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1. 发明申请

US20080045546A1 Tetradydro-Naphthalene And Urea Derivatives 审中-公开
标题翻译：十四氢萘和尿素衍生物
公开(公告)号：US20080045546A1
公开(公告)日：2008-02-21
申请号：US10575027
申请日：2004-10-02
申请人： Axel Bouchon , Nicole Diedrichs , Achim Hermann , Klemens Lustig , Heinrich Meier , Josef Pemerstorfer , Elke Reissmuller , Muneto Mogi , Takeshi Yura , Hiroshi Fujishima , Masanori Seki , Yuji Koriyama , Kayo Yasoshima , Keiko Misawa , Masaomi Tajimi , Noriyuki Yammoto , Klaus Urbahns , Fumihiko Hayashi , Yasuhiro Tsukimi , Jang Gupta
发明人： Axel Bouchon , Nicole Diedrichs , Achim Hermann , Klemens Lustig , Heinrich Meier , Josef Pemerstorfer , Elke Reissmuller , Muneto Mogi , Takeshi Yura , Hiroshi Fujishima , Masanori Seki , Yuji Koriyama , Kayo Yasoshima , Keiko Misawa , Masaomi Tajimi , Noriyuki Yammoto , Klaus Urbahns , Fumihiko Hayashi , Yasuhiro Tsukimi , Jang Gupta
IPC分类号： A61K31/519 , A61K31/44 , C07D211/68 , C07D213/06
CPC分类号： C07C275/32 , A61K31/167 , A61K31/17 , A61K31/357 , A61K31/42 , A61K31/433 , A61K31/4406 , A61K31/4409 , A61K31/4412 , A61K31/455 , A61K31/4706 , A61K31/472 , A61K31/517 , A61K47/54 , C07C233/29 , C07C233/75 , C07C235/24 , C07C235/38 , C07C235/56 , C07C235/64 , C07C237/04 , C07C275/30 , C07C275/38 , C07C2602/08 , C07C2602/10 , C07D209/18 , C07D213/40 , C07D213/56 , C07D213/89 , C07D215/46 , C07D217/22 , C07D239/94 , C07D261/14 , C07D285/06 , C07D317/66
摘要： This invention relates to tetrahydro-naphthalene and urea derivatives and salts thereof which are useful as active ingredients of pharmaceutical preparations. The tetrahydro-naphthalene and urea derivatives of the present invention have vanilloid receptor (VR1) antagonistic activity, and can be used for the prophylaxis and treatment of diseases associated with VR1 activity, in particular for the treatment of urological diseases or disorders, such as detrusor overactivity (overactive bladder), urinary incontinence, neurogenic detrusor overactivity (detrusor hyperflexia), idiopathic detrusor overactivity (detrusor instability), benign prostatic hyperplasia, and lower urinary tract symptoms; chronic pain, neuropathic pain, postoperative pain, rheumatoid arthritic pain, neuralgia, neuropathies, algesia, nerve injury, ischaemia, neurodegeneration, stroke, and inflammatory disorders such as asthma and chronic obstructive pulmonary (or airways) disease (COPD).
摘要翻译：本发明涉及四氢萘和脲衍生物及其盐，其可用作药物制剂的活性成分。本发明的四氢萘和脲衍生物具有香草素受体（VR1）拮抗活性，可用于预防和治疗与VR1活性相关的疾病，特别是用于治疗泌尿系统疾病或病症，如逼尿肌过度活动（膀胱过度活动），尿失禁，神经源性逼尿肌过度活动（逼尿肌hyperflexia），特发性逼尿肌过度活动（逼尿肌不稳定），良性前列腺增生和下尿路症状; 慢性疼痛，神经性疼痛，术后疼痛，类风湿性关节炎疼痛，神经痛，神经病，痛觉，神经损伤，局部缺血，神经变性，中风和炎性疾病如哮喘和慢性阻塞性肺（或气道）疾病（COPD）。

