专利快速检索-快速检索全球专利，免费商用专利数据库-IPRDB

1. 发明申请

WO2008009963A2 PYRIMIDINE DERIVATIVES 审中-公开
标题翻译：吡嗪衍生物
公开(公告)号：WO2008009963A2
公开(公告)日：2008-01-24
申请号：PCT/GB2007002767
申请日：2007-07-20
申请人： BLACK JAMES FOUNDATION , LOW CAROLINE MINLI RACHEL , MCDONALD LAIN MAIR , PETHER MICHAEL JOHN , SPENCER JOHN , TISSELLI PATRIZIA , WRIGHT PAUL TREVOR
发明人： LOW CAROLINE MINLI RACHEL , MCDONALD LAIN MAIR , PETHER MICHAEL JOHN , SPENCER JOHN , TISSELLI PATRIZIA , WRIGHT PAUL TREVOR
IPC分类号： C07D239/26 , A61K31/505 , A61K31/506 , A61P35/00 , C07D239/28 , C07D239/34 , C07D239/42 , C07D403/12
CPC分类号： C07D403/12 , C07D239/26 , C07D239/28 , C07D239/34 , C07D239/42
摘要： The present invention is concerned with pyrimidine derivatives, their intermediates, uses thereof and processes for their production. In particular, the present invention relates to parathyroid hormone (PTH) and parathyroid hormone related protein (PTHrp) receptor ligands, (PTH-I or PTH/PTHrp receptor ligands). The invention also relates to methods of preparing such ligands and to compounds which are useful as intermediates in such methods.
摘要翻译：本发明涉及嘧啶衍生物，其中间体，其用途及其生产方法。特别地，本发明涉及甲状旁腺激素（PTH）和甲状旁腺激素相关蛋白（PTHrp）受体配体（PTH-1或PTH / PTHrp受体配体）。本发明还涉及制备这种配体的方法和可用作这些方法中的中间体的化合物。

2. 发明申请

WO9504720A3 GASTRIN AND CCK RECEPTOR LIGANDS 审中-公开
标题翻译： GASTRIN和CCK受体配体
公开(公告)号：WO9504720A3
公开(公告)日：1995-08-03
申请号：PCT/GB9401741
申请日：1994-08-09
申请人： BLACK JAMES FOUNDATION , KALINDJIAN SARKIS BARRET , STEEL KATHERINE ISOBEL MARY , PETHER MICHAEL JOHN , DAVIES JONATHAN MICHAEL R , LOW CAROLINE MINLI RACHEL , HUDSON MARTIN LYN , BUCK ILDIKO MARIA , MCDONALD IAIN MAIR , DUNSTONE DAVID JOHN , TOZER MATTHEW JOHN
发明人： KALINDJIAN SARKIS BARRET , STEEL KATHERINE ISOBEL MARY , PETHER MICHAEL JOHN , DAVIES JONATHAN MICHAEL RICHAR , LOW CAROLINE MINLI RACHEL , HUDSON MARTIN LYN , BUCK ILDIKO MARIA , MCDONALD IAIN MAIR , DUNSTONE DAVID JOHN , TOZER MATTHEW JOHN
IPC分类号： A61K31/38 , A61K31/40 , A61K31/403 , A61K31/404 , A61K31/41 , A61K31/415 , A61K31/4184 , A61K31/47 , A61K31/472 , A61P1/00 , A61P1/16 , A61P3/04 , A61P25/20 , A61P29/00 , A61P35/00 , A61P43/00 , C07C233/65 , C07C233/81 , C07C233/82 , C07C233/83 , C07C237/22 , C07C237/48 , C07D207/09 , C07D207/16 , C07D209/08 , C07D209/42 , C07D209/88 , C07D217/26 , C07D235/04 , C07D235/06 , C07D235/22 , C07D235/24 , C07D307/79 , C07D307/84 , C07D333/70 , C07D401/06 , C07D403/06 , C07D403/12 , C07D403/14 , C07D453/02 , C07D471/04 , C07D215/54 , C07D307/85
CPC分类号： C07D235/06 , C07C233/65 , C07C233/82 , C07C237/22 , C07C237/48 , C07C2603/74 , C07D207/16 , C07D209/08 , C07D209/42 , C07D209/88 , C07D217/26 , C07D235/24 , C07D307/84 , C07D333/70 , C07D401/06 , C07D403/06 , C07D403/12 , C07D403/14 , C07D453/02 , C07D471/04
摘要： Compounds of formula (Ia), (Ib) or (Ic), wherein A represents a group having two fused rings, or a group of formula (Id), R1(m) represents up to 6 substituents, K represents -O-, -S-, -CH2-, -N(R2)- or -N(COR2)-, in which R2 is H or C¿1? to C3 alkyl, W is a carbonyl, sulphonyl or sulphinyl group, and X is a carbonyl, sulphonyl or sulphinyl group, provided that at least one of W and X contains carbonyl, Y and Z are as given in the description and their pharmaceutically acceptable salts are ligands at CCK and/or gastrin receptors.

