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1. 发明申请

WO9905114A3 1H-4(5)-SUBSTITUTED IMIDAZOLE DERIVATIVES, THEIR PREPARATION AND THEIR USE AS HISTAMINE H3 RECEPTOR LIGANDS 审中-公开
标题翻译： 1H-4（5） - 取代的咪唑衍生物，它们的制备及其作为组胺H3受体配体的用途
公开(公告)号：WO9905114A3
公开(公告)日：1999-04-22
申请号：PCT/GB9802067
申请日：1998-07-14
申请人： BLACK JAMES FOUNDATION , TOZER MATTHEW JOHN , KALINDJIAN SARKIS BARRET , LINNEY IAN DUNCAN , STEEL KATHERINE ISABEL MARY , PETHER MICHAEL JOHN , COOKE TRACEY
发明人： TOZER MATTHEW JOHN , KALINDJIAN SARKIS BARRET , LINNEY IAN DUNCAN , STEEL KATHERINE ISABEL MARY , PETHER MICHAEL JOHN , COOKE TRACEY
IPC分类号： C07D233/54 , C07D417/04 , A61K31/415 , A61K31/425
CPC分类号： C07D233/64 , C07D417/04
摘要： Compounds of formula (I) wherein R is selected from C1 to C6 alkyl, C1 to C6 alkoxy, C1 to C6 alkylthio, carboxy, carboxy (C1 to C6)alkyl, formyl, C1 to C6 alkylcarbonyl, C1 to C6 alkylcarbonylalkoxy, nitro, trihalomethyl, hydroxy, amino, C1 to C6 alkylamino, di(C1 to C6 alkyl)amino, aryl, C1 to C6 alkylaryl, halo, sulfamoyl and cyano; R is C1 to C20 hydrocarbylene, in which one or more hydrogen atoms may be replaced by halogen atoms and up to 6 carbon atoms may be replaced by oxygen, nitrogen or sulfur atoms, provided that R does not contain a -O-O- group, and provided also that the atom in R which is linked to the -SO2- moiety is a carbon atom; R is hydrogen or C1 to C15 hydrocarbyl, in which one or more hydrogen atoms may be replaced by halogen atoms and up to 3 carbon atoms may be replaced by oxygen, nitrogen or sulfur atoms, provided that R does not contain a -O-O- group; X is a bond or -NR -, wherein R is hydrogen or non-aromatic C1 to C5 hydrocarbyl (in which one or more hydrogen atoms may be replaced by halogen atoms and up to 2 carbon atoms may be replaced by oxygen, nitrogen or sulfur atoms, provided that R does not contain a -O-O- group), aryl(C1 to C3)alkyl or R represents a bond to R ; and a is from 0 to 2, and their pharmaceutically acceptable salts are useful as histamine H3 receptor ligands.
摘要翻译：其中R 1选自C 1 -C 6烷基，C 1 -C 6烷氧基，C 1 -C 6烷硫基，羧基，羧基（C 1 -C 6）烷基，甲酰基，C 1 -C 6烷基羰基，C 1 -C 6烷基羰基烷氧基硝基，三卤代甲基，羟基，氨基，C1-C6烷基氨基，二（C1-C6烷基）氨基，芳基，C1-C6烷基芳基，卤素，氨磺酰基和氰基; R 2为C 1至C 20亚烃基，其中一个或多个氢原子可以被卤素原子置换，且至多6个碳原子可以被氧，氮或硫原子置换，条件是R 2不含并且还提供了与-SO 2 - 部分连接的R 2中的原子是碳原子; R 3是氢或C 1至C 15烃基，其中一个或多个氢原子可以被卤素原子代替并且至多3个碳原子可以被氧，氮或硫原子代替，条件是R 3不是包含一个-OO-组; X是键或-NR 4 - ，其中R 4是氢或非芳族C 1 -C 5烃基（其中一个或多个氢原子可以被卤素原子取代并且至多2个碳原子可以被取代（其中R 4不含-OO-基团），芳基（C 1 -C 3）烷基或R 4表示与R 2的键; a为0-2，并且它们的药学上可接受的盐可用作组胺H3受体配体。