2. 发明授权

US07615557B2 Tetrahydro-naphthalene and urea derivatives 失效
标题翻译：四氢萘和脲衍生物
公开(公告)号：US07615557B2
公开(公告)日：2009-11-10
申请号：US10574122
申请日：2004-09-22
申请人： Axel Bouchon , Nicole Diedrichs , Achim Hermann , Klemens Lustig , Heinrich Meier , Josef Pernerstorfer , Elke Reissmuller , Jean De Vry , Muneto Mogi , Klaus Urbahns , Takeshi Yura , Hiroshi Fujishima , Masaomi Tajimi , Noriyuki Yamamoto , Yasuhiro Tsukimi , Hiroaki Yuasa , Jang Gupta , Fumihiko Hayashi
发明人： Axel Bouchon , Nicole Diedrichs , Achim Hermann , Klemens Lustig , Heinrich Meier , Josef Pernerstorfer , Elke Reissmuller , Jean De Vry , Muneto Mogi , Klaus Urbahns , Takeshi Yura , Hiroshi Fujishima , Masaomi Tajimi , Noriyuki Yamamoto , Yasuhiro Tsukimi , Hiroaki Yuasa , Jang Gupta , Fumihiko Hayashi
IPC分类号： A01N43/40 , A61K31/445 , A61K31/4965 , C07D295/00 , C07D241/04
CPC分类号： C07D295/215 , C07D211/62 , C07D401/04
摘要： This invention relates to a hydroxy-tetrahydro-naphthalene or an urea derivative formula (I) and salts thereof which are useful as active ingredients of pharmaceutical preparations, wherein A represents formula (II) or (III) wherein # represents the connection position to the molecule and Q1a, Q2a, Q3a and Q4a are defined, and E represents formula (IV) or (V) wherein # represents the connection position to the molecule and Q1b, Q2b, Q3b, Q4b, Q5b, R1b, na, ma, Xa and Ra are defined.
摘要翻译：本发明涉及用作药物制剂活性成分的羟基 - 四氢 - 萘或脲衍生物式（I）及其盐，其中A表示式（II）或（III），其中＃表示与分子和Q1a，Q2a，Q3a和Q4a，E表示式（IV）或（V），其中＃表示与分子的连接位置，Q1b，Q2b，Q3b，Q4b，Q5b，R1b，na，ma，Xa 和Ra。

3. 发明申请

US20070167458A1 Tetrahydro-naphthalene and urea derivatives 失效
标题翻译：四氢萘和脲衍生物
公开(公告)号：US20070167458A1
公开(公告)日：2007-07-19
申请号：US10574122
申请日：2004-09-22
申请人： Axel Bouchon , Nicole Diedrichs , Achim Hermann , Klemens Lustig , Heinrich Meier , Josef Pernerstorfer , Elke Reissmuller , Jean De Vry , Muneto Mogi , Klaus Urbahns , Takeshi Yura , Hiroshi Fujishima , Masaomi Tajimi , Noriyuki Yamamoto , Hiroaki Yuasa , Jang Gupta , Yasuhiro Tsukimi , Fumihiko Hayashi
发明人： Axel Bouchon , Nicole Diedrichs , Achim Hermann , Klemens Lustig , Heinrich Meier , Josef Pernerstorfer , Elke Reissmuller , Jean De Vry , Muneto Mogi , Klaus Urbahns , Takeshi Yura , Hiroshi Fujishima , Masaomi Tajimi , Noriyuki Yamamoto , Hiroaki Yuasa , Jang Gupta , Yasuhiro Tsukimi , Fumihiko Hayashi
IPC分类号： A61K31/495 , C07D211/40 , C07D241/04
CPC分类号： C07D295/215 , C07D211/62 , C07D401/04
摘要： This invention relates to a hydroxy-tetrahydro-naphthalene or an urea derivative formula (I) and salts thereof which are useful as active ingredients of pharmaceutical preparations, wherein A represents formula (II) or (III) wherein # represents the connection position to the molecule and Q1a, Q2a, Q3a and Q4a are defined, and E represents formula (IV) or (V) wherein # represents the connection position to the molecule and Q1b, Q2b, Q3b, Q4b, Q5b, R1b, na, ma, Xa and Ra are defined.
摘要翻译：本发明涉及用作药物制剂活性成分的羟基 - 四氢 - 萘或脲衍生物式（I）及其盐，其中A表示式（II）或（III），其中＃表示与分子和Q 1a，Q 2a，Q 3a和Q 4a定义，E表示式（IV ）或（V）其中＃表示与分子的连接位置和Q 1b，Q 2b，Q 3b，Q 4b α，α，α，α，α，α，α，α，α和R a a都被定义。

