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1. 发明申请

WO2003076405A1 MONOCYCLIC AROYLPYRIDINONES AS ANTIINFLAMMATORY AGENTS 审中-公开
标题翻译：单烯丙基吡啶类作为抗炎药
公开(公告)号：WO2003076405A1
公开(公告)日：2003-09-18
申请号：PCT/EP2003/002154
申请日：2003-03-03
申请人： BAYER AKTIENGESELLSCHAFT , ALONSO-ALIJA, Cristina , MICHELS, Martin , SCHIROK, Hartmut , SCHLEMMER, Karl-Heinz , BELL, John , FITZGERALD, Mary, F. , DODD, Sara , GILL, Andrew
发明人： ALONSO-ALIJA, Cristina , MICHELS, Martin , SCHIROK, Hartmut , SCHLEMMER, Karl-Heinz , BELL, John , FITZGERALD, Mary, F. , DODD, Sara , GILL, Andrew
IPC分类号： C07D213/73
CPC分类号： C07D213/69 , C07D209/08 , C07D213/70 , C07D213/71 , C07D213/73 , C07D213/74 , C07D263/56 , C07D317/66 , C07D319/18 , C07D333/38 , C07D401/04 , C07D405/04 , C07D405/12 , C07D413/04
摘要： The present invention relates to monocyclic aroylpyridinones, processes for their preparation, and their use in medicaments, especially for the treatment of COPD: (formula I).
摘要翻译：本发明涉及单环芳酰基吡啶酮，其制备方法及其在药物中的用途，特别是用于治疗COPD：（式I）。

2. 发明申请

WO2003008413A1 IMIDAZOPYRIDINONES AS P38 MAP KINASE INHIBITORS 审中-公开
标题翻译：作为P38 MAP激酶抑制剂的咪唑吡啶酮
公开(公告)号：WO2003008413A1
公开(公告)日：2003-01-30
申请号：PCT/EP2002/007834
申请日：2002-07-15
申请人： BAYER AKTIENGESELLSCHAFT , ALONSO-ALIJA, Cristina , MICHELS, Martin , SCHIROK, Hartmut , SCHLEMMER, Karl-Heinz , DODD, Sara , FITZGERALD, Mary , BELL, John , GILL, Andrew
发明人： ALONSO-ALIJA, Cristina , MICHELS, Martin , SCHIROK, Hartmut , SCHLEMMER, Karl-Heinz , DODD, Sara , FITZGERALD, Mary , BELL, John , GILL, Andrew
IPC分类号： C07D471/04
CPC分类号： C07D471/04
摘要： The present invention relates to imidazopyridinones processes for their preparation and their use in medicaments, especially for the treatment of COPD.
摘要翻译：本发明涉及咪唑并吡啶酮的制备方法及其在药物中的应用，特别是用于治疗COPD。

3. 发明申请

WO2003053967A1 AROYL PYRIDINONES 审中-公开
公开(公告)号：WO2003053967A1
公开(公告)日：2003-07-03
申请号：PCT/EP2002/013930
申请日：2002-12-09
申请人： BAYER AKTIENGESELLSCHAFT , ALONSO-ALIJA, Cristina , MICHELS, Martin , SCHIROK, Hartmut , SCHLEMMER, Karl-Heinz , DODD, Sara , FITZGERALD, Mary , BELL, John , GILL, Andrew
发明人： ALONSO-ALIJA, Cristina , MICHELS, Martin , SCHIROK, Hartmut , SCHLEMMER, Karl-Heinz , DODD, Sara , FITZGERALD, Mary , BELL, John , GILL, Andrew
IPC分类号： C07D471/04
CPC分类号： C07D471/04 , C07D233/22 , C07D235/12
摘要： The present invention relates to pyridinones, processes for their preparation and their use in medicaments, especially for the treatment of COPD.
摘要翻译：本发明涉及吡啶酮，其制备方法及其在药物中的用途，特别是用于治疗COPD。

