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1. 发明申请

WO2012028841A1 ANALYTE TEST STRIP WITH ELECTRICALLY DISTINGUISHABLE DIVIDED ELECTRODE 审中-公开
标题翻译：分析电阻分离电极的测试条
公开(公告)号：WO2012028841A1
公开(公告)日：2012-03-08
申请号：PCT/GB2011/001246
申请日：2011-08-19
申请人： CILAG GMBH INTERNATIONAL , BLYTHE, Stephen, Patrick , MILLS, Leanne , MACKINTOSH, Stephen
发明人： BLYTHE, Stephen, Patrick , MILLS, Leanne , MACKINTOSH, Stephen
IPC分类号： C12Q1/00 , G01N35/00
CPC分类号： G01N33/5438 , G01N27/3272
摘要： An analyte test strip for use with a test meter includes a first insulating layer, a first electrically conductive layer disposed on the first insulating layer, a second insulating layer disposed above the first insulating layer, and a patterned spacer layer, positioned between the first insulating layer and the first electrically conductive layer, that defines a sample-receiving chamber. Moreover, the electrically conductive layer includes an electrode portion that is divided into a first electrode sub-portion and a second electrode sub-portion. The electrically conductive layer also includes (i) a first electrical contact pad in electrical communication with the first electrode sub-portion and configured to communicate an electrical response of the first electrical sub-portion to the test meter, and (ii) a second electrical contact pad in electrical communication with the second electrode sub-portion and configured to communicate an electrical response of the second electrical sub-portion to the test meter. In addition, the first electrode sub-portion is electrically isolated from the second electrode sub-portion and the first electrical contact pad is electrically isolated from the second electrical contact pad. Furthermore, the ratio of the area of the first electrode sub-portion and the area of the second electrode sub-portion is predetermined such that the ratio can be electrically distinguished by the test meter based on the first and second electrode sub-portion electrical responses.
摘要翻译：一种与测试仪一起使用的分析物测试条包括第一绝缘层，设置在第一绝缘层上的第一导电层，设置在第一绝缘层上方的第二绝缘层，以及图案化间隔层，位于第一绝缘层之间层和第一导电层，其限定了样品接收室。此外，导电层包括被分成第一电极子部分和第二电极子部分的电极部分。导电层还包括（i）与第一电极子部分电连通并且被配置为将第一电子部分的电响应传递到测试仪的第一电接触焊盘，以及（ii）第二电接触焊盘接触垫与第二电极子部分电连通并且被配置为将第二电子部分的电响应传达到测试仪。此外，第一电极子部分与第二电极子部分电隔离，并且第一电接触焊盘与第二电接触焊盘电隔离。此外，第一电极子部分的面积和第二电极子部分的面积的比率是预定的，使得该比值可以通过测试仪器基于第一和第二电极子部分电响应而被电区分。

2. 发明申请

WO2008040998A3 SYSTEMS AND METHODS FOR DETERMINING A SUBSTANTIALLY HEMATOCRIT INDEPENDENT ANALYTE CONCENTRATION 审中-公开
公开(公告)号：WO2008040998A3
公开(公告)日：2008-04-10
申请号：PCT/GB2007/003791
申请日：2007-10-05
申请人： LIFESCAN SCOTLAND LIMITED , CARDOSI, Marco, F. , BLYTHE, Stephen, Patrick , FINCH, Matthew , THOMPSON, Arlene , NAYLOR, Nina, Antonia , BAILEY, Eric, Jason , DOLAN, Michael, Patrick , ANDERSON, Gretchen , COMSTOCK, Lorraine , MCEVOY, Mary , SUTTON, Thomas , DAY, Richard, Michael , MILLS, Leanne , DAY, Emma, Vanessa, Jayne , LEACH, Christopher, Philip
发明人： CARDOSI, Marco, F. , BLYTHE, Stephen, Patrick , FINCH, Matthew , THOMPSON, Arlene , NAYLOR, Nina, Antonia , BAILEY, Eric, Jason , DOLAN, Michael, Patrick , ANDERSON, Gretchen , COMSTOCK, Lorraine , MCEVOY, Mary , SUTTON, Thomas , DAY, Richard, Michael , MILLS, Leanne , DAY, Emma, Vanessa, Jayne , LEACH, Christopher, Philip
IPC分类号： G01N33/487 , G01N33/50
摘要： Method and system are provided to allow for determination of substantially hematocrit independent analyte concentration. In one example, an analyte measurement system is provided that includes a test strip and a test meter. The test strip includes a reference electrode and a working electrode, in which the working electrode is coated with a reagent layer. The test meter includes an electronic circuit and a signal processor. The electronic circuit applies a plurality of voltages to the reference electrode and the working electrode over respective durations. The signal processor is configured to determine a substantially hematocrit-independent concentration of the analyte from a plurality of current values as measured by the processor upon application of a plurality of test voltages to the reference and working electrodes over a plurality of durations interspersed with rest voltages lower than the test voltages being applied to the electrodes.

