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1. 发明申请

WO2007082928A3 METHOD FOR PRODUCTION OF A RUTHENIUM CATALYST 审中-公开
标题翻译：用于生产钌催化剂
公开(公告)号：WO2007082928A3
公开(公告)日：2008-04-10
申请号：PCT/EP2007050530
申请日：2007-01-19
申请人： BASF AG , JAEKEL CHRISTOPH , HETTCHE FRANK , RUDOLPH JENS , PACIELLO ROCCO
发明人： JAEKEL CHRISTOPH , HETTCHE FRANK , RUDOLPH JENS , PACIELLO ROCCO
IPC分类号： B01J37/04 , B01J31/18 , B01J31/22 , B01J31/24 , C07F15/00
CPC分类号： C07F15/0046 , B01J31/1805 , B01J31/1815 , B01J31/182 , B01J31/183 , B01J31/1845 , B01J31/185 , B01J31/186 , B01J31/1865 , B01J31/1875 , B01J31/2291 , B01J31/2295 , B01J31/24 , B01J31/2409 , B01J31/2414 , B01J31/2419 , B01J31/2438 , B01J31/2452 , B01J31/2457 , B01J31/2471 , B01J31/248 , B01J31/2495 , B01J37/04 , B01J2231/643 , B01J2531/0263 , B01J2531/0266 , B01J2531/821 , C07F15/0053
摘要： The invention relates to a method for production of a ruthenium catalyst comprising i) a bidentate phosphorous ligand or two monodentate phosphorus ligands and ii) a bidentate nitrogen ligand or two monodentate nitrogen ligands.
摘要翻译：本发明涉及一种方法，用于制备的钌催化剂，其中ⅰ）的磷二齿配位体或两个单齿磷配体，和ii）一个氮二齿配位体或两个单齿氮配位体。

2. 发明申请

WO2008046918A3 ADDITION REACTIONS USING TRANSITION METAL CATALYSTS IN HALOGENATED SOLVENTS 审中-公开
标题翻译：在卤化溶剂中过渡金属化的额外反应
公开(公告)号：WO2008046918A3
公开(公告)日：2008-07-31
申请号：PCT/EP2007061229
申请日：2007-10-19
申请人： BASF SE , RUDOLPH JENS , PACIELLO ROCCO , JAEKEL CHRISTOPH , HETTCHE FRANK , BOERNER ARMIN , DUBROVINA NATALIA , BIRKHOLZ MANDY-NICOLE , BREIT BERNHARD
发明人： RUDOLPH JENS , PACIELLO ROCCO , JAEKEL CHRISTOPH , HETTCHE FRANK , BOERNER ARMIN , DUBROVINA NATALIA , BIRKHOLZ MANDY-NICOLE , BREIT BERNHARD
IPC分类号： C07B37/02 , B01J31/18 , C07C29/16 , C07C45/50 , C07D211/76
CPC分类号： C07C45/50 , B01J31/1845 , B01J31/2409 , B01J31/2438 , B01J31/2452 , B01J31/2466 , B01J31/2471 , B01J2231/32 , B01J2231/321 , B01J2231/323 , B01J2231/325 , B01J2231/326 , B01J2231/342 , B01J2231/44 , B01J2231/52 , B01J2231/543 , B01J2231/645 , B01J2531/0266 , B01J2531/0291 , B01J2531/821 , B01J2531/822 , B01J2531/842 , B01J2531/847 , B01J2531/94 , C07B53/00 , C07B2200/07 , C07C45/505 , C07C45/72 , C07C67/303 , C07C231/12 , C07F9/65683 , C07F15/0073 , C07C69/34 , C07C233/47
摘要： The present invention relates to a method for reacting compounds, comprising at least one carbon-carbon or carbon-heteroatom double bond, by 1,2-addition in the presence of a catalyst, comprising at least one transition metal complex having at least two ligands, which each have a pnicogen atom-containing group and at least one functional group enable to form intermolecular, non-covalent bonds, in the presence of a halogenated solvent, which has at least one heteroatom different from halogen. The present invention further relates to a method for producing chiral compounds in the presence of the above-described catalysts and solvents, and to the use of these catalysts in the presence of such solvents.
摘要翻译：本发明涉及一种用于反应包含至少一个碳 - 碳或碳 - 杂原子双键，由1,2-加成在催化剂的存在下的化合物包含至少一种过渡金属配合物具有至少两个配位体各自具有pnicogenatomhaltige的处理基团和至少一个能够形成分子间非共价键官能团的基团，并且在具有至少一个除卤素以外的杂原子的卤化溶剂存在下进行。本发明进一步涉及在上述催化剂和溶剂存在下制备手性化合物的方法以及这些催化剂在这些溶剂存在下的用途。

