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1. 发明申请

WO2006129120A3 BENZOTRIAZEPINONE DERIVATIVES 审中-公开
公开(公告)号：WO2006129120A3
公开(公告)日：2006-12-07
申请号：PCT/GB2006/002042
申请日：2006-06-02
申请人： JAMES BLACK FOUNDATION , MCDONALD, Iain, Mair , BUCK, Ildiko, Maria , DUNSTONE, David, John , LINNEY, Ian, Duncan , PETHER, Michael, John , SPENCER, John , STEEL, Katherine, Isobel, Mary , TISSELLI, Patrizia , WRIGHT, Paul, Trevor , HULL, Robert, Anthony, David , AUSTIN, Carol , HARPER, Elaine, Anne , GRIFFIN, Eric , KALINDJIAN, Sarkis, Barret , LOW, Caroline, Minli, Rachel
发明人： MCDONALD, Iain, Mair , BUCK, Ildiko, Maria , DUNSTONE, David, John , LINNEY, Ian, Duncan , PETHER, Michael, John , SPENCER, John , STEEL, Katherine, Isobel, Mary , TISSELLI, Patrizia , WRIGHT, Paul, Trevor , HULL, Robert, Anthony, David , AUSTIN, Carol , HARPER, Elaine, Anne , GRIFFIN, Eric , KALINDJIAN, Sarkis, Barret , LOW, Caroline, Minli, Rachel
IPC分类号： C07D255/04 , A61K31/55
摘要： The present invention is concerned with benzotriazepinone derivatives, their intermediates, uses thereof and processes for their production. In particular, the present invention relates to parathyroid hormone (PTH) and parathyroid hormone related protein (PTHrp) receptor ligands, (PTH-l or PTH/PTHrp receptor ligands). The invention also relates to methods of preparing such ligands and to compounds which are useful as intermediates in such methods.

2. 发明申请

WO2003041714A1 BENZOTRIAZEPINES AS GASTRIN AND CHOLECYSTOKININ RECEPTOR LIGANDS 审中-公开
标题翻译：作为胃肠素和CHOLECYSTOKININ受体配体的苯并噻唑
公开(公告)号：WO2003041714A1
公开(公告)日：2003-05-22
申请号：PCT/GB2002/005121
申请日：2002-11-12
申请人： JAMES BLACK FOUNDATION LIMITED , MCDONALD, Iain, Mair , BUCK, Ildiko, Maria , HARPER, Elaine, Anne , LINNEY, Ian, Duncan , PETHER, Michael, John , STEEL, Katherine, Isobel, Mary , AUSTIN, Carol , DUNSTONE, David, John , KALINDJIAN, Sarkis, Barret , LOW, Caroline, Minli, Rachel , SPENCER, John , WRIGHT, Paul, Trevor
发明人： MCDONALD, Iain, Mair , BUCK, Ildiko, Maria , HARPER, Elaine, Anne , LINNEY, Ian, Duncan , PETHER, Michael, John , STEEL, Katherine, Isobel, Mary , AUSTIN, Carol , DUNSTONE, David, John , KALINDJIAN, Sarkis, Barret , LOW, Caroline, Minli, Rachel , SPENCER, John , WRIGHT, Paul, Trevor
IPC分类号： A61K31/55
CPC分类号： C07D401/04 , A61K31/4439 , A61K31/545 , A61K31/55 , C07D255/00 , Y02P20/582 , A61K2300/00
摘要： This invention relates to a compound of formula (I) wherein: W is N or N + -O - ; and R 1 to R 5 are as defined in the description, for use for the treatment of gastrin related disorders.
摘要翻译：本发明涉及式（I）的化合物，其中：W是N或N 和R 1至R 5之间的定义如用于治疗胃泌素相关病症的描述中所定义。

