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1. 发明授权

US5138946A Laser diode apparatus for initiation of explosive devices 失效
标题翻译：用于启动爆炸装置的激光二极管装置
公开(公告)号：US5138946A
公开(公告)日：1992-08-18
申请号：US719037
申请日：1991-06-21
申请人： Barbara A. Soltz , Charles R. Chubb , James D. Cook , Victor H. Nettle , Thomas M. Pallett, III , Richard G. Podgornik , Dale F. Waldo
发明人： Barbara A. Soltz , Charles R. Chubb , James D. Cook , Victor H. Nettle , Thomas M. Pallett, III , Richard G. Podgornik , Dale F. Waldo
IPC分类号： F42B3/113
CPC分类号： F42B3/113
摘要： A laser diode apparatus for initiating explosives or other pyrotechnic devices that has capability of checking both the laser diode operation and the optical fiber continuity between the laser diode source and the explosives required to be detonated. Power isolation circuits are provided to control the flow of current to the laser diode, also isolation filters are used to allow only the command signals to initiate the firing circuits employed.
摘要翻译：一种用于启动爆炸物或其他烟火装置的激光二极管装置，其具有检查激光二极管操作和激光二极管源与需要引爆的爆炸物之间的光纤连续性的能力。提供电源隔离电路以控制到激光二极管的电流，而隔离滤波器也仅用于允许指令信号启动采用的点火电路。

2. 发明授权

US5272716A Hand held laser apparatus 失效
标题翻译：手持式激光装置
公开(公告)号：US5272716A
公开(公告)日：1993-12-21
申请号：US775428
申请日：1991-10-15
申请人： Barbara A. Soltz , Charles R. Chubb , James D. Cook , Thomas M. Pallett, III , Richard G. Podgornik , Dale F. Waldo
发明人： Barbara A. Soltz , Charles R. Chubb , James D. Cook , Thomas M. Pallett, III , Richard G. Podgornik , Dale F. Waldo
IPC分类号： A61B17/00 , A61B18/20 , B23K26/00 , B23K26/42 , H01S5/022 , H01S5/042 , H01S5/0683 , H01S3/00
CPC分类号： B23K26/0096 , A61B18/20 , B23K26/702 , A61B2017/00194 , H01S5/0428 , H01S5/06835 , H01S5/4025
摘要： A hand held laser apparatus containing a semiconductor laser diode switchably connected to a power supply. The output of the laser diode is focused and collimated by a pair of lens. Circuitry is provided to allow for either continuous wave or pulsed modes of operation as well as the capability of varying the pulsewidth of the laser. A guide laser or a light emitting diode is provided to guide the operator. The power level of the guide laser is limited so that it transfers minimal power to the workpiece but provides a visible line of laser light along which the output of the semiconductor laser diode will travel. A photodetector may be positioned between the laser diode and the lenses. Additionally, the amount of current delivered to the laser in continuous wave mode of operation or the pulse width and duty cycle of a pulse may be measured and displayed. Embodiments are provided incorporating a plurality of laser diodes to allow continued operation upon failure of a diode, increased power with the simultaneous use of the multiple diodes, or either alternate wavelength selection or wavelength mixing. Alternative embodiments operate at a predetermined voltage level. These embodiments may utilize a set of batteries such that the entire batteries and control circuitry may be contained either within a portable package or the hand held laser apparatus itself. Such alternative embodiments may be made so as to be disposable upon the discharge of their batteries or the exhaustion of the laser.
摘要翻译：一种手持激光装置，其包含可切换地连接到电源的半导体激光二极管。激光二极管的输出由一对透镜聚焦和准直。提供电路以允许连续波或脉冲操作模式以及改变激光器的脉冲宽度的能力。提供引导激光器或发光二极管来引导操作者。引导激光器的功率电平受到限制，使得它将最小的功率传递到工件，但是提供可见的激光线，半导体激光二极管的输出沿着激光的行进。光电检测器可以位于激光二极管和透镜之间。此外，可以测量和显示在连续波模式下的激光输出的电流量或脉冲的脉冲宽度和占空比。提供了结合有多个激光二极管以允许在二极管故障时继续操作的实施例，同时使用多个二极管的增加的功率，或者交替的波长选择或波长混合。替代实施例在预定电压电平下工作。这些实施例可以使用一组电池，使得整个电池和控制电路可以包含在便携式包装或手持式激光装置本身内。这样的替代实施例可以做成在其电池放电或激光耗尽时是一次性的。

