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1. 发明公开

EP2718426A1 ANTIGEN-SPECIFIC CENTRAL-MEMORY T CELL PREPARATIONS HAVING HIGH CD4+ FRACTION 有权
标题翻译：抗精神病药ZenTRALE T-GEDÄCHTNISZELLENPRÄPARATEMIT HOHER CD4 + -FRAKTION
公开(公告)号：EP2718426A1
公开(公告)日：2014-04-16
申请号：EP12732995.1
申请日：2012-06-11
申请人： Volk, Hans-Dieter , Schmück, Michael , Reinke, Petra
发明人： Volk, Hans-Dieter , Schmück, Michael , Reinke, Petra
IPC分类号： C12N5/0783
CPC分类号： A61K35/26 , A61K35/17 , C12N5/0636 , C12N2501/2302 , C12N2501/2307 , C12N2501/727
摘要： The invention relates to a method for generation of T cell preparations that are specific for at least one target antigen, comprising the steps of expanding lymphoid cells in vitro in the presence of a target antigen or peptide fragments thereof in an expansion step, isolating cells that secrete interferon gamma and culturing, the cells in the presence of interleukin 2 and interleukin 7 and either an inhibitor of the mTOR Complex 1, or in the presence of an inhibitor of IL-2/IL-2R interaction. The invention further relates to preparations obtained by the method of the invention.
摘要翻译：本发明涉及一种用于产生对至少一种目标抗原特异性的T细胞制备物的方法，包括以下步骤：在扩增步骤中在靶抗原或其肽片段的存在下体外扩增淋巴样细胞，分离细胞分泌干扰素γ，并在IL-2 / IL-2R相互作用的存在下，在白细胞介素2和白细胞介素7的存在下和mTOR复合物1的抑制剂的存在下培养细胞。本发明还涉及通过本发明的方法获得的制剂。

2. 发明公开

EP2207875A1 ANTIGEN-SPECIFIC T-CELL PREPARATIONS FROM BONE MARROW 审中-公开
标题翻译：骨髓抗原特异性T细胞制剂
公开(公告)号：EP2207875A1
公开(公告)日：2010-07-21
申请号：EP08841819.9
申请日：2008-10-24
申请人： Letsch, Anne , Na, Il-kang , Scheibenbogen, Carmen , Volk, Hans-Dieter
发明人： Letsch, Anne , Na, Il-kang , Scheibenbogen, Carmen , Volk, Hans-Dieter
IPC分类号： C12N5/08 , A61K39/00 , A61P35/00
CPC分类号： C12N5/0636 , A61K39/0011 , A61K2039/5158 , C12N2501/23
摘要： A method for the generation of antigen-specific T-cell preparations for adoptive therapy is provided, comprising the steps of obtaining lymphoid cells from the bone marrow of a patient in a first step, expanding the lymphoid cells in cell culture medium ex-vivo in the presence of at least one of IL2 and IL7 and or more antigens, yielding a T-cell preparation, and isolating the T-cell preparation from the culture medium in an isolation step. T-cell preparations provided according to the inventive method, and the use of such T-cell preparations for the treatment of infectious disease and cancer is also provided.

3. 发明授权

EP2718426B1 ANTIGEN-SPECIFIC CENTRAL-MEMORY T CELL PREPARATIONS HAVING HIGH CD4+ FRACTION 有权
标题翻译：具有高CD4 +分数的抗原特异性中央记忆T细胞制剂
公开(公告)号：EP2718426B1
公开(公告)日：2017-11-22
申请号：EP12732995.1
申请日：2012-06-11
申请人： Volk, Hans-Dieter , Schmück, Michael , Reinke, Petra
发明人： Volk, Hans-Dieter , Schmück, Michael , Reinke, Petra
IPC分类号： A61K35/17 , A61K35/26 , C12N5/0783
CPC分类号： A61K35/26 , A61K35/17 , C12N5/0636 , C12N2501/2302 , C12N2501/2307 , C12N2501/727
摘要： The invention relates to a method for generation of T cell preparations that are specific for at least one target antigen, comprising the steps of expanding lymphoid cells in vitro in the presence of a target antigen or peptide fragments thereof in an expansion step, isolating cells that secrete interferon gamma and culturing, the cells in the presence of interleukin 2 and interleukin 7 and either an inhibitor of the mTOR Complex 1, or in the presence of an inhibitor of IL-2/IL-2R interaction. The invention further relates to preparations obtained by the method of the invention.