4. 发明申请

US20070213363A1 Tetrahydro-Quinolinylurea Derivatives 失效
标题翻译：四氢喹啉基脲衍生物
公开(公告)号：US20070213363A1
公开(公告)日：2007-09-13
申请号：US10578413
申请日：2004-10-26
申请人： Axel Bouchon , Nicole Diedrichs , Achim Hermann , Klemens Lustig , Heinrich Meier , Josef Pernerstorfer , Elke Reissmuller , Mogi Muneto , Hiroshi Fujishima , Masaomi Tajimi , Noriyuki Yamamoto
发明人： Axel Bouchon , Nicole Diedrichs , Achim Hermann , Klemens Lustig , Heinrich Meier , Josef Pernerstorfer , Elke Reissmuller , Mogi Muneto , Hiroshi Fujishima , Masaomi Tajimi , Noriyuki Yamamoto
IPC分类号： A61K31/47 , C07D215/02
CPC分类号： C07D215/38
摘要： This invention relates to tetrahydro-quinolinylurea derivatives and salts thereof which are useful as active ingredi- ents of pharmaceutical preparations. The tetrahydro-quinolinylurea derivative of the present invention has vanilloid receptor (VR I) C antagonistic activity, and can be used for the prophylaxis and treatment of diseases associated with VR1 activity, in particular for =the treatment of urological diseases or disorders, such as detrusor overactivity (overactive bladder), urinary incontinence, neurogenic detrusor oeractivity (detrusor hyperflexia), idiopathic detrusor overactivity (detrusor instability), benign prostatic hyperplasia, and lower urinary tract symptoms; chronic pain, neuropathic pain, postoperative pain, rheumatoid arthritic pain, neuralgia, neuropathies, algesia, nerve injury, ischaemia, neurodegeneration, stroke, and inflammatory disorders such as asthma and chronic obstructive pul- monary (or airways) disease (COPD).
摘要翻译：本发明涉及四氢喹啉基脲衍生物及其盐，其可用作药物制剂的活性成分。本发明的四氢 - 喹啉基脲衍生物具有香草素受体（VR I）C拮抗活性，可用于预防和治疗与VR1活性相关的疾病，特别是用于治疗泌尿系统疾病或病症，例如作为逼尿肌过度活动（膀胱过度活动），尿失禁，神经源性逼尿肌过敏反应（逼尿肌hyperflexia），特发性逼尿肌过度活动（逼尿肌不稳定），良性前列腺增生和下尿路症状; 慢性疼痛，神经性疼痛，术后疼痛，类风湿性关节炎疼痛，神经痛，神经病，痛觉，神经损伤，局部缺血，神经变性，中风和炎性疾病如哮喘和慢性阻塞性肺病（或气道）疾病（COPD）。

