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1. 发明申请

WO2006020791A9 PACER WITH COMBINED DEFIBRILLATOR TAILORED FOR BRADYCARDIA PATIENTS 审中-公开
标题翻译：具有组合的定位器的PACER为BRADYCARDIA患者定制
公开(公告)号：WO2006020791A9
公开(公告)日：2007-04-05
申请号：PCT/US2005028592
申请日：2005-08-10
申请人： CARDIAC PACEMAKERS INC , BOCEK JOSEPH M , DUJMOVIC RICHARD MILON JR , FOSHEE PHIL , WHITE HARLEY , KIM JAEHO , HARRINGTON ANTHONY , SANDERS RICHARD S , DAUM DOUGLAS R , DE CORIOLIS PAUL
发明人： BOCEK JOSEPH M , DUJMOVIC RICHARD MILON JR , FOSHEE PHIL , WHITE HARLEY , KIM JAEHO , HARRINGTON ANTHONY , SANDERS RICHARD S , DAUM DOUGLAS R , DE CORIOLIS PAUL
IPC分类号： A61N1/39
CPC分类号： A61N1/3956 , A61N1/3962
摘要： A combination pacer/defibrillator is tailored for bradycardia patients. In one example, its shock-delivery specificity exceeds its sensitivity to shockable ventricular tachyarrhythmias. In another example, its specificity exceeds 95%, or 99%, or even 99.5%. Sensitivity is programmed to a high desired sensitivity value if it can be done without decreasing the specificity below the desired specificity threshold value. This can be conceptualized as "avoiding at all costs" delivering false shocks, even at the expense of failing to deliver a shock to a treatable ventricular tachyarrhythmia. Specificity enhancements include, among other things, inhibiting shock delivery when the patient is breathing or not supine, using multiple channels or a high rate VT/VF detection threshold. The present pacer/defibrillator device could potentially save the lives of bradyarrhythmia patients who are not presently clinically indicated for a defibrillator/pacer, but who have an increased risk of sudden cardiac death due to one or more risk factors.
摘要翻译：联合起搏器/去纤颤器是为心动过缓患者量身打造的。在一个例子中，其冲击传递特异性超过其对可震荡室性快速性心律失常的敏感性。在另一个实例中，其特异性超过95％，或99％，甚至99.5％。如果可以在不降低所需特异性阈值以下的特异性的情况下将灵敏度编程为高期望的灵敏度值。这可以被概念化为“不惜一切代价”，提供虚假的冲击，即使以不能对可治疗的室性快速性心律失常发生冲击为代价。特异性增强包括当患者呼吸或不仰卧时，使用多个通道或高速率VT / VF检测阈值来抑制冲击输送。本发明的除颤器装置可潜在地节省目前临床指示除颤器/起搏器但由于一个或多个危险因素引起的心脏猝死风险增加的缓慢性心律失常患者的生命。

2. 发明申请

WO2006020791A8 PACER WITH COMBINED DEFIBRILLATOR TAILORED FOR BRADYCARDIA PATIENTS 审中-公开
标题翻译： PACER与针对BRADYCARDIA患者定制的组合式除颤器
公开(公告)号：WO2006020791A8
公开(公告)日：2006-11-16
申请号：PCT/US2005028592
申请日：2005-08-10
申请人： CARDIAC PACEMAKERS INC , BOCEK JOSEPH M , DUJMOVIC RICHARD MILON JR , FOSHEE PHIL , WHITE HARLEY , KIM JAEHO , HARRINGTON ANTHONY , SANDERS RICHARD S , DAUM DOUGLAS R , DE CORIOLIS PAUL
发明人： BOCEK JOSEPH M , DUJMOVIC RICHARD MILON JR , FOSHEE PHIL , WHITE HARLEY , KIM JAEHO , HARRINGTON ANTHONY , SANDERS RICHARD S , DAUM DOUGLAS R , DE CORIOLIS PAUL
IPC分类号： A61B17/56
CPC分类号： A61N1/3956 , A61N1/3962
摘要： A combination pacer/defibrillator is tailored for bradycardia patients. In one example, its shock-delivery specificity exceeds its sensitivity to shockable ventricular tachyarrhythmias. In another example, its specificity exceeds 95%, or 99%, or even 99.5%. Sensitivity is programmed to a high desired sensitivity value if it can be done without decreasing the specificity below the desired specificity threshold value. This can be conceptualized as "avoiding at all costs" delivering false shocks, even at the expense of failing to deliver a shock to a treatable ventricular tachyarrhythmia. Specificity enhancements include, among other things, inhibiting shock delivery when the patient is breathing or not supine, using multiple channels or a high rate VT/VF detection threshold. The present pacer/defibrillator device could potentially save the lives of bradyarrhythmia patients who are not presently clinically indicated for a defibrillator/pacer, but who have an increased risk of sudden cardiac death due to one or more risk factors.
摘要翻译：结合起搏器/除颤器专为心动过缓患者量身定制。在一个例子中，其休克输送特异性超过了其对休克性室性快速心律失常的敏感性。在另一个例子中，其特异性超过95％，或99％，或甚至99.5％。如果可以在不降低特异性低于期望的特异性阈值的情况下完成灵敏度，则将灵敏度编程为高期望的灵敏度值。这可以概念化为“避免不惜代价”提供虚假的冲击，即使以不能对可治疗的室性快速性心律失常产生冲击为代价。除其他外，特异性增强包括使用多通道或高速率VT / VF检测阈值来抑制患者呼吸或不仰卧时的电击输送。目前的起搏器/除颤器装置可以潜在地挽救现在临床上不指定用于除颤器/起搏器但因一个或多个风险因素而具有增加的心脏猝死风险的缓慢心律失常患者的生命。