3. 发明专利

AT299499T 未知
公开(公告)号：AT299499T
公开(公告)日：2005-07-15
申请号：AT99954196
申请日：1999-11-09
申请人： BLACK JAMES FOUNDATION
发明人： KALINDJIAN SARKIS BARRET , BUCK ILDIKO MARIA , LINNEY IAN DUNCAN , WRIGHT PAUL TREVOR , MCDONALD IAIN MAIR , STEEL KATHERINE ISOBEL MARY , HULL ROBERT ANTONY DAVID , ROBERTS SONIA PATRICIA , GAFFEN JOHN DAVID , VINTER JEREMY GILBERT , WALKER MARTIN KEITH , BLACK JAMES WHYTE , WATT GILLIAN FAIRFULL , HARPER ELAINE ANNE , SHANKLEY NIGEL PAUL , TOZER MATTHEW JOHN , DUNSTONE DAVID JOHN , PETHER MICHAEL JOHN , LILLEY ELLIOT JAMES , SYKES DAVID ANDREW , LOW CAROLINE MINLI RACHEL , GRIFFIN ERIC PETER , WRIGHT LAURENCE
IPC分类号： A61K31/40 , A61K31/41 , A61K31/4164 , A61K31/4178 , A61K31/421 , A61K31/426 , A61K31/4427 , A61K31/443 , A61K31/4439 , A61K31/454 , A61P1/14 , A61P1/18 , A61P25/04 , A61P25/18 , A61P25/22 , A61P35/00 , C07B61/00 , C07D207/34 , C07D233/54 , C07D233/88 , C07D233/90 , C07D263/34 , C07D277/20 , C07D277/42 , C07D277/56 , C07D401/04 , C07D401/12 , C07D403/04 , C07D403/06 , C07D403/12 , C07D403/14 , C07D405/04
摘要： Compounds of formula (I) and their pharmaceutically acceptable salts are ligands at gastrin and/or cholecystokinin receptors. X and Y are independently =N-, -N(R5)-=CH-, -S- or -O-. n is from 1 to 4; R1 is H or C1 to C15 hydrocarbyl R2 is selected from H, Me, Et, Pr and OH, R3 is selected from H, Me, Et and Pr; or (when n is greater than 1) each R3 is independently selected from H, Me, Et and Pr, or two R3 groups on neighbouring carbon atoms are linked to form a C3 to C6 carbocylic ring, or R2 and R3 on the same carbon atom together represent an =O group; R4 is C1 to C15 hydrocarbyl Z is -(NR7)a-CO-(NR8)b- (wherein a is 0 or 1, b is 0 or 1, -CO-NR7-CH2-CO-NR8-, -CO-O-, -CH2-CH2-, -CH=CH-, -CH2-NR8- or a bond; Q is -R9V, or (II), (wherein R9 is -CH2-; -CH2-CH2-; or (III), R9 and R8, together with the nitrogen atom to which R8 is attached, form a piperidine or pyrrolidine ring which is substituted by V; V is -CO-NH-SO2-Ph, -SO2-NH-CO-Ph, -CH2OH, or a group of the formula -R10U, (wherein U is -COOH, tetrazolyl, -CONHOH- or -SO3H; and R10 is a bond; C1 to C6 hydrocarbylene, -O-(C1 to C3 alkylene)-; -SO2NR11-CHR12-; -CO-NR11-CHR12-, or -NH-(CO)c-CH2-, c being 0 or 1).