2. 发明申请

WO2004016088A2 NOVEL 2-PYRIDYLETHYLBENZAMIDE DERIVATIVE 审中-公开
标题翻译：新型2-吡啶基苯甲酰胺衍生物
公开(公告)号：WO2004016088A2
公开(公告)日：2004-02-26
申请号：PCT/EP0309516
申请日：2003-08-08
申请人： BAYER CROPSCIENCE SA , MANSFIELD DARREN JAMES , COOKE TRACEY , THOMAS PETER STANLEY , COQUERON PIERRE-YVES , VORS JEAN-PIERRE , BRIGGS GEOFFREY GOWER , LACHAISE HELENE , RIECK HEIKO , DESBORDES PHILIPPE , GROSJEAN-COURNOYER MARIE-CLAIR
发明人： MANSFIELD DARREN JAMES , COOKE TRACEY , THOMAS PETER STANLEY , COQUERON PIERRE-YVES , VORS JEAN-PIERRE , BRIGGS GEOFFREY GOWER , LACHAISE HELENE , RIECK HEIKO , DESBORDES PHILIPPE , GROSJEAN-COURNOYER MARIE-CLAIR
IPC分类号： A01N25/30 , A01N43/40 , C07D213/40 , C07D213/61 , C07D213/89
CPC分类号： C07D213/89 , A01N43/40 , C07D213/40 , C07D213/61
摘要： Compound of general formula (I) in which p is an integer equal to 1, 2, 3 or 4; q is an integer equal to 1, 2, 3, 4 or 5; each substituent X is chosen, independently of the others, as being halogen, alkyl or haloalkyl, at least one of the substituents being a haloalkyl; each substituent Y is chosen, independently of the others, as being halogen, alkyl, alkenyl, alkynyl, haloalkyl, alkoxy, amino, phenoxy, alkylthio, dialkylamino, acyl, cyano, ester, hydroxy, aminoalkyl, benzyl, haloalkoxy, halosulphonyl, halothioalkyl, alkoxyalkenyl, alkylsulphonamide, nitro, alkylsulphonyl, phenylsulphonyl or benzylsulphonyl; as to the N-oxides of 2-pyridine thereof; with the exception of N-{2-[3-chloro-5-(trifluoromethyl)-2-pyridinyl]-ethyl}-2,6-dichlorobenzamide. Method for preparing the compound of general formula (I). Fungicidal composition comprising the compound of general formula (I). Method for treating phytopathogenic diseases.
摘要翻译：通式（I）的化合物，其中p是等于1,2,3或4的整数; q是等于1,2,3,4或5的整数; 每个取代基X独立地选自卤素，烷基或卤代烷基，至少一个取代基是卤代烷基; 氰基，酯，羟基，氨基烷基，苄基，卤代烷氧基，卤代磺酰基，卤代烷基，卤代烷基，卤代烷基，烷氧基烯基，烷基磺酰胺，硝基，烷基磺酰基，苯基磺酰基或苄基磺酰基; 关于其2-吡啶的N-氧化物; 除了N- {2- [3-氯-5-（三氟甲基）-2-吡啶基] - 乙基} -2,6-二氯苯甲酰胺。制备通式（I）化合物的方法。包含通式（I）的化合物的杀真菌组合物。治疗植物病原性疾病的方法