4. 发明授权

EP1158989B1 USE OF INHIBITORS OF ENDOTOXIN FOR THE TREATMENT OF CACHEXIA 有权
标题翻译： ENDOTOXINHEMMERN用于治疗恶病质
公开(公告)号：EP1158989B1
公开(公告)日：2007-06-20
申请号：EP00916915.2
申请日：2000-03-09
申请人： Anker, Stefan , Volk, Hans-Dieter , Schumann, Ralf Reiner , Coats, Andrew
发明人： VOLK, Hans-Dieter , PLAUTH, Mathias , LOCHS, Herbert ,
IPC分类号： A61K31/575 , A61P9/04
CPC分类号： A61K31/575
摘要： The present invention relates to therapy and the use of agents in the therapy of cachexia and wasting syndromes due to diseases other than congestive heart failure. Cachexia occurs in a number of other chronic diseases, like liver cirrhosis, chronic obstructive pulmonary disease, chronic renal failure, diabetes, rheumatoid arthritis. Cachexia and weight loss are linked to inflammatory processes and they are linked to increased mortality and/or morbidity. Cytokine activation is a potential causal mechanism for the development of cachexia also in these other diseases. The invention describes a method of treating or ameliorating body wasting or cachexia in a patient with liver cirrhosis, chronic obstructive pulmonary disease, chronic renal failure, diabetes, rheumatoid arthritis in a patient. The method comprises administering to the patient an effective amount of a compound that is able to reduce the production, absorption and/or the effect of an endotoxin (lipopolysaccharide; LPS). The invention describes also a method of treating, preventing or ameliorating endotoxin-mediated immune activation in body wasting or cachexia in a patient with liver cirrhosis, chronic obstructive pulmonary disease, chronic renal failure, diabetes, rheumatoid arthritis. The method comprises administering to the patient an effective amount of a compound that is able to reduce the production, absorption and/or the effect of an endotoxin (lipopolysaccharide; LPS).

5. 发明公开

EP2532740A1 Antigen-specific CD4+ and CD8+ central-memory T cell preparations for adoptive T cell therapy 审中-公开
标题翻译：抗原CD4 +和CD8 + zentraleGedächtnis-T-Zellpräparatefür收养T-Zelltherapie
公开(公告)号：EP2532740A1
公开(公告)日：2012-12-12
申请号：EP11177524.3
申请日：2011-08-12
申请人： Schmück, Michael , Reinke, Petra , Volk, Hans-Dieter
发明人： Schmück, Michael , Reinke, Petra , Volk, Hans-Dieter
IPC分类号： C12N5/0783
CPC分类号： A61K35/26 , A61K35/17 , C12N5/0636 , C12N2501/2302 , C12N2501/2307 , C12N2501/727
摘要： The invention relates to a method for generation of T cell preparations that are specific for at least one target antigen, comprising the steps of expanding lymphoid cells in vitro in the presence of a target antigen or peptide fragments thereof in an expansion step, isolating cells that secrete interferon gamma and culturing, the cells in the presence of interleukin 2 and interleukin 7 and either an inhibitor of the mTOR Complex 1, or in the presence of an inhibitor of IL-2/IL-2R interaction. The invention further relates to preparations obtained by the method of the invention.
摘要翻译：本发明涉及一种用于产生对至少一种目标抗原特异性的T细胞制备物的方法，包括以下步骤：在扩增步骤中在靶抗原或其肽片段的存在下体外扩增淋巴样细胞，分离细胞分泌干扰素γ，并在IL-2 / IL-2R相互作用的存在下，在白细胞介素2和白细胞介素7的存在下和mTOR复合物1的抑制剂的存在下培养细胞。本发明还涉及通过本发明的方法获得的制剂。