5. 发明授权

US07683076B2 Tetrahydro-quinolinylurea derivatives 失效
标题翻译：四氢 - 喹啉基脲衍生物
公开(公告)号：US07683076B2
公开(公告)日：2010-03-23
申请号：US10578413
申请日：2004-10-26
申请人： Axel Bouchon , Nicole Diedrichs , Achim Hermann , Klemens Lustig , Heinrich Meier , Josef Pernerstorfer , Elke Reiβmüller , Muneto Mogi , Hiroshi Fujishima , Masaomi Tajimi , Noriyuki Yamamoto
发明人： Axel Bouchon , Nicole Diedrichs , Achim Hermann , Klemens Lustig , Heinrich Meier , Josef Pernerstorfer , Elke Reiβmüller , Muneto Mogi , Hiroshi Fujishima , Masaomi Tajimi , Noriyuki Yamamoto
IPC分类号： C07D215/38 , A61K31/47
CPC分类号： C07D215/38
摘要： This invention relates to tetrahydro-quinolinylurea derivatives and salts thereof which are useful as active ingredients of pharmaceutical preparations. The tetrahydro-quinolinylurea derivative of the present invention has vanilloid receptor (VR1) antagonistic activity, and can be used for the prophylaxis and treatment of diseases associated with VR1 activity, in particular for the treatment of urological diseases or disorders, such as detrusor overactivity (overactive bladder), urinary incontinence, neurogenic detrusor overactivity (detrusor hyperflexia), idiopathic detrusor overactivity (detrusor instability), benign prostatic hyperplasia, and lower urinary tract symptoms; chronic pain, neuropathic pain, postoperative pain, rheumatoid arthritic pain, neuralgia, neuropathies, algesia, nerve injury, ischaemia, neurodegeneration, stroke, and inflammatory disorders such as asthma and chronic obstructive pulmonary (or airways) disease (COPD).
摘要翻译：本发明涉及可用作药物制剂活性成分的四氢 - 喹啉基脲衍生物及其盐。本发明的四氢 - 喹啉基脲衍生物具有香草素受体（VR1）拮抗活性，可用于预防和治疗与VR1活性有关的疾病，特别是用于治疗泌尿系统疾病或障碍，例如逼尿肌过度活动膀胱过度活动），尿失禁，神经源性逼尿肌过度活动（逼尿肌hyperflexia），特发性逼尿肌过度活动（逼尿肌不稳定），良性前列腺增生和下尿路症状; 慢性疼痛，神经性疼痛，术后疼痛，类风湿性关节炎疼痛，神经痛，神经病，痛觉，神经损伤，局部缺血，神经变性，中风和炎性疾病如哮喘和慢性阻塞性肺（或气道）疾病（COPD）。

6. 发明授权

US08231878B2 Receptor trem (triggering receptor expressed on myeloid cells) and uses thereof 有权
标题翻译：受体trem（在骨髓细胞上表达的触发受体）及其用途
公开(公告)号：US08231878B2
公开(公告)日：2012-07-31
申请号：US12457444
申请日：2009-06-10
申请人： Marco Colonna , Axel Bouchon
发明人： Marco Colonna , Axel Bouchon
IPC分类号： A61K38/00
CPC分类号： C07K14/70503 , C07K16/2803 , C07K2317/54 , C07K2317/55 , C07K2317/77 , C07K2319/30 , C07K2319/32
摘要： Novel activating receptors of the Ig super-family expressed on human myeloid cells, called TREM(s) (triggering receptor expressed on myeloid cells) are provided. Specifically, two (2) members of TREMs, TREM-1 and TREM-2 are disclosed. TREM-1 is a transmembrane glycoprotein expressed selectively on blood neutrophils and a subset of monocytes but not on lymphocytes and other cell types and is upregulated by bacterial and fungal products. Use of TREM-1 in treatment and diagnosis of various inflammatory diseases is also provided. TREM-2 is also a transmembrane glycoprotein expressed selectively on mast cells and peripheral dendritic cells (DCs) but not on granulocytes or monocytes. DC stimulation via TREM-2 leads to DC maturation and resistance to apoptosis, and induces strong upregulation of CCR7 and subsequent chemotaxis toward macrophage inflammatory protein 3-β. TREM-2 has utility in modulating host immune responses in various immune disorders, including autoimmune diseases and allergic disorders.
摘要翻译：提供了称为TREM（在骨髓细胞上表达的触发受体）的人类骨髓细胞上表达的Ig超家族的新型活化受体。具体地说，公开了TREMs，TREM-1和TREM-2的两（2）个成员。 TREM-1是一种在血液嗜中性粒细胞和单核细胞亚群上有选择性表达而不是淋巴细胞和其他细胞类型的跨膜糖蛋白，并被细菌和真菌产品上调。还提供了TREM-1在各种炎性疾病的治疗和诊断中的应用。 TREM-2也是在肥大细胞和外周树突状细胞（DC）上选择性表达但不在粒细胞或单核细胞上表达的跨膜糖蛋白。通过TREM-2的DC刺激导致DC成熟和对细胞凋亡的抗性，并且诱导CCR7的强烈上调和随后对巨噬细胞炎症蛋白质3-＆bgr的趋化性。 TREM-2可用于调节各种免疫疾病中的宿主免疫应答，包括自身免疫性疾病和过敏性疾病。

