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1. 发明授权

US06200802B1 Human peroxisome proliferator activated receptor gamma: compositions and methods 失效
标题翻译：人类过氧化物酶体增殖物活化受体γ：组合物和方法
公开(公告)号：US06200802B1
公开(公告)日：2001-03-13
申请号：US08134557
申请日：1993-10-08
申请人： Marianne E. Greene , Bruce Blumberg
发明人： Marianne E. Greene , Bruce Blumberg
IPC分类号： C12N516
CPC分类号： C07K14/70567
摘要： The invention relates generally to compositions of and methods for obtaining peroxisome proliferator-activated receptors. The invention relates as well to the DNA sequences encoding peroxisome proliferator-activated receptors, the recombinant vectors carrying those sequences, the recombinant host cells including either the sequences or vectors, and recombinant peroxisome proliferator-activated receptor polypeptides. By way of example, the invention discloses the cloning and functional expression of a peroxisome proliferator-activated receptor, designated PPAR-&ggr;, obtained from a human source. The invention includes as well, methods for using the isolated, recombinant peroxisome proliferator-activated receptor polypeptides in assays designed to select and improve substances capable of interacting with peroxisome proliferator-activated receptor polypeptides for use in diagnostic, drug design and therapeutic applications.
摘要翻译：本发明一般涉及获得过氧化物酶体增殖物激活受体的组合物和方法。本发明还涉及编码过氧化物酶体增殖物激活受体的DNA序列，携带这些序列的重组载体，包含序列或载体的重组宿主细胞以及重组过氧化物酶体增殖物激活的受体多肽。举例来说，本发明公开了从人源获得的称为PPAR-γ的过氧化物酶体增殖物激活受体的克隆和功能表达。本发明还包括在测定中使用分离的重组过氧化物酶体增殖物激活受体多肽的方法，其设计用于选择和改善能够与用于诊断，药物设计和治疗应用的能够与过氧化物酶体增殖物激活受体多肽相互作用的物质。

2. 发明授权

US06815168B1 Human peroxisome proliferator activated receptor &ggr; compositions and methods 失效
标题翻译：人类过氧化物酶体增殖物激活受体γ组合物和方法
公开(公告)号：US06815168B1
公开(公告)日：2004-11-09
申请号：US09587549
申请日：2000-06-01
申请人： Marianne E. Greene , Bruce Blumberg
发明人： Marianne E. Greene , Bruce Blumberg
IPC分类号： G01N3353
CPC分类号： C07K14/70567
摘要： The invention relates generally to compositions of and methods for obtaining peroxisome proliferator-activated receptors. The invention relates as well to the DNA sequences encoding peroxisome proliferator-activated receptors, the recombinant vectors carrying those sequences, the recombinant host cells including either the sequences or vectors, and recombinant peroxisome proliferator-activated receptor polypeptides. By way of example, the invention discloses the cloning and functional expression of a peroxisome proliferator-activated receptor, designated PPAR-&ggr;, obtained from a human source. The invention includes as well, methods for using the isolated, recombinant peroxisome proliferator-activated receptor polypeptides in assays designed to select and improve substances capable of interacting with peroxisome proliferator-activated receptor polypeptides for use in diagnostic, drug design and therapeutic applications.
摘要翻译：本发明一般涉及获得过氧化物酶体增殖物激活受体的组合物和方法。本发明还涉及编码过氧化物酶体增殖物激活受体的DNA序列，携带这些序列的重组载体，包含序列或载体的重组宿主细胞以及重组过氧化物酶体增殖物激活的受体多肽。举例来说，本发明公开了从人源获得的称为PPAR-γ的过氧化物酶体增殖物激活受体的克隆和功能表达。本发明还包括在测定中使用分离的重组过氧化物酶体增殖物激活受体多肽的方法，其设计用于选择和改善能够与用于诊断，药物设计和治疗应用的能够与过氧化物酶体增殖物激活受体多肽相互作用的物质。

3. 发明授权

US07250273B1 Human peroxisome proliferator activated receptor γ: compositions and methods 失效
标题翻译：人类过氧化物酶体增殖物激活受体γ：组合物和方法
公开(公告)号：US07250273B1
公开(公告)日：2007-07-31
申请号：US10889421
申请日：2004-07-12
申请人： Marianne E. Greene , Bruce Blumberg
发明人： Marianne E. Greene , Bruce Blumberg
IPC分类号： C12P21/00 , C07K14/705 , A61K38/16
CPC分类号： C07K14/70567 , A61K38/00
摘要： The invention relates generally to compositions of and methods for obtaining peroxisome proliferator-activated receptors. The invention relates as well to the DNA sequences encoding peroxisome proliferator-activated receptors, the recombinant vectors carrying those sequences, the recombinant host cells including either the sequences or vectors, and recombinant peroxisome proliferator-activated receptor polypeptides. By way of example, the invention discloses the cloning and functional expression of a peroxisome proliferator-activated receptor, designated PPAR-γ, obtained from a human source. The invention includes as well, methods for using the isolated, recombinant peroxisome proliferator-activated receptor polypeptides in assays designed to select and improve substances capable of interacting with peroxisome proliferator-activated receptor polypeptides for use in diagnostic, drug design and therapeutic applications.
摘要翻译：本发明一般涉及获得过氧化物酶体增殖物激活受体的组合物和方法。本发明还涉及编码过氧化物酶体增殖物激活受体的DNA序列，携带这些序列的重组载体，包含序列或载体的重组宿主细胞以及重组过氧化物酶体增殖物激活的受体多肽。举例来说，本发明公开了从人源获得的称为PPAR-γ的过氧化物酶体增殖物激活受体的克隆和功能表达。本发明还包括在测定中使用分离的重组过氧化物酶体增殖物激活受体多肽的方法，其设计用于选择和改善能够与用于诊断，药物设计和治疗应用的能够与过氧化物酶体增殖物激活受体多肽相互作用的物质。

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