专利快速检索-快速检索全球专利，免费商用专利数据库-IPRDB

1. 发明申请

WO2003076443A1 SPIRO COMPOUNDS WITH NPY ANTAGONISTIC ACTIVITY 审中-公开
标题翻译：具有NPY拮抗活性的SPIRO化合物
公开(公告)号：WO2003076443A1
公开(公告)日：2003-09-18
申请号：PCT/JP2003/002611
申请日：2003-03-05
申请人： BANYU PHARMACEUTICAL CO., LTD. , FUKAMI, Takehiro , KANATANI, Akio , ISHIHARA, Akane , ISHII, Yasuyuki , TAKAHASHI, Toshiyuki , HAGA, Yuji , SAKAMOTO, Toshihiro , ITOH, Takahiro , CHIBA, Masato
发明人： FUKAMI, Takehiro , KANATANI, Akio , ISHIHARA, Akane , ISHII, Yasuyuki , TAKAHASHI, Toshiyuki , HAGA, Yuji , SAKAMOTO, Toshihiro , ITOH, Takahiro , CHIBA, Masato
IPC分类号： C07D491/10
CPC分类号： C07D213/61 , C07D307/94 , C07D405/12 , C07D471/10 , C07D491/10
摘要： A compound represented by the general formula (I): wherein Ar 1 represents an aryl or heteroaryl which may be substituted, n represents 0 or 1: T, U, V and W each independently represent a nitrogen atom or a methine group which may have a substituent selected from the group consisting of halogen, lower alkyl, hydroxy and lower alkoxy, wherein at least two of which represent said methine group; X represents methine, hydroxy substituted methine or nitrogen atom; Y represents an imino which may be substituted with lower alkyl, or oxygen, and a salt, ester or N-oxide derivative thereof exhibit NPY antagonistic activities and are useful as agents for the treatment of various diseases related to NPY, for example, cardiovascular disorders such as hypertension, nephropathy, heart disease, vasospasm, arteriosclerosis and the like.
摘要翻译：由通式（I）表示的化合物：其中Ar1表示可被取代的n的芳基或杂芳基，表示0或1：T，U，V和W各自独立地表示可以具有取代基的氮原子或次甲基选自卤素，低级烷基，羟基和低级烷氧基，其中至少两个表示所述次甲基; X表示次甲基，羟基取代的次甲基或氮原子; Y表示可以被低级烷基或氧取代的亚氨基，其盐，酯或N-氧化物衍生物表现出NPY拮抗活性，可用作治疗与NPY有关的各种疾病的药剂，例如心血管疾病如高血压，肾病，心脏病，血管痉挛，动脉硬化等。

2. 发明申请

WO2010123150A1 2-ARYL IMIDAZOLINE DERIVATIVES 审中-公开
标题翻译： 2-ARYL咪唑啉衍生物
公开(公告)号：WO2010123150A1
公开(公告)日：2010-10-28
申请号：PCT/JP2010/057533
申请日：2010-04-21
申请人： BANYU PHARMACEUTICAL CO.,LTD. , HAGA, Yuji , MORIYA, Minoru , TAKAHASHI, Toshiyuki
发明人： HAGA, Yuji , MORIYA, Minoru , TAKAHASHI, Toshiyuki
IPC分类号： C07D233/06 , A61K31/4174 , A61P3/04
CPC分类号： C07D233/06
摘要： 2-Aryl imidazoline derivatives are provided that are useful as anti-obesity agents or the like. A compound represented by Formula (I) or a pharmaceutically acceptable salt thereof: wherein R 1 and R 2 each independently represent a hydrogen atom, halogen, C 1-6 alkyl, or the like; R 3a , R 3b , R 4a and R 4b each independently represent a hydrogen atom, C 1-6 alkyl, or haloC 1-6 alkyl; and Ar represents aryl, wherein the aryl may be substituted with 1 to 3 substituents such as halogen, cyano, C 1-6 alkyl, haloC 1-6 alkyl, C 1-6 alkyloxy, haloC 1-6 alkyloxy, hydroxy, amino, monoC 1-6 alkylamino, diC 1-6 alkylamino, and C 1-6 alkyloxycarbonyl.
摘要翻译：提供可用作抗肥胖剂等的2-芳基咪唑啉衍生物。由式（I）表示的化合物或其药学上可接受的盐：其中R 1和R 2各自独立地表示氢原子，卤素，C 1-6烷基等; R3a，R3b，R4a和R4b各自独立地表示氢原子，C1-6烷基或卤代C 1-6烷基; 氰基，C 1-6烷基，卤代C 1-6烷基，C 1-6烷氧基，卤代C 1-6烷氧基，羟基，氨基，单C 1-6烷基氨基，二C 1-6烷基氨基，和C 1-6烷氧基羰基。