7. 发明申请

US20100305306A1 NOVEL RECEPTOR TREM (TRIGGERING RECEPTOR EXPRESSED ON MYELOID CELLS) AND USES THEREOF 审中-公开
标题翻译：新生受体TREM（在MYELOID细胞上表达的触发受体）及其用途
公开(公告)号：US20100305306A1
公开(公告)日：2010-12-02
申请号：US12687038
申请日：2010-01-13
申请人： Marco COLONNA , Axel Bouchon
发明人： Marco COLONNA , Axel Bouchon
IPC分类号： C07K16/00
CPC分类号： C07K14/70503
摘要： Novel activating receptors of the Ig super-family expressed on human myeloid cells, called TREM(s) (triggering receptor expressed on myeloid cells) are provided. Specifically, two (2) members of TREMs, TREM-1 and TREM-2 are disclosed. TREM-1 is a transmembrane glycoprotein expressed selectively on blood neutrophils and a subset of monocytes but not on lymphocytes and other cell types and is upregulated by bacterial and fungal products. Use of TREM-1 in treatment and diagnosis of various inflammatory diseases is also provided. TREM-2 is also a transmembrane glycoprotein expressed selectively on mast cells and peripheral dendritic cells (DCs) but not on granulocytes or monocytes. DC stimulation via TREM-2 leads to DC maturation and resistance to apoptosis, and induces strong upregulation of CCR7 and subsequent chemotaxis toward macrophage inflammatory protein 3-β. TREM-2 has utility in modulating host immune responses in various immune disorders, including autoimmune diseases and allergic disorders.
摘要翻译：提供了称为TREM（在骨髓细胞上表达的触发受体）的人类骨髓细胞上表达的Ig超家族的新型活化受体。具体地说，公开了TREMs，TREM-1和TREM-2的两（2）个成员。 TREM-1是一种在血液嗜中性粒细胞和单核细胞亚群上有选择性表达而不是淋巴细胞和其他细胞类型的跨膜糖蛋白，并被细菌和真菌产品上调。还提供了TREM-1在各种炎性疾病的治疗和诊断中的应用。 TREM-2也是在肥大细胞和外周树突状细胞（DC）上选择性表达但不在粒细胞或单核细胞上表达的跨膜糖蛋白。通过TREM-2的DC刺激导致DC成熟和对细胞凋亡的抗性，并且诱导CCR7的强烈上调和随后对巨噬细胞炎症蛋白质3-＆bgr的趋化性。 TREM-2可用于调节各种免疫疾病中的宿主免疫应答，包括自身免疫性疾病和过敏性疾病。

