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1. 发明申请

WO2006049983A2 PEPTIDE YY MODIFIED TRANSFERRIN FUSION PROTEINS 审中-公开
标题翻译：肽类改性转铁蛋白融合蛋白
公开(公告)号：WO2006049983A2
公开(公告)日：2006-05-11
申请号：PCT/US2005/038531
申请日：2005-10-27
申请人： BIOREXIS PHARMACEUTICAL CORPORATION , PRIOR, Christopher, P. , SADEGHI, Homayoun , BALLANCE, David, J. , TURNER, Andrew
发明人： PRIOR, Christopher, P. , SADEGHI, Homayoun , BALLANCE, David, J. , TURNER, Andrew
CPC分类号： C07K14/575 , C07K2319/01
摘要： Modified fusion proteins of transferring and therapeutic proteins or peptides including, with increased serum half-life or serum stability are disclosed. Preferred fusion proteins include those modified so that the transferrin moiety exhibits no or reduced glycosylation, binding to iron and/or binding to the transferrin receptor.
摘要翻译：公开了转移和治疗性蛋白质或肽的修饰融合蛋白，包括具有增加的血清半衰期或血清稳定性的融合蛋白。优选的融合蛋白包括经修饰的融合蛋白，使得转铁蛋白部分不显示或降低糖基化，结合铁和/或结合转铁蛋白受体。

2. 发明申请

WO2004019872A2 ORAL DELIVERY OF MODIFIED TRANSFERRIN FUSION PROTEINS 审中-公开
标题翻译：口服递送改性转铁蛋白融合蛋白
公开(公告)号：WO2004019872A2
公开(公告)日：2004-03-11
申请号：PCT/US2003/026778
申请日：2003-08-28
申请人： BIOREXIS PHARMACEUTICAL CORPORATION , PRIOR, Christopher, P. , SADEGHI, Homayoun , TURNER, Andrew
发明人： PRIOR, Christopher, P. , SADEGHI, Homayoun , TURNER, Andrew
IPC分类号： A61K
CPC分类号： C07K14/70582 , C07K14/79 , C07K2319/035
摘要： Pharmaceutical compositions containing modified fusion proteins of transferrin and therapeutic proteins or peptides with increased serum half-life or increased serum stability are disclosed. Preferred fusion proteins include those modified so that the transferrin moiety exhibits no or reduced glycosylation, but does exhibit binding to iron and/or the transferrin receptor. Such fusion proteins may be administered orally.
摘要翻译：公开了含有转铁蛋白的修饰融合蛋白和具有增加的血清半衰期或增加的血清稳定性的治疗性蛋白质或肽的药物组合物。优选的融合蛋白包括那些经过修饰以使转铁蛋白部分不显示或减少糖基化，但显示与铁和/或转铁蛋白受体结合的融合蛋白。这种融合蛋白可以口服给药。

3. 发明申请

WO2004020404A3 MODIFIED TRANSFERIN-ANTIBODY FUSION PROTEINS 审中-公开
公开(公告)号：WO2004020404A3
公开(公告)日：2004-03-11
申请号：PCT/US2003/026744
申请日：2003-08-28
申请人： BIOREXIS PHARMACEUTICAL CORPORATION , SADEGHI, Homayoun , PRIOR, Christopher, P. , TURNER, Andrew
发明人： SADEGHI, Homayoun , PRIOR, Christopher, P. , TURNER, Andrew
IPC分类号： C07H21/04
摘要： Modified fusion proteins of transferrin and therapeutic proteins or peptides, preferably antibody variable regions, with increased serum half-life or serum stability are disclosed. Preferred fusion proteins include those modified so that the transferrin moiety exhibits no or reduced glycosylation, binding to iron and/or binding to the transferrin receptor.

4. 发明申请

WO2011020091A1 MODIFIED VASOACTIVE INTESTINAL PEPTIDES 审中-公开
标题翻译：改良的VASOACTIVE INTESTINAL PEPTIDES
公开(公告)号：WO2011020091A1
公开(公告)日：2011-02-17
申请号：PCT/US2010/045605
申请日：2010-08-16
申请人： PHASEBIO PHARMACEUTICALS, INC. , SADEGHI, Homayoun , TURNER, Andrew , DAGHER, Suzanne
发明人： SADEGHI, Homayoun , TURNER, Andrew , DAGHER, Suzanne
IPC分类号： A61K38/00 , A61K38/24
CPC分类号： A61K38/2278 , A61K38/39 , A61K2300/00
摘要： The present invention provides modified Vasoactive Intestinal Peptides (VIPs), encoding polynucleotides and vectors, as well as pharmaceutical compositions comprising the same. The invention further provides methods of making and using the modified VIP agents. In accordance with the invention the VIP exhibits an extended circulatory half-life, receptor-binding or biological potency, and/or altered receptor binding profile with respect to unmodified VIP.
摘要翻译：本发明提供了修饰的血管活性肽肽（VIPs），编码多核苷酸和载体，以及包含其的药物组合物。本发明还提供了制备和使用经修饰的VIP试剂的方法。根据本发明，VIP相对于未修饰的VIP显示出延长的循环半衰期，受体结合或生物效力和/或改变的受体结合特征。