4. 发明申请

WO2009149162A1 METHOD AND APPARATUS FOR THERMAL SEALING A FILLED CHEWING GUM PRODUCT 审中-公开
标题翻译：用于热封密封的CHEWING GUM产品的方法和装置
公开(公告)号：WO2009149162A1
公开(公告)日：2009-12-10
申请号：PCT/US2009/046096
申请日：2009-06-03
申请人： WM. WRIGLEY JR. COMPANY , FABRE, Juan , ABAD, Dennis , BORDERA, Luis , GILL, Andrew , BLAZQUEZ, Melchor , CARCASONA, Emilio
发明人： FABRE, Juan , ABAD, Dennis , BORDERA, Luis , GILL, Andrew , BLAZQUEZ, Melchor , CARCASONA, Emilio
IPC分类号： A23G4/00
CPC分类号： A23G4/205 , A23G4/043 , A23G4/20
摘要： The present disclosure provides a method for thermally sealing a filled chewing gum product. The fill material of the chewing gum product is heated to a temperature greater than 40°C which correspondingly heats the inner portion of the chewing gum material to an elevated temperature. The method further includes sealing the heated inner portion of the chewing gum material to form a sealed, filled chewing gum product. The present disclosure advantageously increases the bond strength of the sealed ends of the sealed and filled chewing gum product and reduces the amount of unacceptable product or leakers.
摘要翻译：本公开提供了一种用于热密封填充的口香糖产品的方法。将口香糖产品的填充材料加热至大于40℃的温度，这相应地将口香糖材料的内部部分加热到升高的温度。该方法还包括密封加热的口香糖材料的内部部分以形成密封填充的口香糖产品。本公开有利地增加了密封和填充的口香糖产品的密封端的粘合强度并减少了不可接受的产品或泄漏物的量。

5. 发明申请

WO2002100263A1 ANALYTICAL DEVICES HAVING THE SENSOR WITHIN THE TROCAR 审中-公开
标题翻译：具有TROCAR中传感器的分析装置
公开(公告)号：WO2002100263A1
公开(公告)日：2002-12-19
申请号：PCT/GB2002/002632
申请日：2002-06-12
申请人： IIT LIMITED , BUCKLEY, Neil , GILL, Andrew , ROSE, Daniel , STONE, Suzy , BIELENBERG, Maximilian , PULLIN, Graham Michael , SOUTH, Paul, Stephen
发明人： BUCKLEY, Neil , GILL, Andrew , ROSE, Daniel , STONE, Suzy , BIELENBERG, Maximilian , PULLIN, Graham Michael , SOUTH, Paul, Stephen
IPC分类号： A61B5/00
CPC分类号： A61B5/14865 , A61B5/0002 , A61B5/6849 , A61B17/3468
摘要： Devices, kits and methods are disclosed that employ a electrode for insertion into a patient in which a flow of liquid is supplied to the sensing surface of the electrode to keep away undesirable contaminants or fouling components, while allowing the desired analyse to diffuse towards the electrode and thus be determined. The invention is particularly concerned with a device which enables the electrode to be correctly inserted at a site in a patient's body, e.g. in the interstitial space between the skin and vascularised tissue below, and in a way that is acceptable to the patient and which does not damage the electrode and with a fluid priming and delivery system for supplying the a microflow fluid to the inserted electrode.
摘要翻译：公开了使用电极插入到患者体内的装置，试剂盒和方法，其中将液体流供应到电极的感测表面，以避免不期望的污染物或结垢组分，同时允许所需的分析物向电极扩散并由此确定。本发明特别涉及一种能够使电极正确插入患者体内的部位的装置，例如，在皮肤和血管化组织之间的间隙空间中，并且以对患者可接受的方式，并且不损坏电极以及用于将微流体流体供应到插入的电极的流体引发和递送系统。

