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1. 发明授权

US10118042B2 Lead integrity testing triggered by sensed asystole 有权
公开(公告)号：US10118042B2
公开(公告)日：2018-11-06
申请号：US12262443
申请日：2008-10-31
申请人： Bruce D. Gunderson , William J. Havel
发明人： Bruce D. Gunderson , William J. Havel
IPC分类号： A61N1/00 , A61N1/37 , A61N1/372 , A61N1/08
摘要： A method includes sensing a cardiac electrogram (EGM) signal of a patient via one or more electrodes on at least one implantable medical lead. An asystolic EGM signal is detected from the patient, and a lead integrity test of the at least one implantable medical lead is initiated in response to the asystolic EGM signal.

2. 发明申请

US20100114222A1 LEAD INTEGRITY TESTING TRIGGERED BY SENSED ASYSTOLE 审中-公开
标题翻译：由传感器ASYSTOLE触发的引导完整性测试
公开(公告)号：US20100114222A1
公开(公告)日：2010-05-06
申请号：US12262443
申请日：2008-10-31
申请人： Bruce D. Gunderson , William J. Havel
发明人： Bruce D. Gunderson , William J. Havel
IPC分类号： A61N1/37 , A61N1/08 , A61N1/39
CPC分类号： A61N1/37 , A61N1/37258 , A61N2001/083
摘要： A method includes sensing a cardiac electrogram (EGM) signal of a patient via one or more electrodes on at least one implantable medical lead. An asystolic EGM signal is detected from the patient, and a lead integrity test of the at least one implantable medical lead is initiated in response to the asystolic EGM signal.
摘要翻译：一种方法包括通过至少一个可植入医疗引线上的一个或多个电极感测患者的心电图（EGM）信号。从患者检测到收缩期EGM信号，并且响应于收缩期EGM信号启动至少一个可植入医疗引线的引线完整性测试。

3. 发明授权

US09308107B2 Endoluminal prosthesis and delivery device 有权
标题翻译：腔内假体和输送装置
公开(公告)号：US09308107B2
公开(公告)日：2016-04-12
申请号：US13595636
申请日：2012-08-27
申请人： William J. Havel
发明人： William J. Havel
IPC分类号： A61F2/06 , A61F2/954 , A61F2/966
CPC分类号： A61F2/954 , A61F2/07 , A61F2/966 , A61F2002/065 , A61F2002/067
摘要： A system for treating a body vessel may include a delivery device and a prosthesis retained on the delivery device. The prosthesis may include a main body and first and second legs each extending from the main body. The main body may include a lumen, and the first leg may include a lumen in fluid communication with the lumen of the main body. The second leg may include a tubular graft body and a stent attached to the graft body. The prosthesis may have a predeployment configuration in which the graft body of the second leg is inverted into and positioned within the lumen of the first leg, and the stent is positioned outside of the inverted graft body. The prosthesis may have a deployed configuration in which the second leg extends outward from the main body, and the stent is positioned within a lumen of the graft body.
摘要翻译：用于治疗身体血管的系统可以包括输送装置和保留在输送装置上的假体。假体可以包括主体以及从主体延伸的第一和第二腿。主体可以包括腔，并且第一腿可以包括与主体的内腔流体连通的内腔。第二腿部可以包括管状移植体和附接到移植物体的支架。假体可以具有预部署构造，其中第二腿的移植物体被倒置并位于第一腿的内腔内，并且支架位于倒置的移植物体的外侧。假体可以具有展开构造，其中第二腿从主体向外延伸，并且支架位于移植物主体的内腔内。

