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1. 发明申请

US20080038313A1 Systems, methods, and compositions for mixing and applying lyophilized biomaterials 审中-公开
标题翻译：用于混合和应用冻干生物材料的系统，方法和组合物
公开(公告)号：US20080038313A1
公开(公告)日：2008-02-14
申请号：US11973526
申请日：2007-10-09
申请人： Bruce Addis , Charles Milo , Olexander Hnojewyj
发明人： Bruce Addis , Charles Milo , Olexander Hnojewyj
IPC分类号： A61K31/74 , A61F2/06 , A61K9/00 , A61M31/00 , A61P17/02 , C07K1/107
CPC分类号： A61B17/0057 , A61B17/00491 , A61B2017/00004 , A61B2017/00495 , A61B2017/00637 , A61B2017/0065
摘要： A method of treating tissue lyophilizes a biocompatible polymer having a functionality equal to or greater than three. The method provides a protein solution. The method mixes the protein solution with the lyophilized polymer to reconstitute the polymer and form a mixture, wherein, upon mixing, the protein solution and the polymer cross-link to form a material composition. The method applies the material composition to a tissue region. The biocompatible polymer can comprise, e.g., poly(ethylene glycol) PEG. The protein solution can comprise, e.g., albumin.
摘要翻译：治疗组织的方法将具有等于或大于3的功能的生物相容性聚合物冻干。该方法提供蛋白质溶液。该方法将蛋白质溶液与冻干聚合物混合以重构聚合物并形成混合物，其中在混合时，蛋白质溶液和聚合物交联以形成材料组成。该方法将材料组合物应用于组织区域。生物相容性聚合物可以包括例如聚（乙二醇）PEG。蛋白质溶液可以包含例如白蛋白。

2. 发明授权

US07279001B2 Systems, methods, and compositions for achieving closure of vascular puncture sites 有权
标题翻译：用于实现血管穿刺部位闭合的系统，方法和组合物
公开(公告)号：US07279001B2
公开(公告)日：2007-10-09
申请号：US10141510
申请日：2002-05-08
申请人： Bruce Addis , Charles Milo , Olexander Hnojewyj
发明人： Bruce Addis , Charles Milo , Olexander Hnojewyj
IPC分类号： A61B17/08 , A61D1/00
CPC分类号： A61B17/0057 , A61B17/00491 , A61B2017/00004 , A61B2017/00495 , A61B2017/00637 , A61B2017/0065
摘要： Systems and methods convey a closure material into a catheter, e.g., to seal a puncture site in a blood vessel. The closure material comprises a mixture of first and second components, which, upon mixing, undergo a reaction to form solid closure material composition. The first component may be a lyophilized polyethylene glycol (PEG) material contained within a vial. The second component may be a buffered albumin solution plus water contained within a syringe. An applicator provides easy and effective mixing of the components and delivery of the mixture to the puncture site.
摘要翻译：系统和方法将封闭材料输送到导管中，例如以密封血管中的穿刺部位。封闭材料包括第一和第二组分的混合物，其在混合时经历反应以形成固体封闭材料组合物。第一组分可以是包含在小瓶内的冻干聚乙二醇（PEG）材料。第二组分可以是缓冲的白蛋白溶液和加在注射器内的水。施用器提供容易且有效地混合组分并将混合物输送到穿刺部位。

3. 发明申请

US20060024371A1 Biocompatible material composition adaptable to diverse therapeutic indications 有权
标题翻译：适用于多种治疗适应症的生物相容性材料组合物
公开(公告)号：US20060024371A1
公开(公告)日：2006-02-02
申请号：US11002837
申请日：2004-12-02
申请人： Olexander Hnojewyj , Charles Milo , Gregory Cruise
发明人： Olexander Hnojewyj , Charles Milo , Gregory Cruise
IPC分类号： A61K38/28 , A61K9/14
CPC分类号： A61K9/0024 , A61B17/0057 , A61B2017/00004 , A61B2017/00495 , A61K47/34 , A61L24/043 , A61L31/041 , Y10S530/815 , C08L89/00
摘要： A biocompatible material genus serves as the foundation for multiple material composition species, each adapted to a specific therapeutic indication.
摘要翻译：生物相容性材料属于多种材料组成物种的基础，每一种物质都适合特定的治疗适应症。

