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1. 发明授权

US06940493B2 Socializing remote communication 失效
标题翻译：社会化远程通信
公开(公告)号：US06940493B2
公开(公告)日：2005-09-06
申请号：US10112246
申请日：2002-03-29
申请人： Bruce Blumberg , Angela Chang , Hiroshi Ishii , Brad Koerner , Benjamin Resner , XingChen Wang
发明人： Bruce Blumberg , Angela Chang , Hiroshi Ishii , Brad Koerner , Benjamin Resner , XingChen Wang
IPC分类号： G06F3/00 , G06F3/01 , G09G5/00
CPC分类号： G06F3/017
摘要： Remote, non-verbal interpersonal communication is facilitated between communication stations located remotely from each other. A first communication station registers proximity of a user thereto and communicates to a second communication station a signal indicative of the registered proximity. The first communication station also registers a physical gesture and communicates a signal indicative of the gesture to the second communication station. The second communication station, in turn, receives the signals and, in response thereto, produces a visual output indicative of proximity and of the gestural input.
摘要翻译：在彼此远程定位的通信站之间促进了远程非语言人际沟通。第一通信站向用户注册接近，并向第二通信站通信指示登记的接近度的信号。第一通信站还注册一个物理手势，并将表示手势的信号传送给第二通信站。第二通信站又接收信号，并响应于此产生指示接近度和手势输入的视觉输出。

2. 发明授权

US09043025B2 Systems and methods for safe robot operation 有权
标题翻译：安全机器人操作的系统和方法
公开(公告)号：US09043025B2
公开(公告)日：2015-05-26
申请号：US14016664
申请日：2013-09-03
申请人： Rodney Brooks , Michael Sussman , Matthew Murray Williamson , William A. Goodwin , Noelle Dye , Bruce Blumberg
发明人： Rodney Brooks , Michael Sussman , Matthew Murray Williamson , William A. Goodwin , Noelle Dye , Bruce Blumberg
IPC分类号： G05B19/04 , G05B19/18 , B25J9/16
CPC分类号： B25J9/1676 , G05B2219/40202 , G05B2219/40203 , G05B2219/43202
摘要： In various embodiments, safe collaboration between a robot and humans is achieved by operating the robot continuously at or below a first threshold speed at which any collisions with a person's arms do not cause harm, and, upon detection of the person's torso or head within a danger zone around the robot, reducing the speed to or below a second threshold at which any collisions with the person's torso or head do not cause harm.
摘要翻译：在各种实施例中，机器人与人类之间的安全协作是通过以与人的手臂的任何碰撞不造成伤害的第一阈值速度或低于第一阈值速度连续地操作机器人，并且在检测到人的躯干或头部机器人周围的危险区域，将人体躯干或头部的任何碰撞的速度降低到或低于第二阈值，不会造成伤害。

3. 发明申请

US20140067121A1 SYSTEMS AND METHODS FOR SAFE ROBOT OPERATION 有权
标题翻译：用于安全机器人操作的系统和方法
公开(公告)号：US20140067121A1
公开(公告)日：2014-03-06
申请号：US14016664
申请日：2013-09-03
申请人： Rodney Brooks , Michael Sussman , Matthew Murray Williamson , William A. Goodwin , Noelle Dye , Bruce Blumberg
发明人： Rodney Brooks , Michael Sussman , Matthew Murray Williamson , William A. Goodwin , Noelle Dye , Bruce Blumberg
IPC分类号： B25J9/16
CPC分类号： B25J9/1676 , G05B2219/40202 , G05B2219/40203 , G05B2219/43202
摘要： In various embodiments, safe collaboration between a robot and humans is achieved by operating the robot continuously at or below a first threshold speed at which any collisions with a person's arms do not cause harm, and, upon detection of the person's torso or head within a danger zone around the robot, reducing the speed to or below a second threshold at which any collisions with the person's torso or head do not cause harm.
摘要翻译：在各种实施例中，机器人与人类之间的安全协作是通过以与人的手臂的任何碰撞不造成伤害的第一阈值速度或低于第一阈值速度连续地操作机器人，并且在检测到人的躯干或头部机器人周围的危险区域，将人体躯干或头部的任何碰撞的速度降低到或低于第二阈值，不会造成伤害。