3. 发明专利

AU8235898A 1h-4(5)-substituted imidazole derivatives, their preparation and their use as histamine h₃ receptor ligands 未知
公开(公告)号：AU8235898A
公开(公告)日：1999-02-16
申请号：AU8235898
申请日：1998-07-14
申请人： BLACK JAMES FOUNDATION
发明人： TOZER MATTHEW JOHN , KALINDJIAN SARKIS BARRET , LINNEY IAN DUNCAN , STEEL KATHERINE ISABEL MARY , PETHER MICHAEL JOHN , COOKE TRACEY
IPC分类号： C07D233/54 , C07D417/04 , A61K31/415 , A61K31/425
摘要： A compound of the formulawherein R2 is an optionally substituted Cz to Cg alkylene or alkylene chain; R3 is C2 to C15 optionally substituted hydrocarbyl; X is a bond or -NR4-, wherein R4 is hydrogen or non-aromatic C1 to C5 optionally substituted hydrocarbyl, or aryl(C1 to C3)alkyl, or a pharmaceutically acceptable salt thereof.A method of modifing histamine activity in a patient comprising administering to said patient a pharmaceutical composition containing an effective amount of a compound of formulawherein R1 is selected from C1 to C6 alkyl, C1 to C6 alkoxy, C1 to C6 alkylthio, carboxy, carboxy(C1 to C6)alkyl, formyl, C1 to C6 alkylcarbonyl, C1 to C6 alkylcarbonylalkoxy, nitro, trihalomethyl, hydroxy, amino, C1 to C6 alkylcarbonylalkoxy, nitro, trihalomethyl, hydroxy, amino, C1 to C6 alkylamino, di(C1 to C6 alkyl)amino, aryl, C1 to C6 alkylaryl, halo, sulfamoyl and cyano; R2 is optionally substituted C2 to C20 hydrocarbylene, in which one or more hydrogen atoms may be replaced by halogen atoms and up to 6 carbon atoms may be replaced by oxygen or nitrogen atoms, R2 being in the form of an optionally substituted C2 to C8 alkylene or alkenylene chain; R3 is hydrogen or C1 to C15 optionally substituted hydrocarbyl; X is a bond or -NR4-; and a is from 0 to 2, or a pharmaceutically acceptable salt thereof.

4. 发明专利

PL328369A1 LIGANDS OF HISTAMIN H RECEPTOR 未知
公开(公告)号：PL328369A1
公开(公告)日：1999-01-18
申请号：PL32836997
申请日：1997-02-10
申请人： BLACK JAMES FOUNDATION
发明人： KALINDJIAN SARKIS BARRET , SHANKLEY NIGEL PAUL , TOZER MATTHEW JOHN , MCDONALD IAIN MAIR , PETHER MICHAEL JOHN , HARPER ELAINE ANNE , WATT GILLIAN FAIRFULL , COOKE TRACEY , LOW CAROLINE MINLI RACHEL
IPC分类号： A61K31/00 , A61K31/415 , A61K31/4164 , A61K31/417 , A61P43/00 , C07D233/54 , C07D233/64 , C07D401/12
摘要： PCT No. PCT/GB97/00358 Sec. 371 Date Oct. 6, 1998 Sec. 102(e) Date Oct. 6, 1998 PCT Filed Feb. 10, 1997 PCT Pub. No. WO97/29092 PCT Pub. Date Aug. 14, 1997Compounds of formula (I) or (II) wherein R1 is C4 to C20 hydrocarbyl (in which one or more hydrogen atoms may be replaced by halogen, and up to three carbon atoms may be replaced by oxygen, nitrogen or sulphur atoms, provided that R1 does not contain an -O-O- group), R2 is H or C1 to C3 alkyl, m is from 1 to 15, n is from 2 to 6, each X group is independently (a), or one X group is -N(R4)-, -O- or -S- and the remaining X groups are independently (a), wherein R3 is H, C1 to C6 alkyl, -CO2R5, -CONR52, -CR52OR6 or -OR5 (in which R5 and R6 are H or C1 to C3 alkyl), and R4 is H or C1 to C6 alkyl, each Y group is independently -C(R3)R4-, or up to two Y groups are -N(R4)-, -O- or -S- and the remaining Y groups are independently -C(R3)R4-, wherein R3 is as defined above, one R4 group in the structure is imidazoyl or imidazoylalkyl and the remaining R4 groups are H or C1 to C6 alkyl, and Z is >C(R7)NR2- or >N-, wherein R7 is any of the groups recited above for R3, and pharmaceutically acceptable salts thereof are ligands at histamine H3 receptors.

