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1. 发明专利

CA2236598C TREATMENT OF CARDIOMYOPATHY BY REMOVAL OF AUTOANTIBODIES 未知
公开(公告)号：CA2236598C
公开(公告)日：2006-09-12
申请号：CA2236598
申请日：1996-11-15
申请人： BAXTER INT , FELIX STEPHAN , BREHME STEFAN , REINKE PETRA , BAUMANN GERT
发明人： FELIX STEPHAN , BREHME STEFAN , REINKE PETRA , SPAETHE REINER , BAUMANN GERT , KOLL ROBERT , MULLER-DERLICH JUTTA
IPC分类号： A61M1/36 , A61M1/38 , A61K35/14 , A61K35/16 , A61K38/00 , A61K39/395 , A61K45/00 , A61P9/00 , C07K1/22 , C07K16/28
摘要： Immunoapheresis treatment for cardiomyopathy comprises passing the patient's plasma over a column having coupled thereto a specific ligand for human immunoglobulin, thereby removing a significant portion of the immunoglobulin from the patient's plasma, and then reinfusing the plasma to the patient. The invention is the use of a specific ligand for human immunoglobulin in the manufacture of a column having the ligand coupled thereto, the column being useful for immunoapheresis treatment of a patient with cardiomyopathy. The specific ligand binds, and thereby removes, human autoantibodies which a re harmful to cardiac tissue such as antibodies against .beta.1-adrenergic receptors, ADP-ATP carriers, .alpha. and .beta. myosin heavy chains, and adenine nucleotide translocators. Immunoapheresis treatmen t using the column results in improvement of hemodynamic parameters such as me an arterial pressure, mean pulmonary pressure, pulmonary capillary wedge pressure, right atrial pressure, cardiac output, cardiac index, stroke volume index, and systemic vascular resistance.

2. 发明专利

AU1054097A Treatment of cardiomyopathy by removal of autoantibodies 未知
公开(公告)号：AU1054097A
公开(公告)日：1997-06-05
申请号：AU1054097
申请日：1996-11-15
申请人： BAUMANN GERT , BAXTER INT , BREHME STEFAN , FELIX STEPHAN , REINKE PETRA
发明人： REINKE PETRA , BREHME STEFAN , BAUMANN GERT , KOLL ROBERT , MULLER-DERLICH JUTTA , FELIX STEPHAN , SPAETHE REINER
IPC分类号： A61M1/36 , A61K35/14 , A61K35/16 , A61K38/00 , A61K45/00 , A61P9/00 , C07K1/22 , C07K16/28 , C07K14/72

3. 发明专利

CA2236598A1 TREATMENT OF CARDIOMYOPATHY BY REMOVAL OF AUTOANTIBODIES 未知
公开(公告)号：CA2236598A1
公开(公告)日：1997-05-22
申请号：CA2236598
申请日：1996-11-15
申请人： FELIX STEPHAN , BAXTER INT , REINKE PETRA , BAUMANN GERT , BREHME STEFAN
发明人： SPAETHE REINER , KOLL ROBERT , FELIX STEPHAN , REINKE PETRA , MULLER-DERLICH JUTTA , BAUMANN GERT , BREHME STEFAN
IPC分类号： A61M1/36 , A61K35/14 , A61K35/16 , A61K38/00 , A61K45/00 , A61P9/00 , C07K1/22 , C07K16/28 , A61M1/38 , A61K39/395
摘要： Immunoapheresis treatment for cardiomyopathy comprises passing the patient's plasma over a column having coupled thereto a specific ligand for human immunoglobulin, thereby removing a significant portion of the immunoglobulin from the patient's plasma, and then reinfusing the plasma to the patient. The invention is the use of a specific ligand for human immunoglobulin in the manufacture of a column having the ligand coupled thereto, the column being useful for immunoapheresis treatment of a patient with cardiomyopathy. The specific ligand binds, and thereby removes, human autoantibodies which are harmful to cardiac tissue such as antibodies against .beta.1-adrenergic receptors, ADP-ATP carriers, .alpha. and .beta. myosin heavy chains, and adenine nucleotide translocators. Immunoapheresis treatment using the column results in improvement of hemodynamic parameters such as mean arterial pressure, mean pulmonary pressure, pulmonary capillary wedge pressure, right atrial pressure, cardiac output, cardiac index, stroke volume index, and systemic vascular resistance.