3. 发明申请

WO2010126164A1 INDOLE-2-CARBOXAMIDE DERIVATIVE 审中-公开
标题翻译：吲哚-2-羧酰胺衍生物
公开(公告)号：WO2010126164A1
公开(公告)日：2010-11-04
申请号：PCT/JP2010/057848
申请日：2010-04-27
申请人： BANYU PHARMACEUTICAL CO.,LTD. , HAGA, Yuji , MIZUTANI, Sayaka , SATO, Nagaaki
发明人： HAGA, Yuji , MIZUTANI, Sayaka , SATO, Nagaaki
IPC分类号： C07D403/06 , A61K31/4725 , A61P3/04 , A61P3/06 , A61P3/10 , A61P5/00 , A61P9/00 , A61P9/10 , A61P9/12 , A61P13/12 , A61P19/06 , A61P19/10 , A61P23/00 , A61P25/04 , A61P43/00 , C07D403/12 , C07D403/14
CPC分类号： C07D403/06 , C07D403/12 , C07D403/14
摘要： To provide an indole compound having a human QRFP receptor antagonistic activity and useful as a preventive or a remedy for various disorders. A compound of a formula (I) or a pharmaceutically-acceptable salt thereof is provided: [wherein, R 1 represents a hydrogen atom, a halogen, a C 1-6 alkyl, etc,; R 2 represents a C 1-6 alkyl, or a halo-C 1-6 alkyl; R 3 represents a hydrogen atom, a C 1-6 alkyl, etc.; R 4 represents a hydrogen atom, a C 1-6 alkyl, a halo-C 1-6 alkyl, etc.; or R 3 and R 4 , taken together with the nitrogen atom to which they bond, form a 3- to 6-membered aliphatic nitrogen-containing hetero ring; or R 3 and Y 3 , taken together, form -CH 2 -CH 2 -; Y 1 and Y 2 are both hydrogen atoms; or Y 1 and Y 2 , taken together, form -CH 2 -CH 2 -; and Y 3 represents a hydrogen atom; or Y 3 and R 3 , taken together, form -CH 2 -CH 2 -].
摘要翻译：提供具有人QRFP受体拮抗活性的吲哚化合物，并且可用作各种疾病的预防或补救。提供式（I）化合物或其药学上可接受的盐：[其中，R 1表示氢原子，卤素，C 1-6烷基等; R 2表示C 1-6烷基或卤代C 1-6烷基; R3代表氢原子，C1-6烷基等; R 4表示氢原子，C 1-6烷基，卤代C 1-6烷基等; 或R 3和R 4与它们键合的氮原子一起形成3至6元脂族含氮杂环; 或R 3和Y 3一起形成-CH 2 -CH 2 - ; Y1和Y2都是氢原子; 或Y1和Y2一起形成-CH 2 -CH 2 - ; Y 3表示氢原子; 或Y 3和R 3一起形成-CH 2 -CH 2 - ]。

4. 发明申请

WO2007016028A2 SYNTHESIS AND CRYSTALLINE FORMS OF NPY5 ANTAGONIST 审中-公开
标题翻译： NPY5拮抗剂的合成和结晶形式
公开(公告)号：WO2007016028A2
公开(公告)日：2007-02-08
申请号：PCT/US2006/028650
申请日：2006-07-24
申请人： MERCK & CO., INC. , BANYU PHARMACEUTICAL CO., LTD. , FERLITA, Russell, R. , HAGA, Yuji , ISHIKAWA, Makoto , KAMEI, Keisuke , KATO, Shinji , KOJIMA, Hisaki , MOMENT, Aaron , NONOYAMA, Nobuaki , SATAKE, Nobuya , SHIGEMORI, Kazuki , WADA, Toshihiro , WANG, Yaling , WEISSMAN, Steven, A. , WENSLOW, Robert, M.
发明人： FERLITA, Russell, R. , HAGA, Yuji , ISHIKAWA, Makoto , KAMEI, Keisuke , KATO, Shinji , KOJIMA, Hisaki , MOMENT, Aaron , NONOYAMA, Nobuaki , SATAKE, Nobuya , SHIGEMORI, Kazuki , WADA, Toshihiro , WANG, Yaling , WEISSMAN, Steven, A. , WENSLOW, Robert, M.
IPC分类号： A61K31/137
CPC分类号： C07D491/10
摘要： The present invention relates to a process for producing crystalline trans- N -[l-(2-fluorophenyl)- S-pyrazoly]-3-oxospiro[6-azaisobenzofuran-1(3H),1'-cyclohexane]-4'-carboxamide and novel salts, hydrates and polymorphs thereof.
摘要翻译：本发明涉及生产结晶反式-N- [1-（2-氟苯基）-3-吡唑基] -3-氧代螺[6-氮杂异苯并呋喃 -1（3H），1'-环己烷] -4'-甲酰胺及其新的盐，水合物和多晶型物。