6. 发明申请

WO2007057744A2 CROSS REFERENCE TO RELATED APPLICATIONS 审中-公开
标题翻译：相关申请的交叉引用
公开(公告)号：WO2007057744A2
公开(公告)日：2007-05-24
申请号：PCT/IB2006/003206
申请日：2006-11-14
申请人： INVERNESS MEDICAL SWITZERLAND GMBH , PANESAR, Satwinder, Singh , HANNA, Colin , LANG, David, Kinniburgh , GILL, Andrew , MARQUORDT, Claus
发明人： PANESAR, Satwinder, Singh , HANNA, Colin , LANG, David, Kinniburgh , GILL, Andrew , MARQUORDT, Claus
IPC分类号： G01N33/68 , B01L3/00
CPC分类号： B01L3/502715 , B01L2200/16 , B01L2300/0672 , B01L2300/0816 , B01L2400/0478 , B01L2400/0481 , B01L2400/0683
摘要： Devices can include fluid reservoirs for storage of small amounts of liquid. Methods of removal of the liquid stored in a fluid reservoirs can include fluid activators such as an indentor, a slider, or a piston.
摘要翻译：设备可以包括用于储存少量液体的流体储存器。去除存储在流体储存器中的液体的方法可以包括流体活化剂，例如压头，滑块或活塞。

7. 发明申请

WO2008075194A2 ASSAY DEVICE AND METHOD 审中-公开
标题翻译：测定装置和方法
公开(公告)号：WO2008075194A2
公开(公告)日：2008-06-26
申请号：PCT/IB2007/004022
申请日：2007-12-19
申请人： INVERNESS MEDICAL SWITZERLAND GMBH , DILLEEN, John William , LOWE, Philip , GILL, Andrew
发明人： DILLEEN, John William , LOWE, Philip , GILL, Andrew
CPC分类号： G01N33/54326 , G01N33/54366 , G01N33/84 , G01N2333/765 , G01N2800/2871 , G01N2800/32
摘要： A method for detecting an analyte can include binding an analyte with a first reagent which is associated with a magnetic particle, allowing analyte to interact with an excess amount of a second reagent capable of interacting with the analyte, and magnetically separating a portion of analyte-bound second reagent from excess second reagent. After the magnetic separation, the interaction of the analyte and the second reagent can be disrupted to produce a detectable form of the second reagent, which can be detected. A device and system suited to performing the method are also described.
摘要翻译：用于检测分析物的方法可包括使分析物与与磁性颗粒缔合的第一试剂结合，使分析物与过量的能够与分析物相互作用的第二试剂相互作用，并从过量的第二试剂中磁性分离一部分分析物结合的第二试剂。磁性分离后，分析物与第二试剂的相互作用可被破坏以产生可检测的可检测形式的第二试剂。还描述了适合于执行该方法的设备和系统。