3. 发明授权

US5204490A Laser diode apparatus for initiation of explosive devices 失效
标题翻译：用于启动爆炸装置的激光二极管装置
公开(公告)号：US5204490A
公开(公告)日：1993-04-20
申请号：US719038
申请日：1991-06-21
申请人： Barbara A. Soltz , Charles R. Chubb , John M. Haake , Richard G. Podgornik , Dale F. Waldo
发明人： Barbara A. Soltz , Charles R. Chubb , John M. Haake , Richard G. Podgornik , Dale F. Waldo
IPC分类号： F42B3/113 , F42C15/40
CPC分类号： F42C15/40 , F42B3/113
摘要： A laser diode apparatus for initiating explosives or other pyrotechnic devices that has capability of checking both the laser diode operation and the optical fiber continuity between the laser diode source and the explosives required to be detonated. Power isolation circuits are provided to control the flow of current to the laser diode, also isolation filters are used to allow only the command signals to initiate the firing circuits employed.
摘要翻译：一种用于启动爆炸物或其他烟火装置的激光二极管装置，其具有检查激光二极管操作和激光二极管源与需要引爆的爆炸物之间的光纤连续性的能力。提供电源隔离电路以控制到激光二极管的电流，而隔离滤波器也仅用于允许指令信号启动采用的点火电路。

4. 发明授权

US06780840B1 Method for making a light energized tissue adhesive 有权
标题翻译：制造光通电组织粘合剂的方法
公开(公告)号：US06780840B1
公开(公告)日：2004-08-24
申请号：US09973263
申请日：2001-10-09
申请人： Dale P. DeVore , Braden P. DeVore , Barbara A. Soltz , Robert Soltz , Michael A. Soltz
发明人： Dale P. DeVore , Braden P. DeVore , Barbara A. Soltz , Robert Soltz , Michael A. Soltz
IPC分类号： A61K3800
CPC分类号： A61B18/22 , A61B17/00491 , A61B2017/0007 , A61B2017/00084 , A61B2017/005 , A61B2017/00508 , A61B2017/00517 , A61L24/102
摘要： Consistent with the present invention, tissue adhesive compositions and an associated laser exposure system are provided for bonding or sealing biological tissues. The compositions are comprised of chemically derivatized soluble collagen which is formulated to concentrations ranging from 300 mg/ml (30%) to 800 mg/ml (80%) collagen protein. In particular, Type I collagen, for example, is first prepared by extraction from bovine or porcine hide and purified. The collagen preparations are then chemically derivatized with sulfhydryl reagents to improve cohesive strength and with secondary derivatizing agents, such as carboxyl groups, to improve the adhesive strength of the solder to the tissue. The compositions are then formed into viscous solutions, gels or solid films, which when exposed to energy generated from an infrared laser, for example, undergo thermally induced phase transitions. Solid or semi-solid protein compositions become less viscous enabling the high concentration protein to penetrate the interstices of treated biological tissue or to fill voids in tissue. As thermal energy is released into the surrounding environment, the protein compositions again become solid or semi-solid, adhering to the treated tissue or tissue space.
摘要翻译：根据本发明，提供组织粘合剂组合物和相关联的激光曝光系统用于粘合或密封生物组织。组合物由化学衍生的可溶性胶原组成，其被配制成浓度范围为300mg / ml（30％）至800mg / ml（80％））的胶原蛋白。特别地，例如，首先通过从牛或猪皮提取而制备I型胶原并纯化。然后将胶原蛋白制剂用巯基试剂进行化学衍生，以提高内聚强度，并与二级衍生剂（如羧基）一起提高焊料对组织的粘合强度。然后将组合物形成粘稠溶液，凝胶或固体膜，当暴露于由红外激光产生的能量时，例如经历热诱导相变。固体或半固体蛋白质组合物变得粘稠，使得高浓度蛋白质能够渗透经处理的生物组织的间隙或填充组织中的空隙。随着热能释放到周围环境中，蛋白质组合物再次变得固体或半固体，粘附到处理过的组织或组织空间。