6. 发明申请

WO2004004749A1 PROTEASEOME INHIBITORS FOR THE TREATMENT OF HERPESVIRIDAE INFECTED INDIVIDUALS 审中-公开
标题翻译：用于治疗感染性感染个体的PROTEASEOME抑制剂
公开(公告)号：WO2004004749A1
公开(公告)日：2004-01-15
申请号：PCT/EP2003/007062
申请日：2003-07-02
申请人： UNIVERSITÄTSKLINIKUM CHARITE DER HUMBOLDT-UNIVERSITÄT ZU BERLIN TECHNOLOGIETRANS FERSTELLE , PRÖSCH, Susanne , VOLK, Hans, Dieter , KRÜGER, Detlev
发明人： PRÖSCH, Susanne , VOLK, Hans, Dieter , KRÜGER, Detlev
IPC分类号： A61K38/00
CPC分类号： A61K38/55 , A61K31/69 , A61K38/06
摘要： The present invention relates to the use of a substance or composition comprising one or more proteasome inhibitors for the manufacture of a medicament for the treatment of an individual infected with a virus selected from the group comprising varicella zoster virus, human cytomegalovirus, human herpesvirus 6 and 7 and Epstein-Barr virus and Karposi's sarcoma herpesvirus. The invention further relates to methods of treatment of individuals infected with a virus selected from the group comprising varicella zoster virus, human cytomegalovirus, human herpesvirus 6 and 7 and Epstein-Barr virus and Karposi's sarcoma herpesvirus.
摘要翻译：本发明涉及包含一种或多种蛋白酶体抑制剂的物质或组合物在制备用于治疗感染病毒的个体的药物的用途，所述病毒选自水痘带状疱疹病毒，人巨细胞病毒，人疱疹病毒6和 7和爱泼斯坦 - 巴尔病毒和卡洛斯氏肉瘤疱疹病毒。本发明还涉及治疗感染病毒的个体的方法，所述病毒选自水痘带状疱疹病毒，人巨细胞病毒，人疱疹病毒6和7以及爱泼斯坦 - 巴尔病毒和卡波西氏肉瘤疱疹病毒。

7. 发明申请

WO1996012500A1 INTERFERON-'gamma' TREATMENT OF HLA-DR-ASSOCIATED IMMUNODEFICIENCY 审中-公开
标题翻译： HLA-DR相关联免疫缺陷γ干扰素治疗
公开(公告)号：WO1996012500A1
公开(公告)日：1996-05-02
申请号：PCT/EP1995004099
申请日：1995-10-19
申请人： BOEHRINGER INGELHEIM INTERNATIONAL GMBH , VON BAEHR, Rüdiger , VOLK, Hans-Dieter , STEINMANN, Gerhard, Gustav , QUERNER, Susanne, Christine
发明人： BOEHRINGER INGELHEIM INTERNATIONAL GMBH
IPC分类号： A61K38/21
CPC分类号： A61K38/217 , A61K2300/00
摘要： The invention pertains to the use of interferon- gamma in treating diseases involving a reduction in HLA-DR expression on monocytes, especially certain forms of septic diseases.
摘要翻译：本发明涉及使用干扰素γ的用于其与降低单核细胞的HLA-DR表达的，在脓毒性疾病的特定某些形式相关的疾病的治疗。

8. 发明申请

WO2011138609A1 METHOD OF DETERMINING KIDNEY TRANSPLANTATION TOLERANCE 审中-公开
标题翻译：确定KIDNEY移植耐力的方法
公开(公告)号：WO2011138609A1
公开(公告)日：2011-11-10
申请号：PCT/GB2011/050874
申请日：2011-05-04
申请人： KING'S COLLEGE LONDON , CHARITÉ - UNIVERITÄTSMEDIZIN BERLIN , MILTENYI BIOTEC GMBH , HERNANDEZ-FUENTES, Maria , MESA, Irene , JANSSEN, Uwe , TOMIUK, Stefan , SAWITZKI, Birgit , VOLK, Hans-Dieter , LECHLER, Robert
发明人： HERNANDEZ-FUENTES, Maria , MESA, Irene , JANSSEN, Uwe , TOMIUK, Stefan , SAWITZKI, Birgit , VOLK, Hans-Dieter , LECHLER, Robert
IPC分类号： C12Q1/68
CPC分类号： C12Q1/6876 , C12Q1/6837 , C12Q1/6883 , C12Q2600/158
摘要： The present invention relates to a method of determining an individual's transplantation tolerance by determining the level of a number of biomarkers. The present invention also relates to a kit comprising reagents for detecting the levels of the biomarkers. The present invention also relates to a sensor for detecting the expression levels of a plurality of genes that can be used to determine an individual's transplantation tolerance.
摘要翻译：本发明涉及通过确定多个生物标志物的水平来确定个体的移植耐受性的方法。本发明还涉及包含用于检测生物标志物水平的试剂的试剂盒。本发明还涉及用于检测可用于确定个体移植耐受性的多种基因的表达水平的传感器。