3. 发明申请

WO2006002999A3 METHOD FOR THE PRODUCTION OF OPTICALLY ACTIVE ALKYL SUCCINIC ACID MONOALKYL ESTERS 审中-公开
标题翻译：工艺制备光学活性ALKYLBERNSTEINSÄUREMONOALKYLESTERN
公开(公告)号：WO2006002999A3
公开(公告)日：2006-09-08
申请号：PCT/EP2005007289
申请日：2005-07-06
申请人： BASF AG , HETTCHE FRANK , JAEKEL CHRISTOPH , FRIEDRICH MARKO , PACIELLO ROCCO
发明人： HETTCHE FRANK , JAEKEL CHRISTOPH , FRIEDRICH MARKO , PACIELLO ROCCO
IPC分类号： C07C67/303 , C07C69/34
CPC分类号： C07C67/303 , C07B2200/07 , C07C69/34
摘要： The invention relates to a method for producing optically active alkyl succinic acid monoalkyl esters of formula (I), wherein D and E independently represent H, C 1 -C 10 alkyl, RC 1 -C 10 alkyl, aryl, or alkylaryl.
摘要翻译：本发明涉及一种制备式的旋光活性Alkylbernsteinsäuremonoalkylestern（I），其中D和E彼此独立地H，C _{1 -C _{10 烷基，RC _{的制备 1 -C _{10 - 烷基，芳基，或烷芳基。}}}}

4. 发明专利

DE102005029228A1 Preparation of optically active 3-phenylpropionic acid derivatives, used for preparing halo-phenyl compounds, comprises hydrogenating cis-isomer mixture of phenyl compound, crystallizing enantiomer mixture and isolating solid material 未知
公开(公告)号：DE102005029228A1
公开(公告)日：2006-12-28
申请号：DE102005029228
申请日：2005-06-23
申请人： BASF AG
发明人： HETTCHE FRANK , VOELKERT MARTIN , JAEKEL CHRISTOPH , BEY OLIVER
IPC分类号： C07C59/64 , C07C43/225
摘要： Preparation of an optically active 3-phenylpropionic acid derivative (I) comprises: (a) an enantioselective hydrogenation of a cis-isomer or cis/trans-isomer mixture of a phenyl compound (II) in the presence of a chiral hydrogenation catalyst to give an enantiomer enriched enantiomer mixture; (b) crystallization of the enantiomer enriched enantiomer mixture by supplementation of a basic salt former in a solvent and isolating the stereoisomer enriched solid material; and (c) optionally isolation of the protonated isomer or a substitutional cation. Preparation of an optically active 3-phenylpropionic acid derivative of formula (I) comprises: (a) an enantioselective hydrogenation of a cis-isomer or cis/trans-isomer mixture of a phenyl compound of formula (II) in the presence of a chiral hydrogenation catalyst to give an enantiomer enriched enantiomer mixture; (b) crystallization of the enantiomer enriched enantiomer mixture by supplementation of a basic salt former in a solvent and isolating the stereoisomer enriched solid material; and (c) optionally isolation of the protonated isomer or a substitutional cation. R 1>-R 4>H, 1-6C alkyl, halo-1-6C alkyl, OH-1-6C alkyl, 1-6C alkoxy, OH-1-6C alkoxy, 1-6C alkoxy-1-6C alkyl, OH-1-6C alkoxy-1-6C alkyl, 1-6C alkoxy-1-6C alkoxy or OH-1-6C alkoxy-1-6C alkoxy; R 5>1-6C alkyl, 5-8C cycloalkyl, phenyl or benzyl; and A : H or cationic equivalent. Independent claims are also included for: (1) the preparation of optically active halo-phenyl compound of formula (III), which comprises protonating (I) in to an acid; reducing the acids or the metal salts to give an alcohol compound of formula (IV); and halodehydroxylating (IV); and (2) an optically active compound 3-phenylpropionic acid derivative (I). Hal : Cl, Br or I. [Image] [Image].