5. 发明申请

WO2004037794A1 PROCESS FOR MAKING PYRAZOLE COMPOUNDS 审中-公开
标题翻译：制备吡唑化合物的方法
公开(公告)号：WO2004037794A1
公开(公告)日：2004-05-06
申请号：PCT/JP2003/013507
申请日：2003-10-22
申请人： BANYU PHARMACEUTICAL CO., LTD , MASE, Toshiaki , IIDA, Takehiko , KADOWAKI, Chie , KAWASAKI, Masashi , ASAKAWA, Kenichi , HAGA, Yuji
发明人： MASE, Toshiaki , IIDA, Takehiko , KADOWAKI, Chie , KAWASAKI, Masashi , ASAKAWA, Kenichi , HAGA, Yuji
IPC分类号： C07D231/38
CPC分类号： C07D231/38 , C07D401/04
摘要： This invention relates to a process for making pyrazole compoundsof formula I.
摘要翻译：本发明涉及制备式I的吡唑化合物的方法。

6. 发明授权

EP1921065B1 PHENYLPYRIDONE DERIVATIVE 有权
标题翻译：苯基吡啶酮衍生物
公开(公告)号：EP1921065B1
公开(公告)日：2010-10-20
申请号：EP06797001.2
申请日：2006-08-23
申请人： BANYU PHARMACEUTICAL CO., LTD.
发明人： NAYA, Akira , SAKAMOTO, Toshihiro , HAGA, Yuji , OTAKE, Norikazu
IPC分类号： C07D213/64 , A61K31/4412 , A61K31/4439 , A61K31/444 , A61K31/454 , A61K31/4545 , A61K31/5377 , A61P1/00 , A61P1/16 , A61P3/04 , A61P3/06 , A61P3/10 , A61P5/00 , A61P7/08 , A61P9/04 , A61P9/10 , A61P9/12 , A61P11/00 , A61P13/12 , A61P15/06
CPC分类号： C07D213/69 , C07D213/64 , C07D401/10 , C07D413/10
摘要： A compound represented by the formula (I) is contained as an active ingredient: wherein R1 and R2 independently represent a hydrogen atom, a lower alkyl group or the like, or R1 together with a nitrogen atom to which L, Z2 and R1 are attached may form an aliphatic nitrogenated heterocyclic group and R1 and R2 together with a nitrogen atom to which they are attached may form an aliphatic nitrogenated heterocyclic group; X represents a methine group or a nitrogen atom; Y represents -CH2-O-, -CH=CH- or the like; Z1 represents a single bond, a C1-4 alkylene group or the like; Z2 represents a single bond or a C1-4 alkylene group; L represents a methylene group, a C3-8 cycloalkylene group or the like; and Ar represents an aromatic carbocyclic group or the like. The compound is useful as a pharmaceutical for a central nerves system disease, a cardiovascular disease or a metabolic disease.
摘要翻译：含有由式（I）表示的化合物作为活性成分：其中R 1和R 2独立地表示氢原子，低级烷基等，或R 1与连接有L，Z 2和R 1的氮原子一起可以形成脂肪族含氮杂环基，并且R 1和R 2与它们所连接的氮原子一起可以形成脂肪族含氮杂环基; X代表次甲基或氮原子; Y表示-CH 2 -O - ， - CH = CH-等; Z1表示单键，C1-4亚烷基等; Z2表示单键或C1-4亚烷基; L表示亚甲基，C 3-8亚环烷基等; Ar表示芳族碳环基团等。该化合物可用作中枢神经系统疾病，心血管疾病或代谢疾病的药物。