8. 发明申请

US20050260670A1 Novel receptor trem (triggering receptor expressed on myeloid cells) and uses thereof 审中-公开
标题翻译：新型受体trem（在骨髓细胞上表达的触发受体）及其用途
公开(公告)号：US20050260670A1
公开(公告)日：2005-11-24
申请号：US11188281
申请日：2005-07-25
申请人： Marco Colonna , Axel Bouchon
发明人： Marco Colonna , Axel Bouchon
IPC分类号： A61K38/17 , A61K48/00 , C07K14/705 , C12N5/08 , C12N15/12 , C12P21/02 , C12Q1/68 , C07H21/04 , C12N15/09 , C12P21/06
CPC分类号： C07K14/70503
摘要： Novel activating receptors of the Ig super-family expressed on human myeloid cells, called TREM(s) (triggering receptor expressed on myeloid cells) are provided. Specifically, two (2) members of TREMs, TREM-1 and TREM-2 are disclosed. TREM-1 is a transmembrane glycoprotein expressed selectively on blood neutrophils and a subset of monocytes but not on lymphocytes and other cell types and is upregulated by bacterial and fungal products. Use of TREM-1 in treatment and diagnosis of various inflammatory diseases is also provided. TREM-2 is also a transmembrane glycoprotein expressed selectively on mast cells and peripheral dendritic cells (DCs) but not on granulocytes or monocytes. DC stimulation via TREM-2 leads to DC maturation and resistance to apoptosis, and induces strong upregulation of CCR7 and subsequent chemotaxis toward macrophage inflammatory protein 3-β. TREM-2 has utility in modulating host immune responses in various immune disorders, including autoimmune diseases and allergic disorders.
摘要翻译：提供了称为TREM（在骨髓细胞上表达的触发受体）的人类骨髓细胞上表达的Ig超家族的新型活化受体。具体地说，公开了TREMs，TREM-1和TREM-2的两（2）个成员。 TREM-1是一种在血液嗜中性粒细胞和单核细胞亚群上有选择性表达而不是淋巴细胞和其他细胞类型的跨膜糖蛋白，并被细菌和真菌产品上调。还提供了TREM-1在各种炎性疾病的治疗和诊断中的应用。 TREM-2也是在肥大细胞和外周树突状细胞（DC）上选择性表达但不在粒细胞或单核细胞上表达的跨膜糖蛋白。通过TREM-2的DC刺激导致DC成熟和对细胞凋亡的抗性，并且诱导CCR7的强烈上调和随后对巨噬细胞炎症蛋白3-β的趋化性。 TREM-2可用于调节各种免疫疾病中的宿主免疫应答，包括自身免疫性疾病和过敏性疾病。

9. 发明申请

US20100310560A1 Novel receptor trem (triggering receptor expressed on myeloid cells) and uses thereof 有权
标题翻译：新型受体trem（在骨髓细胞上表达的触发受体）及其用途
公开(公告)号：US20100310560A1
公开(公告)日：2010-12-09
申请号：US12457444
申请日：2009-06-10
申请人： Marco Colonna , Axel Bouchon
发明人： Marco Colonna , Axel Bouchon
IPC分类号： A61K39/395 , A61K31/711 , A61K38/17 , A61P1/00
CPC分类号： C07K14/70503 , C07K16/2803 , C07K2317/54 , C07K2317/55 , C07K2317/77 , C07K2319/30 , C07K2319/32
摘要： Novel activating receptors of the Ig super-family expressed on human myeloid cells, called TREM(s) (triggering receptor expressed on myeloid cells) are provided. Specifically, two (2) members of TREMs, TREM-1 and TREM-2 are disclosed. TREM-1 is a transmembrane glycoprotein expressed selectively on blood neutrophils and a subset of monocytes but not on lymphocytes and other cell types and is upregulated by bacterial and fungal products. Use of TREM-1 in treatment and diagnosis of various inflammatory diseases is also provided. TREM-2 is also a transmembrane glycoprotein expressed selectively on mast cells and peripheral dendritic cells (DCs) but not on granulocytes or monocytes. DC stimulation via TREM-2 leads to DC maturation and resistance to apoptosis, and induces strong upregulation of CCR7 and subsequent chemotaxis toward macrophage inflammatory protein 3-β. TREM-2 has utility in modulating host immune responses in various immune disorders, including autoimmune diseases and allergic disorders.
摘要翻译：提供了称为TREM（在骨髓细胞上表达的触发受体）的人类骨髓细胞上表达的Ig超家族的新型活化受体。具体地说，公开了TREMs，TREM-1和TREM-2的两（2）个成员。 TREM-1是一种在血液嗜中性粒细胞和单核细胞亚群上有选择性表达而不是淋巴细胞和其他细胞类型的跨膜糖蛋白，并被细菌和真菌产品上调。还提供了TREM-1在各种炎性疾病的治疗和诊断中的应用。 TREM-2也是在肥大细胞和外周树突状细胞（DC）上选择性表达但不在粒细胞或单核细胞上表达的跨膜糖蛋白。通过TREM-2的DC刺激导致DC成熟和对凋亡的抗性，并且诱导CCR7的强烈上调和随后对巨噬细胞炎症蛋白3-＆bgr的趋化性。 TREM-2可用于调节各种免疫疾病中的宿主免疫应答，包括自身免疫性疾病和过敏性疾病。

