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1. 发明申请

WO2011088222A1 CLOSED LOOP NEURAL STIMULATION SYNCHRONIZED TO CARDIAC CYCLES 审中-公开
标题翻译：闭环循环神经刺激同步心脏循环
公开(公告)号：WO2011088222A1
公开(公告)日：2011-07-21
申请号：PCT/US2011/021154
申请日：2011-01-13
申请人： CARDIAC PACEMAKERS, INC. , MCCABE, Aaron , LIBBUS, Imad , ZHANG, Yi , HAEFNER, Paul, A. , SATHAVE, Alok, S. , CAPARSO, Anthony, V. , BROOKE, M., Jason
发明人： MCCABE, Aaron , LIBBUS, Imad , ZHANG, Yi , HAEFNER, Paul, A. , SATHAVE, Alok, S. , CAPARSO, Anthony, V. , BROOKE, M., Jason
IPC分类号： A61N1/36
CPC分类号： A61N1/36114 , A61N1/36053 , A61N1/3606 , A61N1/36128 , A61N1/36139
摘要： Various aspects of the present subject matter relate to a method. According to various method embodiments, cardiac activity is detected, and neural stimulation is synchronized with a reference event in the detected cardiac activity. Neural stimulation is titrated based on a detected response to the neural stimulation. Other aspects and embodiments are provided herein.
摘要翻译：本主题的各个方面涉及一种方法。根据各种方法实施例，检测心脏活动，并且神经刺激与检测到的心脏活动中的参考事件同步。基于对神经刺激的检测反应来滴定神经刺激。本文提供了其它方面和实施例。

2. 发明申请

WO2009143177A3 IMPLANTABLE NEURAL STIMULATION ELECTRODE ASSEMBLIES AND METHODS FOR STIMULATING SPINAL NEURAL SITES 审中-公开
公开(公告)号：WO2009143177A3
公开(公告)日：2009-11-26
申请号：PCT/US2009/044555
申请日：2009-05-19
申请人： NEVRO CORPORATION , BOLING, C., Lance , CAPARSO, Anthony, V.
发明人： BOLING, C., Lance , CAPARSO, Anthony, V.
IPC分类号： A61N1/05
摘要： An implantable neurostimulation electrode assembly comprises a first electrode unit and a second electrode unit configured to be arranged in a side-by-side configuration. The first electrode unit includes a dielectric first paddle, a plurality of first electrodes carried by the first paddle, and a guideline. The guideline has a distal section affixed to the first paddle and a proximal section having a length configured to extend externally of a patient. The second electrode unit has a dielectric second paddle and a plurality of second electrodes carried by the second paddle. The second paddle is configured to travel along the guideline and contact the first paddle in the side-by-side configuration. As a result, the first and second electrode units of this embodiment can be passed percutaneously through the same percutaneous entry hole and assembled in vivo at the stimulation site to form a larger paddle-type electrode array without surgical implantation.

3. 发明申请

WO2008027339A2 SYSTEM FOR NEURAL STIMULATION WITH RESPIRATORY FEEDBACK 审中-公开
标题翻译：神经刺激系统与呼吸反馈
公开(公告)号：WO2008027339A2
公开(公告)日：2008-03-06
申请号：PCT/US2007/018846
申请日：2007-08-24
申请人： CARDIAC PACEMAKERS, INC. , HAEFNER, Paul, A. , JAMES, Kristofer, J. , LEE, Kent , LIBBUS, Imad , CAPARSO, Anthony, V. , KWOK, Jonathan , PU, Yachuan
发明人： HAEFNER, Paul, A. , JAMES, Kristofer, J. , LEE, Kent , LIBBUS, Imad , CAPARSO, Anthony, V. , KWOK, Jonathan , PU, Yachuan
CPC分类号： A61N1/36053 , A61B5/08 , A61B5/4035 , A61B5/4818 , A61N1/3601 , A61N1/36114
摘要： A neural stimulation system controls the delivery of neural stimulation using a respiratory signal as a therapy feedback input. The respiratory signal is used to increase the effectiveness of the neural stimulation, such as vagal nerve stimulation, while decreasing potentially adverse side effects in respiratory functions. In one embodiment, the neural stimulation system synchronizes the delivery of the neural stimulation pulses to the respiratory cycles using a respiratory fiducial point in the respiratory signal and a delay interval. In another embodiment, the neural stimulation system detects a respiratory disorder and, in response, adjusts the delivery of the neural stimulation pulses and/or delivers a respiratory therapy treating the detected respiratory disorder.
摘要翻译：神经刺激系统使用呼吸信号作为治疗反馈输入来控制神经刺激的传递。呼吸信号用于增加神经刺激的有效性，例如迷走神经刺激，同时减少呼吸功能的潜在不利副作用。在一个实施例中，神经刺激系统使用呼吸信号中的呼吸基准点和延迟间隔将神经刺激脉冲的传送同步到呼吸周期。在另一个实施例中，神经刺激系统检测呼吸障碍，并且作为响应调整神经刺激脉冲的递送和/或递送治疗所检测的呼吸障碍的呼吸治疗。