3. 发明申请

WO2008040998A2 SYSTEMS AND METHODS FOR DETERMINING A SUBSTANTIALLY HEMATOCRIT INDEPENDENT ANALYTE CONCENTRATION 审中-公开
标题翻译：用于确定主要血红细胞独立分析物浓度的系统和方法
公开(公告)号：WO2008040998A2
公开(公告)日：2008-04-10
申请号：PCT/GB2007003791
申请日：2007-10-05
申请人： LIFESCAN SCOTLAND LTD , CARDOSI MARCO F , BLYTHE STEPHEN PATRICK , FINCH MATTHEW , THOMPSON ARLENE , NAYLOR NINA ANTONIA , BAILEY ERIC JASON , DOLAN MICHAEL PATRICK , ANDERSON GRETCHEN , COMSTOCK LORRAINE , MCEVOY MARY , SUTTON THOMAS , DAY RICHARD MICHAEL , MILLS LEANNE , DAY EMMA VANESSA JAYNE , LEACH CHRISTOPHER PHILIP
发明人： CARDOSI MARCO F , BLYTHE STEPHEN PATRICK , FINCH MATTHEW , THOMPSON ARLENE , NAYLOR NINA ANTONIA , BAILEY ERIC JASON , DOLAN MICHAEL PATRICK , ANDERSON GRETCHEN , COMSTOCK LORRAINE , MCEVOY MARY , SUTTON THOMAS , DAY RICHARD MICHAEL , MILLS LEANNE , DAY EMMA VANESSA JAYNE , LEACH CHRISTOPHER PHILIP
IPC分类号： G01N33/487 , G01N33/50
CPC分类号： G01N27/3274
摘要： Method and system are provided to allow for determination of substantially hematocrit independent analyte concentration. In one example, an analyte measurement system is provided that includes a test strip and a test meter. The test strip includes a reference electrode and a working electrode, in which the working electrode is coated with a reagent layer. The test meter includes an electronic circuit and a signal processor. The electronic circuit applies a plurality of voltages to the reference electrode and the working electrode over respective durations. The signal processor is configured to determine a substantially hematocrit-independent concentration of the analyte from a plurality of current values as measured by the processor upon application of a plurality of test voltages to the reference and working electrodes over a plurality of durations interspersed with rest voltages lower than the test voltages being applied to the electrodes.
摘要翻译：提供方法和系统以允许确定基本不依赖于血细胞比容的分析物浓度。在一个示例中，提供了包括测试条和测试仪的分析物测量系统。测试条包括参比电极和工作电极，其中工作电极涂覆有试剂层。测试仪包括一个电子电路和一个信号处理器。电子电路在相应的持续时间内向参考电极和工作电极施加多个电压。信号处理器被配置为在多个测试电压施加到参考电极和工作电极上的多个持续时间中由处理器测量的多个电流值中确定分析物的基本上不依赖于血细胞比容的浓度，低于施加到电极上的测试电压。