4. 发明授权

US09101389B2 Apparatus for guiding the placement of a subcutaneous device 有权
标题翻译：用于引导皮下装置的放置的装置
公开(公告)号：US09101389B2
公开(公告)日：2015-08-11
申请号：US12431926
申请日：2009-04-29
申请人： William J. Havel , Teresa A. Whitman , Laurie D. Foerster , Mark T. Marshall
发明人： William J. Havel , Teresa A. Whitman , Laurie D. Foerster , Mark T. Marshall
IPC分类号： A61B17/34 , A61N1/04 , A61M5/42 , A61M5/158 , A61B17/00 , A61B17/30 , A61B17/32 , A61N1/05
CPC分类号： A61B17/3468 , A61B17/3462 , A61B17/3472 , A61B2017/00026 , A61B2017/0003 , A61B2017/00561 , A61B2017/306 , A61B2017/320044 , A61B2017/320056 , A61M5/425 , A61M5/427 , A61M2005/1586 , A61N1/046 , A61N1/0504
摘要： An apparatus for guiding the placement of a subcutaneous device that includes a strap having an indentation configured for a fold of skin and fat layer to be positioned within the indentation as the subcutaneous device is advanced to a desired implantation site.
摘要翻译：一种用于引导皮下装置的放置的装置，所述装置包括当皮下装置前进到期望的植入部位时具有构造成用于皮肤和脂肪层的折叠的凹陷的带以定位在凹陷内。

5. 发明授权

US08630708B2 Method and apparatus for post-shock evaluation using tissue oxygenation measurements 有权
标题翻译：使用组织氧合测量进行休克后评估的方法和装置
公开(公告)号：US08630708B2
公开(公告)日：2014-01-14
申请号：US12845818
申请日：2010-07-29
申请人： Jonathan L. Kuhn , Can Cinbis , David A. Anderson , William J. Havel
发明人： Jonathan L. Kuhn , Can Cinbis , David A. Anderson , William J. Havel
IPC分类号： A61N1/365
CPC分类号： A61B5/14551 , A61B5/1459 , A61B5/6846 , A61B5/7285 , A61N1/36557 , A61N1/3925 , A61N1/3956
摘要： A method and device for delivering therapy that includes an electrode to sense cardiac signals and to deliver a therapy, a therapy delivery module coupled to the electrode to deliver a therapy via the electrode in response to the sensed cardiac signals, a sensor emitting light and detecting emitted light scattered by a tissue volume adjacent the sensor to generate a corresponding detected light intensity output signal, a control module coupled to the sensor to control light emission of the sensor in response to delivering the therapy; and a controller coupled to the therapy delivery module and the sensor, the controller configured to determine a tissue oxygenation measurement in response to the output signal, and determine whether the delivered therapy was successful in restoring cardiac hemodynamic function in response to the tissue oxygenation measurement.
摘要翻译：一种用于递送治疗的方法和装置，其包括用于感测心脏信号并递送治疗的电极，治疗递送模块，其耦合到所述电极，以响应于感测到的心脏信号经由所述电极递送治疗;发射光和检测的传感器发射由邻近传感器的组织体积散射的光，以产生相应的检测到的光强度输出信号;控制模块，其耦合到所述传感器，以响应于递送所述治疗来控制所述传感器的光发射; 以及耦合到所述治疗递送模块和所述传感器的控制器，所述控制器被配置为响应于所述输出信号确定组织氧合测量，并且确定所递送的治疗是否成功响应于所述组织氧合测量来恢复心脏血液动力学功能。