4. 发明专利

AU731452B2 Treatment of cardiomyopathy by removal of autoantibodies 未知
公开(公告)号：AU731452B2
公开(公告)日：2001-03-29
申请号：AU1054097
申请日：1996-11-15
申请人： BAXTER INT , BAUMANN GERT , FELIX STEPHAN , REINKE PETRA , BREHME STEFAN
发明人： REINKE PETRA , BREHME STEFAN , BAUMANN GERT , FELIX STEPHAN , KOLL ROBERT , MULLER-DERLICH JUTTA , SPAETHE REINER
IPC分类号： A61M1/36 , A61K35/14 , A61K35/16 , A61K38/00 , A61K45/00 , A61P9/00 , C07K1/22 , C07K16/28 , C07K14/72

5. 发明专利

DE69632476D1 未知
公开(公告)号：DE69632476D1
公开(公告)日：2004-06-17
申请号：DE69632476
申请日：1996-11-15
申请人： EDWARDS LIFESCIENCES CORP , REINKE PETRA , BREHME STEFAN , BAUMANN GERT , FELIX STEPHAN
发明人： REINKE PETRA , BREHME STEFAN , BAUMANN GERT , KOLL ROBERT , MUELLER-DERLICH JUTTA , FELIX STEPHAN , SPAETHE REINER
IPC分类号： A61M1/36 , A61K35/14 , A61K35/16 , A61K38/00 , A61K45/00 , A61P9/00 , C07K1/22 , C07K16/28

6. 发明专利

DE69632476T3 BEHANDLUNG VON DILATIERTE KARDIOMYOPATHIE DURCH ENTFERNUNG VON AUTOANTIKOERPERN 未知
公开(公告)号：DE69632476T3
公开(公告)日：2014-05-22
申请号：DE69632476
申请日：1996-11-15
申请人： EDWARDS LIFESCIENCES CORP , REINKE PETRA , BREHME STEFAN , BAUMANN GERT , FELIX STEPHAN
发明人： REINKE PETRA , BREHME STEFAN , BAUMANN GERT , KOLL ROBERT , MÜLLER-DERLICH JUTTA , FELIX STEPHAN , SPAETHE REINER
IPC分类号： A61K35/14 , A61M1/36 , A61K35/16 , A61K38/00 , A61K45/00 , A61P9/00 , C07K1/22 , C07K16/28

7. 发明专利

DE69632476T2 BEHANDLUNG VON DILATIERTE KARDIOMYOPATHIE DURCH ENTFERNUNG VON AUTOANTIKOERPERN 未知
公开(公告)号：DE69632476T2
公开(公告)日：2005-05-12
申请号：DE69632476
申请日：1996-11-15
申请人： EDWARDS LIFESCIENCES CORP , REINKE PETRA , BREHME STEFAN , BAUMANN GERT , FELIX STEPHAN
发明人： REINKE PETRA , BREHME STEFAN , BAUMANN GERT , KOLL ROBERT , MÜLLER-DERLICH JUTTA , FELIX STEPHAN , SPAETHE REINER
IPC分类号： A61K35/14 , A61M1/36 , A61K35/16 , A61K38/00 , A61K45/00 , A61P9/00 , C07K1/22 , C07K16/28

8. 发明专利

AT266415T 未知
公开(公告)号：AT266415T
公开(公告)日：2004-05-15
申请号：AT96941378
申请日：1996-11-15
申请人： EDWARDS LIFESCIENCES CORP , REINKE PETRA , BREHME STEFAN , BAUMANN GERT , FELIX STEPHAN
发明人： REINKE PETRA , BREHME STEFAN , BAUMANN GERT , KOLL ROBERT , MUELLER-DERLICH JUTTA , FELIX STEPHAN , SPAETHE REINER
IPC分类号： A61M1/36 , A61K35/14 , A61K35/16 , A61K38/00 , A61K45/00 , A61P9/00 , C07K1/22 , C07K16/28 , C07K14/72