3. 发明申请

WO1997029092A1 HISTAMINE H3 RECEPTOR LIGANDS 审中-公开
标题翻译：组胺H3受体配体
公开(公告)号：WO1997029092A1
公开(公告)日：1997-08-14
申请号：PCT/GB1997000358
申请日：1997-02-10
申请人： JAMES BLACK FOUNDATION LIMITED , KALINDJIAN, Sarkis, Barret , SHANKLEY, Nigel, Paul , TOZER, Matthew, John , McDONALD, Iain, Mair , PETHER, Michael, John , HARPER, Elaine, Anne , WATT, Gillian, Fairfull , COOKE, Tracey , LOW, Caroline, Minli, Rachel
发明人： JAMES BLACK FOUNDATION LIMITED
IPC分类号： C07D233/54
CPC分类号： C07D233/64 , C07D401/12
摘要： Compounds of formula (I) or (II) wherein R is C4 to C20 hydrocarbyl (in which one or more hydrogen atoms may be replaced by halogen, and up to three carbon atoms may be replaced by oxygen, nitrogen or sulphur atoms, provided that R does not contain an -O-O- group), R is H or C1 to C3 alkyl, m is from 1 to 15, n is from 2 to 6, each X group is independently (a), or one X group is -N(R )-, -O- or -S- and the remaining X groups are independently (a), wherein R is H, C1 to C6 alkyl, -CO2R , -CONR 2, -CR 2OR or -OR (in which R and R are H or C1 to C3 alkyl), and R is H or C1 to C6 alkyl, each Y group is independently -C(R )R -, or up to two Y groups are -N(R )-, -O- or -S- and the remaining Y groups are independently -C(R )R -, wherein R is as defined above, one R group in the structure is imidazoyl or imidazoylalkyl and the remaining R groups are H or C1 to C6 alkyl, and Z is > C(R )NR - or > N-, wherein R is any of the groups recited above for R , and pharmaceutically acceptable salts thereof are ligands at histamine H3 receptors.
摘要翻译：其中R 1为C 4 -C 20烃基（其中一个或多个氢原子可被卤素取代，最多三个碳原子）可以被氧，氮或硫原子代替的式（I）或（II）化合物条件是R 1不含-OO-基），R 2为H或C 1至C 3烷基，m为1至15，n为2至6，每个X基团独立地为（a ）或一个X基团是-N（R 4） - ， - O-或-S-，其余的X基团独立地为（a），其中R 3为H，C 1至C 6烷基，-CO 2 R -CONR 5，-CR 5 OR 2或-OR 5（其中R 5和R 6为H或C 1至C 3烷基） 4>是H或C 1至C 6烷基，每个Y基团独立地是-C（R 3）R 4 - 或至多两个Y基团是-N（R 4） - ， - O-或 -S-，其余的Y基团独立地是-C（R 3）R 4 - ，其中R 3如上定义，结构中的一个R 4基团是咪唑基或咪唑基烷基，剩余的 R 4基团是H或C 1至C 6烷基，Z是> C（R 7）NR 2 - 或> N-，其中R 7是任何基团 R 3所示的化合物及其药学上可接受的盐是组胺H3受体的配体。

4. 发明申请

WO1995004720A2 GASTRIN AND CCK RECEPTOR LIGANDS 审中-公开
标题翻译： GASTRIN和CCK受体配体
公开(公告)号：WO1995004720A2
公开(公告)日：1995-02-16
申请号：PCT/GB1994001741
申请日：1994-08-09
申请人： JAMES BLACK FOUNDATION LIMITED , KALINDJIAN, Sarkis, Barret , STEEL, Katherine, Isobel, Mary , PETHER, Michael, John , DAVIES, Jonathan, Michael, Richard , LOW, Caroline, Minli, Rachel , HUDSON, Martin, Lyn , BUCK, Ildiko, Maria , MCDONALD, Iain, Mair , DUNSTONE, David, John , TOZER, Matthew, John
发明人： JAMES BLACK FOUNDATION LIMITED
IPC分类号： C07D209/42
CPC分类号： C07D235/06 , C07C233/65 , C07C233/82 , C07C237/22 , C07C237/48 , C07C2603/74 , C07D207/16 , C07D209/08 , C07D209/42 , C07D209/88 , C07D217/26 , C07D235/24 , C07D307/84 , C07D333/70 , C07D401/06 , C07D403/06 , C07D403/12 , C07D403/14 , C07D453/02 , C07D471/04
摘要： Compounds of formula (Ia), (Ib) or (Ic), wherein A represents a group having two fused rings, or a group of formula (Id), R (m) represents up to 6 substituents, K represents -O-, -S-, -CH2-, -N(R )- or -N(COR )-, in which R is H or C1 to C3 alkyl, W is a carbonyl, sulphonyl or sulphinyl group, and X is a carbonyl, sulphonyl or sulphinyl group, provided that at least one of W and X contains carbonyl, Y and Z are as given in the description and their pharmaceutically acceptable salts are ligands at CCK and/or gastrin receptors.
摘要翻译：式（Ia），（Ib）或（Ic）的化合物，其中A表示具有两个稠环的基团或式（Id）的基团，R 1（m）表示至多6个取代基，K表示 - O，-S - ， - CH 2 - ， - N（R 2） - 或-N（COR 2） - ，其中R 2是H或C 1至C 3烷基，W是羰基，磺酰基或亚磺酰基，X是羰基，磺酰基或亚磺酰基，条件是W和X中的至少一个含有羰基，Y和Z如说明书中所给出，并且其药学上可接受的盐是CCK和/或胃泌素受体。