4. 发明授权

US06398798B1 Catheter system for treating a vascular occlusion 失效
公开(公告)号：US06398798B1
公开(公告)日：2002-06-04
申请号：US09032773
申请日：1998-02-28
申请人： Matthew R. Selmon , Gerald Hansen , Charles Milo
发明人： Matthew R. Selmon , Gerald Hansen , Charles Milo
IPC分类号： A61B1722
摘要： A catherer system and method are provided including a blunt end assembly with a catheter and a blunt end member. The blunt end member includes jaw sections which have a first position or closed position for locating the blunt end member at the site of the occlusion within the native lumen of the blood vessel and a second position or open position wherein the jaw sections are able to press against the interior walls of the lumen adjacent the occlusion. The assembly includes an actuation member for moving the jaw sections from the closed to the open positions repeatedly resulting in a fracturing of the occlusion. A guide wire may be thread through an internal opening in the catheter and the blunt end member and after fracturing, across the occlusion.

5. 发明授权

US5704899A Protective sheath for a fiberoptic image guide within an articulated endoscope 失效
标题翻译：铰链内窥镜内光纤图像引导件的保护护套
公开(公告)号：US5704899A
公开(公告)日：1998-01-06
申请号：US541987
申请日：1995-10-10
申请人： Charles Milo
发明人： Charles Milo
IPC分类号： A61B1/005 , B29C47/00 , A61B1/06
CPC分类号： A61B1/0056 , B29C47/0014 , B29C47/00
摘要： An improved endoscope prevents abrasion of a fiberoptic image guide with a braid reinforced sheath. Abrasion of fiberoptic image guides within articulating endoscopes quickly wear through a conventional fiberoptic mantle, decreasing the useful life of the endoscope. Preferably, the sheath comprises a metal braid disposed within a polyimide, which effectively protects the image guide from abrasion against the endoscope components and substantially extends useful life.
摘要翻译：改进的内窥镜防止光纤图像引导件与编织增强护套的磨损。关节内窥镜内光纤图像引导件的磨损通过传统的光纤套管快速磨损，从而降低了内窥镜的使用寿命。优选地，护套包括设置在聚酰亚胺内的金属编织物，其有效地保护图像引导件免受内窥镜部件的磨损并且基本上延长了使用寿命。

6. 发明授权

US5429136A Imaging atherectomy apparatus 失效
标题翻译：成像粥样斑块切除术
公开(公告)号：US5429136A
公开(公告)日：1995-07-04
申请号：US91160
申请日：1993-07-13
申请人： Charles Milo , Gerald Hansen , Fred H. Co
发明人： Charles Milo , Gerald Hansen , Fred H. Co
IPC分类号： A61B8/12 , A61B17/22 , A61B19/00
CPC分类号： A61B17/320783 , A61B8/12 , A61B8/445 , A61B2017/22038 , A61B2017/22052 , A61B2017/22075 , A61B2090/378
摘要： An atherectomy catheter having ultrasound imaging capability provided by an acoustic transducer disposed within a catheter housing which includes a circular cutting edge for removal of stenotic tissue. Risk of induced emboli is reduced by arrangements of transducer and cutter maneuvering members which permit the cutting edge to remain shielded by the housing during catheter positioning and scanning. Both single and array transducers are employed in a variety of configurations.
摘要翻译：一种具有超声成像能力的粥样斑块切除术导管，其由设置在导管外壳内的声学换能器提供，其包括用于移除狭窄组织的圆形切割边缘。在导管定位和扫描期间，通过传感器和切割器操纵构件的布置可以减少诱发栓塞的危险，从而允许切割边缘保持被壳体屏蔽。单个和阵列换能器都采用各种配置。