9. 发明专利

DE112012002430T5 Antigenspezifische zentrale Gedächtnis-T-Zellpräparationen mit hohem CD4+ Anteil 未知
公开(公告)号：DE112012002430T5
公开(公告)日：2014-03-06
申请号：DE112012002430
申请日：2012-06-11
申请人： REINKE PETRA , SCHMUECK MICHAEL , VOLK HANS-DIETER
发明人： VOLK HANS-DIETER , SCHMUECK MICHAEL , REINKE PETRA
IPC分类号： C12N5/0783 , A61K35/17
摘要： Die Erfindung betrifft ein Verfahrung zur Erzeugung von T-Zellpräparationen, die für mindestens ein Zielantigen spezifisch sind, umfassend die Schritte Expandieren von lymphoiden Zellen in vitro in der Gegenwart eines Zielantigens oder Peptidfragmenten davon in einem Expansionsschritt, Isolieren von Zellen, die Interferon gamma sekretieren und Kultivieren der Zellen in Gegenwart von Interleukin-2 und Interleukin-7 und enweder eines Inhibitors des mTor Komplexes 1 oder in Gegenwart eines Inhibitors der Interleukin-2(IL-2)-Interleukin-2-Rezeptor(IL-2R)-Interaktion. Die Erfindung betrifft weiterhin Präparationen, die durch das Verfahren der Erfindung erhalten werden.