5. 发明申请

WO2007135417A1 BENZOTRIAZEPINONE DERIVATIVES 审中-公开
标题翻译：苯并噻唑酮衍生物
公开(公告)号：WO2007135417A1
公开(公告)日：2007-11-29
申请号：PCT/GB2007/001883
申请日：2007-05-18
申请人： JAMES BLACK FOUNDATION , MCDONALD, Lain, Mair , SPENCER, John , BUCK, Ildiko, Maria , LINNEY, Ian, Duncan , PETHER, Michael, John , TISSELLI, Patricia , STEEL, Katherine, Isobel, Mary , WRIGHT, Paul, Trevor
发明人： MCDONALD, Lain, Mair , SPENCER, John , BUCK, Ildiko, Maria , LINNEY, Ian, Duncan , PETHER, Michael, John , TISSELLI, Patricia , STEEL, Katherine, Isobel, Mary , WRIGHT, Paul, Trevor
IPC分类号： C07D403/10 , C07D407/14 , A61K31/55 , A61P9/00
CPC分类号： C07D403/10 , C07D407/14
摘要： The present invention is concerned with benzotriazepinone derivatives, their intermediates, uses thereof and processes for their production. In particular, the present invention relates to parathyroid hormone (PTH) and parathyroid hormone related protein (PTHrp) receptor ligands, (PTH-I or PTH/PTHrp receptor ligands). The invention also relates to methods of preparing such ligands and to compounds which are useful as intermediates in such methods.
摘要翻译：本发明涉及苯并三氮杂酮衍生物，其中间体，其用途及其制备方法。特别地，本发明涉及甲状旁腺激素（PTH）和甲状旁腺激素相关蛋白（PTHrp）受体配体（PTH-1或PTH / PTHrp受体配体）。本发明还涉及制备这种配体的方法和可用作这些方法中的中间体的化合物。

6. 发明申请

WO2006129120A2 BENZOTRIAZEPINONE DERIVATIVES 审中-公开
标题翻译：苯并噻唑酮衍生物
公开(公告)号：WO2006129120A2
公开(公告)日：2006-12-07
申请号：PCT/GB2006002042
申请日：2006-06-02
申请人： JAMES BLACK FOUNDATION , MCDONALD IAIN MAIR , BUCK ILDIKO MARIA , DUNSTONE DAVID JOHN , LINNEY IAN DUNCAN , PETHER MICHAEL JOHN , SPENCER JOHN , STEEL KATHERINE ISOBEL MARY , TISSELLI PATRIZIA , WRIGHT PAUL TREVOR , HULL ROBERT ANTHONY DAVID , AUSTIN CAROL , HARPER ELAINE ANNE , GRIFFIN ERIC , KALINDJIAN SARKIS BARRET , LOW CAROLINE MINLI RACHEL
发明人： MCDONALD IAIN MAIR , BUCK ILDIKO MARIA , DUNSTONE DAVID JOHN , LINNEY IAN DUNCAN , PETHER MICHAEL JOHN , SPENCER JOHN , STEEL KATHERINE ISOBEL MARY , TISSELLI PATRIZIA , WRIGHT PAUL TREVOR , HULL ROBERT ANTHONY DAVID , AUSTIN CAROL , HARPER ELAINE ANNE , GRIFFIN ERIC , KALINDJIAN SARKIS BARRET , LOW CAROLINE MINLI RACHEL
IPC分类号： C07D255/04 , A61K31/55 , C07D401/04 , C07D401/06 , C07D401/12 , C07D401/14 , C07D403/12 , C07D405/14 , C07D471/04
CPC分类号： C07D255/04 , C07D401/04 , C07D401/06 , C07D401/12 , C07D401/14 , C07D403/12 , C07D405/14 , C07D471/04
摘要： The present invention is concerned with benzotriazepinone derivatives, their intermediates, uses thereof and processes for their production. In particular, the present invention relates to parathyroid hormone (PTH) and parathyroid hormone related protein (PTHrp) receptor ligands, (PTH-l or PTH/PTHrp receptor ligands). The invention also relates to methods of preparing such ligands and to compounds which are useful as intermediates in such methods.
摘要翻译：本发明涉及苯并三氮杂酮衍生物，其中间体，其用途及其制备方法。特别地，本发明涉及甲状旁腺激素（PTH）和甲状旁腺激素相关蛋白（PTHrp）受体配体（PTH-1或PTH / PTHrp受体配体）。本发明还涉及制备这种配体的方法和可用作这些方法中的中间体的化合物。

