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    • 6. 发明授权
    • miRNAs as therapeutic targets in cancer
    • miRNA作为癌症治疗靶点
    • US08927207B2
    • 2015-01-06
    • US12996249
    • 2009-06-05
    • Jingfang JuBo SongYuan Wang
    • Jingfang JuBo SongYuan Wang
    • C12Q1/68C12N15/113
    • C12N15/1137A61K31/7088A61K45/06C12N15/113C12N15/1135C12N2310/113C12N2310/14C12N2320/31C12Q1/6886C12Q2600/136C12Q2600/178
    • MicroRNAs (miRNAs) are a class of non-coding small RNA molecules that regulate gene expression at the post-transcriptional level by interacting with 3′ untranslated regions (UTRs) of their target mRNAs. The invention relates to the application of miR-192 and miR-215. Both of these miRNAs impact cellular proliferation through the p53-miRNA circuit, and interact with dihydrofolate reductase (DHFR) and thymidylate synthase (TS). Particularly, upregulation of these miRNAs reduces cellular proliferation. The invention relates to this discovery. For example, inhibiting miR-192 and/or miR-215 sensitizes a neoplasm or a subject with a neoplasm to chemotherapeutic agents. Furthermore, measuring the levels of miR-192 and/or miR-215 provides one with information regarding whether the neoplasm or subject will respond to chemotherapeutic agents. Accordingly, the invention relates to composition and methods relating to the identification, characterization and modulation of the expression of miR-192 and miR-215.
    • 微RNA(miRNA)是一类非编码小RNA分子,通过与其靶mRNA的3'非翻译区(UTR)相互作用,在转录后水平调节基因表达。 本发明涉及miR-192和miR-215的应用。 这两种miRNA通过p53-miRNA电路影响细胞增殖,并与二氢叶酸还原酶(DHFR)和胸苷酸合酶(TS)相互作用。 特别地,这些miRNA的上调减少细胞增殖。 本发明涉及这一发现。 例如,抑制miR-192和/或miR-215使肿瘤或具有肿瘤的受试者对化学治疗剂敏感。 此外,测量miR-192和/或miR-215的水平提供了关于肿瘤或受试者是否将对化学治疗剂作出反应的信息。 因此,本发明涉及与miR-192和miR-215的表达的鉴定,表征和调节相关的组合物和方法。
    • 10. 发明授权
    • Multimedia device capable of detecting connection status of external display devices
    • 能够检测外部显示装置的连接状态的多媒体装置
    • US08253858B2
    • 2012-08-28
    • US12868740
    • 2010-08-26
    • Bo-Song Huang
    • Bo-Song Huang
    • H04N5/44H04N5/08
    • H04N21/4122H04N5/18H04N21/44231
    • A multimedia device generates and outputs video signals to a display component and an external display device, and includes a video output circuit and a load detection circuit. The load detection circuit isolates and buffers the video output circuit and the load detection circuit, and retrieves horizontal sync signals from the video signals. The load detection circuit further amplifies and integrates the retrieved horizontal sync signals to output direct current signals, and finally compares the direct current signals with a predetermined voltage to output a control signal indicating a connection between the video output circuit and the external display device. The multimedia device turns off the display component according to the control signal indicating that the video output circuit has been connected to the external display device.
    • 多媒体装置生成并将视频信号输出到显示部件和外部显示装置,并且包括视频输出电路和负载检测电路。 负载检测电路隔离并缓冲视频输出电路和负载检测电路,并从视频信号中检索水平同步信号。 负载检测电路进一步放大并积分所检索的水平同步信号以输出直流信号,并且最终将直流信号与预定电压进行比较,以输出指示视频输出电路和外部显示装置之间的连接的控制信号。 多媒体设备根据指示视频输出电路已经连接到外部显示设备的控制信号来关闭显示组件。