8. 发明申请

WO2008040982A1 METHOD FOR DETERMINING HEMATOCRIT CORRECTED ANALYTE CONCENTRATIONS 审中-公开
标题翻译：用于确定HEMATOCRIT校正分析物浓度的方法
公开(公告)号：WO2008040982A1
公开(公告)日：2008-04-10
申请号：PCT/GB2007/003770
申请日：2007-10-05
申请人： LIFESCAN SCOTLAND LIMITED , BLYTHE, Stephen, Patrick , CARDOSI, Marco, F. , GILL, Andrew , MILLS, Leanne , LEACH, Christopher, Philip
发明人： BLYTHE, Stephen, Patrick , CARDOSI, Marco, F. , GILL, Andrew , MILLS, Leanne , LEACH, Christopher, Philip
IPC分类号： G01N33/50 , G01N27/32
CPC分类号： C12Q1/006 , G01N27/3271
摘要： Description is provided herein for an embodiment of a method determining a hematocrit-corrected glucose concentration. The exemplary method includes providing a test strip having a reference electrode and a working electrode, wherein the working electrode includes a plurality of microelectrodes and is coated with at least an enzyme and a mediator. The method can be achieved by: providing a test strip comprising a reference electrode and a working electrode formed with a plurality of microelectrodes and coated with a reagent layer; applying a fluid sample to the test strip for a reaction period; applying a test voltage between the reference electrode and the working electrode; measuring a test current as a function of time; measuring a steady state current value when the test current has reached an equilibrium; calculating a ratio of the test current to the steady state current value; plotting the ratio of the test current to the steady state current value as a function of the inverse square root of time; calculating an effective diffusion coefficient from the slope of the linearly regressed plot of the ratio of the test current to the steady state current value as a function of the inverse square root of time; and calculating a hematocrit-corrected concentration of analyte.
摘要翻译：本文提供了确定血细胞比容校正葡萄糖浓度的方法的实施方案的描述。该示例性方法包括提供具有参考电极和工作电极的测试条，其中工作电极包括多个微电极并且至少涂覆有酶和介体。该方法可以通过以下方式实现：提供包括参考电极和形成有多个微电极并涂覆有试剂层的工作电极的测试条; 将流体样品施加到测试条上一段反应期; 在参考电极和工作电极之间施加测试电压; 测量作为时间的函数的测试电流; 当测试电流达到平衡时测量稳态电流值; 计算测试电流与稳态电流值的比值; 将测试电流与稳态电流值的比率绘制为时间的逆平方根的函数; 根据测试电流与稳态电流值的比值的线性回归曲线的斜率计算有效扩散系数作为时间的平方根的函数; 并计算分析物的血细胞比容校正浓度。

9. 发明申请

WO2007110756A3 ASSAY DEVICE AND METHOD WITH MAGNETIC FIELD AND TIME-VARYING SIGNALS 审中-公开
公开(公告)号：WO2007110756A3
公开(公告)日：2007-10-04
申请号：PCT/IB2007/000779
申请日：2007-03-27
申请人： INVERNESS MEDICAL SWITZERLAND GMBH , TAYLOR, David, William , GILL, Andrew
发明人： TAYLOR, David, William , GILL, Andrew
IPC分类号： G01N33/58 , G01N33/543
摘要： An assay device includes a first reagent including a magnetic particle and a second reagent including detectable component. The first and second reagent can each independently bind to an analyte in a sample. A time-varying magnetic field can be used to distinguish detectable components that are associated with analyte from detectable components not associated with analyte.

10. 发明公开

EP1487794A1 MONOCYCLIC AROYLPYRIDINONES AS ANTIINFLAMMATORY AGENTS 审中-公开
标题翻译：单环芳酰基吡啶酮作为抗炎剂
公开(公告)号：EP1487794A1
公开(公告)日：2004-12-22
申请号：EP03720315.5
申请日：2003-03-03
申请人： Bayer Aktiengesellschaft
发明人： ALONSO-ALIJA, Cristina , MICHELS, Martin , SCHIROK, Hartmut , SCHLEMMER, Karl-Heinz , BELL, John , FITZGERALD, Mary, F. , DODD, Sara , GILL, Andrew
IPC分类号： C07D213/73 , C07D213/74 , C07D401/04 , C07D401/12 , C07D405/04 , C07D405/12 , C07D409/04 , C07D413/04 , A61K31/4418 , A61K31/443 , A61K31/4433 , A61K31/4436 , A61K31/4439 , A61K31/444 , A61K31/496
CPC分类号： C07D213/69 , C07D209/08 , C07D213/70 , C07D213/71 , C07D213/73 , C07D213/74 , C07D263/56 , C07D317/66 , C07D319/18 , C07D333/38 , C07D401/04 , C07D405/04 , C07D405/12 , C07D413/04
摘要： The present invention relates to monocyclic aroylpyridinones, processes for their preparation, and their use in medicaments, especially for the treatment of COPD: (formula I).
摘要翻译：本发明涉及单环芳酰基吡啶酮，其制备方法，以及它们在药物中的用途，特别是用于治疗COPD的用途：（式I）。

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