10. 发明申请

WO0075180A3 PEPTIDES FOR VACCINATING AGAINST HUMAN CMV 审中-公开
标题翻译：肽疫苗接种反对人类巨细胞病毒
公开(公告)号：WO0075180A3
公开(公告)日：2001-07-26
申请号：PCT/DE0001854
申请日：2000-06-02
申请人： KERN FLORIAN , VOLK HANS DIETER , REINKE PETRA , FAULHABER NICOLE , SUREL INGOLF PASCAL , KHATAMZAS ELHAM
发明人： KERN FLORIAN , VOLK HANS-DIETER , REINKE PETRA , FAULHABER NICOLE , SUREL INGOLF-PASCAL , KHATAMZAS ELHAM
IPC分类号： C12N15/09 , A61K38/00 , A61K39/00 , A61K39/25 , A61P31/12 , C07K7/00 , C07K14/045 , C12N15/38 , C12N15/63 , G01N33/68
CPC分类号： C07K14/005 , A61K39/00 , C12N2710/16122 , C12N2710/16134 , Y02P20/55
摘要： The invention relates to peptides which are optionally fragments of the IE-1 or pp65 protein selected from the following group having sequence RN - Gln Thr Met Leu Arg Lys Glu Val Asn Ser Gln Leu Ser Leu Gly - RC; RN - Cys Asn Glu Asn Pro Glu Lys Asp Val Leu Ala Glu Leu Val Lys - RC; RN - Leu Val Lys Gln Ile Lys Val Arg Val Asp Met Val Arg His Arg - RC; RN - Ala Ala Asn Lys Leu Gly Gly Ala Leu Gln Ala Lys Ala Arg Ala - RC; RN - Ala Arg Ala Lys Lys Asp Glu Leu Arg Arg Lys Met Met Tyr Met - RC; RN - Asp Glu Leu Arg Arg Lys Met Met Tyr Met - RC; RN - Glu Leu Arg Arg Lys Met Met Tyr Met Cys Tyr Arg Asn Ile Glu - RC; RN - Val Thr Ser Asp Ala Cys Met Met Thr Met Tyr Gly Gly Ile Ser - RC; RN - Glu Phe Cys Arg Val Leu Cys Cys Tyr Val Leu Glu Glu Thr Ser - RC; RN - Met Ser Ile Tyr Val Tyr Ala Leu Pro Leu Lys Met Leu Asn Ile - RC; RN - Val Tyr Ala Leu Pro Leu Lys Met Leu Asn Ile Pro Ser Ile Asn - RC; RN - Ala Leu Pro Leu Lys Met Leu Asn Ile - RC; RN - His Ile Met Leu Asp Val Ala Phe Thr Ser His Glu His Phe Gly RC; RN - Asp Val Ala Phe Thr Ser His Glu His Phe Gly Leu Leu Cys Pro - RC; RN - Val Ala Phe Thr Ser His Glu His Phe - RC; RN - Ala Phe Thr Ser His Glu His Phe Gly - RC; RN - Ala Asn Asp Ile Tyr Arg Ile Phe Ala Glu Leu Glu Gly Val Trp - RC; RN - Val Cys Ser Met Glu Asn Thr Arg Ala Thr Lys Met Gln Val Ile - RC; RN - Glu Asn Thr Arg Ala Thr Lys Met Gln Val Ile Gly Asp Gln Tyr - RC; RN - Asn Thr Arg Ala Thr Lys Met Gln Val - RC; RN - Thr Arg Ala Thr Lys Met Gln Val Ile - RC; RN - Gln Pro Phe Met Arg Pro His Glu Arg Asn Gly Phe Thr Val Leu - RC; RN - Pro Leu Lys Met Leu Asn Ile Pro Ser Ile Asn Val His His Tyr - RC; RN - Leu Asn Ile Pro Ser Ile Asn Val His His Tyr Pro Ser Ala Ala - RC; RN Glu Asp Val Pro Ser Glu Lys Leu Phe Met His Val Thr Leu Gly - RC; RN - Cys Arg Val Leu Cys Cys Tyr Val Leu - RC; RN - Arg Val Leu Cys Cys Tyr