3. 发明申请

WO2009114096A1 SYSTEMS AND DEVICES FOR MODULATING AUTONOMIC TONE 审中-公开
标题翻译：用于调制自动音调的系统和设备
公开(公告)号：WO2009114096A1
公开(公告)日：2009-09-17
申请号：PCT/US2009/001374
申请日：2009-03-04
申请人： CARDIAC PACEMAKERS, INC. , SHUROS, Allan, C. , ARCOT-KRISHNAMURTHY, Shantha , KENKNIGHT, Bruce, H. , DAUM, Douglas, R.
发明人： SHUROS, Allan, C. , ARCOT-KRISHNAMURTHY, Shantha , KENKNIGHT, Bruce, H. , DAUM, Douglas, R.
IPC分类号： A61N1/36
CPC分类号： A61N1/362 , A61N1/36114 , A61N1/3627
摘要： Various system embodiments comprise means for intermittently delivering a sympathetic stimulus, including means for delivering a sequence of stress-inducing pacing pulses adapted to increase sympathetic tone during the stress-inducing pacing. The stress-inducing pacing results in a parasympathetic reflex after the sequence of stress-inducing pacing. The embodiment further includes means for delivering neural stimulation to elicit a parasympathetic response or a sympathetic response in a coordinated manner with respect to the sequence of stress-inducing pacing pulses. The neural stimulation is timed to elicit the parasympathetic response after the sequence of stress-inducing pacing pulses and concurrent with at least a portion of the parasympathetic reflex to the sequence of stress-inducing pacing to enhance a parasympathetic effect of the parasympathetic reflex, or to elicit the sympathetic response during the sequence of stress-inducing pulses to provide a larger sympathetic stimulus, resulting in an enhanced parasympathetic reflex in response to the large sympathetic stimulus.
摘要翻译：各种系统实施例包括用于间歇地递送交感刺激的装置，包括用于递送适于在应力诱导起搏期间增加交感神经张力的应力诱发起搏脉冲序列的装置。应激诱导起搏导致应激诱导起搏顺序后的副交感神经反射。该实施方案还包括用于递送神经刺激以相对于应力诱导起搏脉冲的序列以协调的方式引发副交感神经反应或交感反应的装置。神经刺激被定时以在应力诱发起搏脉冲序列之后引起副交感神经反应，并且与应激诱导起搏序列的至少一部分副交感神经反射并发，以增强副交感神经反射的副交感作用，或在应激诱导脉冲序列期间引起交感神经反应以提供更大的交感神经刺激，导致响应于大的交感神经刺激的增强的副交感神经反射。