9. 发明申请

WO2010118890A1 B-LYMPHOCYTE TARGETING AGENTS FOR USE IN A METHOD FOR THE TREATMENT OF A DISEASE 审中-公开
标题翻译：用于治疗疾病的方法中使用的B-LYMPHOCYTE靶向药物
公开(公告)号：WO2010118890A1
公开(公告)日：2010-10-21
申请号：PCT/EP2010/002362
申请日：2010-04-16
申请人： CHARITE - UNIVERSITÄTSMEDIZIN BERLIN , TSCHÖPE, Carsten , SCHULTHEISS, H.-P. , ESCHER, Felicitas , VOLK, Hans-Dieter , REINKE, Petra
发明人： TSCHÖPE, Carsten , SCHULTHEISS, H.-P. , ESCHER, Felicitas , VOLK, Hans-Dieter , REINKE, Petra
IPC分类号： C07K16/28 , A61K39/395 , G01N33/68
CPC分类号： C07K16/2803 , A61K39/39541 , A61K47/6849 , A61K49/0002 , A61K49/0004 , C07K16/2896 , G01N33/56972 , G01N2800/325 , G01N2800/52
摘要： The present invention is related to a B-lymphocyte targeting agent for use in a method for the treatment or diagnosis of cardiac insufficiency. Furthermore, it is related to a composition comprising such B-lymphocyte targeting agent and methods for determining whether a patient suffering from cardiac insufficiency is amenable to the use of the B-lymphocyte targeting agent for its treatment.
摘要翻译：本发明涉及用于治疗或诊断心功能不全的方法中的B淋巴细胞靶向剂。此外，它涉及包含这种B淋巴细胞靶向剂的组合物和用于确定患有心脏功能不全的患者是否适用于使用B淋巴细胞靶向剂进行治疗的方法。

10. 发明申请

WO2009053109A1 ANTIGEN-SPECIFIC T-CELL PREPARATIONS FROM BONE MARROW 审中-公开
标题翻译：骨骼特异性T细胞的制备
公开(公告)号：WO2009053109A1
公开(公告)日：2009-04-30
申请号：PCT/EP2008/009186
申请日：2008-10-24
申请人： LETSCH, Anne , NA, Il-Kang , SCHEIBENBOGEN, Carmen , VOLK, Hans-Dieter
发明人： LETSCH, Anne , NA, Il-Kang , SCHEIBENBOGEN, Carmen , VOLK, Hans-Dieter
IPC分类号： C12N5/08 , A61K39/00 , A61P35/00
CPC分类号： C12N5/0636 , A61K39/0011 , A61K2039/5158 , C12N2501/23
摘要： A method for the generation of antigen-specific T-cell preparations for adoptive therapy is provided, comprising the steps of obtaining lymphoid cells from the bone marrow of a patient in a first step, expanding the lymphoid cells in cell culture medium ex-vivo in the presence of at least one of IL2 and IL7 and or more antigens, yielding a T-cell preparation, and isolating the T-cell preparation from the culture medium in an isolation step. T-cell preparations provided according to the inventive method, and the use of such T-cell preparations for the treatment of infectious disease and cancer is also provided.
摘要翻译：提供了用于产生用于过继治疗的抗原特异性T细胞制剂的方法，包括以下步骤：在第一步中从患者的骨髓中获得淋巴样细胞，将细胞培养基中的淋巴细胞在体外扩增存在IL2和IL7和/或更多抗原中的至少一种，产生T细胞制剂，并在分离步骤中从培养基中分离T细胞制剂。还提供了根据本发明方法提供的T细胞制剂，并且还提供了用于治疗感染性疾病和癌症的这种T细胞制剂的用途。

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