4. 发明申请

WO2009143177A2 IMPLANTABLE NEURAL STIMULATION ELECTRODE ASSEMBLIES AND METHODS FOR STIMULATING SPINAL NEURAL SITES 审中-公开
标题翻译：可植入神经刺激电极组件及刺激脊髓神经网站的方法
公开(公告)号：WO2009143177A2
公开(公告)日：2009-11-26
申请号：PCT/US2009044555
申请日：2009-05-19
申请人： NEVRO CORP , BOLING C LANCE , CAPARSO ANTHONY V
发明人： BOLING C LANCE , CAPARSO ANTHONY V
IPC分类号： A61N1/05
CPC分类号： A61N1/0553
摘要： An implantable neurostimulation electrode assembly comprises a first electrode unit and a second electrode unit configured to be arranged in a side-by-side configuration. The first electrode unit includes a dielectric first paddle, a plurality of first electrodes carried by the first paddle, and a guideline. The guideline has a distal section affixed to the first paddle and a proximal section having a length configured to extend externally of a patient. The second electrode unit has a dielectric second paddle and a plurality of second electrodes carried by the second paddle. The second paddle is configured to travel along the guideline and contact the first paddle in the side-by-side configuration. As a result, the first and second electrode units of this embodiment can be passed percutaneously through the same percutaneous entry hole and assembled in vivo at the stimulation site to form a larger paddle-type electrode array without surgical implantation.
摘要翻译：可植入式神经刺激电极组件包括第一电极单元和第二电极单元，该第二电极单元被配置为并排配置。第一电极单元包括电介质第一桨，由第一桨承载的多个第一电极和指南。所述指南具有固定到所述第一桨叶的远端部分和具有被配置为在患者体外延伸的长度的近端部分。第二电极单元具有电介质第二电极和由第二电极承载的多个第二电极。第二桨被配置为沿着准线行进并且以并排配置接触第一桨叶。结果，本实施方式的第一电极单元和第二电极单元可以经皮通过相同的经皮进入孔，并且在刺激部位体内组装形成较大的桨状电极阵列而无需手术植入。

5. 发明申请

WO2008027297A3 SYSTEM FOR NEURAL STIMULATION DURING DISORDERED BREATHING 审中-公开
公开(公告)号：WO2008027297A3
公开(公告)日：2008-03-06
申请号：PCT/US2007/018697
申请日：2007-08-24
申请人： CARDIAC PACEMAKERS, INC. , LEE, Kent , LIBBUS, Imad , CAPARSO, Anthony, V. , KWOK, Jonathan , PU, Yachuan , HAEFNER, Paul, A. , JAMES, Kristofer, J.
发明人： LEE, Kent , LIBBUS, Imad , CAPARSO, Anthony, V. , KWOK, Jonathan , PU, Yachuan , HAEFNER, Paul, A. , JAMES, Kristofer, J.
IPC分类号： A61N1/36
摘要： A neural stimulation system controls the delivery of neural stimulation using a respiratory signal as a therapy feedback input. The respiratory signal is used to increase the effectiveness of the neural stimulation, such as vagal nerve stimulation, while decreasing potentially adverse side effects in respiratory functions. In one embodiment, the neural stimulation system detects apnea and, in response, adjusts the delivery of the neural stimulation pulses and/or delivers a respiratory therapy treating the detected apnea.