4. 发明申请

WO2008040990A2 METHODS FOR DETERMINING AN ANALYTE CONCENTRATION USING SIGNAL PROCESSING ALGORITHMS 审中-公开
标题翻译：使用信号处理算法确定分析浓度的方法
公开(公告)号：WO2008040990A2
公开(公告)日：2008-04-10
申请号：PCT/GB2007/003781
申请日：2007-10-05
申请人： LIFESCAN SCOTLAND LIMITED , BLYTHE, Stephen, Patrick , CARDOSI, Marco, F. , MILLS, Leanne , ALVAREZ-ICAZA, Manuel , DAY, Emma, Vanessa, Jayne , DAY, Richard, Michael , LEACH, Christopher, Philip
发明人： BLYTHE, Stephen, Patrick , CARDOSI, Marco, F. , MILLS, Leanne , ALVAREZ-ICAZA, Manuel , DAY, Emma, Vanessa, Jayne , DAY, Richard, Michael , LEACH, Christopher, Philip
IPC分类号： G01N33/487
CPC分类号： G01N27/3273
摘要： A method for determining an analyte concentration in blood is described that reduces the effects of hematocrit using a test strip attached to a test meter. The test strip includes a working electrode and a reference electrode. The test meter applies a test voltage between the working electrode and the reference electrode. After a user applies a blood sample containing an analyte onto the test strip, the test meter measures a plurality of test currents for a test time interval. The test meter thereafter calculates an analyte correlation value. An accurate glucose concentration may be determined based on the analyte correlation value.
摘要翻译：描述了用于测定血液中分析物浓度的方法，其使用连接到测试仪的测试条减少了血细胞比容的影响。测试条包括工作电极和参考电极。测试仪在工作电极和参比电极之间施加测试电压。在用户将含有分析物的血液样本应用到测试条上之后，测试仪测量测试时间间隔的多个测试电流。然后，测试仪计算分析物相关值。可以基于分析物相关值来确定精确的葡萄糖浓度。

5. 发明申请

WO2008040982A1 METHOD FOR DETERMINING HEMATOCRIT CORRECTED ANALYTE CONCENTRATIONS 审中-公开
标题翻译：用于确定HEMATOCRIT校正分析物浓度的方法
公开(公告)号：WO2008040982A1
公开(公告)日：2008-04-10
申请号：PCT/GB2007/003770
申请日：2007-10-05
申请人： LIFESCAN SCOTLAND LIMITED , BLYTHE, Stephen, Patrick , CARDOSI, Marco, F. , GILL, Andrew , MILLS, Leanne , LEACH, Christopher, Philip
发明人： BLYTHE, Stephen, Patrick , CARDOSI, Marco, F. , GILL, Andrew , MILLS, Leanne , LEACH, Christopher, Philip
IPC分类号： G01N33/50 , G01N27/32
CPC分类号： C12Q1/006 , G01N27/3271
摘要： Description is provided herein for an embodiment of a method determining a hematocrit-corrected glucose concentration. The exemplary method includes providing a test strip having a reference electrode and a working electrode, wherein the working electrode includes a plurality of microelectrodes and is coated with at least an enzyme and a mediator. The method can be achieved by: providing a test strip comprising a reference electrode and a working electrode formed with a plurality of microelectrodes and coated with a reagent layer; applying a fluid sample to the test strip for a reaction period; applying a test voltage between the reference electrode and the working electrode; measuring a test current as a function of time; measuring a steady state current value when the test current has reached an equilibrium; calculating a ratio of the test current to the steady state current value; plotting the ratio of the test current to the steady state current value as a function of the inverse square root of time; calculating an effective diffusion coefficient from the slope of the linearly regressed plot of the ratio of the test current to the steady state current value as a function of the inverse square root of time; and calculating a hematocrit-corrected concentration of analyte.
摘要翻译：本文提供了确定血细胞比容校正葡萄糖浓度的方法的实施方案的描述。该示例性方法包括提供具有参考电极和工作电极的测试条，其中工作电极包括多个微电极并且至少涂覆有酶和介体。该方法可以通过以下方式实现：提供包括参考电极和形成有多个微电极并涂覆有试剂层的工作电极的测试条; 将流体样品施加到测试条上一段反应期; 在参考电极和工作电极之间施加测试电压; 测量作为时间的函数的测试电流; 当测试电流达到平衡时测量稳态电流值; 计算测试电流与稳态电流值的比值; 将测试电流与稳态电流值的比率绘制为时间的逆平方根的函数; 根据测试电流与稳态电流值的比值的线性回归曲线的斜率计算有效扩散系数作为时间的平方根的函数; 并计算分析物的血细胞比容校正浓度。

