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1. 发明申请

US20110123532A1 Method for Making Heteromultimeric Molecules 有权
标题翻译：制备异源多聚体分子的方法
公开(公告)号：US20110123532A1
公开(公告)日：2011-05-26
申请号：US12768650
申请日：2010-04-27
申请人： Austin L. GURNEY , Aaron K. Sato
发明人： Austin L. GURNEY , Aaron K. Sato
IPC分类号： A61K39/395 , C07K16/22 , C07H21/04 , C12N5/10 , C12P21/04 , A61P35/00 , C12N1/21
CPC分类号： C07K16/22 , A61K39/3955 , A61K45/06 , A61K47/6845 , A61K51/1021 , A61K2039/505 , C07K16/18 , C07K16/468 , C07K2317/20 , C07K2317/31 , C07K2317/52 , C07K2317/526 , C07K2317/55 , C07K2317/565 , C07K2317/64 , C07K2317/73 , C07K2317/76 , C12N15/00
摘要： The present invention provides methods for making heteromultimeric molecules, such as bispecific antibodies, and compositions comprising said molecules. The method includes introducing mutations in amino acids that are in contact at the interface of two polypeptides, such that the electrostatic interaction between the ion pairs is altered.
摘要翻译：本发明提供了制备异源多聚体分子（例如双特异性抗体）和包含所述分子的组合物的方法。该方法包括在两个多肽的界面处接触的氨基酸中引入突变，使得离子对之间的静电相互作用改变。

2. 发明授权

US09067986B2 Method for making heteromultimeric molecules 有权
标题翻译：制备异源多聚体分子的方法
公开(公告)号：US09067986B2
公开(公告)日：2015-06-30
申请号：US12768650
申请日：2010-04-27
申请人： Austin L. Gurney , Aaron K. Sato
发明人： Austin L. Gurney , Aaron K. Sato
IPC分类号： C12P21/08 , C07K16/00 , C07K16/22 , C07K16/18 , C07K16/46 , A61K47/48
CPC分类号： C07K16/22 , A61K39/3955 , A61K45/06 , A61K47/6845 , A61K51/1021 , A61K2039/505 , C07K16/18 , C07K16/468 , C07K2317/20 , C07K2317/31 , C07K2317/52 , C07K2317/526 , C07K2317/55 , C07K2317/565 , C07K2317/64 , C07K2317/73 , C07K2317/76 , C12N15/00
摘要： Methods for making heteromultimeric molecules, such as bispecific antibodies, and compositions comprising these molecules are disclosed. The methods include introducing mutations in amino acids that are in contact at the interface of two polypeptides, such that the electrostatic interaction between the ion pairs is altered.
摘要翻译：公开了制备异源多聚体分子的方法，例如双特异性抗体，以及包含这些分子的组合物。所述方法包括在两个多肽的界面处接触的氨基酸中引入突变，从而改变离子对之间的静电相互作用。

3. 发明授权

US08158757B2 Compositions and methods for treating and diagnosing cancer 有权
标题翻译：用于治疗和诊断癌症的组合物和方法
公开(公告)号：US08158757B2
公开(公告)日：2012-04-17
申请号：US12167172
申请日：2008-07-02
申请人： Austin L. Gurney , Aaron K. Sato
发明人： Austin L. Gurney , Aaron K. Sato
IPC分类号： C12P21/08
CPC分类号： A61K39/39558 , A61K39/3955 , A61K45/06 , A61K2039/505 , C07K14/723 , C07K16/18 , C07K16/28 , C07K16/30 , C07K2317/14 , C07K2317/21 , C07K2317/24 , C07K2317/76 , C07K2319/30
摘要： The present invention relates to compositions and methods for characterizing, diagnosing and treating cancer. In particular, the present invention identifies LGR5 as a protein over-expressed in solid tumor stem cell. The present invention further identifies an interaction between RSPO1 and LGR5 as an alternative pathway for the activation of beta-catenin signaling. In certain embodiments, the present invention provides biomolecules that disrupt functional signaling via a LGR protein, including, in certain embodiments, molecules that inhibit the interaction between one or more RSPO proteins and one or more LGR proteins, such as LGR5. In certain embodiments, the present invention provides methods of treating cancer comprising disrupting functional LGR signaling and inhibiting growth of a solid tumor comprising solid tumor stem cells.
摘要翻译：本发明涉及用于表征，诊断和治疗癌症的组合物和方法。特别地，本发明将LGR5鉴定为在实体瘤干细胞中过表达的蛋白质。本发明进一步鉴定了RSPO1和LGR5之间的相互作用，作为β-连环蛋白信号传导活化的替代途径。在某些实施方案中，本发明提供了通过LGR蛋白破坏功能性信号传导的生物分子，包括在某些实施方案中抑制一种或多种RSPO蛋白与一种或多种LGR蛋白如LGR5之间相互作用的分子。在某些实施方案中，本发明提供了治疗癌症的方法，包括破坏功能性LGR信号并抑制包含固体肿瘤干细胞的实体瘤的生长。