5. 发明专利

DE102006041064A1 New phosphorous compound useful as ligand in catalyst for e.g. hydroformylation-, hydrocyanation-, carbonylation-, hydroacylation-, hydroamination- and hydro esterification reactions 未知
公开(公告)号：DE102006041064A1
公开(公告)日：2007-03-08
申请号：DE102006041064
申请日：2006-09-01
申请人： BASF AG
发明人： JAEKEL CHRISTOPH , HETTCHE FRANK , VOLLAND MARTIN , BREIT BERNHARD , LAUNGANI ANDY
IPC分类号： C07K5/062 , B01J31/24 , C07B53/00 , C07C45/50 , C07F9/6564
摘要： Phosphorous compound (I) is new. Phosphorous compound of formula (I) is new. Y1>bivalent bridge group with bridge atoms between the flanking bonds; Ra, Rb : (cyclo)alkyl, heterocycloalkyl or (het)aryl (where alkyl is substituted by 1-5 (hetero)cycloalkyl, (het)aryl,(cyclo)alkoxy, heterocycloalkoxy, (het)aryloxy, OH, SH, polyalkyleneoxide, polyalkylene imine, COOH, carboxylate, SO3H, sulfonate, NE1>E2>, NE1>E2>E3>X->, halo, NO2, acyl or CN), where (hetero)cycloalkyl- and (het)aryl are substituted with 1-5 alkyl; or RaRb+P+X1>X2>5-8 membered heterocycle, optionally substituted with 1-3 (hetero)cycloalkyl or (het)aryl, where heterocycle and the substituted group consists of 1-4 of (cyclo)alkyl, heterocycloalkyl, (het)aryl, OH, SH, polyalkylene oxide, polyalkylene imine, alkoxy, halo, COOH, carboxylate, SO3H, sulfonate, NE4>E5>, NE4>E5>E6>X-, NO2, alkoxycarbonyl, acyl or CN; E1>-E8>H, (cyclo)alkyl or aryl; X->anion; Ry : peptide group comprising at least two amino acid units; X1>, X2>O, S, SiRcRd or NRe; Z : NR9> or CR9>R10>; Rc, Rd, Re : H, (cyclo)alkyl, heterocycloalkyl or (het)aryl; R1>-R10>H, (cyclo)alkyl, heterocycloalkyl, (het)aryl, OH, SH, polyalkylene oxide, polyalkylene imine, alkoxy, halo, SO3H, sulfonate, NE7>E8>, alkylene-NE7>E8>, CF3, NO2, alkoxycarbonyl, carboxyl, acyl or CN; or two adjacent groups of R1>, R2>, R4>, R6>, R8>, R9> (for a bonding portion of double bond between the ring atoms) : six membered ring exhibiting a maximum of three non-cumulative double bonds; and a, b, c : 0 or 1. Independent claims are also included for: (1) a catalyst comprising at least a complex having a transition metal and (I) as ligand; (2) a method for hydroformylating a compound containing at least an ethylenic unsaturated double bond comprising reacting the ethylenic unsaturated double bond with carbon monoxide and hydrogen in the presence of the catalyst; and (3) a method for the preparation of chiral compounds comprising reacting the prochiral compound containing at least an ethylenic unsaturated double bond with a substrate in the presence of a chiral catalyst. [Image].

6. 发明专利

DE102004052040A1 未知
公开(公告)号：DE102004052040A1
公开(公告)日：2006-04-27
申请号：DE102004052040
申请日：2004-10-26
申请人： BASF AG
发明人： AHLERS WOLFGANG , EGEN MARTINA , VOLLAND MARTIN , JAEKEL CHRISTOPH , HETTCHE FRANK , PACIELLO ROCCO
IPC分类号： C07F9/645 , B01J31/24 , C07B31/00 , C07B37/00 , C07B37/02 , C07B41/00 , C07B41/06 , C07B43/00 , C07B47/00 , C07B53/00 , C07F17/00
摘要： The invention relates to chiral phosphorus chelate compounds, to catalysts comprising such a compound such a compound as the ligand, and to asymmetric synthesis methods in the presence of such a catalyst.