5. 发明申请

WO2010124180A1 PHENYLALANINE HYDROXYLASE FUSION PROTEIN AND METHODS FOR TREATING PHENYLKETONURIA 审中-公开
标题翻译：苯丙氨酸羟化酶融合蛋白及其治疗方法
公开(公告)号：WO2010124180A1
公开(公告)日：2010-10-28
申请号：PCT/US2010/032194
申请日：2010-04-23
申请人： PHASEBIO PHARMACEUTICALS, INC. , TURNER, Andrew , SADEGHI, Homayoun
发明人： TURNER, Andrew , SADEGHI, Homayoun
IPC分类号： A61K38/00 , C07K16/00
CPC分类号： C12N9/0071 , A61K38/00 , C07K2319/00
摘要： The present invention provides Phenylalanine Hydroxylase (PAH) fusion proteins and pharmaceutical compositions comprising the same, as well as encoding polynucleotides and vectors, and methods for treating hyperphenylalaninemia, including PKU, by enzyme replacement therapy. The fusion proteins have phenylalanine hydroxylase activity when administered, and have an increased half-life or persistence in circulation, as compared to unfused counterparts. The PAH fusion proteins are suitable for enzyme replacement therapy in PKU patients by converting phenylalanine in the circulation to tyrosine, thereby controlling phenylalanine levels.
摘要翻译：本发明提供苯丙氨酸羟化酶（PAH）融合蛋白和包含其的药物组合物，以及编码多核苷酸和载体，以及通过酶替代疗法治疗高苯丙氨酸血症（包括PKU）的方法。融合蛋白在施用时具有苯丙氨酸羟化酶活性，并且与未融合的对应物相比具有增加的半衰期或循环持久性。通过将循环中的苯丙氨酸转化为酪氨酸，PAH融合蛋白适用于PKU患者的酶替代治疗，从而控制苯丙氨酸水平。

6. 发明公开

EP1534730A2 MODIFIED TRANSFERIN-ANTIBODY FUSION PROTEINS 审中-公开
标题翻译：转和抗体的修饰的融合蛋白
公开(公告)号：EP1534730A2
公开(公告)日：2005-06-01
申请号：EP03754414.5
申请日：2003-08-28
申请人： Biorexis Pharmaceutical Corporation
发明人： SADEGHI, Homayoun , PRIOR, Christopher, P. , TURNER, Andrew
IPC分类号： C07H21/04 , C12N15/63 , C12N15/65 , C12N15/86 , A01K67/00 , C07K16/00 , A61K39/395
CPC分类号： C12N15/62 , A01K2217/05 , A61K38/00 , A61K47/644 , C07K14/79 , C07K16/241 , C07K2318/20 , C07K2319/00 , C07K2319/035
摘要： Modified fusion proteins of transferrin and therapeutic proteins or peptides, preferably antibody variable regions, with increased serum half-life or serum stability are disclosed. Preferred fusion proteins include those modified so that the transferrin moiety exhibits no or reduced glycosylation, binding to iron and/or binding to the transferrin receptor.

7. 发明申请

WO2008044049A2 ACTUATOR ARRANGEMENTS 审中-公开
标题翻译：执行机构安排
公开(公告)号：WO2008044049A2
公开(公告)日：2008-04-17
申请号：PCT/GB2007/003898
申请日：2007-10-15
申请人： RICARDO UK LTD. , WHEALS, Jonathan, C. , RAMSAY, Keith , TURNER, Andrew , MCMICKIN, James
发明人： WHEALS, Jonathan, C. , RAMSAY, Keith , TURNER, Andrew , MCMICKIN, James
IPC分类号： F16H61/28 , F16H63/20
CPC分类号： F16H63/46 , F16H61/32 , F16H63/34 , F16H2061/2823 , F16H2061/2853 , F16H2061/2861
摘要： A vehicle transmission has an actuator with an output shaft, which is movable for independent operation of two gear shift devices and a clutch. The output shaft is movable in an axial direction and in a rotary sense. The gear shift devices and the clutch each have an associated input member. The output shaft includes a selection finger, which is movable for engagement with a respective input member. The gear shift devices are located at one end of the actuator and the clutch is located at the opposite end of the actuator. The input member for the clutch includes a shaft which extends back through the output shaft and actuator. An electromagnetic latch, is used to hold the clutch in a closed state.
摘要翻译：车辆变速器具有带有输出轴的致动器，该输出轴可移动以用于两个换档装置和离合器的独立操作。输出轴可沿轴向和旋转方向移动。变速装置和离合器各具有相关联的输入构件。输出轴包括可选择的手指，其可移动以与相应的输入构件接合。变速装置位于致动器的一端，并且离合器位于致动器的相对端。用于离合器的输入构件包括通过输出轴和致动器向后延伸的轴。电磁闩锁用于将离合器保持在关闭状态。