4. 发明专利

HU0402068A2 BENZOTRIAZEPINES AS GASTRIN AND CHOLECYSTOKININ RECEPTOR LIGANDS, PROCESS FOR THEIR PREPARATION AND PHARMACEUTICAL COMPOSITIONS CONTAINING THEM 未知
公开(公告)号：HU0402068A2
公开(公告)日：2005-02-28
申请号：HU0402068
申请日：2002-11-12
申请人： BLACK JAMES FOUNDATION
发明人： MCDONALD IAIN MAIR , BUCK ILDIKO MARIA , HARPER ELAINE ANNE , LINNEY IAN DUNCAN , PETHER MICHAEL JOHN , STEEL KATHERINE ISOBEL MARY , AUSTIN CAROL , DUNSTONE DAVID JOHN , KALINDJIAN SARKIS BARRET , LOW CAROLINE MINLI RACHEL , SPENCER JOHN , WRIGHT PAUL TREVOR
IPC分类号： A61K31/4439 , A61K31/545 , A61K31/55 , A61P1/00 , A61P1/04 , A61P1/14 , C07D255/00 , C07D255/04 , C07D401/04 , C07D403/12 , C07D413/06 , C07D417/12
摘要： This invention relates to a compound of formula (I) wherein: W is N or N + -O - ; and R 1 to R 5 are as defined in the description, for use for the treatment of gastrin related disorders.

5. 发明专利

AU5241001A Pyrazole derivatives and their use as gastrin and cholecystokin in receptor ligands 未知
公开(公告)号：AU5241001A
公开(公告)日：2001-12-03
申请号：AU5241001
申请日：2001-05-04
申请人： BLACK JAMES FOUNDATION
发明人： MCDONALD IAIN MAIR , LOW CAROLINE MINLI RACHEL , STEEL KATHERINE ISOBEL MARY , SPENCER JOHN
IPC分类号： A61K31/415 , A61K31/4439 , A61P1/04 , C07D231/14 , C07D231/20 , C07D231/22
摘要： Compounds of formula (I), (IIa) or (IIb) wherein R 1 -R 6 , Z, Q and n are as defined in claim 1 and their pharmaceutically acceptable salts are ligands at gastrin and/or cholecystokinin receptors. Compositions comprising a compound of formula (I), (IIa) or (IIb) are also described.