4. 发明授权

US09386938B2 Methods for collagen imaging 有权
标题翻译：胶原成像方法
公开(公告)号：US09386938B2
公开(公告)日：2016-07-12
申请号：US13229900
申请日：2011-09-12
申请人： Peter D. Caravan , Andrew Kolodziej , Zhaoda Zhang , Stephane Dumas , Biplab Kumar Das , Vincent Jacques , Richard Looby , Steffi K. Koerner , Wei-Chuan Sun , David R. Buckler , Aida Abujoub , Aaron K. Sato
发明人： Peter D. Caravan , Andrew Kolodziej , Zhaoda Zhang , Stephane Dumas , Biplab Kumar Das , Vincent Jacques , Richard Looby , Steffi K. Koerner , Wei-Chuan Sun , David R. Buckler , Aida Abujoub , Aaron K. Sato
IPC分类号： A61B5/05 , A61B5/055 , A61B5/00
CPC分类号： A61B5/055 , A61B5/4519 , A61B5/7289 , A61B5/7292
摘要： Diagnostic compositions and methods for imaging and/or assessing collagen are described. The diagnostic compositions can include collagen binding peptides.
摘要翻译：描述用于成像和/或评估胶原的诊断组合物和方法。诊断组合物可以包括胶原结合肽。

5. 发明授权

US08642010B2 KDR and VEGF/KDR binding peptides and their use in diagnosis and therapy 有权
标题翻译： KDR和VEGF / KDR结合肽及其在诊断和治疗中的应用
公开(公告)号：US08642010B2
公开(公告)日：2014-02-04
申请号：US12480578
申请日：2009-06-08
申请人： Aaron K. Sato , Daniel J. Sexton , Daniel T. Dransfield , Robert C. Ladner , Christophe Arbogast , Philippe Bussat , Hong Fan , Sudha Khurana , Karen E. Linder , Edmund R. Marinelli , Palaniappa Nanjappan , Adrian D. Nunn , Radhakrishna K. Pillai , Sibylle Pochon , Feng Yan , Kondareddiar Ramalingam , Ajay Shrivastava , Bo Song , Rolf E. Swenson , Mathew A. Von Wronski
发明人： Aaron K. Sato , Daniel J. Sexton , Daniel T. Dransfield , Robert C. Ladner , Christophe Arbogast , Philippe Bussat , Hong Fan , Sudha Khurana , Karen E. Linder , Edmund R. Marinelli , Palaniappa Nanjappan , Adrian D. Nunn , Radhakrishna K. Pillai , Sibylle Pochon , Feng Yan , Kondareddiar Ramalingam , Ajay Shrivastava , Bo Song , Rolf E. Swenson , Mathew A. Von Wronski
IPC分类号： A61K49/00 , A61B8/00
CPC分类号： A61K49/221 , A61K38/00 , A61K47/62 , A61K49/223 , A61K51/088 , C07K7/08 , C07K14/001 , C07K14/52 , C07K14/71 , C07K2319/00 , Y02A50/411 , Y02A50/58
摘要： The present invention provides polypeptides, peptide dimer, and multimeric complexes comprising at least one binding moiety for KDR or VEGF/KDR complex, which have a variety of uses wherever treating, detecting, isolating or localizing angiogenesis is advantageous. Particularly disclosed are synthetic, isolated polypeptides capable of binding KDR or VEGF/KDR complex with high affinity (e.g., having a KD
摘要翻译：本发明提供了包含用于KDR或VEGF / KDR复合物的至少一个结合部分的多肽，肽二聚体和多聚体复合物，其具有各种用途，无论何处治疗，检测，分离或定位血管发生都是有利的。特别公开的是能够以高亲和力（例如具有KD <1μM）结合KDR或VEGF / KDR复合物的合成，分离的多肽，以及包含这些多肽的二聚体和多聚体构建体。

6. 发明申请

US20130115206A1 Compositions and Methods for Treating and Diagnosing Cancer 有权
公开(公告)号：US20130115206A1
公开(公告)日：2013-05-09
申请号：US13408704
申请日：2012-02-29
申请人： Austin Gurney , Aaron K. Sato
发明人： Austin Gurney , Aaron K. Sato
IPC分类号： C07K16/30 , A61K45/06 , A61K39/395
CPC分类号： A61K39/39558 , A61K39/3955 , A61K45/06 , A61K2039/505 , C07K14/723 , C07K16/18 , C07K16/28 , C07K16/30 , C07K2317/14 , C07K2317/21 , C07K2317/24 , C07K2317/76 , C07K2319/30
摘要： The present invention relates to compositions and methods for characterizing, diagnosing and treating cancer. In particular, the present invention identifies LGR5 as a protein over-expressed in solid tumor stem cell. The present invention further identifies an interaction between RSPO1 and LGR5 as an alternative pathway for the activation of beta-catenin signaling. In certain embodiments, the present invention provides biomolecules that disrupt functional signaling via a LGR protein, including, in certain embodiments, molecules that inhibit the interaction between one or more RSPO proteins and one or more LGR proteins, such as LGR5. In certain embodiments, the present invention provides methods of treating cancer comprising disrupting functional LGR signaling and inhibiting growth of a solid tumor comprising solid tumor stem cells.