6. 发明授权

US07957799B2 Non-invasive cardiac potentiation therapy 有权
标题翻译：非侵入性心脏增强疗法
公开(公告)号：US07957799B2
公开(公告)日：2011-06-07
申请号：US11742063
申请日：2007-04-30
申请人： Joseph L. Sullivan , Fred W. Chapman , Robert G. Walker , William J. Havel , D. Curtis Deno
发明人： Joseph L. Sullivan , Fred W. Chapman , Robert G. Walker , William J. Havel , D. Curtis Deno
IPC分类号： A61N1/39
CPC分类号： A61N1/3625 , A61B5/02028 , A61B5/029 , A61B5/7217 , A61N1/3627 , A61N1/3925
摘要： An external cardiac medical device for delivering Cardiac Potentiation Therapy (CPT). Techniques used with the device include initial diagnosis of the patient, delivery of the CPT, and configuration of the external device, so that CPT can be effectively and efficiently provided. In particular, these techniques include initially determining whether a patient should receive CPT, how to set the coupling interval for delivering CPT, how to configure the external medical device to deliver CPT stimulation pulses while not adversely affecting the device's ability to sense a patient's cardiac parameters and/or signals.
摘要翻译：用于输送心脏增强疗法（CPT）的外部心脏医疗装置。与该装置一起使用的技术包括患者的初始诊断，CPT的传递和外部设备的配置，使得可以有效和高效地提供CPT。具体地说，这些技术包括最初确定患者是否应该接受CPT，如何设定用于递送CPT的耦合间隔，如何配置外部医疗设备以递送CPT刺激脉冲，同时不会不利地影响设备感测患者心脏参数的能力和/或信号。

7. 发明申请

US20100030230A1 MEDICAL DEVICE SYSTEM AND APPARATUS FOR GUIDING THE PLACEMENT OF A SUBCUTANEOUS DEVICE 审中-公开
标题翻译：医疗装置系统及用于指导装置的装置
公开(公告)号：US20100030230A1
公开(公告)日：2010-02-04
申请号：US12432052
申请日：2009-04-29
申请人： William J. Havel , Vladimir P. Nikolski , Matthew D. Bonner
发明人： William J. Havel , Vladimir P. Nikolski , Matthew D. Bonner
IPC分类号： A61B17/32
CPC分类号： A61B17/3468 , A61B17/3462 , A61B17/3472 , A61B2017/00026 , A61B2017/0003 , A61B2017/00561 , A61B2017/306 , A61B2017/320044 , A61B2017/320056 , A61M5/425 , A61M5/427 , A61M2005/1586 , A61N1/046 , A61N1/0504
摘要： A medical device system for guiding placement of a subcutaneous medical device that includes a strap extending along a length from a proximal end to a distal end, a first flange and a second flange extending along a portion of the length of the strap, a base portion extending along a portion of the length of the strap between the first flange and the second flange, an orientation member extending along the strap to limit a predetermined radius of curvature of the strap, and an indentation extending from the proximal end to the distal end of the strap, the indentation formed by the first flange, the second flange, and the base portion, wherein the first flange and the second flange include curved bottom portions that make contact with and compress a tissue layer to position the tissue layer within the indentation during the placement of the subcutaneous device.
摘要翻译：一种用于引导皮下医疗装置的放置的医疗装置系统，该皮下医疗装置包括沿着从近端到远端的长度延伸的带，沿着带的长度的一部分延伸的第一凸缘和第二凸缘，沿着所述带的长度的一部分延伸在所述第一凸缘和所述第二凸缘之间，定向构件沿着所述带延伸以限制所述带的预定曲率半径，以及从所述近端延伸到所述第二凸缘的远端所述带，由所述第一凸缘，所述第二凸缘和所述基部形成的所述凹口，其中所述第一凸缘和所述第二凸缘包括弯曲的底部部分，所述弯曲底部部分与所述组织层接触并压缩所述组织层以将所述组织层定位在所述凹陷内放置皮下装置。

