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1. 发明授权

US09067986B2 Method for making heteromultimeric molecules 有权
标题翻译：制备异源多聚体分子的方法
公开(公告)号：US09067986B2
公开(公告)日：2015-06-30
申请号：US12768650
申请日：2010-04-27
申请人： Austin L. Gurney , Aaron K. Sato
发明人： Austin L. Gurney , Aaron K. Sato
IPC分类号： C12P21/08 , C07K16/00 , C07K16/22 , C07K16/18 , C07K16/46 , A61K47/48
CPC分类号： C07K16/22 , A61K39/3955 , A61K45/06 , A61K47/6845 , A61K51/1021 , A61K2039/505 , C07K16/18 , C07K16/468 , C07K2317/20 , C07K2317/31 , C07K2317/52 , C07K2317/526 , C07K2317/55 , C07K2317/565 , C07K2317/64 , C07K2317/73 , C07K2317/76 , C12N15/00
摘要： Methods for making heteromultimeric molecules, such as bispecific antibodies, and compositions comprising these molecules are disclosed. The methods include introducing mutations in amino acids that are in contact at the interface of two polypeptides, such that the electrostatic interaction between the ion pairs is altered.
摘要翻译：公开了制备异源多聚体分子的方法，例如双特异性抗体，以及包含这些分子的组合物。所述方法包括在两个多肽的界面处接触的氨基酸中引入突变，从而改变离子对之间的静电相互作用。

2. 发明授权

US08158757B2 Compositions and methods for treating and diagnosing cancer 有权
标题翻译：用于治疗和诊断癌症的组合物和方法
公开(公告)号：US08158757B2
公开(公告)日：2012-04-17
申请号：US12167172
申请日：2008-07-02
申请人： Austin L. Gurney , Aaron K. Sato
发明人： Austin L. Gurney , Aaron K. Sato
IPC分类号： C12P21/08
CPC分类号： A61K39/39558 , A61K39/3955 , A61K45/06 , A61K2039/505 , C07K14/723 , C07K16/18 , C07K16/28 , C07K16/30 , C07K2317/14 , C07K2317/21 , C07K2317/24 , C07K2317/76 , C07K2319/30
摘要： The present invention relates to compositions and methods for characterizing, diagnosing and treating cancer. In particular, the present invention identifies LGR5 as a protein over-expressed in solid tumor stem cell. The present invention further identifies an interaction between RSPO1 and LGR5 as an alternative pathway for the activation of beta-catenin signaling. In certain embodiments, the present invention provides biomolecules that disrupt functional signaling via a LGR protein, including, in certain embodiments, molecules that inhibit the interaction between one or more RSPO proteins and one or more LGR proteins, such as LGR5. In certain embodiments, the present invention provides methods of treating cancer comprising disrupting functional LGR signaling and inhibiting growth of a solid tumor comprising solid tumor stem cells.
摘要翻译：本发明涉及用于表征，诊断和治疗癌症的组合物和方法。特别地，本发明将LGR5鉴定为在实体瘤干细胞中过表达的蛋白质。本发明进一步鉴定了RSPO1和LGR5之间的相互作用，作为β-连环蛋白信号传导活化的替代途径。在某些实施方案中，本发明提供了通过LGR蛋白破坏功能性信号传导的生物分子，包括在某些实施方案中抑制一种或多种RSPO蛋白与一种或多种LGR蛋白如LGR5之间相互作用的分子。在某些实施方案中，本发明提供了治疗癌症的方法，包括破坏功能性LGR信号并抑制包含固体肿瘤干细胞的实体瘤的生长。

