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1. 发明专利

CA2236598C TREATMENT OF CARDIOMYOPATHY BY REMOVAL OF AUTOANTIBODIES 未知
公开(公告)号：CA2236598C
公开(公告)日：2006-09-12
申请号：CA2236598
申请日：1996-11-15
申请人： BAXTER INT , FELIX STEPHAN , BREHME STEFAN , REINKE PETRA , BAUMANN GERT
发明人： FELIX STEPHAN , BREHME STEFAN , REINKE PETRA , SPAETHE REINER , BAUMANN GERT , KOLL ROBERT , MULLER-DERLICH JUTTA
IPC分类号： A61M1/36 , A61M1/38 , A61K35/14 , A61K35/16 , A61K38/00 , A61K39/395 , A61K45/00 , A61P9/00 , C07K1/22 , C07K16/28
摘要： Immunoapheresis treatment for cardiomyopathy comprises passing the patient's plasma over a column having coupled thereto a specific ligand for human immunoglobulin, thereby removing a significant portion of the immunoglobulin from the patient's plasma, and then reinfusing the plasma to the patient. The invention is the use of a specific ligand for human immunoglobulin in the manufacture of a column having the ligand coupled thereto, the column being useful for immunoapheresis treatment of a patient with cardiomyopathy. The specific ligand binds, and thereby removes, human autoantibodies which a re harmful to cardiac tissue such as antibodies against .beta.1-adrenergic receptors, ADP-ATP carriers, .alpha. and .beta. myosin heavy chains, and adenine nucleotide translocators. Immunoapheresis treatmen t using the column results in improvement of hemodynamic parameters such as me an arterial pressure, mean pulmonary pressure, pulmonary capillary wedge pressure, right atrial pressure, cardiac output, cardiac index, stroke volume index, and systemic vascular resistance.

2. 发明专利

AU1054097A Treatment of cardiomyopathy by removal of autoantibodies 未知
公开(公告)号：AU1054097A
公开(公告)日：1997-06-05
申请号：AU1054097
申请日：1996-11-15
申请人： BAUMANN GERT , BAXTER INT , BREHME STEFAN , FELIX STEPHAN , REINKE PETRA
发明人： REINKE PETRA , BREHME STEFAN , BAUMANN GERT , KOLL ROBERT , MULLER-DERLICH JUTTA , FELIX STEPHAN , SPAETHE REINER
IPC分类号： A61M1/36 , A61K35/14 , A61K35/16 , A61K38/00 , A61K45/00 , A61P9/00 , C07K1/22 , C07K16/28 , C07K14/72

3. 发明专利

CA2236598A1 TREATMENT OF CARDIOMYOPATHY BY REMOVAL OF AUTOANTIBODIES 未知
公开(公告)号：CA2236598A1
公开(公告)日：1997-05-22
申请号：CA2236598
申请日：1996-11-15
申请人： FELIX STEPHAN , BAXTER INT , REINKE PETRA , BAUMANN GERT , BREHME STEFAN
发明人： SPAETHE REINER , KOLL ROBERT , FELIX STEPHAN , REINKE PETRA , MULLER-DERLICH JUTTA , BAUMANN GERT , BREHME STEFAN
IPC分类号： A61M1/36 , A61K35/14 , A61K35/16 , A61K38/00 , A61K45/00 , A61P9/00 , C07K1/22 , C07K16/28 , A61M1/38 , A61K39/395
摘要： Immunoapheresis treatment for cardiomyopathy comprises passing the patient's plasma over a column having coupled thereto a specific ligand for human immunoglobulin, thereby removing a significant portion of the immunoglobulin from the patient's plasma, and then reinfusing the plasma to the patient. The invention is the use of a specific ligand for human immunoglobulin in the manufacture of a column having the ligand coupled thereto, the column being useful for immunoapheresis treatment of a patient with cardiomyopathy. The specific ligand binds, and thereby removes, human autoantibodies which are harmful to cardiac tissue such as antibodies against .beta.1-adrenergic receptors, ADP-ATP carriers, .alpha. and .beta. myosin heavy chains, and adenine nucleotide translocators. Immunoapheresis treatment using the column results in improvement of hemodynamic parameters such as mean arterial pressure, mean pulmonary pressure, pulmonary capillary wedge pressure, right atrial pressure, cardiac output, cardiac index, stroke volume index, and systemic vascular resistance.

4. 发明专利

AU731452B2 Treatment of cardiomyopathy by removal of autoantibodies 未知
公开(公告)号：AU731452B2
公开(公告)日：2001-03-29
申请号：AU1054097
申请日：1996-11-15
申请人： BAXTER INT , BAUMANN GERT , FELIX STEPHAN , REINKE PETRA , BREHME STEFAN
发明人： REINKE PETRA , BREHME STEFAN , BAUMANN GERT , FELIX STEPHAN , KOLL ROBERT , MULLER-DERLICH JUTTA , SPAETHE REINER
IPC分类号： A61M1/36 , A61K35/14 , A61K35/16 , A61K38/00 , A61K45/00 , A61P9/00 , C07K1/22 , C07K16/28 , C07K14/72

5. 发明公开

EP0775493A3 Extracorporeal xenogeneic organ perfusion following antibody depletion by immunoapheresis 失效
标题翻译：抗体后体外异种器官灌注通过还原Immunoapherese
公开(公告)号：EP0775493A3
公开(公告)日：1998-08-12
申请号：EP96118698
申请日：1996-11-21
申请人： BAXTER INT
发明人： MULLER-DERLICH JUTTA
IPC分类号： A61K35/14 , A61M1/36 , A61M1/34
CPC分类号： A61K35/16 , A61M1/3621 , A61M2202/0417 , B01D15/3809 , A61M2202/0057
摘要： The invention provides a method for treating a patient in need of ex vivo perfusion of his/her blood through a pig organ comprising first passing plasma from the patient over a column coupled to anti-human immunoglobulin antibodies, thereby removing a significant portion of the immunoglobulin from the patient's plasma, recombining the patient's immunoglobulin-depleted plasma with the patient's red blood cells, perfusing the patient's immunoglobulin-depleted blood through the pig organ, and then reinfusing the blood to the patient. Depletion of immunoglobulin removes anti-pig natural antibodies which would otherwise cause a hyperacute rejection reaction in the pig organ, thus quickly destroying the organ within 2-6 hours. The invention allows a single pig organ to function well in ex vivo perfusion for a much longer time, without signs of hyperacute rejection in the organ. The invention is especially useful in cases of acute liver failure where ex vivo perfusion of the patient's blood through a pig liver can bring the patient out of hepatic coma and bridge the patient to liver transplant. In some cases, the patient's liver may begin functioning on its own again after the treatment, thus altogether abrogating the need for liver transplant. The invention is also directed to the use of anti-human immunoglobulin antibodies in the manufacture of a column coupled to said antibodies for the pre-treatment of the plasma of a patient prior to ex vivo perfusion of the patient's blood through a pig organ.

6. 发明专利

AU2514595A Prevention of hyperacute rejection in pig to primate organ transplant 未知
公开(公告)号：AU2514595A
公开(公告)日：1995-12-05
申请号：AU2514595
申请日：1995-05-12
申请人： BAXTER INT , UNIV MINNESOTA
发明人： LEVENTHAL JOSEPH R , MULLER-DERLICH JUTTA , BOHM WOLFGANG , BIEBER FRANZ A , SALIT MARC , SPAETHE REINER , BOLMAN R MORTON III , MATAS ARTHUR J
IPC分类号： A61K35/16 , A61M1/34 , A61M1/38 , A61M37/00

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