8. 发明申请

US20090177242A1 Apparatus and method for non-invasive induction of ventricular fibrillation 有权
标题翻译：用于非侵入性诱发心室颤动的装置和方法
公开(公告)号：US20090177242A1
公开(公告)日：2009-07-09
申请号：US11969663
申请日：2008-01-04
申请人： Vladimir P. Nikolski , William J. Havel , Joseph L. Sullivan , Daniel W. Piraino , Eric R. Williams
发明人： Vladimir P. Nikolski , William J. Havel , Joseph L. Sullivan , Daniel W. Piraino , Eric R. Williams
IPC分类号： A61N1/39
CPC分类号： A61N1/39 , A61N1/3943 , A61N1/3962
摘要： An apparatus and method for delivering an external shock pulse receive pacing pulses generated by a first device and a shock pulse generated by a second device. An output of the apparatus is coupled to patient electrodes and the apparatus controls delivery of the received pacing pulses to the output and delivery of the received shock pulse to the output. A control module, pacing control and shock control included in the apparatus cooperatively control delivery of the received shock pulse to the output at a predetermined delay after one of the received pacing pulses.
摘要翻译：用于递送外部冲击脉冲的装置和方法接收由第一装置产生的起搏脉冲和由第二装置产生的冲击脉冲。该装置的输出耦合到患者电极，并且该装置控制所接收的起搏脉冲的输出到接收的冲击脉冲的输出和输出。装置中包括的控制模块，起搏控制和冲击控制协调地控制接收到的冲击脉冲在一个接收到的起搏脉冲之后以预定延迟输出到输出端。

9. 发明申请

US20080269818A1 Non-Invasive Cardiac Potentiation Therapy 有权
标题翻译：非侵入性心脏电位治疗
公开(公告)号：US20080269818A1
公开(公告)日：2008-10-30
申请号：US11742063
申请日：2007-04-30
申请人： Joseph L. Sullivan , Fred W. Chapman , Robert G. Walker , William J. Havel , D. Curtis Deno
发明人： Joseph L. Sullivan , Fred W. Chapman , Robert G. Walker , William J. Havel , D. Curtis Deno
IPC分类号： A61N1/362
CPC分类号： A61N1/3625 , A61B5/02028 , A61B5/029 , A61B5/7217 , A61N1/3627 , A61N1/3925
摘要： An external cardiac medical device for delivering Cardiac Potentiation Therapy (CPT). Techniques used with the device include initial diagnosis of the patient, delivery of the CPT, and configuration of the external device, so that CPT can be effectively and efficiently provided. In particular, these techniques include initially determining whether a patient should receive CPT, how to set the coupling interval for delivering CPT, how to configure the external medical device to deliver CPT stimulation pulses while not adversely affecting the device's ability to sense a patient's cardiac parameters and/or signals.
摘要翻译：用于输送心脏增强疗法（CPT）的外部心脏医疗装置。与该装置一起使用的技术包括患者的初始诊断，CPT的传递和外部设备的配置，使得可以有效和高效地提供CPT。具体地说，这些技术包括最初确定患者是否应该接受CPT，如何设定用于递送CPT的耦合间隔，如何配置外部医疗设备以递送CPT刺激脉冲，同时不会不利地影响设备感测患者心脏参数的能力和/或信号。

10. 发明授权

US07151963B2 Control of arbitrary waveforms for constant delivered energy 有权
公开(公告)号：US07151963B2
公开(公告)日：2006-12-19
申请号：US10308832
申请日：2002-12-03
申请人： William J. Havel , Paul J. DeGroot , Thomas W. Sinner , Kevin Kuehn , Gary Kemmetmueller , Warren W. Wold
发明人： William J. Havel , Paul J. DeGroot , Thomas W. Sinner , Kevin Kuehn , Gary Kemmetmueller , Warren W. Wold
IPC分类号： A61N1/39
CPC分类号： A61N1/3906 , A61N1/3912 , A61N1/3937
摘要： The present invention outlines structures and methods for delivering a controllable amount of energy to a patient by automatically compensating for the load impedance detected by an implantable-cardioverter defibrillator (ICD). The invention employs high speed, switching power converter technology for the efficient generation of high energy, arbitrary waveforms. Unlike a linear amplifier, switching power converters deliver high-energy waveforms with an efficiency that is independent of the size and amplitude of the desired waveform. An ICD that uses a switching power converter to deliver the desired energy to the patient stores the energy to be delivered in a storage capacitor. The converter then transforms this energy into an arbitrarily shaped output voltage-controlled or current-controlled waveform by switching the storage capacitor in and out of the output circuit at a high rate of speed. Preferably, the waveform comprises a ramp-type waveform.

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