3. 发明授权

US08642740B2 Antibodies to lymphotoxin-alpha 失效
标题翻译：淋巴毒素-α抗体
公开(公告)号：US08642740B2
公开(公告)日：2014-02-04
申请号：US13543485
申请日：2012-07-06
申请人： Camellia W. Adams , Jane L. Grogan , Austin L. Gurney , Krista McCutcheon
发明人： Camellia W. Adams , Jane L. Grogan , Austin L. Gurney , Krista McCutcheon
IPC分类号： C07K16/00 , C12P21/08
CPC分类号： C07K16/242 , A61K2039/505 , C07K2317/24 , C07K2317/41 , C07K2317/565 , C07K2317/567 , C07K2317/732 , C07K2317/76 , C07K2317/92 , G06Q99/00
摘要： The invention provides various antibodies that bind to lymphotoxin-α, methods for making such antibodies, compositions and articles incorporating such antibodies, and their uses in treating, for example, an autoimmune disorder. The antibodies include murine, chimeric, and humanized antibodies.
摘要翻译：本发明提供了与淋巴毒素-α结合的各种抗体，制备此类抗体的方法，掺入此类抗体的组合物和制品及其在治疗例如自身免疫性疾病中的用途。抗体包括鼠，嵌合和人源化抗体。

4. 发明授权

US08551789B2 Frizzled-binding agents and their use in screening for WNT inhibitors 有权
标题翻译：卷曲结合剂及其在筛选WNT抑制剂中的应用
公开(公告)号：US08551789B2
公开(公告)日：2013-10-08
申请号：US13078728
申请日：2011-04-01
申请人： Austin L. Gurney
发明人： Austin L. Gurney
IPC分类号： G01N33/566 , C07K14/435 , C07K7/06 , C07K7/64
CPC分类号： C07K16/30 , C07K14/4702 , C07K14/71 , C07K16/28 , C07K2317/34 , C07K2317/55 , C07K2317/76 , C07K2317/92
摘要： Novel anti-cancer agents, including, but not limited to, antibodies and other polypeptides, that bind to human frizzled receptors are provided. Novel epitopes within the human frizzled receptors which are suitable as targets for anti-cancer agents are also identified. Methods of using the agents or antibodies, such as methods of using the agents or antibodies to inhibit Wnt signaling and/or inhibit tumor growth are further provided. Screening methods are also provided.
摘要翻译：提供了与人类卷曲受体结合的新型抗癌剂，包括但不限于抗体和其他多肽。还鉴定了适合作为抗癌剂靶标的人类卷曲受体中的新表位。进一步提供使用试剂或抗体的方法，例如使用该试剂或抗体抑制Wnt信号传导和/或抑制肿瘤生长的方法。还提供筛选方法。

5. 发明授权

US08541552B2 Antibodies to lymphotoxin-α 失效
标题翻译：淋巴毒素-α抗体
公开(公告)号：US08541552B2
公开(公告)日：2013-09-24
申请号：US13026123
申请日：2011-02-11
申请人： Camellia W. Adams , Jane L. Grogan , Austin L. Gurney , Krista McCutcheon
发明人： Camellia W. Adams , Jane L. Grogan , Austin L. Gurney , Krista McCutcheon
IPC分类号： C07K16/00 , C12P21/08
CPC分类号： C07K16/242 , A61K2039/505 , C07K2317/24 , C07K2317/41 , C07K2317/565 , C07K2317/567 , C07K2317/732 , C07K2317/76 , C07K2317/92 , G06Q99/00
摘要： The invention provides various antibodies that bind to lymphotoxin-α, methods for making such antibodies, compositions and articles incorporating such antibodies, and their uses in treating, for example, an autoimmune disorder. The antibodies include murine, chimeric, and humanized antibodies.
摘要翻译：本发明提供了与淋巴毒素-α结合的各种抗体，制备此类抗体的方法，掺入此类抗体的组合物和制品及其在治疗例如自身免疫性疾病中的用途。抗体包括鼠，嵌合和人源化抗体。