7. 发明授权

US08628774B2 Compositions and methods for treating and diagnosing cancer 有权
标题翻译：用于治疗和诊断癌症的组合物和方法
公开(公告)号：US08628774B2
公开(公告)日：2014-01-14
申请号：US13408704
申请日：2012-02-29
申请人： Austin Gurney , Aaron K. Sato
发明人： Austin Gurney , Aaron K. Sato
IPC分类号： A61K39/395
CPC分类号： A61K39/39558 , A61K39/3955 , A61K45/06 , A61K2039/505 , C07K14/723 , C07K16/18 , C07K16/28 , C07K16/30 , C07K2317/14 , C07K2317/21 , C07K2317/24 , C07K2317/76 , C07K2319/30
摘要： The present invention relates to compositions and methods for characterizing, diagnosing and treating cancer. In particular, the present invention identifies LGR5 as a protein over-expressed in solid tumor stem cell. The present invention further identifies an interaction between RSPO1 and LGR5 as an alternative pathway for the activation of beta-catenin signaling. In certain embodiments, the present invention provides biomolecules that disrupt functional signaling via a LGR protein, including, in certain embodiments, molecules that inhibit the interaction between one or more RSPO proteins and one or more LGR proteins, such as LGR5. In certain embodiments, the present invention provides methods of treating cancer comprising disrupting functional LGR signaling and inhibiting growth of a solid tumor comprising solid tumor stem cells.
摘要翻译：本发明涉及用于表征，诊断和治疗癌症的组合物和方法。特别地，本发明将LGR5鉴定为在实体瘤干细胞中过表达的蛋白质。本发明进一步鉴定了RSPO1和LGR5之间的相互作用，作为β-连环蛋白信号传导活化的替代途径。在某些实施方案中，本发明提供了通过LGR蛋白破坏功能性信号传导的生物分子，包括在某些实施方案中抑制一种或多种RSPO蛋白与一种或多种LGR蛋白如LGR5之间相互作用的分子。在某些实施方案中，本发明提供了治疗癌症的方法，包括破坏功能性LGR信号并抑制包含固体肿瘤干细胞的实体瘤的生长。

8. 发明申请

US20120039802A1 PEPTIDES THAT SPECIFICALLY BIND HGF RECEPTOR (CMET) AND USES THEREOF 审中-公开
标题翻译：特异性结合HGF受体（CMET）的特异性及其用途
公开(公告)号：US20120039802A1
公开(公告)日：2012-02-16
申请号：US13227213
申请日：2011-09-07
申请人： Daniel T. DRANSFIELD , Aaron K. Sato , Robert Charles Ladner , Regi Thomas , Palaniappa Nanjappan
发明人： Daniel T. DRANSFIELD , Aaron K. Sato , Robert Charles Ladner , Regi Thomas , Palaniappa Nanjappan
IPC分类号： A61K51/08 , A61K49/22 , A61P35/00 , A61K49/00
CPC分类号： C07K7/08 , A61K47/543 , A61K47/60 , A61K47/665 , A61K49/0043 , A61K49/0056 , A61K51/08 , B82Y5/00 , C07K14/00 , C07K14/4753
摘要： A polypeptide or multimeric polypeptide construct having the ability to bind to cMet or a complex comprising cMet and HGF, and methods for use are disclosed.
摘要翻译：公开了具有结合cMet或包含cMet和HGF的复合物的能力的多肽或多聚体多肽构建体及其使用方法。

9. 发明授权

US07041790B2 Fibrinogen binding moieties 有权
公开(公告)号：US07041790B2
公开(公告)日：2006-05-09
申请号：US10396073
申请日：2003-03-25
申请人： Charles R. Wescott , Aaron K. Sato
发明人： Charles R. Wescott , Aaron K. Sato
IPC分类号： A61K38/00 , A61K35/14
CPC分类号： C07K7/06 , C07K7/08 , C07K14/00 , G01N33/86 , G01N2333/75
摘要： Compositions comprising non-naturally occurring fibrinogen binding moieties are described, together with methods of use thereof, e.g., for detecting or isolating fibrinogen molecules in a solution, for blood circulation imaging, and for linking therapeutics or other molecules to fibrinogen. Preferred binding peptides having a high affinity for fibrinogen are particularly disclosed.

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