6. 发明申请

WO2008027233A1 SYSTEM FOR NEURAL STIMULATION 审中-公开
标题翻译：神经刺激系统
公开(公告)号：WO2008027233A1
公开(公告)日：2008-03-06
申请号：PCT/US2007/018371
申请日：2007-08-20
申请人： CARDIAC PACEMAKERS, INC. , LIBBUS, Imad , KRAMER, Andrew, P. , CAPARSO, Anthony V. , JAMES, Kristofer J. , RUBLE, Stephen , ZHAO, Weiying
发明人： LIBBUS, Imad , KRAMER, Andrew, P. , CAPARSO, Anthony V. , JAMES, Kristofer J. , RUBLE, Stephen , ZHAO, Weiying
IPC分类号： A61N1/362
CPC分类号： A61N1/365 , A61N1/36053 , A61N1/36114
摘要： Various aspects provide an implantable device. In various embodiments, the device comprises at least one port, where each port is adapted to connect a lead with an electrode to the device. The device further includes a stimulation platform, including a sensing circuit connected to the at least one port to sense an intrinsic cardiac signal and a stimulation circuit connected to the at least one port via a stimulation channel to deliver a stimulation signal through the stimulation channel to the electrode. The stimulation circuit is adapted to deliver stimulation signals through the stimulation channel for both neural stimulation therapy and CRM therapy. The sensing and stimulation circuits are adapted to perform CRM functions. The device further includes a controller connected to the sensing circuit and the stimulation circuit to control the neural stimulation therapy and the CRM therapy. Other aspects and embodiments are provided herein.
摘要翻译：各种方面提供可植入装置。在各种实施例中，设备包括至少一个端口，其中每个端口适于将引线与电极连接到设备。所述装置还包括刺激平台，包括连接到所述至少一个端口以感测固有心脏信号的感测电路和经由刺激通道连接到所述至少一个端口的刺激电路，以将刺激信号通过所述刺激通道递送到电极。刺激电路适于通过刺激通道输送刺激信号用于神经刺激治疗和CRM治疗。感测和刺激电路适于执行CRM功能。该装置还包括连接到感测电路和刺激电路的控制器，以控制神经刺激疗法和CRM治疗。本文提供了其它方面和实施例。

7. 发明申请

WO2007050657A1 IMPLANTABLE AND RECHARGEABLE NEURAL STIMULATOR 审中-公开
标题翻译：可植入和可补充的神经刺激器
公开(公告)号：WO2007050657A1
公开(公告)日：2007-05-03
申请号：PCT/US2006/041569
申请日：2006-10-23
申请人： CARDIAC PACEMAKERS, INC. , CHAVAN, Abhi , CAPARSO, Anthony V. , SCHEINER, Avram
发明人： CHAVAN, Abhi , CAPARSO, Anthony V. , SCHEINER, Avram
IPC分类号： A61N1/36 , A61N1/372 , A61N1/34
CPC分类号： A61N1/36117 , A61N1/3605 , A61N1/36071 , A61N1/36135 , A61N1/37205 , A61N1/37217 , A61N1/37288 , A61N1/3787
摘要： One aspect of the present subject matter relates to an implantable medical device. An embodiment of the device comprises a rechargeable power supply adapted to be recharged through an ultrasound signal, a neural stimulator connected to the rechargeable power supply, and a controller connected to the rechargeable power supply. The neural stimulator is adapted to generate a neural stimulation signal for delivery to a neural stimulation target through an electrode. The controller is further connected to the neural stimulator to control the neural stimulator according to a neural stimulation protocol. Other aspects are provided herein.
摘要翻译：本主题的一个方面涉及可植入医疗装置。该装置的实施例包括适于通过超声信号再充电的可再充电电源，连接到可再充电电源的神经刺激器和连接到可再充电电源的控制器。神经刺激器适于产生用于通过电极递送到神经刺激靶的神经刺激信号。控制器进一步连接到神经刺激器，以根据神经刺激方案来控制神经刺激器。本文提供了其他方面。