7. 发明申请

WO9504720A3 GASTRIN AND CCK RECEPTOR LIGANDS 审中-公开
标题翻译： GASTRIN和CCK受体配体
公开(公告)号：WO9504720A3
公开(公告)日：1995-08-03
申请号：PCT/GB9401741
申请日：1994-08-09
申请人： BLACK JAMES FOUNDATION , KALINDJIAN SARKIS BARRET , STEEL KATHERINE ISOBEL MARY , PETHER MICHAEL JOHN , DAVIES JONATHAN MICHAEL R , LOW CAROLINE MINLI RACHEL , HUDSON MARTIN LYN , BUCK ILDIKO MARIA , MCDONALD IAIN MAIR , DUNSTONE DAVID JOHN , TOZER MATTHEW JOHN
发明人： KALINDJIAN SARKIS BARRET , STEEL KATHERINE ISOBEL MARY , PETHER MICHAEL JOHN , DAVIES JONATHAN MICHAEL RICHAR , LOW CAROLINE MINLI RACHEL , HUDSON MARTIN LYN , BUCK ILDIKO MARIA , MCDONALD IAIN MAIR , DUNSTONE DAVID JOHN , TOZER MATTHEW JOHN
IPC分类号： A61K31/38 , A61K31/40 , A61K31/403 , A61K31/404 , A61K31/41 , A61K31/415 , A61K31/4184 , A61K31/47 , A61K31/472 , A61P1/00 , A61P1/16 , A61P3/04 , A61P25/20 , A61P29/00 , A61P35/00 , A61P43/00 , C07C233/65 , C07C233/81 , C07C233/82 , C07C233/83 , C07C237/22 , C07C237/48 , C07D207/09 , C07D207/16 , C07D209/08 , C07D209/42 , C07D209/88 , C07D217/26 , C07D235/04 , C07D235/06 , C07D235/22 , C07D235/24 , C07D307/79 , C07D307/84 , C07D333/70 , C07D401/06 , C07D403/06 , C07D403/12 , C07D403/14 , C07D453/02 , C07D471/04 , C07D215/54 , C07D307/85
CPC分类号： C07D235/06 , C07C233/65 , C07C233/82 , C07C237/22 , C07C237/48 , C07C2603/74 , C07D207/16 , C07D209/08 , C07D209/42 , C07D209/88 , C07D217/26 , C07D235/24 , C07D307/84 , C07D333/70 , C07D401/06 , C07D403/06 , C07D403/12 , C07D403/14 , C07D453/02 , C07D471/04
摘要： Compounds of formula (Ia), (Ib) or (Ic), wherein A represents a group having two fused rings, or a group of formula (Id), R1(m) represents up to 6 substituents, K represents -O-, -S-, -CH2-, -N(R2)- or -N(COR2)-, in which R2 is H or C¿1? to C3 alkyl, W is a carbonyl, sulphonyl or sulphinyl group, and X is a carbonyl, sulphonyl or sulphinyl group, provided that at least one of W and X contains carbonyl, Y and Z are as given in the description and their pharmaceutically acceptable salts are ligands at CCK and/or gastrin receptors.