6. 发明授权

US08425903B2 Methods of treatment by administering antibodies to notch receptors 有权
标题翻译：通过向切口受体施用抗体来治疗的方法
公开(公告)号：US08425903B2
公开(公告)日：2013-04-23
申请号：US13472305
申请日：2012-05-15
申请人： Austin L. Gurney , Timothy Charles Hoey , Edward Thein Htun van der Horst , Aaron Ken Sato , Yuan Ching Liu , Maureen Fitch Bruhns , John A. Lewicki
发明人： Austin L. Gurney , Timothy Charles Hoey , Edward Thein Htun van der Horst , Aaron Ken Sato , Yuan Ching Liu , Maureen Fitch Bruhns , John A. Lewicki
IPC分类号： A61K39/395 , A61P35/00 , C07K16/28
CPC分类号： C07K16/22 , A61K31/337 , A61K39/3955 , A61K39/39558 , A61K45/06 , A61K2039/505 , A61N5/10 , C07H21/04 , C07K14/435 , C07K14/71 , C07K16/28 , C07K16/30 , C07K16/3046 , C07K16/462 , C07K16/464 , C07K2317/21 , C07K2317/24 , C07K2317/34 , C07K2317/56 , C07K2317/565 , C07K2317/73 , C07K2317/732 , C07K2317/734 , C07K2317/76 , C07K2317/92 , C12N5/0693 , C12N5/12 , C12N15/63 , C12N15/79 , C12N2501/998
摘要： The present invention relates to Notch-binding agents and Notch antagonists and methods of using the agents and/or antagonists for treating diseases such as cancer. The present invention provides antibodies that specifically bind to a non-ligand binding region of the extracellular domain of one or more human Notch receptor, such as Notch2 and/or Notch3, and inhibit tumor growth. The present invention further provides methods of treating cancer, the methods comprising administering a therapeutically effective amount of an antibody that specifically binds to a non-ligand binding region of the extracellular domain of a human Notch receptor protein and inhibits tumor growth.
摘要翻译：本发明涉及Notch结合剂和Notch拮抗剂以及使用这些药剂和/或拮抗剂治疗诸如癌症的疾病的方法。本发明提供了特异性结合一种或多种人Notch受体如Notch2和/或Notch3的细胞外结构域的非配体结合区并抑制肿瘤生长的抗体。本发明还提供了治疗癌症的方法，所述方法包括施用治疗有效量的特异性结合人Notch受体蛋白的细胞外结构域的非配体结合区的抗体并抑制肿瘤生长。

7. 发明申请

US20130045209A1 WNT-Binding Agents and Uses Thereof 审中-公开
标题翻译： WNT-结合剂及其用途
公开(公告)号：US20130045209A1
公开(公告)日：2013-02-21
申请号：US13521331
申请日：2011-01-12
申请人： Austin L. Gurney
发明人： Austin L. Gurney
IPC分类号： A61K39/395 , C07K16/46 , C12N1/21 , C12P21/08 , C12N5/10 , C07K16/18 , A61P35/00
CPC分类号： C07K16/22
摘要： Novel anti-cancer agents, including, but not limited to, antibodies, that bind to human Wnt(s) are provided. A conserved domain within Wnt that is suitable as a target for anti-cancer agents is also identified. Methods of using the agents or antibodies, such as methods of using the agents or antibodies to inhibit Wnt signaling and/or inhibit tumor growth are further provided.
摘要翻译：提供了与人Wnt结合的新型抗癌剂，包括但不限于抗体。还鉴定了适合作为抗癌剂靶标的Wnt内的保守结构域。进一步提供使用试剂或抗体的方法，例如使用该试剂或抗体抑制Wnt信号传导和/或抑制肿瘤生长的方法。

8. 发明申请

US20130011412A1 ANTIBODIES TO LYMPHOTOXIN-ALPHA 失效
标题翻译： LYMPHOTOXIN-ALPHA抗体
公开(公告)号：US20130011412A1
公开(公告)日：2013-01-10
申请号：US13543485
申请日：2012-07-06
申请人： Camellia W. Adams , Jane L. Grogan , Austin L. Gurney , Krista McCutcheon
发明人： Camellia W. Adams , Jane L. Grogan , Austin L. Gurney , Krista McCutcheon
IPC分类号： A61K39/395 , C07K16/46 , C12N15/13 , C12N15/63 , C12P21/02 , C12N5/10 , A61P1/00 , A61P21/00 , A61P3/10 , A61P1/16 , C12N1/21 , C07K16/24 , C12N5/071
CPC分类号： C07K16/242 , A61K2039/505 , C07K2317/24 , C07K2317/41 , C07K2317/565 , C07K2317/567 , C07K2317/732 , C07K2317/76 , C07K2317/92 , G06Q99/00
摘要： The invention provides various antibodies that bind to lymphotoxin-α, methods for making such antibodies, compositions and articles incorporating such antibodies, and their uses in treating, for example, an autoimmune disorder. The antibodies include murine, chimeric, and humanized antibodies.
摘要翻译：本发明提供了与淋巴毒素-α结合的各种抗体，制备此类抗体的方法，掺入此类抗体的组合物和制品及其在治疗例如自身免疫性疾病中的用途。抗体包括鼠，嵌合和人源化抗体。