6. 发明专利

AU5241301A Gastrin and cholecystokinin receptor ligands (iii) 未知
公开(公告)号：AU5241301A
公开(公告)日：2001-11-20
申请号：AU5241301
申请日：2001-05-04
申请人： BLACK JAMES FOUNDATION
发明人： KALINDJIAN SARKIS BARRET , BUCK ILDIKO MARIA , LOW CAROLINE MINLI RACHEL , TOZER MATTHEW JOHN
IPC分类号： A61K31/415 , A61K31/42 , A61K45/06 , A61P1/04 , C07D403/04 , C07D413/04
摘要： Compounds of formula (I) and their pharmaceutically acceptable salts are ligands at gastrin and/or cholecystokinin receptors. X and Y are independently -N-, -N(R 5 )-(R 5 being selected from H, Me, Et, Pr, Bn, OH and -CH 2 COOR 6 , wherein R 6 represents H, Me, Et, Pr or Bn), -CH-, -O- or -S-; n is from 1 to 4; A is an optionally substituted 5- or 6-membered carbocyclic ring wherein (a) 1 or 2 C atoms may optionally be replaced by N, O and/or S atoms, (b) A is fused with the aromatic group in formula (I) to form a fused bicycle, and (c) the ring containing X and Y is linked to a C atom of A; R 1 is H or C 1 to C 15 hydrocarbyl wherein up to three C atoms may optionally be replaced by N, O and/or S atoms and up to three H atoms may optionally be replaced by halogen atoms; R 2 is selected from H, Me, Et, Pr and OH, each R 2 being independently selected from H, Me, Et, Pr and OH when n is greater than 1; R 3 (when n is 1) is selected from H, Me, Et and Pr; or (when n is greater than 1) each R 3 is independently selected from H, Me, Et and Pr, or two R 3 groups on neighbouring carbon atoms are linked to form a C 3 to C 6 carbocylic ring, or two R 3 groups are absent from neighbouring carbon atoms which are linked by a double bond; or R 2 and R 3 on the same carbon atom together represent an -O group; R 4 is C 1 to C 15 hydrocarbyl wherein up to two C atoms may optionally be replaced by N, O and/or S atoms and up to three H atoms may optionally be replaced by halogen atoms; V is -CO-NH-SO 2 -Ph, -SO 2 -NH-CO-PH, -CH 2 OH, or a group of the formula -R 7 U, (wherein U is -COOH, tetrazolyl, -CONHOH or -SO 3 H; and R 7 is a bond; C 1 to C 6 hydrocarbylene optionally substituted by hydroxy, amino or acetamido; -O-(C 1 to C 3 alkylene)-; -SO 2 NR 8 -CHR 9 -; -CO-NR 8 -CHR 9 -, R 8 and R 9 being independently selected from H and methyl; or -NH-(CO) c -CH 2 , c being 0 or 1); or a pharmaceutically acceptable salt thereof. Compositions comprising a compound a formula (I) are also described

7. 发明专利

BR9915194A 未知
公开(公告)号：BR9915194A
公开(公告)日：2001-08-07
申请号：BR9915194
申请日：1999-11-09
申请人： BLACK JAMES FOUNDATION
发明人： KALINDJIAN SARKIS BARRET , BUCK ILDIKO MARIA , LINNEY IAN DUNCAN , WRIGHT PAUL TREVOR , MCDONALD IAIN MAIR , STEEL KATHERINE ISOBEL MARY , HULL ROBERT ANTHONY DAVID , ROBERTS SONIA PATRICIA , GAFFEN JOHN DAVID , VINTER JEREMY GILBERT , WALKER MARTIN KEITH , BLACK JAMES WHYTE , WATT GILLIAN FAIRFULL , HARPER ELAINE ANNE , SHANKLEY NIGEL PAUL , TOZER MATTHEW JOHN , DUNSTONE DAVID JOHN , PETHER MICHAEL JOHN , LILLEY ELLIOT JAMES , SYKES DAVID ANDREW , LOW CAROLINE MINLI RACHEL , GRIFFIN ERIC PETER , WRIGHT LAURENCE
IPC分类号： A61K31/40 , A61K31/41 , A61K31/4164 , A61K31/4178 , A61K31/421 , A61K31/426 , A61K31/4427 , A61K31/443 , A61K31/4439 , A61K31/454 , A61P1/14 , A61P1/18 , A61P25/04 , A61P25/18 , A61P25/22 , A61P35/00 , C07B61/00 , C07D207/34 , C07D233/54 , C07D233/88 , C07D233/90 , C07D263/34 , C07D277/20 , C07D277/42 , C07D277/56 , C07D401/04 , C07D401/12 , C07D403/04 , C07D403/06 , C07D403/12 , C07D403/14 , C07D405/04
摘要： Compounds of formula (I) and their pharmaceutically acceptable salts are ligands at gastrin and/or cholecystokinin receptors. X and Y are independently =N-, -N(R5)-=CH-, -S- or -O-. n is from 1 to 4; R1 is H or C1 to C15 hydrocarbyl R2 is selected from H, Me, Et, Pr and OH, R3 is selected from H, Me, Et and Pr; or (when n is greater than 1) each R3 is independently selected from H, Me, Et and Pr, or two R3 groups on neighbouring carbon atoms are linked to form a C3 to C6 carbocylic ring, or R2 and R3 on the same carbon atom together represent an =O group; R4 is C1 to C15 hydrocarbyl Z is -(NR7)a-CO-(NR8)b- (wherein a is 0 or 1, b is 0 or 1, -CO-NR7-CH2-CO-NR8-, -CO-O-, -CH2-CH2-, -CH=CH-, -CH2-NR8- or a bond; Q is -R9V, or (II), (wherein R9 is -CH2-; -CH2-CH2-; or (III), R9 and R8, together with the nitrogen atom to which R8 is attached, form a piperidine or pyrrolidine ring which is substituted by V; V is -CO-NH-SO2-Ph, -SO2-NH-CO-Ph, -CH2OH, or a group of the formula -R10U, (wherein U is -COOH, tetrazolyl, -CONHOH- or -SO3H; and R10 is a bond; C1 to C6 hydrocarbylene, -O-(C1 to C3 alkylene)-; -SO2NR11-CHR12-; -CO-NR11-CHR12-, or -NH-(CO)c-CH2-, c being 0 or 1).