8. 发明申请

WO1994000421A1 BICYCLOOCTANE AND BICYCLOHEPTANE DERIVATIVES 审中-公开
标题翻译：双氰胺和双酚化合物衍生物
公开(公告)号：WO1994000421A1
公开(公告)日：1994-01-06
申请号：PCT/GB1993001301
申请日：1993-06-18
申请人： JAMES BLACK FOUNDATION LIMITED , KALINDJIAN, Sarkis, Barret , LOW, Caroline, Minli, Rachel , PETHER, Michael, John , DAVIES, Jonathan, Michael, Richard , DUNSTONE, David, John , MCDONALD, Iain, Mair
发明人： JAMES BLACK FOUNDATION LIMITED
IPC分类号： C07C233/63
CPC分类号： C07K5/06165 , A61K38/00 , C07C233/58 , C07C233/63 , C07C237/22 , C07C2603/66 , C07C2603/72 , C07C2603/74 , C07C2603/88 , C07D207/16 , C07D209/20
摘要： Compounds of formula (I), wherein A is selected from (a), (b) (c), (d), (e), (f) and B is selected from (g), (h) and (i), wherein W is a carbonyl, sulphonyl or sulphinyl group, and X is a carbonyl, sulphonyl or sulphinyl group or -C(O)-CH2- (in which the carbonyl group is bonded to Y), provided that at least one of W and X contains carbonyl, Y is R9-O- or R9-N(R10)-, Z is selected from (i), (ii), (iii), (iv) or Z is absent and W is H, with a number of provisions and pharmaceutically acceptable salts thereof are ligands at CCK and/or gastrin receptors.
摘要翻译：其中A选自（a），（b）（c），（d），（e），（f）和B中的式（I）化合物选自（g），（h）和（i）其中W是羰基，磺酰基或亚磺酰基，X是羰基，磺酰基或亚磺酰基或-C（O）-CH 2 - （其中羰基与Y键合），条件是W中的至少一个并且X包含羰基，Y是R9-O-或R9-N（R10） - ，Z选自（i），（ii），（iii），（iv）或Z不存在，W是H，其规定的数量和药学上可接受的盐是CCK和/或胃泌素受体的配体。

9. 发明申请

WO2008009963A3 PYRIMIDINE DERIVATIVES AS MODULATORS OF PARATHYROID HORMONE RECEPTORS 审中-公开
公开(公告)号：WO2008009963A3
公开(公告)日：2008-01-24
申请号：PCT/GB2007/002767
申请日：2007-07-20
申请人： JAMES BLACK FOUNDATION LIMITED , LOW, Caroline, Minli, Rachel , MCDONALD, Lain, Mair , PETHER, Michael, John , SPENCER, John , TISSELLI, Patrizia , WRIGHT, Paul, Trevor
发明人： LOW, Caroline, Minli, Rachel , MCDONALD, Lain, Mair , PETHER, Michael, John , SPENCER, John , TISSELLI, Patrizia , WRIGHT, Paul, Trevor
IPC分类号： C07D239/26 , C07D239/28 , C07D239/34 , C07D239/42 , C07D403/12 , A61K31/505 , A61K31/506 , A61P35/00
摘要： The present invention is concerned with pyrimidine derivatives, their intermediates, uses thereof and processes for their production. In particular, the present invention relates to parathyroid hormone (PTH) and parathyroid hormone related protein (PTHrp) receptor ligands, (PTH-I or PTH/PTHrp receptor ligands). The invention also relates to methods of preparing such ligands and to compounds which are useful as intermediates in such methods.

10. 发明申请

WO2008009963A2 PYRIMIDINE DERIVATIVES 审中-公开
标题翻译：吡嗪衍生物
公开(公告)号：WO2008009963A2
公开(公告)日：2008-01-24
申请号：PCT/GB2007002767
申请日：2007-07-20
申请人： BLACK JAMES FOUNDATION , LOW CAROLINE MINLI RACHEL , MCDONALD LAIN MAIR , PETHER MICHAEL JOHN , SPENCER JOHN , TISSELLI PATRIZIA , WRIGHT PAUL TREVOR
发明人： LOW CAROLINE MINLI RACHEL , MCDONALD LAIN MAIR , PETHER MICHAEL JOHN , SPENCER JOHN , TISSELLI PATRIZIA , WRIGHT PAUL TREVOR
IPC分类号： C07D239/26 , A61K31/505 , A61K31/506 , A61P35/00 , C07D239/28 , C07D239/34 , C07D239/42 , C07D403/12
CPC分类号： C07D403/12 , C07D239/26 , C07D239/28 , C07D239/34 , C07D239/42
摘要： The present invention is concerned with pyrimidine derivatives, their intermediates, uses thereof and processes for their production. In particular, the present invention relates to parathyroid hormone (PTH) and parathyroid hormone related protein (PTHrp) receptor ligands, (PTH-I or PTH/PTHrp receptor ligands). The invention also relates to methods of preparing such ligands and to compounds which are useful as intermediates in such methods.
摘要翻译：本发明涉及嘧啶衍生物，其中间体，其用途及其生产方法。特别地，本发明涉及甲状旁腺激素（PTH）和甲状旁腺激素相关蛋白（PTHrp）受体配体（PTH-1或PTH / PTHrp受体配体）。本发明还涉及制备这种配体的方法和可用作这些方法中的中间体的化合物。

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