7. 发明公开

EP1912642A2 SYNTHESIS AND CRYSTALLINE FORMS OF NPY5 ANTAGONIST 有权转让
标题翻译：作者NPY5拮抗剂的结晶形式
公开(公告)号：EP1912642A2
公开(公告)日：2008-04-23
申请号：EP06788290.2
申请日：2006-07-24
申请人： Merck & Co., Inc. , BANYU PHARMACEUTICAL CO., LTD.
发明人： FERLITA, Russell, R. , HAGA, Yuji , ISHIKAWA, Makoto , KAMEI, Keisuke , KATO, Shinji , KOJIMA, Hisaki , MOMENT, Aaron , NONOYAMA, Nobuaki , SATAKE, Nobuya , SHIGEMORI, Kazuki , WADA, Toshihiro , WANG, Yaling , WEISSMAN, Steven, A. , WENSLOW, Robert, M.
IPC分类号： A61K31/4355 , C07D491/048
CPC分类号： C07D491/10
摘要： The present invention relates to a process for producing crystalline trans-N-[l-(2-fluorophenyl)- S-pyrazoly]-3-oxospiro[6-azaisobenzofuran-1(3H),1'-cyclohexane]-4'-carboxamide and novel salts, hydrates and polymorphs thereof.

8. 发明公开

EP1939194A1 BICYCLIC AROMATIC SUBSTITUTED PYRIDONE DERIVATIVE 审中-公开
标题翻译： BICYCLISCHES AROMATISCHES SUBSTITUIERTES PYRIDON-DERIVAT
公开(公告)号：EP1939194A1
公开(公告)日：2008-07-02
申请号：EP06797767.8
申请日：2006-09-05
申请人： BANYU PHARMACEUTICAL CO., LTD.
发明人： SAKURABA, Shunji , KAMEDA, Minoru , KISHINO, Hiroyuki , HAGA, Yuji , OTAKE, Norikazu , MORIYA, Minoru
IPC分类号： C07D401/04 , A61K31/4439 , A61K31/444 , A61K31/4709 , A61K31/4725 , A61K31/498 , A61K31/517 , A61K31/55 , A61P1/16 , A61P3/04 , A61P3/06 , A61P3/10 , A61P5/00 , A61P9/00 , A61P9/10 , A61P9/12 , A61P11/00 , A61P13/12 , A61P15/00
CPC分类号： C07D401/14 , C07D401/04 , C07D405/04 , C07D471/04
摘要： Disclosed is a compound represented by the formula (I):

Wherein R 1 and R 2 independently represent a hydrogen atom, a lower alkyl group or the like; X 1 , X 2 and X 3 independently represent a methine group or a nitrogen atom; Y 1 and Y 3 independently represent a single bond, -O- or the like; Y 2 represents a lower alkylene group or the like; W1 to W4 independently represent a single bond, a methylene group or the like; L represents a single bond, a methylene group or the like; Z 1 and Z 2 independently represent a single bond, a C 1-4 alkylene group or the like; Ar 1 represents an aromatic carbocyclic ring or the like; and Ar 2 represents a bicyclic aromatic carbocyclic ring or the like. The compound is useful as a pharmaceutical for a central disease, a cardiovascular disease or a metabolic disease.
摘要翻译：公开了由式（I）表示的化合物：其中R 1和R 2独立地表示氢原子，低级烷基等; X 1，X 2和X 3独立地表示次甲基或氮原子; Y 1和Y 3独立地表示单键，-O-等; Y 2表示低级亚烷基等; W1至W4独立地表示单键，亚甲基等; L表示单键，亚甲基等; Z 1和Z 2独立地表示单键，C 1-4亚烷基等; Ar 1表示芳族碳环等; Ar 2表示双环芳香族碳环等。该化合物可用作中枢性疾病，心血管疾病或代谢疾病的药物。

9. 发明公开

EP1921065A1 PHENYLPYRIDONE DERIVATIVE 有权
标题翻译： PHENYLPYRIDONDERIVAT
公开(公告)号：EP1921065A1
公开(公告)日：2008-05-14
申请号：EP06797001.2
申请日：2006-08-23
申请人： BANYU PHARMACEUTICAL CO., LTD.
发明人： NAYA, Akira , SAKAMOTO, Toshihiro , HAGA, Yuji , OTAKE, Norikazu
IPC分类号： C07D213/64 , A61K31/4412 , A61K31/4439 , A61K31/444 , A61K31/454 , A61K31/4545 , A61K31/5377 , A61P1/00 , A61P1/16 , A61P3/04 , A61P3/06 , A61P3/10 , A61P5/00 , A61P7/08 , A61P9/04 , A61P9/10 , A61P9/12 , A61P11/00 , A61P13/12 , A61P15/06
CPC分类号： C07D213/69 , C07D213/64 , C07D401/10 , C07D413/10
摘要： A compound represented by the formula (I) is contained as an active ingredient:

wherein R 1 and R 2 independently represent a hydrogen atom, a lower alkyl group or the like, or R 1 together with a nitrogen atom to which L, Z 2 and R 1 are attached may form an aliphatic nitrogenated heterocyclic group and R 1 and R 2 together with a nitrogen atom to which they are attached may form an aliphatic nitrogenated heterocyclic group; X represents a methine group or a nitrogen atom; Y represents -CH 2 -O-, -CH=CH- or the like; Z 1 represents a single bond, a C 1-4 alkylene group or the like; Z 2 represents a single bond or a C 1-4 alkylene group; L represents a methylene group, a C 3-8 cycloalkylene group or the like; and Ar represents an aromatic carbocyclic group or the like. The compound is useful as a pharmaceutical for a central nerves system disease, a cardiovascular disease or a metabolic disease.
摘要翻译：作为活性成分，含有式（I）表示的化合物：其中，R 1和R 2分别独立地表示氢原子，低级烷基等，或者R 1与氮原子一起，L，Z 2 R 1可以形成脂族氮杂环基，R 1和R 2与它们所连接的氮原子一起形成脂族氮杂环基; X表示次甲基或氮原子; Y表示-CH 2 -O-，-CH = CH-等; Z 1表示单键，C 1-4亚烷基等; Z 2表示单键或C 1-4亚烷基; L表示亚甲基，C 3-8亚环烷基等; Ar表示芳香族碳环基等。该化合物可用作中枢神经系统疾病，心血管疾病或代谢疾病的药物。

10. 发明公开

EP1916239A1 PYRIDONE COMPOUND 审中-公开
标题翻译：吡啶酮化合物
公开(公告)号：EP1916239A1
公开(公告)日：2008-04-30
申请号：EP06782591.9
申请日：2006-08-03
申请人： BANYU PHARMACEUTICAL CO., LTD.
发明人： ANDO, Makoto , SEKINO, Etsuko , HAGA, Yuji , OTAKE, Norikazu , MORIYA, Minoru
IPC分类号： C07D213/64 , A61P1/16
CPC分类号： C07D213/69 , C07D213/64 , C07D213/89 , C07D239/52 , C07D401/10 , C07D401/14 , C07D405/10 , C07D487/08
摘要： An active ingredient is a compound represented by the general formula [I]:

[wherein R 1 and R 2 represent a lower alkyl group, a C 3-6 cycloalkyl group or the like, X 1 and X 2 represent methine, an Ar-Y 1 -Y 2 -Y 3 -substituted methine or the like, however either of them is an Ar-Y 1 -Y 2 -Y 3 -substituted methine, X 3 to X 8 represent methine, -N- or the like, Y 1 and Y 3 represent a single bond, -O- or the like, Y 2 represent a single bond, a lower alkylene group or the like, W represent -(O)-(CH 2 )n-(O)- or the like, n represents an integer of 1 to 4, L and Z 2 represent a single bond or a methylene group, Z 1 represents a single bond, a C 1-4 alkylene group or the like, and Ar represents an aromatic carbocyclic group or the like]. The compound acts as a melanin-concentrating hormone receptor antagonist and useful as a therapeutic agent for obesity or the like.
摘要翻译：活性成分是由通式[I]表示的化合物：[其中R1和R2代表低级烷基，C3-6环烷基等，X1和X2代表次甲基，Ar-Y1-Y2-Y3 取代的次甲基等，然而它们中的任一个都是Ar-Y1-Y2-Y3-取代的次甲基，X3至X8代表次甲基，N-等，Y1和Y3代表单键，-O-或 Y 2表示单键，低级亚烷基等，W表示 - （O） - （CH 2）n - （O） - 等，n表示1至4的整数，L和Z 2表示单键或亚甲基，Z 1表示单键，C 1-4亚烷基等，Ar表示芳香族碳环基等]。该化合物作为黑色素浓缩激素受体拮抗剂发挥作用，可用作肥胖症等的治疗剂。

你已经成功收藏专利！

检索式保存成功!

IPRDB

热门服务

关于我们

友情链接

联系方式