4. 发明授权

US07972782B2 Steroid-activated nuclear receptors and uses therefor 有权
标题翻译：类固醇激活的核受体及其用途
公开(公告)号：US07972782B2
公开(公告)日：2011-07-05
申请号：US11495263
申请日：2006-07-27
申请人： Ronald M. Evans , Bruce Blumberg
发明人： Ronald M. Evans , Bruce Blumberg
IPC分类号： C12Q1/68
CPC分类号： A01K67/0275 , A01K2217/05 , A01K2227/105 , A01K2267/03 , A61K38/00 , C07K14/70567 , C07K2319/71 , C12N15/8509 , C12N2830/008 , C12Q1/6897 , G01N33/743 , G01N2333/90245 , G01N2500/00
摘要： A novel nuclear receptor, termed the steroid and xenobiotic receptor (SXR), a broad-specificity sensing receptor that is a novel branch of the nuclear receptor superfamily, has been discovered. SXR forms a heterodimer with RXR that can bind to and induce transcription from response elements present in steroid-inducible cytochrome P450 genes in response to hundreds of natural and synthetic compounds with biological activity, including therapeutic steroids as well as dietary steroids and lipids. Instead of hundreds of receptors, one for each inducing compound, the invention SXR receptors monitor aggregate levels of inducers to trigger production of metabolizing enzymes in a coordinated metabolic pathway. Agonists and antagonists of SXR are administered to subjects to achieve a variety of therapeutic goals dependent upon modulating metabolism of one or more endogenous steroids or xenobiotics to establish homeostasis. An assay is provided for identifying steroid drugs that are likely to cause drug interaction if administered to a subject in therapeutic amounts. Transgenic animals are also provided which express human SXR, thereby serving as useful models for human response to various agents which potentially impact P450-dependent metabolic processes.
摘要翻译：已经发现了一种称为类固醇和异种生物受体（SXR）的新型核受体，作为核受体超家族的新分支的广泛特异性感受器受体。 SXR与RXR形成异源二聚体，其可以结合并诱导存在于类固醇诱导细胞色素P450基因中的响应元件的转录，以响应数百种具有生物活性的天然和合成化合物，包括治疗类固醇以及膳食类固醇和脂质。代替数百个受体，每个诱导化合物一个，本发明SXR受体监测诱导剂的总体水平以引发协同代谢途径中代谢酶的产生。 SXR的激动剂和拮抗剂被施用于受试者以实现依赖于调节一种或多种内源性类固醇或异种生物的代谢以建立体内平衡的多种治疗目标。提供了用于鉴定如果以治疗量施用给受试者的可能引起药物相互作用的类固醇药物的测定。还提供了表达人SXR的转基因动物，从而作为人类对各种可能影响P450依赖性代谢过程的药物的反应的有用模型。

5. 发明申请

US20070026445A1 Novel steroid-activated nuclear receptors and uses therefor 有权
标题翻译：新型类固醇激活的核受体及其用途
公开(公告)号：US20070026445A1
公开(公告)日：2007-02-01
申请号：US11495263
申请日：2006-07-27
申请人： Ronald Evans , Bruce Blumberg
发明人： Ronald Evans , Bruce Blumberg
IPC分类号： C12Q1/68 , G01N33/567 , G01N33/53
CPC分类号： A01K67/0275 , A01K2217/05 , A01K2227/105 , A01K2267/03 , A61K38/00 , C07K14/70567 , C07K2319/71 , C12N15/8509 , C12N2830/008 , C12Q1/6897 , G01N33/743 , G01N2333/90245 , G01N2500/00
摘要： A novel nuclear receptor, termed the steroid and xenobiotic receptor (SXR), a broad-specificity sensing receptor that is a novel branch of the nuclear receptor superfamily, has been discovered. SXR forms a heterodimer with RXR that can bind to and induce transcription from response elements present in steroid-inducible cytochrome P450 genes in response to hundreds of natural and synthetic compounds with biological activity, including therapeutic steroids as well as dietary steroids and lipids. Instead of hundreds of receptors, one for each inducing compound, the invention SXR receptors monitor aggregate levels of inducers to trigger production of metabolizing enzymes in a coordinated metabolic pathway. Agonists and antagonists of SXR are administered to subjects to achieve a variety of therapeutic goals dependent upon modulating metabolism of one or more endogenous steroids or xenobiotics to establish homeostasis. An assay is provided for identifying steroid drugs that are likely to cause drug interaction if administered to a subject in therapeutic amounts. Transgenic animals are also provided which express human SXR, thereby serving as useful models for human response to various agents which potentially impact P450-dependent metabolic processes.
摘要翻译：已经发现了一种称为类固醇和异种生物受体（SXR）的新型核受体，作为核受体超家族的新分支的广泛特异性感受器受体。 SXR与RXR形成异源二聚体，其可以结合并诱导存在于类固醇诱导细胞色素P450基因中的响应元件的转录，以响应数百种具有生物活性的天然和合成化合物，包括治疗类固醇以及膳食类固醇和脂质。代替数百个受体，每个诱导化合物一个，本发明SXR受体监测诱导剂的总体水平以引发协同代谢途径中代谢酶的产生。 SXR的激动剂和拮抗剂被施用于受试者以实现依赖于调节一种或多种内源性类固醇或异种生物的代谢以建立体内平衡的多种治疗目标。提供了用于鉴定如果以治疗量施用给受试者的可能引起药物相互作用的类固醇药物的测定。还提供了表达人SXR的转基因动物，从而作为人类对各种可能影响P450依赖性代谢过程的药物的反应的有用模型。