5. 发明专利

ZA971078B Histamine H3 receptor ligands 未知
公开(公告)号：ZA971078B
公开(公告)日：1998-08-11
申请号：ZA971078
申请日：1997-02-10
申请人： BLACK JAMES FOUNDATION
发明人： KALINDJIAN SARKIS BARRET , SHANKLEY NIGEL PAUL , TOZER MATTHEW JOHN , MCDONALD IAIN MAIR , PETHER MICHAEL JOHN , HARPER ELAINE ANNE , WATT GILLIAN FAIRFULL , COOKE TRACEY , LOW CAROLINE MINLI RACHEL
IPC分类号： A01N20060101 , A61K20060101 , C07D20060101 , C07D , A01N , A61K

6. 发明专利

CA2244745A1 HISTAMINE H3 RECEPTOR LIGANDS 未知
公开(公告)号：CA2244745A1
公开(公告)日：1997-08-14
申请号：CA2244745
申请日：1997-02-10
申请人： BLACK JAMES FOUNDATION
发明人： LOW CAROLINE MINLI RACHEL , MCDONALD IAIN MAIR , HARPER ELAINE ANNE , KALINDJIAN SARKIS BARRET , WATT GILLIAN FAIRFULL , COOKE TRACEY , TOZER MATTHEW JOHN , SHANKLEY NIGEL PAUL , PETHER MICHAEL JOHN
IPC分类号： A61K31/00 , A61K31/415 , A61K31/4164 , A61K31/417 , A61P43/00 , C07D233/54 , C07D233/64 , C07D401/12 , A61K31/47 , C07D233/66
摘要： Compounds of formula (I) or (II) wherein R1 is C4 to C20 hydrocarbyl (in which one or more hydrogen atoms may be replaced by halogen, and up to three carbon atoms may be replaced by oxygen, nitrogen or sulphur atoms, provided that R1 does not contain an -O-O- group), R2 is H or C1 to C3 alkyl, m is from 1 to 15, n is from 2 to 6, each X group is independently (a), or one X group is N(R4)-, -O- or -S- and the remaining X groups are independently (a), wherein R3 is H, C1 to C6 alkyl, -CO2R5, -CONR52, -CR52OR6 or -OR5 (in which R5 and R6 are H or C1 to C3 alkyl), and R4 is H or C1 to C6 alkyl, each Y group is independently -C(R3)R4-, or up to two Y groups are -N(R4)-, -O- or -S- and the remaining Y groups are independently -C(R3)R4-, wherein R3 is as defined above, one R4 group in the structure is imidazoyl or imidazoylalkyl and the remaining R4 groups are H or C1 to C6 alkyl, and Z is > C(R7)NR2- or > N-, wherein R7 is any of the groups recited above for R3, and pharmaceutically acceptable salts thereof are ligands at histamine H3 receptors.