9. 发明授权

US08226943B2 Antibodies to notch receptors 有权
标题翻译：抗缺陷受体的抗体
公开(公告)号：US08226943B2
公开(公告)日：2012-07-24
申请号：US12499627
申请日：2009-07-08
申请人： Austin L. Gurney , Timothy Charles Hoey , Edward Thein Htun van der Horst , Aaron Ken Sato , Yuan Ching Liu , Maureen Fitch Bruhns , John A. Lewicki
发明人： Austin L. Gurney , Timothy Charles Hoey , Edward Thein Htun van der Horst , Aaron Ken Sato , Yuan Ching Liu , Maureen Fitch Bruhns , John A. Lewicki
IPC分类号： A61K39/395 , C07K16/28 , C07K14/705 , C12N5/00
CPC分类号： C07K16/22 , A61K31/337 , A61K39/3955 , A61K39/39558 , A61K45/06 , A61K2039/505 , A61N5/10 , C07H21/04 , C07K14/435 , C07K14/71 , C07K16/28 , C07K16/30 , C07K16/3046 , C07K16/462 , C07K16/464 , C07K2317/21 , C07K2317/24 , C07K2317/34 , C07K2317/56 , C07K2317/565 , C07K2317/73 , C07K2317/732 , C07K2317/734 , C07K2317/76 , C07K2317/92 , C12N5/0693 , C12N5/12 , C12N15/63 , C12N15/79 , C12N2501/998
摘要： The present invention relates to Notch-binding agents and Notch antagonists and methods of using the agents and/or antagonists for treating diseases such as cancer. The present invention provides antibodies that specifically bind to a non-ligand binding region of the extracellular domain of one or more human Notch receptor, such as Notch2 and/or Notch3, and inhibit tumor growth. The present invention further provides methods of treating cancer, the methods comprising administering a therapeutically effective amount of an antibody that specifically binds to a non-ligand binding region of the extracellular domain of a human Notch receptor protein and inhibits tumor growth.
摘要翻译：本发明涉及Notch结合剂和Notch拮抗剂以及使用这些药剂和/或拮抗剂治疗诸如癌症的疾病的方法。本发明提供了特异性结合一种或多种人Notch受体如Notch2和/或Notch3的细胞外结构域的非配体结合区并抑制肿瘤生长的抗体。本发明还提供了治疗癌症的方法，所述方法包括施用治疗有效量的特异性结合人Notch受体蛋白的细胞外结构域的非配体结合区的抗体并抑制肿瘤生长。

10. 发明授权

US08216807B2 Antibodies to lymphotoxin-α 有权
标题翻译：淋巴毒素-α抗体
公开(公告)号：US08216807B2
公开(公告)日：2012-07-10
申请号：US13026069
申请日：2011-02-11
申请人： Camellia W. Adams , Jane L. Grogan , Austin L. Gurney , Krista McCutcheon
发明人： Camellia W. Adams , Jane L. Grogan , Austin L. Gurney , Krista McCutcheon
IPC分类号： C12P21/04 , C12N15/00 , C12N5/07 , C07H21/02 , C07H21/04
CPC分类号： C07K16/242 , A61K2039/505 , C07K2317/24 , C07K2317/41 , C07K2317/565 , C07K2317/567 , C07K2317/732 , C07K2317/76 , C07K2317/92 , G06Q99/00
摘要： The invention provides various antibodies that bind to lymphotoxin-α, methods for making such antibodies, compositions and articles incorporating such antibodies, and their uses in treating, for example, an autoimmune disorder. The antibodies include murine, chimeric, and humanized antibodies.
摘要翻译：本发明提供了与淋巴毒素-α结合的各种抗体，制备此类抗体的方法，掺入此类抗体的组合物和制品及其在治疗例如自身免疫性疾病中的用途。抗体包括鼠，嵌合和人源化抗体。

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