8. 发明专利

DK0720601T3 未知
公开(公告)号：DK0720601T3
公开(公告)日：2000-11-20
申请号：DK94922318
申请日：1994-08-09
申请人： BLACK JAMES FOUNDATION
发明人： KALINDJIAN SARKIS BARRET , STEEL KATHERINE ISOBEL MARY , PETHER MICHAEL JOHN , DAVIES JONATHAN MICHAEL RICHAR , LOW CAROLINE MINLI RACHEL , HUDSON MARTIN LYN , BUCK ILDIKO MARIA , MCDONALD IAIN MAIR , DUNSTONE DAVID JOHN , TOZER MATTHEW JOHN
IPC分类号： A61K31/38 , A61K31/40 , A61K31/403 , A61K31/404 , A61K31/41 , A61K31/415 , A61K31/4184 , A61K31/47 , A61K31/472 , A61P1/00 , A61P1/16 , A61P3/04 , A61P25/20 , A61P29/00 , A61P35/00 , A61P43/00 , C07C233/65 , C07C233/81 , C07C233/82 , C07C233/83 , C07C237/22 , C07C237/48 , C07D207/09 , C07D207/16 , C07D209/08 , C07D209/42 , C07D209/88 , C07D217/26 , C07D235/04 , C07D235/06 , C07D235/22 , C07D235/24 , C07D307/79 , C07D307/84 , C07D333/70 , C07D401/06 , C07D403/06 , C07D403/12 , C07D403/14 , C07D453/02 , C07D471/04 , C07D215/54 , C07D307/85
摘要： Compounds of formula (Ia), (Ib), or (Ic), wherein A represents a group having two fused rings, or a group of formula (Id), R1(m) represents up to 6 substituents, K represents -O-, -S-, -CH2-, -N(R2)- or -N(COR2)-, in which R2 is H or C1 to C3 alkyl, W is a carbonyl, sulfonyl or sulfinyl group, provided that at least one of W and X contains carbonyl, Y and Z are as given in the description, and their pharmaceutically acceptable salts are ligands at CCK and/or gastrin receptors.

你已经成功收藏专利！

检索式保存成功!

IPRDB

热门服务

关于我们

友情链接

联系方式