7. 发明授权

US06120515A Composite atherectomy cutter 失效
标题翻译：复合粥样斑块切割刀
公开(公告)号：US06120515A
公开(公告)日：2000-09-19
申请号：US895106
申请日：1997-07-16
申请人： Larry Rogers , John Thomas Buckley , Ron Ray Hundertmark , Ferolyn T. Powell , Charles Milo , Anthony J. Castro
发明人： Larry Rogers , John Thomas Buckley , Ron Ray Hundertmark , Ferolyn T. Powell , Charles Milo , Anthony J. Castro
IPC分类号： A61B17/22 , A61B19/00 , A61M29/00 , A61B17/00
CPC分类号： A61B17/320783 , A61B17/320758 , A61B2090/3784
摘要： An athetectomy catheter is disclosed having a composite cutter which is capable of cutting material, including hardened plaque, from a biological conduit. The composite cutter has a cutter and a sensor mount. The cutter has a proximal end and a distal end with a cutting edge. The proximal end of the cutter bonds with the sensor mount. The sensor mount is adaptable for holding a sensor and attaching to a cutter torque cable of an atherectomy catheter. Typically, the atherectomy catheter has a cutter housing with a window. The composite cutter is positioned in the cutter housing and moves in response to movement of the cutter torque cable to cut material from the biological conduit via the window.
摘要翻译：公开了一种具有能够从生物导管切割包括硬化斑块的材料的复合切割器的切除术导管。复合切割机具有切割器和传感器支架。切割器具有近端和具有切割边缘的远端。切割器的近端与传感器支架接合。传感器安装座适用于固定传感器并连接到粥样斑块切除术导管的切割扭矩电缆。通常，粥样斑块切除术导管具有带窗口的切割器壳体。复合切割器定位在切割器壳体中并且响应于切割扭矩电缆的移动而移动，以经由窗口从生物导管切割材料。

8. 发明授权

US5741270A Manual actuator for a catheter system for treating a vascular occlusion 失效
标题翻译：用于治疗血管闭塞的导管系统的手动致动器
公开(公告)号：US5741270A
公开(公告)日：1998-04-21
申请号：US808092
申请日：1997-02-28
申请人： Gerald Hansen , E. Richard Hill, III , Charles Milo
发明人： Gerald Hansen , E. Richard Hill, III , Charles Milo
IPC分类号： A61B17/00 , A61B17/22 , A61B17/28 , A61F11/00
CPC分类号： A61B17/2909 , A61B17/32075 , A61B2017/00469 , A61B2017/2918
摘要： Disclosed herein is manual actuator for retracting and advancing a therapeutic working element of an intravascular catheter system via an actuation shaft or one or more pulling wires. The manual actuator includes a hollow cylindrical bracing member having an open proximal end and a distal end, and a hollow cylindrical retracting member, the retracting member being slidable, in a telescoping fashion, into the open proximal end of the bracing member. An actuation shaft is secured near to the proximal end of the retracting member and the distal end of the actuation shaft is secured to the therapeutic working element. Alternatively, at least one pulling wire is secured proximal to the proximal end of the retracting member. The distal end of the pulling wire is secured to the therapeutic working element. At least one resilient connecting member has a proximal end attached proximate the proximal end of the retracting member, and a distal end attached proximate the distal end of the bracing member. When a manually applied external force is applied by the physician to the resilient connecting members, the resilient connecting members urge the retracting member in a proximal direction with respect to the bracing member, and retracting the actuation shaft to thereby operate the working element of the catheter system. Alternatively, the retracting member is urged in the proximal direction by the manually applied external force and the pulling wires transmit this force to the therapeutic working element.
摘要翻译：这里公开了用于通过致动轴或一个或多个牵引线回缩和推进血管内导管系统的治疗工作元件的手动致动器。手动致动器包括具有开口近端和远端的中空圆柱形支撑构件和中空圆柱形缩回构件，缩回构件可以伸缩方式滑动到支撑构件的开放近端中。致动轴固定在靠近收缩构件的近端并且致动轴的远端固定到治疗工作元件。或者，至少一个拉线被固定在靠近收缩构件的近端的位置。拉线的远端固定在治疗工作元件上。至少一个弹性连接构件具有靠近缩回构件的近端附近的近端，以及靠近支撑构件的远端附近的远端。当医师将手动施加的外力施加到弹性连接构件时，弹性连接构件相对于支撑构件在近端方向上推动缩回构件，并且使致动轴缩回从而操作导管的工作元件系统。或者，缩回构件通过手动施加的外力在近端方向被推压，并且牵引线将该力传递到治疗工作元件。