6. 发明授权

US06274321B1 High throughput functional screening of cDNAs 失效
标题翻译： cDNA的高通量功能筛选
公开(公告)号：US06274321B1
公开(公告)日：2001-08-14
申请号：US09454704
申请日：1999-12-03
申请人： Bruce Blumberg
发明人： Bruce Blumberg
IPC分类号： C12Q168
CPC分类号： C12N15/1086
摘要： Methods for screening cDNAs that express a product interacting with a target molecule. Individual cDNAs are pooled and the cDNA pools are expressed to obtain expression products, for example by coupled in vitro transcription/translation. The interaction of the products with the target molecule is then assayed, for example by scintillation proximity assay (SPA), to identify pools of interest. By selectively re-pooling the cDNAs and repeating the expression and assay steps, individual cDNAs of interest can be rapidly identified. This method is readily automated in a computer-controlled device for high throughput screening. The invention also provides methods of transfecting a cell with a cDNA identified by the screening method to confer a desired property to a cell or identifying cDNAs from a pool of cDNAs by transfection into cells to confer a desired property.
摘要翻译：用于筛选表达与靶分子相互作用的产物的cDNA的方法。汇集单个cDNA并且表达cDNA库以获得表达产物，例如通过偶联的体外转录/翻译。然后测定产物与靶分子的相互作用，例如通过闪烁近邻测定（SPA），以鉴定感兴趣的池。通过选择性重新汇集cDNA并重复表达和测定步骤，可以快速鉴定感兴趣的各个cDNA。该方法在用于高通量筛选的计算机控制装置中容易自动化。本发明还提供了通过筛选方法鉴定的cDNA转染细胞的方法，以通过转染细胞以赋予细胞所需的性质来赋予细胞所需的性质或从cDNA库鉴定cDNA。

7. 发明申请

US20060154335A1 Novel members of the steroid/thyroid superfamily and uses therefor 审中-公开
标题翻译：类固醇/甲状腺超家族的新成员和用途
公开(公告)号：US20060154335A1
公开(公告)日：2006-07-13
申请号：US11235557
申请日：2005-09-26
申请人： Ronald Evans , Barry Forman , Steven Kliewer , Estelita Ong , Bruce Blumberg
发明人： Ronald Evans , Barry Forman , Steven Kliewer , Estelita Ong , Bruce Blumberg
IPC分类号： C07K14/705 , C07H21/04 , C12P21/06
CPC分类号： C07K14/705 , C07K14/70567 , G01N33/74 , G01N2500/00
摘要： Novel peroxisome proliferators-activated receptor subunits designated PPARγ and PPARδ are described. Nucleic acid sequences encoding the receptor subunits, expression vectors containing such sequences and host cells transformed with such vectors are also disclosed, as are heterodimeric PPAR receptors comprising at least one of the invention subunits, and methods for the expression of such novel receptors, and various uses therefor.
摘要翻译：描述了称为PPARγ和PPARδ的新型过氧化物酶体增殖物激活受体亚单位。还公开了编码受体亚单位的核酸序列，含有此类序列的表达载体和用这些载体转化的宿主细胞，以及包含本发明亚基中的至少一个的异二聚体PPAR受体，以及表达这种新受体的方法以及各种用它。