4. 发明申请

WO2005089643A1 WIRELESS ECG IN IMPLANTABLE DEVICES 审中-公开
标题翻译：无线心电图在可植入设备
公开(公告)号：WO2005089643A1
公开(公告)日：2005-09-29
申请号：PCT/US2005/006984
申请日：2005-03-03
申请人： CARDIAC PACEMAKERS, INC. , MCCABE, Aaron , SCHEINER, Avram , ZHANG, Geng , NI, Quan , DAUM, Douglas, R. , ZHANG, Yi
发明人： MCCABE, Aaron , SCHEINER, Avram , ZHANG, Geng , NI, Quan , DAUM, Douglas, R. , ZHANG, Yi
IPC分类号： A61B5/0402
CPC分类号： A61B5/0402 , A61N1/365 , A61N1/3756
摘要： An implantable medical device (220A) such as an implantable pacemaker or implantable cardioverter/defibrillator includes a programmable sensing circuit (222) providing for sensing of a signal approximating a surface electrocardiogram (ECG) through implanted electrodes (210A, 210B). With various electrode configurations, signals approximating various standard surface ECG signals are acquired without the need for attaching electrodes with cables onto the skin. The various electrode configurations include, but are not limited to various combinations of intracardiac pacing electrodes, portions of the implantable medical device contacting tissue, and electrodes incorporated onto the surface of the implantable medical device.
摘要翻译：诸如可植入起搏器或植入式心律转复/除纤颤器之类的可植入医疗装置（220A）包括可编程感测电路（222），用于通过植入电极（210A，210B）感测接近表面心电图（ECG）的信号。通过各种电极配置，获取近似各种标准表面ECG信号的信号，而不需要将电极与电缆连接在皮肤上。各种电极配置包括但不限于心内起搏电极的各种组合，可植入医疗器件接触组织的部分，以及结合到可植入医疗装置的表面上的电极。

5. 发明申请

WO2006020791A1 PACER WITH COMBINED DEFIBRILLATOR TAILORED FOR BRADYCARDIA PATIENTS 审中-公开
标题翻译：用于BRADYCARDIA患者定期使用的组合式除颤器的PACER
公开(公告)号：WO2006020791A1
公开(公告)日：2006-02-23
申请号：PCT/US2005/028592
申请日：2005-08-10
申请人： CARDIAC PACEMAKERS, INC. , BOCEK, Joseph, M. , DUJMOVIC, Richard, Milon, Jr. , FOSHEE, Phil , WHITE, Harley , KIM, Jaeho , HARRINGTON, Anthony , SANDERS, Richard, S. , DAUM, Douglas, R. , DE CORIOLIS, Paul
发明人： BOCEK, Joseph, M. , DUJMOVIC, Richard, Milon, Jr. , FOSHEE, Phil , WHITE, Harley , KIM, Jaeho , HARRINGTON, Anthony , SANDERS, Richard, S. , DAUM, Douglas, R. , DE CORIOLIS, Paul
IPC分类号： A61N1/39
CPC分类号： A61N1/3956 , A61N1/3962
摘要： A combination pacer/defibrillator is tailored for bradycardia patients. In one example, its shock-delivery specificity exceeds its sensitivity to shockable ventricular tachyarrhythmias. In another example, its specificity exceeds 95%, or 99%, or even 99.5%. Sensitivity is programmed to a high desired sensitivity value if it can be done without decreasing the specificity below the desired specificity threshold value. This can be conceptualized as "avoiding at all costs" delivering false shocks, even at the expense of failing to deliver a shock to a treatable ventricular tachyarrhythmia. Specificity enhancements include, among other things, inhibiting shock delivery when the patient is breathing or not supine, using multiple channels or a high rate VT/VF detection threshold. The present pacer/defibrillator device could potentially save the lives of bradyarrhythmia patients who are not presently clinically indicated for a defibrillator/pacer, but who have an increased risk of sudden cardiac death due to one or more risk factors.
摘要翻译：组合起搏器/除颤器是为心动过缓患者量身打造的。在一个例子中，其冲击传递特异性超过其对可震荡室性快速性心律失常的敏感性。在另一个实例中，其特异性超过95％，或99％，甚至99.5％。如果可以在不降低低于所需特异性阈值的特异性的情况下进行灵敏度编程，达到高期望的灵敏度值。这可以被概念化为“不惜一切代价”，提供虚假的冲击，即使以不能对可治疗的室性快速性心律失常发生冲击为代价。特异性增强包括，当患者呼吸或不仰卧时，使用多个通道或高速率的VT / VF检测阈值来抑制冲击输送。本发明的除颤器装置可以潜在地节省目前临床指示用于除颤器/止痛器但是由于一个或多个危险因素引起的心脏猝死风险增加的缓慢心律失常患者的生命。

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