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1. 发明申请

WO2009145349A1 DETECTION METHOD USING NUCLEIC ACID ARRAY 审中-公开
标题翻译：使用核酸序列的检测方法
公开(公告)号：WO2009145349A1
公开(公告)日：2009-12-03
申请号：PCT/JP2009/060103
申请日：2009-05-27
申请人： FUJIFILM Corporation , National University Corporation Tokyo Medical and Dental University , ISHII, Yasuyuki , INAZAWA, Johji , IMOTO, Issei
发明人： ISHII, Yasuyuki , INAZAWA, Johji , IMOTO, Issei
IPC分类号： C12Q1/68
CPC分类号： C12Q1/6837 , C12Q2545/101 , C12Q2563/107
摘要： A method of comparing a first nucleic acid sequence of a first cell or cell population with a second nucleic acid sequence of a second cell or cell population, includes: a) labeling the first and second nucleic acid sequences with the same label; b) adding the labeled first and second nucleic acid sequences to separate first and second reaction fields respectively, the first and second reaction fields being provided at a nucleic acid array equipped with a plurality of reaction fields, and carrying out hybridization; c) subjecting the first and second reaction fields to the same washing operation by carrying out the washing operation in the identical liquid bath so as to uniform washing conditions; and d) detecting first and second signals at the first and second reaction fields respectively, and comparing obtained signal intensities of the first and second signals between the first and second reaction fields.
摘要翻译：比较第一细胞或细胞群体的第一核酸序列与第二细胞或细胞群体的第二核酸序列的方法包括：a）用相同标记物标记第一和第二核酸序列; b）分别添加标记的第一和第二核酸序列以分离第一和第二反应场，第一和第二反应场在配备有多个反应场的核酸阵列上提供，并进行杂交; c）通过在相同的液浴中进行洗涤操作以使均匀的洗涤条件使第一和第二反应场进行相同的洗涤操作; 以及d）分别在第一和第二反应场检测第一和第二信号，并且比较所获得的第一和第二反应场之间的第一和第二信号的信号强度。

2. 发明申请

WO03076443A9 SPIRO COMPOUNDS WITH NPY ANTAGONISTIC ACTIVITY 审中-公开
标题翻译：具有NPY拮抗活性的SPIRO化合物
公开(公告)号：WO03076443A9
公开(公告)日：2005-01-20
申请号：PCT/JP0302611
申请日：2003-03-05
申请人： BANYU PHARMA CO LTD , FUKAMI TAKEHIRO , KANATANI AKIO , ISHIHARA AKANE , ISHII YASUYUKI , TAKAHASHI TOSHIYUKI , HAGA YUJI , SAKAMOTO TOSHIHIRO , ITOH TAKAHIRO , CHIBA MASATO
发明人： FUKAMI TAKEHIRO , KANATANI AKIO , ISHIHARA AKANE , ISHII YASUYUKI , TAKAHASHI TOSHIYUKI , HAGA YUJI , SAKAMOTO TOSHIHIRO , ITOH TAKAHIRO , CHIBA MASATO
IPC分类号： C07D491/107 , A61K31/438 , A61P1/00 , A61P3/04 , A61P3/06 , A61P3/10 , A61P5/00 , A61P9/00 , A61P9/04 , A61P9/10 , A61P9/12 , A61P11/00 , A61P13/12 , A61P15/00 , A61P25/00 , A61P25/04 , A61P25/08 , A61P25/18 , A61P25/22 , A61P25/24 , A61P25/28 , A61P25/30 , A61P25/32 , A61P27/06 , A61P29/00 , A61P43/00 , C07D213/61 , C07D307/94 , C07D405/12 , C07D471/10 , C07D491/10 , C07D519/00
CPC分类号： C07D213/61 , C07D307/94 , C07D405/12 , C07D471/10 , C07D491/10
摘要： A compound represented by the general formula (I): wherein Ar represents an aryl or heteroaryl which may be substituted, n represents 0 or 1: T, U, V and W each independently represent a nitrogen atom or a methine group which may have a substituent selected from the group consisting of halogen, lower alkyl, hydroxy and lower alkoxy, wherein at least two of which represent said methine group; X represents methine, hydroxy substituted methine or nitrogen atom; Y represents an imino which may be substituted with lower alkyl, or oxygen, and a salt, ester or N-oxide derivative thereof exhibit NPY antagonistic activities and are useful as agents for the treatment of various diseases related to NPY, for example, cardiovascular disorders such as hypertension, nephropathy, heart disease, vasospasm, arteriosclerosis and the like.
摘要翻译：由通式（I）表示的化合物：其中Ar 1表示可被取代的芳基或杂芳基，n表示0或1：T，U，V和W各自独立地表示氮原子或次甲基，可以具有选自卤素，低级烷基，羟基和低级烷氧基的取代基，其中至少两个表示所述次甲基; X表示次甲基，羟基取代的次甲基或氮原子; Y表示可被低级烷基或氧取代的亚氨基，其盐，酯或N-氧化物衍生物表现出NPY拮抗活性，可用作治疗与NPY有关的各种疾病的药剂，例如心血管疾病如高血压，肾病，心脏病，血管痉挛，动脉硬化等。