10. 发明申请

US20090081199A1 Novel receptor trem (triggering receptor expressed on myeloid cells) and uses thereof 审中-公开
标题翻译：新型受体trem（在骨髓细胞上表达的触发受体）及其用途
公开(公告)号：US20090081199A1
公开(公告)日：2009-03-26
申请号：US12149930
申请日：2008-05-09
申请人： Marco Colonna , Axel Bouchon
发明人： Marco Colonna , Axel Bouchon
IPC分类号： A61K38/17 , C07K19/00 , A61K39/395 , A61K31/7088 , C40B30/04 , G01N33/53
CPC分类号： C07K14/70503 , A61K38/00 , A61K2039/505 , C07K16/2803 , C07K2317/33 , C07K2317/54 , C07K2317/55 , C07K2317/76 , C07K2317/77 , C07K2319/00 , C07K2319/30 , C07K2319/32 , C07K2319/43 , G01N2333/70503 , G01N2500/04 , G01N2800/7095
摘要： Novel activating receptors of the Ig super-family expressed on human myeloid cells, called TREM(s) (triggering receptor expressed on myeloid cells) are provided. Specifically, two (2) members of TREMs, TREM-1 and TREM-2 are disclosed. TREM-1 is a transmembrane glycoprotein expressed selectively on blood neutrophils and a subset of monocytes but not on lymphocytes and other cell types and is upregulated by bacterial and fungal products. Use of TREM-1 in treatment and diagnosis of various inflammatory diseases is also provided. TREM-2 is also a transmembrane glycoprotein expressed selectively on mast cells and peripheral dendritic cells (DCs) but not on granulocytes or monocytes. DC stimulation via TREM-2 leads to DC maturation and resistance to apoptosis, and induces strong upregulation of CCR7 and subsequent chemotaxis toward macrophage inflammatory protein 3-β. TREM-2 has utility in modulating host immune responses in various immune disorders, including autoimmune diseases and allergic disorders.
摘要翻译：提供了称为TREM（在骨髓细胞上表达的触发受体）的人类骨髓细胞上表达的Ig超家族的新型活化受体。具体地说，公开了TREMs，TREM-1和TREM-2的两（2）个成员。 TREM-1是一种在血液嗜中性粒细胞和单核细胞亚群上有选择性表达而不是淋巴细胞和其他细胞类型的跨膜糖蛋白，并被细菌和真菌产品上调。还提供了TREM-1在各种炎性疾病的治疗和诊断中的应用。 TREM-2也是在肥大细胞和外周树突状细胞（DC）上选择性表达但不在粒细胞或单核细胞上表达的跨膜糖蛋白。通过TREM-2的DC刺激导致DC成熟和对细胞凋亡的抗性，并且诱导CCR7的强烈上调和随后对巨噬细胞炎症蛋白3-β的趋化性。 TREM-2可用于调节各种免疫疾病中的宿主免疫应答，包括自身免疫性疾病和过敏性疾病。

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