7. 发明专利

DE102006000839A1 Preparation of optically active 3-phenylpropionic acid derivatives, used for preparing halo-phenyl compounds, comprises hydrogenating cis-isomer mixture of phenyl compound, crystallizing enantiomer mixture and isolating solid material 未知
公开(公告)号：DE102006000839A1
公开(公告)日：2007-07-12
申请号：DE102006000839
申请日：2006-01-05
申请人： BASF AG
发明人： HETTCHE FRANK , VOELKERT MARTIN , JAEKEL CHRISTOPH , BEY OLIVER
IPC分类号： C07C53/134 , C07B53/00 , C07B57/00
摘要： Preparation of an optically active 3-phenylpropionic acid derivative (I) comprises: (a) an enantioselective hydrogenation of a cis-isomer or cis/trans-isomer mixture of a phenyl compound (II) in the presence of a chiral hydrogenation catalyst to give an enantiomer enriched enantiomer mixture; (b) crystallization of the enantiomer enriched enantiomer mixture by supplementation of a basic salt former in a solvent and isolating the stereoisomer enriched solid material; and (c) optionally isolation of the protonated isomer or a substitutional cation. Preparation of an optically active 3-phenylpropionic acid derivative of formula (I) comprises: (a) an enantioselective hydrogenation of a cis-isomer or cis/trans-isomer mixture of a phenyl compound of formula (II) in the presence of a chiral hydrogenation catalyst to give an enantiomer enriched enantiomer mixture; (b) crystallization of the enantiomer enriched enantiomer mixture by supplementation of a basic salt former in a solvent and isolating the stereoisomer enriched solid material; and (c) optionally isolation of the protonated isomer or a substitutional cation. R 1>-R 4>H, 1-6C alkyl, halo-1-6C alkyl, OH-1-6C alkyl, 1-6C alkoxy, OH-1-6C alkoxy, 1-6C alkoxy-1-6C alkyl, OH-1-6C alkoxy-1-6C alkyl, 1-6C alkoxy-1-6C alkoxy or OH-1-6C alkoxy-1-6C alkoxy; R 5>1-6C alkyl, 5-8C cycloalkyl, phenyl or benzyl; and A : H or cationic equivalent. Independent claims are also included for: (1) the preparation of optically active halo-phenyl compound of formula (III), which comprises protonating (I) in to an acid; reducing the acids or the metal salts to give an alcohol compound of formula (IV); and halodehydroxylating (IV); and (2) an optically active compound 3-phenylpropionic acid derivative (I). Hal : Cl, Br or I. [Image] [Image].