8. 发明申请

WO2009042030A3 NEUROSTIMULATION SYSTEMS FOR CARDIAC CONDITIONS 审中-公开
标题翻译：心脏病的神经调节系统
公开(公告)号：WO2009042030A3
公开(公告)日：2009-05-14
申请号：PCT/US2008010515
申请日：2008-09-09
申请人： CARDIAC PACEMAKERS INC , ZHANG YI , CAPARSO ANTHONY V , LIBBUS IMAD , MCCABE AARON , MEYER SCOTT A , BROCKWAY MARINA V
发明人： ZHANG YI , CAPARSO ANTHONY V , LIBBUS IMAD , MCCABE AARON , MEYER SCOTT A , BROCKWAY MARINA V
IPC分类号： A61N1/36 , A61B5/04
CPC分类号： A61N1/36114 , A61B5/04012 , A61B5/4519 , A61N1/3622 , A61N1/3627
摘要： Various embodiments provide an implantable medical device comprising a detector, a neural stimulator, and a controller. The detector is configured to detect a pathological condition indicated for an acute neural stimulation therapy. The neural stimulator is capable of delivering a chronic neural stimulation therapy and the acute neural stimulation therapy. The controller is configured to control the neural stimulator to provide the chronic neural stimulation therapy, receive an indicator from the detector that the pathological condition is detected, and control the neural stimulator to integrate the acute neural stimulation therapy with the chronic neural stimulation therapy in response to the indicator.
摘要翻译：各种实施例提供了包括检测器，神经刺激器和控制器的可植入医疗装置。检测器被配置为检测指示用于急性神经刺激治疗的病理状态。神经刺激器能够提供慢性神经刺激疗法和急性神经刺激疗法。控制器被配置为控制神经刺激器以提供慢性神经刺激治疗，从检测器接收指示病理状况被检测到的指示，并且控制神经刺激器将急性神经刺激治疗与慢性神经刺激治疗整合为响应到指标。

9. 发明申请

WO2008027297A2 SYSTEM FOR NEURAL STIMULATION DURING DISORDERED BREATHING 审中-公开
标题翻译：异常呼吸期神经刺激系统
公开(公告)号：WO2008027297A2
公开(公告)日：2008-03-06
申请号：PCT/US2007018697
申请日：2007-08-24
申请人： CARDIAC PACEMAKERS INC , LEE KENT , LIBBUS IMAD , CAPARSO ANTHONY V , KWOK JONATHAN , PU YACHUAN , HAEFNER PAUL A , JAMES KRISTOFER J
发明人： LEE KENT , LIBBUS IMAD , CAPARSO ANTHONY V , KWOK JONATHAN , PU YACHUAN , HAEFNER PAUL A , JAMES KRISTOFER J
CPC分类号： A61N1/36135 , A61B5/0215 , A61B5/08 , A61B5/0816 , A61B5/4035 , A61B5/4818 , A61N1/3601
摘要： A neural stimulation system controls the delivery of neural stimulation using a respiratory signal as a therapy feedback input. The respiratory signal is used to increase the effectiveness of the neural stimulation, such as vagal nerve stimulation, while decreasing potentially adverse side effects in respiratory functions. In one embodiment, the neural stimulation system detects apnea and, in response, adjusts the delivery of the neural stimulation pulses and/or delivers a respiratory therapy treating the detected apnea.
摘要翻译：神经刺激系统使用呼吸信号作为治疗反馈输入来控制神经刺激的传递。呼吸信号用于增加神经刺激的有效性，例如迷走神经刺激，同时减少呼吸功能的潜在不利副作用。在一个实施例中，神经刺激系统检测呼吸暂停，并且作为响应调整神经刺激脉冲的传递和/或递送治疗所检测的呼吸暂停的呼吸治疗。

10. 发明申请

WO2020206032A1 DEVICE AND METHOD FOR WIRELESS MICROSTIMULATION 审中-公开
公开(公告)号：WO2020206032A1
公开(公告)日：2020-10-08
申请号：PCT/US2020/026260
申请日：2020-04-01
申请人： CAPARSO, Anthony V. , DAVIS, Richard J. , KAHOOK, Malik , MANDAVA, Naresh
发明人： CAPARSO, Anthony V. , DAVIS, Richard J. , KAHOOK, Malik , MANDAVA, Naresh
IPC分类号： A61N2/02 , A61N2/00 , A61N1/36 , A61N1/372 , A61N1/375 , A61N1/40
摘要： Systems and methods for wireless neural stimulation are presented. A microstimulator comprising a highly magnetic permeable material is implanted in the tissue of a living body. A wearable external controller creates a time-varying magnetic field that extends to the microstimulator in the tissue. The microstimulator re-shapes and boosts the time-varying magnetic field in the area surrounding the microstimulator, causing neural stimulation in the area around the microstimulator. A physician programmer device is also presented that allows a physician to program the wearable external controller.

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