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1. 发明专利

IL255379D0 Temporary interatrial shunts 未知
公开(公告)号：IL255379D0
公开(公告)日：2017-12-31
申请号：IL25537917
申请日：2017-11-01
申请人： MEDICAL RES INFRASTRUCTURE & HEALTH SERVICES FUND TEL AVIV MEDICAL CT , GAD KEREN
发明人： GAD KEREN
IPC分类号： A61M20060101
摘要： Described embodiments include apparatus (28) that includes a shunt (26). The shunt includes a flared distal portion (40), a flared proximal portion (44), and an intermediate portion (42), disposed between the distal portion and the proximal portion. The apparatus further includes a constricting flexible longitudinal element (38) passing circumferentially along the intermediate portion of the shunt, configured to constrict the intermediate portion of the shunt, and one or more proximal-portion-collapsing flexible longitudinal elements (36) configured to collapse the proximal portion of the shunt. Other embodiments are also described.

2. 发明专利

IL244987D0 Cardiac prostheses and their deployment 未知
公开(公告)号：IL244987D0
公开(公告)日：2016-05-31
申请号：IL24498716
申请日：2016-04-07
申请人： MEDICAL RES INFRASTRUCTURE AND HEALTH SERVICES FUND OF THE TEL AVIV MEDICAL CENTER , GAD KEREN
发明人： GAD KEREN
IPC分类号： A61F20060101

3. 发明专利

IL176973D0 DEVICE AND METHOD FOR CONTROLLING IN-VIVO PRESSURE 未知
公开(公告)号：IL176973D0
公开(公告)日：2006-12-10
申请号：IL17697306
申请日：2006-07-20
申请人： ORI BRAUN , DAN ROTTENBERG , ASCHER SHMULEWITZ , ATRIA MEDICAL INC , AVRAHAM ABA ZAKAY , YORAM ROZY , GAD KEREN
IPC分类号： A61B20100101

4. 发明专利

AU8245101A Drug-eluting membrane for coronary artery stent 未知
公开(公告)号：AU8245101A
公开(公告)日：2002-02-25
申请号：AU8245101
申请日：2001-08-14
申请人： SHAYEN MEDICAL LTD , GAD KEREN
发明人： BARUCH DAVID , ROTMAN AVNER
IPC分类号： A61F2/00 , A61F2/07 , A61L31/06 , A61L31/16 , A61M25/00

5. 发明专利

AU7682600A Sildenafil preparation 未知
公开(公告)号：AU7682600A
公开(公告)日：2001-04-30
申请号：AU7682600
申请日：2000-10-05
申请人： SHLOMO LANIADO , NAFTALI STERN , GAD KEREN
发明人： LANIADO SHLOMO , STERN NAFTALI , KEREN GAD
IPC分类号： A61K31/52 , A61K31/00

6. 发明专利

IL244987A Cardiac prostheses and their deployment 未知
公开(公告)号：IL244987A
公开(公告)日：2019-10-31
申请号：IL24498716
申请日：2016-04-07
申请人： MEDICAL RES INFRASTRUCTURE & HEALTH SERVICES FUND TEL AVIV MEDICAL CT , GAD KEREN
发明人： GAD KEREN
IPC分类号： A61F2/24 , A61F2/95