8. 发明专利

DE102005061642A1 New phosphorous chelate compounds are useful as catalysts for asymmetrical synthesis (preferably as chiral components for the production of pharmaceuticals, plant protecting agents, cosmetics or flavor materials) 未知
公开(公告)号：DE102005061642A1
公开(公告)日：2006-07-06
申请号：DE102005061642
申请日：2005-12-22
申请人： BASF AG
发明人： VOLLAND MARTIN , PAPP RAINER , HETTCHE FRANK , JAEKEL CHRISTOPH , WEISKOPF VERENA , PACIELLO ROCCO , SPRINGMANN STEFFEN
IPC分类号： C07F9/547 , B01J31/24 , C07C29/16 , C07C31/125
摘要： Phosphorous chelate compounds (I) are new. Phosphorous chelate compounds (I) of formula (R1>-P(R2>)-(X)a-Y1>-(O)b-P-((O)c-Rgamma )-(O)d-Rdelta ) are new. either R1>, R2>5-7 membered heterocyclic groups that are bonded over N atom to P atom; or PR1>R2>5-7 membered heterocycle additionally contains optionally substituted N atom and a further under oxygen and optionally substituted N atoms that are bonded directly to P atom; either Rgamma , Rdelta : akyl, cycloalkyl, heterocycloalkyl, aryl or hetaryl (all substituted with 1-5 of cycloalkyl, heterocycloalkyl, aryl, hetaryl, alkoxy, cycloalkoxy, heterocycloalkoxy, aryloxy, hetaryloxy, hydroxy, thiol, polyalkylenoxide, polyalkylenimine, COOH, carboxylate, SO3H, sulfonate, NE1>E2>, NE1>E2>E3>X-, halo, NO2, acyl or CN); or PRgamma Rdelta , ORgamma Rdelta : 5-8 membered heterocycle optionally annealed with 1-3 of cycloalkyl, heterocycloalkyl, aryl or hetaryl, where the heterocycle and optionally the annealed groups are substituted with 1-4 of alkyl, cycloalkyl, heterocycloalkyl, aryl, hetaryl, hydroxy, thiol, polyalkyleneoxide, polyalkylenimine, alkoxy, halo, COOH, carboxylate, SO3H, sulfonate, NE4>E5>, NE4>E5>E6>+>X->, NO2, alkoxycarbonyl, acyl or CN; E4>, E5>, E6>H, alkyl, cycloalkyl or aryl; X : O, S, SiReRf or NRg; Re, Rf, Rg : H, alkyl, cycloalkyl, heterocycloalkyl, aryl or hetaryl; X->anion; Y1>bivalent carbon containing bridge atoms; and a-d : 0-1 (where at least one of b, c or d is 1). Independent claims are also included for: (1) catalyst comprising at least one complex with a transition metal, as ligands of (I); (2) preparation of chiral compounds comprising reacting prochiral compounds containing at least ethylenic unsaturated double bond, with a substrate in the presence of a chiral catalyst; (3) a method for hydroformylation of compounds containing at least ethylenic unsaturated double bond comprising reacting with carbon monoxide and hydrogen in the presence of hydroformylating catalyst; (4) preparation of 2-propylheptanol comprising subjecting butene or butene containing C4-hydrocarbon mixture of hydroformylation to obtain n-valeraldehyde containing hydroformylating products, optionally isolating hydroformylating products under n-valeraldehyde enriched groups, subjecting the obtained hydroformylating products and n-valeraldehyde enriched groups to aldol condensation, hydrogenating the products of aldol condensation, catalytically with hydrogen to alcohols and optionally subjecting the hydrogenation products to isolate 2-propylheptanol enriched groups; and (5) a method of hydroformylation of alpha -olefine and olefine with inner double bonds containing a composition, comprising reacting with carbon monoxide and hydrogen in the presence of hydroformylating catalyst in two-stage reaction system (where the first step comprises feeding an inlet containing olefin, carbon monoxide and hydrogen and converting partly catalytically; feeding and converting the discharge from the above step; and feeding the discharge from the second step with a stream obtained from non-reacted olefine and saturated hydrocarbons).

9. 发明专利

DE102004032968A1 Preparation of optically active alkyl succinic acid monoalkyl esters comprising enantioselective hydrogenation of ester compound in presence of catalyst, which carries phospholane ligand 未知
公开(公告)号：DE102004032968A1
公开(公告)日：2006-02-09
申请号：DE102004032968
申请日：2004-07-07
申请人： BASF AG
发明人： HETTCHE FRANK , JAEKEL CHRISTOPH , FRIEDRICH MARKO , PACIELLO ROCCO
IPC分类号： B01J31/24 , C07C67/303 , C07C69/40
摘要： Preparation of optically active alkyl succinic acid monoalkyl esters (I) comprises enantioselective hydrogenation of ester compounds (II) in the presence of a catalyst, which carries a phospholane ligand (L). Preparation of optically active alkyl succinic acid monoalkyl esters of formula (I) comprises enantioselective hydrogenation of ester compound of formula (II) in the presence of a catalyst, which carries a phospholane ligand of formula (L). D, E : H or 1-10C alkyl; R : 1-10C alkyl, aryl or alkylaryl; R 2>1-6C alkyl, aryl or alkylaryl; R 1>H or R 2>; A : R 1>or heterocyclic compound of formula (b); and B1 : bridge member with 1-5C between two P-atom or Cp-Fe-Cp. [Image] [Image].

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