. , TOCKMAN, Bruce A. , SCHEINER, Avram
发明人： BLY, Mark J. , SOLTIS, Brian D. , TOCKMAN, Bruce A. , SCHEINER, Avram
IPC分类号： A61N1/05
摘要： A lead for sensing and pacing a left ventricle of the heart includes a lead body having a proximal portion and a distal portion, a lumen extending through the lead body, a conductor extending through the lead body from the proximal portion to the distal portion and an electrode disposed on the distal portion of the lead body and electrically coupled to the conductor. A distal tip of the lead body is continuously deflectable upon advancement and withdrawal of a stylet through the lumen at the distal portion to access a selected branch of the coronary sinus. The distal tip of the lead body may be offset before or after continuously deflecting the distal tip.

10. 发明申请

WO2007050657A1 IMPLANTABLE AND RECHARGEABLE NEURAL STIMULATOR 审中-公开
标题翻译：可植入和可补充的神经刺激器
公开(公告)号：WO2007050657A1
公开(公告)日：2007-05-03
申请号：PCT/US2006/041569
申请日：2006-10-23
申请人： CARDIAC PACEMAKERS, INC. , CHAVAN, Abhi , CAPARSO, Anthony V. , SCHEINER, Avram
发明人： CHAVAN, Abhi , CAPARSO, Anthony V. , SCHEINER, Avram
IPC分类号： A61N1/36 , A61N1/372 , A61N1/34
CPC分类号： A61N1/36117 , A61N1/3605 , A61N1/36071 , A61N1/36135 , A61N1/37205 , A61N1/37217 , A61N1/37288 , A61N1/3787
摘要： One aspect of the present subject matter relates to an implantable medical device. An embodiment of the device comprises a rechargeable power supply adapted to be recharged through an ultrasound signal, a neural stimulator connected to the rechargeable power supply, and a controller connected to the rechargeable power supply. The neural stimulator is adapted to generate a neural stimulation signal for delivery to a neural stimulation target through an electrode. The controller is further connected to the neural stimulator to control the neural stimulator according to a neural stimulation protocol. Other aspects are provided herein.
摘要翻译：本主题的一个方面涉及可植入医疗装置。该装置的实施例包括适于通过超声信号再充电的可再充电电源，连接到可再充电电源的神经刺激器和连接到可再充电电源的控制器。神经刺激器适于产生用于通过电极递送到神经刺激靶的神经刺激信号。控制器进一步连接到神经刺激器，以根据神经刺激方案来控制神经刺激器。本文提供了其他方面。

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