5. 发明授权

US09006182B2 Light activated composite tissue adhesives 有权
标题翻译：光活化复合组织粘合剂
公开(公告)号：US09006182B2
公开(公告)日：2015-04-14
申请号：US12943763
申请日：2010-11-10
申请人： Barbara A. Soltz , Robert Soltz
发明人： Barbara A. Soltz , Robert Soltz
IPC分类号： A61K38/39 , A61K47/48 , A61K38/00 , A61P43/00 , A61B17/50 , A61B17/08 , A61D1/00 , A61K38/17 , C07K1/00 , C07K14/00 , C07K16/00 , C09H1/00 , C07K17/00 , C08H1/00 , A61F13/00 , A61F2/00 , A61K9/70 , A61B17/00 , A61K31/525 , A61K47/42 , A61L31/04 , A61L31/14
CPC分类号： A61L24/102 , A61B17/00491 , A61B2017/00004 , A61B2017/005 , A61B2017/00517 , A61B2017/00884 , A61B2017/00951 , A61K9/7007 , A61K31/525 , A61K38/39 , A61K47/42 , A61L24/0015 , A61L31/044 , A61L31/14 , A61L2300/428 , A61K2300/00
摘要： A light activated collagen-flavin composite layer incorporating riboflavin is applied as treatment for infected lesions. These composites have also been found to be strong tissue adheives that are effective in closing and sealing wounds, fixation of grafts/ implants and anastomoses. Advantages include speed of closure, reduced infection due to the elimination of foreign matter, evidence of accelerated wound healing and the ease of use in complex surgery, especially when watertight seals, limited access or small repair size are important factors. The riboflavin in the collagen layer is exposed to light (e.g., light having a wavelength between 360-375 nm or 440-480 nm), decomposing the riboflavin to form reactive oxygen species (ROS). Strong crosslinks between the collagen composite and tissue results. In addition, similar exposures eradicate pathogens in the wound.
摘要翻译：应用包含核黄素的光活化胶原蛋白 - 黄素复合物层作为感染病变的治疗。这些复合材料也被发现是有效的关闭和密封伤口，移植物/植入物的固定和吻合的强组织粘附。优点包括闭合速度，消除异物减少的感染，加速伤口愈合的证据和复杂手术中的易用性，特别是当密封密封，限制进入或小修复尺寸是重要因素时。将胶原层中的核黄素暴露于光（例如，波长在360-375nm或440-480nm之间的光），分解核黄素以形成活性氧（ROS）。胶原蛋白复合物和组织之间的强烈交联结果。此外，类似的暴露可以消除伤口中的病原体。

6. 发明授权

US06773699B1 Light energized tissue adhesive conformal patch 有权
标题翻译：光通电组织粘贴贴片
公开(公告)号：US06773699B1
公开(公告)日：2004-08-10
申请号：US09973385
申请日：2001-10-09
申请人： Barbara A. Soltz , Dale P. DeVore , Braden P. DeVore , Robert Soltz , Michael A. Soltz
发明人： Barbara A. Soltz , Dale P. DeVore , Braden P. DeVore , Robert Soltz , Michael A. Soltz
IPC分类号： A61K3800
CPC分类号： A61B18/22 , A61B17/00491 , A61B2017/0007 , A61B2017/00084 , A61B2017/005 , A61B2017/00508 , A61B2017/00517 , A61L31/044
摘要： Consistent with the present invention, tissue adhesive compositions and an associated laser exposure system are provided for bonding or sealing biological tissues. The compositions are comprised of chemically derivatized soluble collagen which is formulated to concentrations ranging from 300 mg/ml (30%) to 80 mg/ml (80%) collagen protein. In particular, Type I collagen, for example, is first prepared by extraction from bovine or porcine hide and purified. The collagen preparations are then chemically derivatized with sulfhydryl reagents to improve cohesive strength and with secondary derivatizing agents, such as carboxyl groups, to improve the adhesive strength of the solder to the tissue. The compositions are then formed into viscous solutions, gels or solid films which are used to encapsulate structural components such as a cojoinal network or mesh. The resultant patch which when exposed to energy generated from an infrared laser, for example, undergo thermally induced phase transitions. Solid or semi-solid protein compositions become less viscous enabling the high concentration protein to penetrate the interstices of treated biological tissue or to fill voids in tissue. As thermal energy is released into the surrounding environment, the protein compositions again become solid or semi-solid, adhering to the treated tissue or tissue space and are reinforced by the embedded cojoinal network or mesh.
摘要翻译：根据本发明，提供组织粘合剂组合物和相关联的激光曝光系统用于粘合或密封生物组织。组合物由化学衍生的可溶性胶原组成，其被配制成浓度范围为300mg / ml（30％）至80mg / ml（80％））的胶原蛋白。特别地，例如，I型胶原首先通过从牛或猪皮提取而纯化而制备。然后将胶原蛋白制剂用巯基试剂进行化学衍生化，以提高内聚强度，并与二级衍生剂（如羧基）一起提高焊料对组织的粘合强度。然后将组合物形成粘稠溶液，凝胶或固体膜，其用于包封结构组分如共同网络或网状物。例如，当暴露于由红外激光器产生的能量时，产生的贴片经历热诱导相变。固体或半固体蛋白质组合物变得粘稠，使得高浓度蛋白质能够渗透经处理的生物组织的间隙或填充组织中的空隙。随着热能释放到周围环境中，蛋白质组合物再次变成固体或半固体，粘附到经处理的组织或组织空间，并通过嵌入的共同网络或网来加强。