8. 发明授权

US06815168B1 Human peroxisome proliferator activated receptor &ggr; compositions and methods 失效
标题翻译：人类过氧化物酶体增殖物激活受体γ组合物和方法
公开(公告)号：US06815168B1
公开(公告)日：2004-11-09
申请号：US09587549
申请日：2000-06-01
申请人： Marianne E. Greene , Bruce Blumberg
发明人： Marianne E. Greene , Bruce Blumberg
IPC分类号： G01N3353
CPC分类号： C07K14/70567
摘要： The invention relates generally to compositions of and methods for obtaining peroxisome proliferator-activated receptors. The invention relates as well to the DNA sequences encoding peroxisome proliferator-activated receptors, the recombinant vectors carrying those sequences, the recombinant host cells including either the sequences or vectors, and recombinant peroxisome proliferator-activated receptor polypeptides. By way of example, the invention discloses the cloning and functional expression of a peroxisome proliferator-activated receptor, designated PPAR-&ggr;, obtained from a human source. The invention includes as well, methods for using the isolated, recombinant peroxisome proliferator-activated receptor polypeptides in assays designed to select and improve substances capable of interacting with peroxisome proliferator-activated receptor polypeptides for use in diagnostic, drug design and therapeutic applications.
摘要翻译：本发明一般涉及获得过氧化物酶体增殖物激活受体的组合物和方法。本发明还涉及编码过氧化物酶体增殖物激活受体的DNA序列，携带这些序列的重组载体，包含序列或载体的重组宿主细胞以及重组过氧化物酶体增殖物激活的受体多肽。举例来说，本发明公开了从人源获得的称为PPAR-γ的过氧化物酶体增殖物激活受体的克隆和功能表达。本发明还包括在测定中使用分离的重组过氧化物酶体增殖物激活受体多肽的方法，其设计用于选择和改善能够与用于诊断，药物设计和治疗应用的能够与过氧化物酶体增殖物激活受体多肽相互作用的物质。

9. 发明授权

US06391847B1 Method, polypeptides, nucleotide sequence of XOR-6, a vitamin D-like receptor from xenopus 失效
标题翻译：使用XOR-6的方法，一种来自砧木的维生素D样受体
公开(公告)号：US06391847B1
公开(公告)日：2002-05-21
申请号：US08875082
申请日：1997-07-17
申请人： Ronald M. Evans , Bruce Blumberg , Kazuhiko Umesono
发明人： Ronald M. Evans , Bruce Blumberg , Kazuhiko Umesono
IPC分类号： A01N3718
CPC分类号： C07K14/463 , A01K2217/05 , A61K38/00 , C07K14/70567 , C07K14/721
摘要： In accordance with the present invention, there are provided new members of the steroid receptor superfamily of receptors, a representative member of which has been designated XOR-6. Invention receptors are responsive to hydroxy, mercapto or amino benzoates, and are expressed, for example, in Xenopus laevis embryos. XOR-6 is most closely, although distantly, related to the vitamin D3 receptor (VDR). The proteins are about 73% identical in amino acid sequence in the DNA-binding domains and about 42% identical in the ligand binding domain. Like VDR, XOR-6 has an extended D region between the DNA and ligand binding domains. Notably, the region amino-terminal to the XOR-6 DNA-binding domain is extremely acidic. This may influence its ability to activate target genes. XOR-6 is not restricted to Xenopus because southern blots show the presence of XOR-6-related sequences in a variety of other vertebrates. Indeed, a human genomic clone for an XOR-6 related gene has recently been isolated. In accordance with a particular aspect of the present invention, there are also provided nucleic acid sequences encoding the above-identified receptor, as well as constructs and cells containing same, and probes derived therefrom. Furthermore, we have also discovered that hydroxy, mercapto or amino benzoates modulate the transcription activating effects of invention receptors.
摘要翻译：根据本发明，提供了类固醇受体超家族受体的新成员，其代表性成员被称为XOR-6。发明受体对羟基，巯基或氨基苯甲酸酯有反应，并且例如在非洲爪蟾胚胎中表达。 XOR-6与维生素D3受体（VDR）有密切的关系。蛋白质在DNA结合结构域中的氨基酸序列约为73％，配体结合域约为42％。像VDR一样，XOR-6在DNA和配体结合域之间具有扩展的D区。值得注意的是，XOR-6 DNA结合结构域的氨基末端区域是极酸性的。这可能会影响其激活靶基因的能力。 XOR-6不仅限于非洲爪蟾，因为南部印迹显示在各种其他脊椎动物中存在XOR-6相关序列。事实上，最近已经分离了XOR-6相关基因的人基因组克隆。根据本发明的特定方面，还提供了编码上述受体的核酸序列，以及含有该受体的构建体和细胞，以及由其衍生的探针。此外，我们还发现羟基，巯基或氨基苯甲酸酯调节本发明受体的转录激活作用。

10. 外观设计

USD769953S1 Compliant manufacturing robot interface 有权
标题翻译：符合制造机器人界面
公开(公告)号：USD769953S1
公开(公告)日：2016-10-25
申请号：US29520632
申请日：2015-03-17
申请人： Miri Bauman , Christopher John Smith , Bruce Blumberg , Matthew Knoll , Umberto Scarfogliero
设计人： Miri Bauman , Christopher John Smith , Bruce Blumberg , Matthew Knoll , Umberto Scarfogliero

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