6. 发明申请

WO2012001365A1 METHODS TO ENSURE STATISTICAL POWER FOR AVERAGE PRE AND POST - PRANDIAL GLUCOSE DIFFERENCE MESSAGING 审中-公开
标题翻译：确保平均预处理和后期功能的方法葡萄糖差异消息传递
公开(公告)号：WO2012001365A1
公开(公告)日：2012-01-05
申请号：PCT/GB2011000992
申请日：2011-06-30
申请人： LIFESCAN SCOTLAND LTD , BLYTHE STEPHEN PATRICK , MALECHA MICHAEL
发明人： BLYTHE STEPHEN PATRICK , MALECHA MICHAEL
IPC分类号： A61B5/145 , G06F19/00
CPC分类号： G06F19/10 , A61B5/14532 , G06F19/3456 , G16H15/00 , G16H40/63 , G16H50/20
摘要： A diabetes management system and method are provided herein that may be used to analyze a patient's level of control of their diabetes, by looking at the difference between blood glucose measurements taken before and after a meal. If the standard deviation of the differences D calculated between pre- and post-prandial results is found to vary significantly from a predetermined threshold value, then a message or graphical indication may be displayed to the user. Messages may provide suggestions to the user as to ways to better manage their condition to ensure compliance of any prescribed diabetes regimen or to guide the patient in managing their diabetes.
摘要翻译：本文提供的糖尿病管理系统和方法可用于通过观察餐前和服用之后的血糖测量值之间的差异来分析患者的糖尿病控制水平。如果发现在餐前和餐后结果之间计算的差异D的标准差从预定阈值显着变化，则可以向用户显示消息或图形指示。消息可以向用户提供关于如何更好地管理其状况以确保任何规定的糖尿病方案的依从性或指导患者管理其糖尿病的方法的建议。

7. 发明申请

WO2008040990A3 METHODS FOR DETERMINING AN ANALYTE CONCENTRATION USING SIGNAL PROCESSING ALGORITHMS 审中-公开
标题翻译：使用信号处理算法确定分析浓度的方法
公开(公告)号：WO2008040990A3
公开(公告)日：2008-05-22
申请号：PCT/GB2007003781
申请日：2007-10-05
申请人： LIFESCAN SCOTLAND LTD , BLYTHE STEPHEN PATRICK , CARDOSI MARCO F , MILLS LEANNE , ALVAREZ-ICAZA MANUEL , DAY EMMA VANESSA JAYNE , DAY RICHARD MICHAEL , LEACH CHRISTOPHER PHILIP
发明人： BLYTHE STEPHEN PATRICK , CARDOSI MARCO F , MILLS LEANNE , ALVAREZ-ICAZA MANUEL , DAY EMMA VANESSA JAYNE , DAY RICHARD MICHAEL , LEACH CHRISTOPHER PHILIP
IPC分类号： G01N33/487
CPC分类号： G01N27/3273
摘要： A method for determining an analyte concentration in blood is described that reduces the effects of hematocrit using a test strip (100, 300, 400, 500) attached to a test meter (200). The test strip includes a working electrode and a reference electrode. The test meter applies a test voltage between the working electrode and the reference electrode. After a user applies a blood sample containing an analyte onto the test strip, the test meter measures a plurality of test currents for a test time interval. The test meter thereafter calculates an analyte correlation value. An accurate glucose concentration may be determined based on the analyte correlation value.
摘要翻译：描述了一种用于测定血液中分析物浓度的方法，其使用附着在测试仪（200）上的测试条（100,300,400,500）来降低血细胞比容的影响。测试条包括工作电极和参考电极。测试仪在工作电极和参比电极之间施加测试电压。在用户将含有分析物的血液样本应用到测试条上之后，测试仪测量测试时间间隔的多个测试电流。然后，测试仪计算分析物相关值。可以基于分析物相关值来确定精确的葡萄糖浓度。

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