9. 发明授权

US5716321A Method for maintaining separation between a falloposcope and a tubal wall 失效
标题翻译：保持阴茎镜与输卵管壁之间分离的方法
公开(公告)号：US5716321A
公开(公告)日：1998-02-10
申请号：US544384
申请日：1995-10-10
申请人： John Kerin , Charles Milo , Julian Nikolchev , James Doty
发明人： John Kerin , Charles Milo , Julian Nikolchev , James Doty
IPC分类号： A61B1/04 , A61B1/06 , A61B1/303 , A61B1/32 , A61B17/22 , A61B19/00 , A61B1/01
CPC分类号： A61B1/04 , A61B1/0008 , A61B1/00082 , A61B1/00085 , A61B1/00135 , A61B1/00149 , A61B1/01 , A61B1/303 , A61B1/32 , A61B5/6886 , A61B90/50 , A61B1/00165 , A61B1/07 , A61B17/221 , A61B2017/2215 , A61B2090/0815
摘要： A method and apparatus are provided for imaging a narrow body lumen, the method comprising maintaining separation between a distal end of an optical viewing scope and a lumen wall with a spacing structure which extends distally from the distal end of an access catheter. Optional spacing structures include distal cages and a guidewire which is fixed to and extends distally from the access catheter body. The invention is particularly beneficial during retrograde imaging of the fallopian tube, as it prevents the tubal wall from coming into such close proximity to a falloposcope as to produce "white-out" on the imaging monitor.
摘要翻译：提供了一种用于对狭窄的体腔进行成像的方法和装置，所述方法包括保持光学观察镜的远端与管腔壁之间的间隔，其间隔结构从远端远离入口导管延伸。可选的间隔结构包括远端保持架和导线，其被固定到远离导管主体并向远端延伸。本发明在输卵管逆行成像期间是特别有利的，因为它可以防止输卵管壁进入如此接近于眼底镜，从而在成像监视器上产生“白光”。

10. 发明授权

US5427107A Optical encoder for catheter device 失效
标题翻译：用于导管装置的光学编码器
公开(公告)号：US5427107A
公开(公告)日：1995-06-27
申请号：US163248
申请日：1993-12-07
申请人： Charles Milo , Gerald L. Hansen
发明人： Charles Milo , Gerald L. Hansen
IPC分类号： A61B8/12
CPC分类号： A61B8/12 , A61B8/445 , A61B8/4461
摘要： Disclosed herein is a catheter apparatus which supports high resolution imaging of the interior of a biological conduit. The apparatus includes an imaging atherectomy catheter of the type having a cutter housing attached to the distal end of a catheter. A tissue cutting member and an ultrasonic imaging transducer are disposed within the housing and are secured to the distal end of a rotatable torque cable. An elongated aperture formed along one side of the housing allows ultrasonic imaging and the intrusion of stenotic material which is removed by axially rotating and translating the cutting member. A miniature rotary encoder is slidably coupled to the end of the torque cable within the housing for precisely determining the rotational orientation of the ultrasonic imaging transducer with respect to the elongated aperture. The rotary encoder is read optically via a fiber optical cable which extends through the catheter. Placement of the rotary encoder at the imaging transducer overcomes distortions resulting from instantaneous speed variations between the two ends of the torque cable. The accurate rotational information permits use of ultrasonic imaging transducers having resolution better than 100 microns without significant image distortion.
摘要翻译：本文公开了一种支持生物导管内部的高分辨率成像的导管装置。该装置包括具有连接到导管的远端的切割器壳体的类型的成像粥样斑块切除术导管。组织切割构件和超声波成像换能器设置在壳体内并且固定到可旋转扭矩电缆的远端。沿着壳体的一侧形成的细长孔允许超声成像和通过轴向旋转和平移切割构件而移除的狭窄材料的侵入。微型旋转编码器可滑动地联接到壳体内的转矩电缆的端部，用于精确地确定超声波成像换能器相对于细长孔的旋转取向。旋转编码器通过延伸穿过导管的光纤光缆光学读取。旋转编码器在成像传感器处的放置克服了扭矩电缆两端之间的瞬时速度变化引起的扭曲。精确的旋转信息允许使用具有优于100微米的分辨率的超声成像换能器，而没有显着的图像失真。

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