7. 发明申请

US20160250377A1 LIGHT ACTIVATED COMPOSITE TISSUE ADHESIVES 审中-公开
标题翻译：轻活性复合组织粘合剂
公开(公告)号：US20160250377A1
公开(公告)日：2016-09-01
申请号：US14656994
申请日：2015-03-13
申请人： Barbara A. Soltz , Robert Soltz
发明人： Barbara A. Soltz , Robert Soltz
IPC分类号： A61L24/10 , A61L24/00 , A61B17/00
CPC分类号： A61L24/102 , A61B17/00491 , A61B2017/00004 , A61B2017/005 , A61B2017/00517 , A61B2017/00884 , A61B2017/00951 , A61K9/7007 , A61K31/525 , A61K38/39 , A61K47/42 , A61L24/0015 , A61L31/044 , A61L31/14 , A61L2300/428 , A61K2300/00
摘要： A light activated collagen-flavin composite layer incorporating riboflavin is applied as treatment for infected lesions. These composites have also been found to be strong tissue adhesives that are effective in closing and sealing wounds, fixation of grafts/ implants and anastomoses. Advantages include speed of closure, reduced infection due to the elimination of foreign matter, evidence of accelerated wound healing and the ease of use in complex surgery, especially when watertight seals, limited access or small repair size are important factors. The riboflavin in the collagen layer is exposed to light (e.g., light having a wavelength between 360-375 nm or 440-480 nm), decomposing the riboflavin to form reactive oxygen species (ROS). Strong crosslinks between the collagen composite and tissue results. In addition, similar exposures eradicate pathogens in the wound.
摘要翻译：应用包含核黄素的光活化胶原蛋白 - 黄素复合物层作为感染病变的治疗。这些复合材料也被发现是有效的关闭和密封伤口，移植物/植入物的固定和吻合的强力组织粘合剂。优点包括闭合速度，消除异物减少的感染，加速伤口愈合的证据和复杂手术中的易用性，特别是当密封密封，限制进入或小修复尺寸是重要因素时。将胶原层中的核黄素暴露于光（例如，波长在360-375nm或440-480nm之间的光），分解核黄素以形成活性氧（ROS）。胶原蛋白复合物和组织之间的强烈交联结果。此外，类似的暴露可以消除伤口中的病原体。

8. 发明申请

US20130190245A1 Light Activated Composite Tissue Adhesives 审中-公开
标题翻译：光活性复合组织粘合剂
公开(公告)号：US20130190245A1
公开(公告)日：2013-07-25
申请号：US12943771
申请日：2010-11-10
申请人： Barbara A. Soltz , Robert Soltz
发明人： Barbara A. Soltz , Robert Soltz
IPC分类号： A61L24/00
CPC分类号： A61L24/001 , A61L24/102 , A61L29/043 , Y10S514/801 , C08L89/06
摘要： A light activated collagen-flavin composite layer incorporating riboflavin is applied as treatment for infected lesions caused by bacteria and as the consequence of surgical procedures. These composites have also been found to be strong tissue adhesives that are effective in closing and sealing wounds, fixation of grafts/ implants and anastomoses. Advantages include speed of closure, reduced infection due to the elimination of foreign matter, evidence of accelerated wound healing and the ease of use in complex surgery, especially when watertight seals, limited access or small repair size are important factors. The riboflavin in the collagen layer is exposed to light (e.g., light having a wavelength between 360-375 nm or 440-480 nm), decomposing the riboflavin to form reactive oxygen species (ROS). Strong crosslinks between the collagen composite and tissue results. In addition, similar exposures eradicate pathogens in the wound is eradicated resulting in a sterile wound. In other examples, the composite film may instead contain lumichrome or lumiflavin.
摘要翻译：应用含有核黄素的光活化胶原蛋白复合材料层作为由细菌引起的感染病变的治疗，作为外科手术的结果。这些复合材料也被发现是有效的关闭和密封伤口，移植物/植入物的固定和吻合的强力组织粘合剂。优点包括闭合速度，消除异物减少的感染，加速伤口愈合的证据和复杂手术中的易用性，特别是当密封密封，限制进入或小修复尺寸是重要因素时。将胶原层中的核黄素暴露于光（例如，波长在360-375nm或440-480nm之间的光），分解核黄素以形成活性氧（ROS）。胶原蛋白复合物和组织之间的强烈交联结果。此外，消除伤口中类似的根除病原体的暴露导致无菌伤口。在其它实例中，复合膜可以替代地含有lumichrome或lumiflavin。