Val Leu Glu - RC; RN - Val Leu Cys Cys Tyr Val Leu Glu Glu - RC; RN - Glu Leu Arg Arg Lys Met Met Tyr Met - RC; RN - Asp Glu Leu Arg Arg Lys Met Met Tyr - RC; RN Asp Glu Leu Arg Arg Lys Met Met Tyr Met - RC; RN - Asp Glu Glu Glu Ala Ile Val Ala Tyr Tyr Leu Ala Thr Ala Gly - RC or RN - Glu Asn Ser Asp Gln Glu Ser Glu Gln Ser Asp Glu Glu Glu - RC, whereby RN represents -H or an amino protecting group; RC represents -OH or a carboxyl protecting group. The inventive peptides are used in the preparation of a medicaments for vaccination against HVMV infections or a diagnostic reagent for identifying an immune response against HCMV.
摘要翻译：肽，其是IE-1蛋白或病毒pp65的任选片段，选自下组，其具有序列：RN - 谷氨酰胺苏氨酸亮氨酸蛋氨酸赖氨酸精氨酸谷氨酸的Asn缬氨酸丝氨酸谷氨酰胺亮氨酸亮氨酸丝氨酸甘氨酸 - RC; RN - 半胱氨酸天冬酰胺谷氨酸天冬酰胺临谷氨酸天冬氨酸赖氨酸缬氨酸丙氨酸谷氨酸亮氨酸亮氨酸缬氨酸赖氨酸 - RC; RN - 亮氨酸缬氨酸赖氨酸谷氨酰胺异亮氨酸赖氨酸精氨酸瓦尔瓦尔会见瓦尔天冬氨酸精氨酸他精氨酸 - RC; RN - 丙氨酸丙氨酸天冬酰胺赖氨酸列伊甘氨酸甘氨酸丙氨酸亮氨酸谷氨酰胺丙氨酸赖氨酸丙氨酸精氨酸丙氨酸 - RC; RN - 丙氨酸精氨酸丙氨酸赖氨酸赖氨酸天冬氨酸谷氨酸列伊ARG ARG赖氨酸蛋氨酸的Met酪氨酸蛋氨酸 - RC; RN - 天冬氨酸谷氨酸列伊ARG ARG赖氨酸蛋氨酸的Met酪氨酸蛋氨酸 - RC; RN - 谷氨酸列伊ARG ARG赖氨酸蛋氨酸的Met酪氨酸蛋氨酸半胱氨酸酪氨酸天冬酰胺精氨酸谷氨酸岛 - RC; RN - 瓦尔苏氨酸丝氨酸天冬氨酸丙氨酸半胱氨酸苏氨酸蛋氨酸蛋氨酸蛋氨酸酪氨酸甘氨酸甘氨酸丝氨酸岛 - RC; RN - 谷氨酸苯丙氨酸半胱氨酸精氨酸瓦尔·莱半胱氨酸半胱氨酸酪氨酸瓦尔·莱谷氨酸谷氨酸苏氨酸丝氨酸 - RC; RN - 蛋氨酸序列异亮氨酸酪氨酸酪氨酸丙氨酸瓦尔·莱临赖氨酸列伊列伊蛋氨酸天冬酰胺岛 - RC; RN - 瓦尔酪氨酸亮氨酸丙氨酸临列伊赖氨酸列伊蛋氨酸天冬酰胺岛临天冬酰胺丝氨酸岛 - RC; RN - 阿拉列伊临亮氨酸赖氨酸蛋氨酸亮氨酸天冬酰胺岛 - RC; RN - 他的异亮氨酸天冬氨酸列伊会见瓦尔丙氨酸苯丙氨酸苏氨酸丝氨酸谷氨酸他的苯丙氨酸甘氨酸他的RC; RN - 天冬氨酸缬氨酸丙氨酸苯丙氨酸苏氨酸丝氨酸谷氨酸他对他的苯丙氨酸亮氨酸亮氨酸甘氨酸半胱氨酸临 - RC; RN - 瓦尔丙氨酸苯丙氨酸苏氨酸丝氨酸谷氨酸他对他的苯丙氨酸 - RC; RN - 丙氨酸苯丙氨酸苏氨酸丝氨酸谷氨酸他对他的苯丙氨酸甘氨酸 - RC; RN - 丙氨酸天冬酰胺天冬氨酸异亮氨酸酪氨酸精氨酸异亮氨酸苯丙氨酸丙氨酸亮氨酸谷氨酸谷氨酸甘氨酸缬氨酸色氨酸 - RC; RN - 瓦尔丝氨酸半胱氨酸蛋氨酸谷氨酸苏氨酸天冬酰胺精氨酸丙氨酸苏氨酸谷氨酰胺赖氨酸会见瓦尔岛 - RC; RN - 谷氨酸天冬酰胺苏氨酸丙氨酸苏氨酸精氨酸赖氨酸蛋氨酸谷氨酰胺异亮氨酸缬氨酸甘氨酸天冬氨酸谷氨酰胺酪氨酸 - RC; RN - 天冬酰胺苏氨酸精氨酸苏氨酸丙氨酸赖氨酸谷氨酰胺会见瓦尔 - RC; RN - 苏氨酸精氨酸苏氨酸丙氨酸赖氨酸谷氨酰胺会见瓦尔岛 - RC; RN - 谷氨酰胺临苯丙氨酸精氨酸会见临他天冬酰胺谷氨酸精氨酸甘氨酸苯丙氨酸苏氨酸瓦尔·莱 - RC; RN - 临亮氨酸赖氨酸蛋氨酸亮氨酸天冬酰胺岛临丝氨酸天冬酰胺异亮氨酸缬氨酸他对他的酪氨酸 - RC; RN - 亮氨酸天冬酰胺岛临丝氨酸天冬酰胺异亮氨酸缬氨酸他对他的酪氨酸丝氨酸临丙氨酸丙氨酸 - RC; RN谷氨酸天冬氨酸丝氨酸缬氨酸临谷氨酸赖氨酸列伊苯丙氨酸遇见了他的Val苏氨酸亮氨酸甘氨酸 - RC; RN - 半胱氨酸精氨酸瓦尔·莱半胱氨酸半胱氨酸酪氨酸瓦尔·莱 - RC; RN - 精氨酸瓦尔·莱半胱氨酸半胱氨酸酪氨酸瓦尔·莱谷氨酸 - RC; RN - 瓦尔·莱半胱氨酸半胱氨酸酪氨酸瓦尔·莱谷氨酸谷氨酸 - RC; RN - 谷氨酸列伊ARG ARG赖氨酸蛋氨酸的Met酪氨酸蛋氨酸 - RC; RN - 天冬氨酸谷氨酸列伊ARG ARG赖氨酸蛋氨酸的Met酪氨酸 - RC; RN - 天冬氨酸谷氨酸列伊ARG ARG赖氨酸蛋氨酸的Met酪氨酸蛋氨酸 - RC; RN - 天冬氨酸谷氨酸谷氨酸谷氨酸丙氨酸异亮氨酸缬氨酸丙氨酸酪氨酸酪氨酸亮氨酸丙氨酸苏氨酸丙氨酸甘氨酸 - RC或RN - 谷氨酸的Asn丝氨酸天冬氨酸谷氨酰胺谷氨酸丝氨酸谷氨酸谷氨酰胺丝氨酸天冬氨酸谷氨酸谷氨酸谷氨酸 - RC焦点是RN是-H或一个氨基保护基; RC -OH或羧基保护基团。新颖的肽用于制备药物的免疫接种抗感染HVMV或诊断剂，以确定针对HCMV的免疫应答。

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