7. 发明专利

DE69722592D1 未知
公开(公告)号：DE69722592D1
公开(公告)日：2003-07-10
申请号：DE69722592
申请日：1997-02-10
申请人： BLACK JAMES FOUNDATION
发明人： KALINDJIAN BARRET , SHANKLEY PAUL , TOZER JOHN , MCDONALD MAIR , PETHER JOHN , HARPER ANNE , WATT FAIRFULL , COOKE TRACEY , LOW MINLI
IPC分类号： A61K31/00 , A61K31/415 , A61K31/4164 , A61K31/417 , A61P43/00 , C07D233/54 , C07D233/64 , C07D401/12
摘要： PCT No. PCT/GB97/00358 Sec. 371 Date Oct. 6, 1998 Sec. 102(e) Date Oct. 6, 1998 PCT Filed Feb. 10, 1997 PCT Pub. No. WO97/29092 PCT Pub. Date Aug. 14, 1997Compounds of formula (I) or (II) wherein R1 is C4 to C20 hydrocarbyl (in which one or more hydrogen atoms may be replaced by halogen, and up to three carbon atoms may be replaced by oxygen, nitrogen or sulphur atoms, provided that R1 does not contain an -O-O- group), R2 is H or C1 to C3 alkyl, m is from 1 to 15, n is from 2 to 6, each X group is independently (a), or one X group is -N(R4)-, -O- or -S- and the remaining X groups are independently (a), wherein R3 is H, C1 to C6 alkyl, -CO2R5, -CONR52, -CR52OR6 or -OR5 (in which R5 and R6 are H or C1 to C3 alkyl), and R4 is H or C1 to C6 alkyl, each Y group is independently -C(R3)R4-, or up to two Y groups are -N(R4)-, -O- or -S- and the remaining Y groups are independently -C(R3)R4-, wherein R3 is as defined above, one R4 group in the structure is imidazoyl or imidazoylalkyl and the remaining R4 groups are H or C1 to C6 alkyl, and Z is >C(R7)NR2- or >N-, wherein R7 is any of the groups recited above for R3, and pharmaceutically acceptable salts thereof are ligands at histamine H3 receptors.

8. 发明专利

AT242219T 未知
公开(公告)号：AT242219T
公开(公告)日：2003-06-15
申请号：AT97902509
申请日：1997-02-10
申请人： BLACK JAMES FOUNDATION
发明人： KALINDJIAN SARKIS BARRET , SHANKLEY NIGEL PAUL , TOZER MATTHEW JOHN , MCDONALD IAIN MAIR , PETHER MICHAEL JOHN , HARPER ELAINE ANNE , WATT GILLIAN FAIRFULL , COOKE TRACEY , LOW CAROLINE MINLI RACHEL
IPC分类号： A61K31/00 , A61K31/415 , A61K31/4164 , A61K31/417 , A61P43/00 , C07D233/54 , C07D233/64 , C07D401/12
摘要： PCT No. PCT/GB97/00358 Sec. 371 Date Oct. 6, 1998 Sec. 102(e) Date Oct. 6, 1998 PCT Filed Feb. 10, 1997 PCT Pub. No. WO97/29092 PCT Pub. Date Aug. 14, 1997Compounds of formula (I) or (II) wherein R1 is C4 to C20 hydrocarbyl (in which one or more hydrogen atoms may be replaced by halogen, and up to three carbon atoms may be replaced by oxygen, nitrogen or sulphur atoms, provided that R1 does not contain an -O-O- group), R2 is H or C1 to C3 alkyl, m is from 1 to 15, n is from 2 to 6, each X group is independently (a), or one X group is -N(R4)-, -O- or -S- and the remaining X groups are independently (a), wherein R3 is H, C1 to C6 alkyl, -CO2R5, -CONR52, -CR52OR6 or -OR5 (in which R5 and R6 are H or C1 to C3 alkyl), and R4 is H or C1 to C6 alkyl, each Y group is independently -C(R3)R4-, or up to two Y groups are -N(R4)-, -O- or -S- and the remaining Y groups are independently -C(R3)R4-, wherein R3 is as defined above, one R4 group in the structure is imidazoyl or imidazoylalkyl and the remaining R4 groups are H or C1 to C6 alkyl, and Z is >C(R7)NR2- or >N-, wherein R7 is any of the groups recited above for R3, and pharmaceutically acceptable salts thereof are ligands at histamine H3 receptors.