7. 发明授权

US09067989B2 Eotaxin-2 (CCL24) inhibitors in inflammatory, autoimmune, and cardiovascular disorders 有权
标题翻译：嗜酸性粒细胞趋化因子-2（CCL24）抑制剂在炎症，自身免疫和心血管疾病中的作用
公开(公告)号：US09067989B2
公开(公告)日：2015-06-30
申请号：US13146711
申请日：2010-01-28
申请人： Jacob George , Gad Keren
发明人： Jacob George , Gad Keren
IPC分类号： A61K39/395 , A61K38/13 , A61K38/21 , C07K16/24 , A61K39/00
CPC分类号： C07K16/24 , A61K38/13 , A61K38/215 , A61K2039/505 , A61K2300/00
摘要： The presently described subject matter is based on the finding that inhibition of eotaxin-2 by polyclonal or monoclonal antibodies, has a significant protective effect in animal models of inflammatory diseases such as rheumatoid arthritis, experimental autoimmune encephalomyelitis (EAE), colitis, diabetes, and atherosclerosis. Thus, provided are pharmaceutical compositions including specific anti-eotaxin 2 antibodies for use alone or in combination with other therapeutic agents in the treatment of inflammatory, autoimmune and cardiovascular diseases. Also provided are specific anti-eotaxin-2 monoclonal antibodies, and methods of treatment utilizing such antibodies.
摘要翻译：目前描述的主题是基于以下发现：通过多克隆或单克隆抗体抑制嗜酸性粒细胞趋化因子-2在诸如类风湿性关节炎，实验性自身免疫性脑脊髓炎（EAE），结肠炎，糖尿病和炎性疾病的动物模型的动物模型中具有显着的保护作用动脉粥样硬化。因此，提供了药物组合物，其包括单独使用或与其它治疗剂组合用于治疗炎性，自身免疫性和心血管疾病的特异性抗 - 嗜酸性粒细胞趋化因子2抗体。还提供特异性抗 - 嗜酸性粒细胞趋化因子-2单克隆抗体，以及利用这种抗体的治疗方法。

8. 发明授权

US08091556B2 Methods and apparatus for reducing localized circulatory system pressure 有权
标题翻译：减少局部循环系统压力的方法和装置
公开(公告)号：US08091556B2
公开(公告)日：2012-01-10
申请号：US09839643
申请日：2001-04-20
申请人： Gad Keren , Randy Kesten
发明人： Gad Keren , Randy Kesten
IPC分类号： A61B19/00
CPC分类号： A61M27/006 , A61B17/00234 , A61B2017/00243 , A61B2017/00252 , A61F2/2412 , A61F2/2493 , A61M1/1008 , A61M1/101 , A61M1/1098 , A61M1/122 , A61M1/125 , A61M27/002
摘要： Methods and apparatus for decreasing cardiac pressure in a patient by implanting a shunt communicating with an area outside a first portion, whereby a volume of blood sufficient to reduce pressure in a first portion is released. Preferably, the end diastolic pressure in the left ventricle is reduced, which is accomplished by having the shunt communicate with the left ventricle so a small volume of blood is released from the left ventricle. Most preferably, the shunt selectively permits flow when a pressure differential between the left ventricle and another chamber of a heart above a threshold pressure, so that shunting is prevented during left ventricular systole, or, alternatively, selectively permits flow when a pressure differential between the left ventricle and another chamber of a heart is between a lower threshold and a higher threshold. In certain embodiments a semi-passive check-valve is controlled and actuated by an external signal.
摘要翻译：通过植入与第一部分之外的区域连通的分流器来降低患者心脏压力的方法和装置，由此释放足以减少第一部分中的压力的体积的血液。优选地，左心室的舒张末期压力降低，这是通过使分流器与左心室连通而实现的，因此从左心室释放少量的血液。最优选地，当左心室和心脏另一腔室之间的压差高于阈值压力时，分流器选择性地允许流动，使得在左心室收缩期间防止分流，或者当选择性地允许左心室和心脏的另一个腔室处于较低阈值和较高阈值之间。在某些实施例中，半被动止回阀由外部信号控制和致动。