8. 发明申请

WO2005012290A1 PIPERIDYL-QUINAZOLINE DERIVATIVES AS TYROSINE KINASE INHIBITORS 审中-公开
标题翻译：作为酪氨酸激酶抑制剂的哌啶 - 喹喔啉衍生物
公开(公告)号：WO2005012290A1
公开(公告)日：2005-02-10
申请号：PCT/GB2004/003259
申请日：2004-07-27
申请人： ASTRAZENECA AB , ASTRAZENECA UK LIMITED , BRADBURY, Robert, Hugh , HENNEQUIN, Laurent, Francois, Andre , KETTLE, Jason, Grant , MCCABE, James , TURNER, Andrew
发明人： BRADBURY, Robert, Hugh , HENNEQUIN, Laurent, Francois, Andre , KETTLE, Jason, Grant , MCCABE, James , TURNER, Andrew
IPC分类号： C07D401/12
CPC分类号： C04B35/632 , C07D401/12
摘要： The invention concerns quinazoline derivatives of formula (I) wherein R 1 and R 2 have any of the meanings defined in the description; processes for their preparation, pharmaceutical compositions containing them and their use in the manufacture of a medicament for use as an antiproliferative agent in the prevention or treatment of tumours which are sensitive to inhibition of erbB, particularly EGF, receptor tyrosine kinases.
摘要翻译：本发明涉及式（I）的喹唑啉衍生物，其中R 1和R 2具有本说明书中定义的任何含义; 其制备方法，含有它们的药物组合物及其在制备用于预防或治疗对erbB特别是EGF受体酪氨酸激酶的抑制敏感的肿瘤中的抗增殖剂的药物中的用途。

9. 发明申请

WO2008131949A2 POSITIONING MEANS AND METHOD OF USE THEREOF 审中-公开
标题翻译：定位手段及其使用方法
公开(公告)号：WO2008131949A2
公开(公告)日：2008-11-06
申请号：PCT/EP2008/003426
申请日：2008-04-28
申请人： TURNER, Andrew
发明人： TURNER, Andrew
IPC分类号： B23K9/127 , B23K9/167 , B23K9/29 , B23K9/32 , B23Q17/24 , B25J19/02
CPC分类号： B23K9/127 , B23K9/296 , B23K9/32
摘要： A positioning device (13) for producing a light signal (32) to position a robot tool (2) relative to a workpiece (14) is provided. The positioning device (13) comprises a frame (16) and a pair of light sources (22, 24) mounted at the free end of the frame and arranged to direct a pair of light beams (28, 30) therefrom in converging directions which intersect with each other and provide a light signal (32) at a predetermined distance from the free end of the frame (16). The positioning device (13) can include two pairs of light sources to generate two pairs of intersecting light beams (28, 30; 29, 31). The two pairs of light sources can be arranged so that the two pairs of light beams (28, 30; 29, 31) are located substantially 90 degrees apart.
摘要翻译：提供了一种用于产生相对于工件（14）定位机器人工具（2）的光信号（32）的定位装置（13）。定位装置（13）包括框架（16）和安装在框架的自由端处的一对光源（22,24），并且布置成从一个光束（28,30）的会聚方向引导一对光束彼此相交并且提供距离框架（16）的自由端预定距离的光信号（32）。定位装置（13）可以包括两对光源以产生两对相交的光束（28,30; 29,31）。两对光源可以被布置成使得两对光束（28,30; 29,31）分开大致90度。

10. 发明申请

WO2007054721A1 MOVEMENT APPARATUS & METHOD OF USE THEREOF 审中-公开
标题翻译：运动装置及其使用方法
公开(公告)号：WO2007054721A1
公开(公告)日：2007-05-18
申请号：PCT/GB2006/004219
申请日：2006-11-10
申请人： DISABILITY TRANSFER SYSTEMS LTD , TURNER, Andrew
发明人： TURNER, Andrew
IPC分类号： A61G7/10
CPC分类号： A61G7/1067 , A61G7/1019 , A61G7/1038 , A61G7/1046 , A61G7/1048 , A61G7/1076 , A61G2200/34
摘要： Movement apparatus is provided including frame means and support means (34) associated with the frame means for supporting a user in a required manner. The frame means include at least a first upper frame portion (4) and a second lower frame portion (6) . At least one of the frame portions and/or the support means is capable of undergoing movement relative to the other frame portion and/or a frame portion respectively in two or more directions.
摘要翻译：提供了移动装置，其包括与框架装置相关联的框架装置和支撑装置（34），用于以所需方式支撑用户。框架装置至少包括第一上框架部分（4）和第二下框架部分（6）。框架部分和/或支撑装置中的至少一个能够在两个或更多个方向上分别相对于另一个框架部分和/或框架部分进行移动。

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