9. 发明专利

NZ331272A Histamine H3 receptor ligands 未知
公开(公告)号：NZ331272A
公开(公告)日：2000-01-28
申请号：NZ33127297
申请日：1997-02-10
申请人： BLACK JAMES FOUNDATION
发明人： KALINDJIAN SARKIS BARRET , SHANKLEY NIGEL PAUL , TOZER MATTHEW JOHN , MCDONALD IAIN MAIR , PETHER MICHAEL JOHN , HARPER ELAINE ANNE , WATT GILLIAN FAIRFULL , COOKE TRACEY , LOW CAROLINE MINLI RACHEL
IPC分类号： A61K31/00 , A61K31/415 , A61K31/4164 , A61K31/417 , A61P43/00 , C07D233/54 , C07D233/64 , C07D401/12 , C07D33/54
摘要： ompounds of formula (I) or (II) wherein R1 is C4 to C20 hydrocarbyl (in which one or more hydrogen atoms may be replaced by halogen, and up to three carbon atoms may be replaced by oxygen, nitrogen or sulphur atoms, provided that R1 does not contain an -O-O- group), R2 is H or C1 to C3 alkyl, m is from 1 to 15, n is from 2 to 6, each X group is independently -C(R3)(R4)- or one X group is -N(R4)-, -O- or -S- and the remaining X groups are independently -C(R3)(R4)-, wherein R3 is H, C1 to C6 alkyl, -CO2R5, -CONR52, -CR52OR6 or -OR5 (in which R5 and R6 are H or C1 to C3 alkyl), and R4 is H or C1 to C6 alkyl, each Y group is independently -C(R3)(R4)-, or up to two Y groups are -N(R4)-, -O- or -S- and the remaining Y groups are independently -C(R3)(R4)-, wherein R3 is as defined above, one R4 group in the structure is imidazoyl or imidazoylalkyl and the remaining R4 groups are H or C1 to C6 alkyl, and Z is =C(R7)NR2- or =N-, wherein R7 is any of the groups recited above for R3, and pharmaceutically acceptable salts thereof are ligands at histamine H3 receptors.

10. 发明专利

NO983596L 未知
公开(公告)号：NO983596L
公开(公告)日：1998-09-16
申请号：NO983596
申请日：1998-08-05
申请人： BLACK JAMES FOUNDATION
发明人： KALINDJIAN SARKIS BARRET , SHANKLEY NIGEL PAUL , TOZER MATTHEW JOHN , MCDONALD IAIN MAIR , PETHER MICHAEL JOHN , HARPER ELAINE ANNE , WATT GILLIAN FAIRFULL , COOKE TRACEY , LOW CAROLINE MINLI RACHEL
IPC分类号： A61K31/00 , A61K31/415 , A61K31/4164 , A61K31/417 , A61P43/00 , C07D233/54 , C07D233/64 , C07D401/12
摘要： PCT No. PCT/GB97/00358 Sec. 371 Date Oct. 6, 1998 Sec. 102(e) Date Oct. 6, 1998 PCT Filed Feb. 10, 1997 PCT Pub. No. WO97/29092 PCT Pub. Date Aug. 14, 1997Compounds of formula (I) or (II) wherein R1 is C4 to C20 hydrocarbyl (in which one or more hydrogen atoms may be replaced by halogen, and up to three carbon atoms may be replaced by oxygen, nitrogen or sulphur atoms, provided that R1 does not contain an -O-O- group), R2 is H or C1 to C3 alkyl, m is from 1 to 15, n is from 2 to 6, each X group is independently (a), or one X group is -N(R4)-, -O- or -S- and the remaining X groups are independently (a), wherein R3 is H, C1 to C6 alkyl, -CO2R5, -CONR52, -CR52OR6 or -OR5 (in which R5 and R6 are H or C1 to C3 alkyl), and R4 is H or C1 to C6 alkyl, each Y group is independently -C(R3)R4-, or up to two Y groups are -N(R4)-, -O- or -S- and the remaining Y groups are independently -C(R3)R4-, wherein R3 is as defined above, one R4 group in the structure is imidazoyl or imidazoylalkyl and the remaining R4 groups are H or C1 to C6 alkyl, and Z is >C(R7)NR2- or >N-, wherein R7 is any of the groups recited above for R3, and pharmaceutically acceptable salts thereof are ligands at histamine H3 receptors.

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