9. 发明授权

US07780628B1 Apparatus and methods for treating congestive heart disease 失效
标题翻译：用于治疗充血性心脏病的装置和方法
公开(公告)号：US07780628B1
公开(公告)日：2010-08-24
申请号：US09562493
申请日：2000-05-01
申请人： Gad Keren , Ascher Shmulewitz , Benjamin Spenser , Michael Arad , Randy J. Kesten , Sophia Pesotchinsky , Michael H. Rosenthal , Andrew W. Kramer , Sam G. Payne
发明人： Gad Keren , Ascher Shmulewitz , Benjamin Spenser , Michael Arad , Randy J. Kesten , Sophia Pesotchinsky , Michael H. Rosenthal , Andrew W. Kramer , Sam G. Payne
IPC分类号： A61M29/00
CPC分类号： A61M25/00 , A61B17/12013 , A61B2017/00243 , A61B2017/061 , A61B2017/22054 , A61F2002/068 , A61M1/101 , A61M1/1018 , A61M1/1034 , A61M1/106 , A61M1/107 , A61M1/1072 , A61M1/1096 , A61M1/122 , A61M1/125 , A61M1/3653 , A61M1/3659 , A61M25/0075 , A61M25/10 , A61M25/1011 , A61M2025/1052 , A61M2210/1082 , A61M2210/125
摘要： Methods and apparatus are provided for treating congestive heart by actively or passively enhancing perfusion to the renal arteries. A first embodiment comprises a specially configured balloon catheter and extracorporeal pump, wherein the pump operates in a “once-through” fashion or alternating volume displacement mode. In another embodiment the catheter includes a pair of balloons to isolate a region of the aorta, and a third balloon that directs flow into the renal arteries. In still further embodiments, a stent or cuff having a constricted region is deployed in or around the aorta, respectively, to create a backpressure upstream of the stent or cuff. Methods of enhancing renal perfusion also are provided.
摘要翻译：提供了通过积极或被动地增强对肾动脉灌注的治疗充血性心脏的方法和装置。第一实施例包括特别配置的气囊导管和体外泵，其中泵以“一次通过”方式或交替容积位移模式操作。在另一个实施例中，导管包括一对隔离主动脉区域的气球和将流动引导到肾动脉的第三气囊。在另外的实施例中，具有收缩区域的支架或袖带分别展开在主动脉或其周围，以在支架或袖带的上游产生背压。还提供了增强肾脏灌注的方法。

10. 发明授权

US07335192B2 Apparatus and methods for treating congestive heart disease 有权
标题翻译：用于治疗充血性心脏病的装置和方法
公开(公告)号：US07335192B2
公开(公告)日：2008-02-26
申请号：US10438176
申请日：2003-05-13
申请人： Gad Keren , Ascher Shmulewitz , Benjamin Spenser , Michael Arad , Randy J Kesten , Sophia Pesotchinsky , Michael H. Rosenthal , Andrew W. Kramer , Sam G. Payne
发明人： Gad Keren , Ascher Shmulewitz , Benjamin Spenser , Michael Arad , Randy J Kesten , Sophia Pesotchinsky , Michael H. Rosenthal , Andrew W. Kramer , Sam G. Payne
IPC分类号： A61M31/00 , A61M29/00
CPC分类号： A61B17/1219 , A61B17/12013 , A61B17/12036 , A61B17/12045 , A61B17/12109 , A61B17/12136 , A61B2017/00243 , A61B2017/00898 , A61B2017/061 , A61B2017/22054 , A61F2002/068 , A61M1/1006 , A61M1/1008 , A61M1/101 , A61M1/1018 , A61M1/1034 , A61M1/1072 , A61M1/122 , A61M1/125 , A61M1/3653 , A61M1/3659 , A61M25/00 , A61M25/0075 , A61M25/10 , A61M25/1011 , A61M27/002 , A61M2025/1052 , A61M2210/1082 , A61M2210/125
摘要： Methods and apparatus are provided for treating congestive heart by actively or passively enhancing perfusion to the renal arteries. A first embodiment comprises a specially configured balloon catheter and extracorporeal pump, wherein the pump operates in a “once-through” fashion or alternating volume displacement mode. In another embodiment the catheter includes a pair of balloons to isolate a region of the aorta, and a third balloon that directs flow into the renal arteries. In still further embodiments, a stent or cuff having a constricted region is deployed in or around the aorta, respectively, to create a backpressure upstream of the stent or cuff. Methods of enhancing renal perfusion also are provided.
摘要翻译：提供了通过积极或被动地增强对肾动脉灌注的治疗充血性心脏的方法和装置。第一实施例包括特别配置的气囊导管和体外泵，其中泵以“一次通过”方式或交替容积位移模式操作。在另一个实施例中，导管包括一对隔离主动脉区域的气球和将流动引导到肾动脉的第三气囊。在另外的实施例中，具有收缩区域的支架或袖带分别展开在主动脉或其周围，以在支架或袖带的上游产生背压。还提供了增强肾脏灌注的方法。

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