9. 发明申请

US20130035629A1 OPTICAL BANDAGE TO STERILIZE WOUNDS 审中-公开
标题翻译：光束灭菌灭菌
公开(公告)号：US20130035629A1
公开(公告)日：2013-02-07
申请号：US13567985
申请日：2012-08-06
申请人： Barbara A. Soltz , Robert Soltz
发明人： Barbara A. Soltz , Robert Soltz
IPC分类号： A61M37/00 , A61M35/00
CPC分类号： A61L15/56 , A61L15/325 , A61L15/42 , A61L15/44 , A61L2300/404 , A61M35/00 , A61N5/0616 , A61N5/062 , A61N5/0624 , A61N2005/0645 , A61N2005/0652 , A61N2005/0662
摘要： A pad is provided that supplies light to a composite layer, which may be provided on a wound. The composite layer may include a combination including a form of collagen and a chromophore that releases a reactive oxygen species upon exposure to the light. The reactive oxygen species may then act to kill bacteria or other microorganisms in the wound.
摘要翻译：提供了一种将光提供给可以设置在伤口上的复合层的垫。复合层可以包括包含胶原形式和在暴露于光时释放活性氧物质的发色团的组合。然后，活性氧可以起到杀伤伤口中的细菌或其他微生物的作用。

10. 发明授权

US06875427B1 Light energized tissue adhesive 有权
标题翻译：光通电组织粘合剂
公开(公告)号：US06875427B1
公开(公告)日：2005-04-05
申请号：US09973332
申请日：2001-10-09
申请人： Dale P. DeVore , Braden P. DeVore , Barbara A. Soltz , Robert Soltz , Michael A. Soltz
发明人： Dale P. DeVore , Braden P. DeVore , Barbara A. Soltz , Robert Soltz , Michael A. Soltz
IPC分类号： A61K38/00 , A61K38/39 , A61L24/00 , A61L24/10 , A61L31/04 , A61L31/14
CPC分类号： A61L31/044 , A61K38/39 , A61L24/001 , A61L24/102 , A61L31/14
摘要： Consistent with the present invention, tissue adhesive compositions and an associated laser exposure system are provided for bonding or sealing biological tissues. The compositions are comprised of chemically derivatized soluble collagen which is formulated to concentrations ranging from 300 mg/ml (30%) to 800 mg/ml (80%) collagen protein. In particular, Type I collagen, for example, is first prepared by extraction from bovine or porcine hide and purified. The collagen preparations are then chemically derivatized with sulfhydryl reagents to improve cohesive strength and with secondary derivatizing agents, such as carboxyl groups, to improve the adhesive strength of the solder to the tissue. The compositions are then formed into viscous solutions, gels or solid films, which when exposed to energy generated from an infrared laser, for example, undergo thermally induced phase transitions. Solid or semi-solid protein compositions become less viscous enabling the high concentration protein to penetrate the interstices of treated biological tissue or to fill voids in tissue. As thermal energy is released into the surrounding environment, the protein compositions again become solid or semi-solid, adhering to the treated tissue or tissue space.
摘要翻译：根据本发明，提供组织粘合剂组合物和相关联的激光曝光系统用于粘合或密封生物组织。组合物由化学衍生的可溶性胶原组成，其被配制成浓度范围为300mg / ml（30％）至800mg / ml（80％））的胶原蛋白。特别地，例如，I型胶原首先通过从牛或猪皮提取而纯化而制备。然后将胶原蛋白制剂用巯基试剂进行化学衍生化，以提高内聚强度，并与二级衍生剂（如羧基）一起提高焊料对组织的粘合强度。然后将组合物形成粘稠溶液，凝胶或固体膜，当暴露于由红外激光产生的能量时，例如经历热诱导相变。固体或半固体蛋白质组合物变得粘稠，使得高浓度蛋白质能够渗透经处理的生物组织的间隙或填充组织中的空隙。随着热能释放到周围环境中，蛋白质组合物再次变得固体或半固体，粘附到处理过的组织或组织空间。

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