3. 发明申请

WO2003076443A1 SPIRO COMPOUNDS WITH NPY ANTAGONISTIC ACTIVITY 审中-公开
标题翻译：具有NPY拮抗活性的SPIRO化合物
公开(公告)号：WO2003076443A1
公开(公告)日：2003-09-18
申请号：PCT/JP2003/002611
申请日：2003-03-05
申请人： BANYU PHARMACEUTICAL CO., LTD. , FUKAMI, Takehiro , KANATANI, Akio , ISHIHARA, Akane , ISHII, Yasuyuki , TAKAHASHI, Toshiyuki , HAGA, Yuji , SAKAMOTO, Toshihiro , ITOH, Takahiro , CHIBA, Masato
发明人： FUKAMI, Takehiro , KANATANI, Akio , ISHIHARA, Akane , ISHII, Yasuyuki , TAKAHASHI, Toshiyuki , HAGA, Yuji , SAKAMOTO, Toshihiro , ITOH, Takahiro , CHIBA, Masato
IPC分类号： C07D491/10
CPC分类号： C07D213/61 , C07D307/94 , C07D405/12 , C07D471/10 , C07D491/10
摘要： A compound represented by the general formula (I): wherein Ar 1 represents an aryl or heteroaryl which may be substituted, n represents 0 or 1: T, U, V and W each independently represent a nitrogen atom or a methine group which may have a substituent selected from the group consisting of halogen, lower alkyl, hydroxy and lower alkoxy, wherein at least two of which represent said methine group; X represents methine, hydroxy substituted methine or nitrogen atom; Y represents an imino which may be substituted with lower alkyl, or oxygen, and a salt, ester or N-oxide derivative thereof exhibit NPY antagonistic activities and are useful as agents for the treatment of various diseases related to NPY, for example, cardiovascular disorders such as hypertension, nephropathy, heart disease, vasospasm, arteriosclerosis and the like.
摘要翻译：由通式（I）表示的化合物：其中Ar1表示可被取代的n的芳基或杂芳基，表示0或1：T，U，V和W各自独立地表示可以具有取代基的氮原子或次甲基选自卤素，低级烷基，羟基和低级烷氧基，其中至少两个表示所述次甲基; X表示次甲基，羟基取代的次甲基或氮原子; Y表示可以被低级烷基或氧取代的亚氨基，其盐，酯或N-氧化物衍生物表现出NPY拮抗活性，可用作治疗与NPY有关的各种疾病的药剂，例如心血管疾病如高血压，肾病，心脏病，血管痉挛，动脉硬化等。

4. 发明申请

WO0114376A8 NOVEL SPIRO COMPOUNDS 审中-公开
标题翻译：新型SPIRO化合物
公开(公告)号：WO0114376A8
公开(公告)日：2001-08-09
申请号：PCT/JP0005427
申请日：2000-08-11
申请人： BANYU PHARMA CO LTD , FUKAMI TAKEHIRO , KANATANI AKIO , ISHIHARA AKANE , ISHII YASUYUKI , TAKAHASHI TOSHIYUKI , HAGA YUJI , SAKAMOTO TOSHIHIRO , ITOH TAKAHIRO
发明人： FUKAMI TAKEHIRO , KANATANI AKIO , ISHIHARA AKANE , ISHII YASUYUKI , TAKAHASHI TOSHIYUKI , HAGA YUJI , SAKAMOTO TOSHIHIRO , ITOH TAKAHIRO
IPC分类号： A61K20060101 , A61K31/438 , A61P20060101 , A61P9/00 , A61P25/00 , C07D20060101 , C07D213/61 , C07D307/94 , C07D405/12 , C07D471/10 , C07D491/10 , C07D491/107 , C07D519/00
CPC分类号： C07D405/12 , C07D213/61 , C07D307/94 , C07D471/10 , C07D491/10
摘要： Compounds of formula (I) wherein T, U, V and W represent independently nitrogen atom or optionally substituted methine group, where at least two of them represent the said methine group; X represents methine or nitrogen; Y represents optionally substituted imino or oxygen atom; and the like. Compounds of the present invention exhibit NPY antagonistic activities and are useful as agents for the treatment of various diseases related to NPY.
摘要翻译：其中T，U，V和W独立地表示氮原子或任选取代的次甲基的式（I）化合物，其中至少两个表示所述次甲基; X表示次甲基或氮; Y表示任选取代的亚氨基或氧原子; 等等。本发明化合物表现出NPY拮抗活性，可用作治疗与NPY有关的各种疾病的药剂。

5. 发明申请

WO1994009812A1 METHOD FOR PRODUCING LARGE LATENT TRANSFORMING GROWTH FACTOR-'beta' COMPLEXES AND LARGE LATENCY ASSOCIATED PEPTIDE 审中-公开
标题翻译：用于生产大量转化生长因子-β复合物和大量相关肽的方法
公开(公告)号：WO1994009812A1
公开(公告)日：1994-05-11
申请号：PCT/US1993010230
申请日：1993-10-25
申请人： KIRIN BREWERY COMPANY, LIMITED , LUDWIG INSTITUTE FOR CANCER RESEARCH , HELDIN, Carl-Henrik , MIYAZONO, Kohei , COLOSETTI, Pascal , HELMANN, Ulf , ISHII, Yasuyuki , OHASHI, Hideya
发明人： KIRIN BREWERY COMPANY, LIMITED , LUDWIG INSTITUTE FOR CANCER RESEARCH
IPC分类号： A61K37/36
CPC分类号： C07K14/47 , A61K38/00 , C07K14/495
摘要： This invention generally provides for a method of producing recombinant large latent TGF- beta by introducing nucleic acid sequences coding for LTBP and pro-TGF- beta into eukaryotic cells. This invention further provides for a method for producing recombinant LL-TGF- beta by introducing a DNA sequence for LTBP to an eukaryotic cell which expresses pro-TGF- beta . The invention also provides for the construction of a pME-TGF- beta 2 plasmid and its co-transfection with pRSVneo plasmid into BP-1-1 CHO cells which contains an amplified LTPBP cDNA sequence in the genome. The invention also provides for a method for treating the LL-TGF- beta 1 complex produced to bind to Ca2 ions during the purification process activity. An antibody to the large latent TGF- beta 1 complex is also disclosed herein. Additionally isolated L-LAP and a method to produce the same is provided herein.
摘要翻译：本发明通常提供通过将编码LTBP和前TGF-β的核酸序列引入真核细胞来生产重组大型潜在TGF-β的方法。本发明进一步提供了通过将LTBP的DNA序列引入表达前TGF-β的真核细胞来产生重组LL-TGF-β的方法。本发明还提供pME-TGF-β2质粒的构建及其与pRSVneo质粒的共转染到在基因组中含有扩增的LTPBP cDNA序列的BP-1-1CHC细胞中。本发明还提供了一种治疗在纯化过程活性期间产生以结合Ca 2+离子的LL-TGF-β1复合物的方法。本文还公开了对大潜伏性TGF-β1复合物的抗体。本文提供了另外分离的L-LAP及其制备方法。

6. 发明专利

JPH1131354A BARRIER-FREE CD AND PRESERVATION CASE 失效
公开(公告)号：JPH1131354A
公开(公告)日：1999-02-02
申请号：JP21890197
申请日：1997-07-09
申请人： ISHII YASUYUKI
发明人： ISHII YASUYUKI
IPC分类号： B65D85/57 , G11B7/24 , G11B19/12 , G11B23/00 , G11B23/03
摘要： PROBLEM TO BE SOLVED: To facilitate the discrimination of a signal surface and the taking-out/ in of a recording medium by providing a slope on the outer peripheral side surface of the recording medium, providing a projection on the upper part of a title surface, making the notch of an internal CD fixing part into half and providing CD pressing parts upward/downward. SOLUTION: The slope of elevation angle of about 45 deg. is made to the outer peripheral side surface of a recording medium such as a CD in a state of making a signal surface downward. A round projection is provided on the upper part of a title surface in a preservation case in a state of making an opening/ closing part a right side, the half of the notch of a CD fixing part 6 in the inside of the case is eliminated and the CD pressing parts 7 are provided upward/downward in the inside. When the recording medium is taken out, it is constituted so that upper/lower, left/right are confirmed by the round projection, are opening/closing part is opened to be lifted up and the CD pressing parts are released to take out the recording medium. Thus, the signal surface of the recording medium is discriminated easily by feeling, a load to the CD fixing part in the preservation case is reduced, a fall is prevented by the CD pressing parts and the recording medium can be dealt in stably.

7. 发明专利

JP2001350560A METHOD FOR CONDUCTING JAPANESE INPUT BY ONE HAND, RECORDING MEDIUM, AND INFORMATION INPUT DEVICE 失效
公开(公告)号：JP2001350560A
公开(公告)日：2001-12-21
申请号：JP2000173569
申请日：2000-06-09
申请人： ISHII YASUYUKI , ISHIGURO YOICHI
发明人： ISHII YASUYUKI , ISHIGURO YOICHI
IPC分类号： G06F3/02
摘要： PROBLEM TO BE SOLVED: To easily input Japanese by one hand with small-sized input keys. SOLUTION: One of the characters ('a' to 'wa') of the ('a' stage) assigned to a ten-key 16 is inputted by one hand and converted into the characters of the ('a' stage) to ('o' stage) by one-hand operation of a return key 12 for KANA (Japanese syllabary) or into the characters of the ('a' stage) to ('o' stage) by operating a multidirectional key 15 in five directions of ('a') to ('o') by one hand. Further, the inputted character or converted character is converted into characters including contracted sounds or long consonants by operating a simple conversion key 14 by one hand or into voiced consonants or 'p'-sounds by operating a voiced consonant key 13 by one hand.

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