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1. 发明专利

JP2014129409A Triazolopyridine compound as pim kinase inhibitor 审中-公开
标题翻译：三唑吡啶化合物作为PIM激酶抑制剂
公开(公告)号：JP2014129409A
公开(公告)日：2014-07-10
申请号：JP2014044674
申请日：2014-03-07
申请人： Array Biopharma Inc , アレイバイオファーマ、インコーポレイテッド
发明人： ALLEN SHELLEY , LAURA L CELESTE , T GREGG DAVIS , ROBERT KIRK DELISLE , JULIE MARIE GRESCHUK , STEFAN D GROSS , ERIK JAMES HICKEN , LEILA J JACKSON , LYSSIKATOS JOSEPH P , KALLEN NICHOLAS C , MARMSATER FREDRIK P , MUNSON MARK C , JED PHENEGER , RAST BRYSON , JOHN E ROBINSON , STEPHEN T SCHLACHTER , GEORGE T TOPALOV , A DALE WRIGHT , ZHAO QIAN
IPC分类号： C07D471/04 , A61K31/4709 , A61K31/55 , A61P1/04 , A61P17/00 , A61P25/00 , A61P29/00 , A61P35/00 , A61P37/06 , A61P43/00 , C07D519/00
CPC分类号： C07D471/04
摘要： PROBLEM TO BE SOLVED: To provide a novel triazolopyridine compound having a PIM kinase inhibition effect and useful for treatment of cancer, autoimmune disease, inflammatory disease and the like.SOLUTION: There is provided a compound represented by the formula I or pharmaceutically acceptable salt thereof. I, where A represents a C1 to 3 alkyloxy substituted by 4 to 7-membered heterocycle and the like, a C1 to 6 alkyloxy substituted by amino and the like, an amino substituted by 4 to 7-membered heterocycle and the like, and the like, B, Rto Rand Rare each independently H, F, Me and the like. cis-3-fluoropiperidine-4-yloxy, piperidine-3-ylmethoxy, 3-amino-2,2-dimethylpropane-1-yloxy, (piperidine-4-yl)amino and the like are preferable as the A.
摘要翻译：要解决的问题：提供具有PIM激酶抑制作用的新型三唑并吡啶化合物，可用于治疗癌症，自身免疫疾病，炎症性疾病等。溶液：提供由式I表示的化合物或其药学上可接受的盐。 I，其中A表示被4至7元杂环等取代的C1至3烷氧基，由氨基等取代的C1至6烷氧基，由4-至7-元杂环取代的氨基等，像B，Rto Rand Rare各自独立地是H，F，Me等。顺式-3-氟哌啶-4-基氧基，哌啶-3-基甲氧基，3-氨基-2,2-二甲基丙烷-1-基氧基，（哌啶-4-基）氨基等优选为A.

2. 发明申请

WO2007027855A3 RAF INHIBITOR COMPOUNDS AND METHODS OF USE THEREOF 审中-公开
标题翻译： RAF抑制剂化合物及其使用方法
公开(公告)号：WO2007027855A3
公开(公告)日：2007-05-03
申请号：PCT/US2006033976
申请日：2006-08-31
申请人： ARRAY BIOPHARMA INC , MIKNIS GREG , LYSSIKATOS JOSEPH P , LAIRD ELLEN , TARLTON EUGENE , BUCKMELTER ALEXANDRE J , REN LI , RAST BRYSON , SCHLACTER STEPHEN T , WENGLOWSKY STEVEN MARK
发明人： MIKNIS GREG , LYSSIKATOS JOSEPH P , LAIRD ELLEN , TARLTON EUGENE , BUCKMELTER ALEXANDRE J , REN LI , RAST BRYSON , SCHLACTER STEPHEN T , WENGLOWSKY STEVEN MARK
IPC分类号： C07D495/04 , A61K31/4355 , A61K31/4365 , A61P35/00 , C07D491/04
CPC分类号： C07D491/04 , C07D495/04
摘要： Compounds of Formula I are useful for inhibiting Raf kinase and for treating disorders mediated thereby. Methods of using compounds of Formula I, and stereoisomers, geometric isomers, tautomers, solvates and pharmaceutically acceptable salts thereof, for in vitro, in situ, and in vivo diagnosis, prevention or treatment of such disorders in mammalian cells, or associated pathological conditions are disclosed.
摘要翻译：式I化合物可用于抑制Raf激酶和治疗由其介导的病症。使用式I化合物及其立体异构体，几何异构体，互变异构体，溶剂合物和药学上可接受的盐用于体外，原位和体内诊断，预防或治疗哺乳动物细胞中这些病症或相关病理学病症的方法是披露。

3. 发明专利

CA2734831C TRIAZOLOPYRIDINE COMPOUNDS AS PIM KINASE INHIBITORS 未知
公开(公告)号：CA2734831C
公开(公告)日：2017-04-18
申请号：CA2734831
申请日：2009-08-18
申请人： ARRAY BIOPHARMA INC
发明人： ALLEN SHELLEY , CELESTE LAURA L , DAVIS T GREGG , DELISLE ROBERT KIRK , GRESCHUK JULIE MARIE , GROSS STEFAN D , HICKEN ERIK JAMES , JACKSON LEILA J , LYSSIKATOS JOSEPH P , KALLAN NICHOLAS C , MARMSAETER FREDRIK P , MUNSON MARK C , PHENEGER JED , RAST BRYSON , ROBINSON JOHN E , SCHLACHTER STEPHEN T , TOPALOV GEORGE T , WRIGHT A DALE , ZHAO QIAN
IPC分类号： C07D471/04 , A61K31/47
摘要： Compounds of Formula (I), in which A, B, R1, R1a, R2, R3, R4, R5, R6, and R7 have the meanings given in the specification, are receptor tyrosine inhibitors useful in the treatment of immune cell-associated diseases and disorders, such as inflammatory and autoimmune diseases.

4. 发明专利

CY1114592T1 ΕΝΩΣΕΙΣ ΤΡΙΑΖΟΛΟΠΥΡΙΔΙΝΗΣ ΩΣ ΑΝΑΣΤΟΛΕΙΣ ΚΙΝΑΣΗΣ PIM 未知
公开(公告)号：CY1114592T1
公开(公告)日：2016-10-05
申请号：CY131100995
申请日：2013-11-08
申请人： ARRAY BIOPHARMA INC
发明人： ALLEN SHELLEY , CELESTE LAURA L , DAVIS T GREGG , DELISLE ROBERT KIRK , GRESCHUK JULIE MARIE , GROSS STEFAN D , HICKEN ERIK JAMES , JACKSON LEILA J , LYSSIKATOS JOSEPH P , KALLAN NICHOLAS C , MARMSΑTER FREDRIK P , MUNSON MARK C , PHENEGER JED , RAST BRYSON , ROBINSON JOHN E , SCHLACHTER STEPHEN T , TOPALOV GEORGE T , WRIGHT A DALE , ZHAO QIAN
IPC分类号： C07D471/04 , A61K31/47
摘要： ΕνώσειςτουΤύπου (Ι), όπουταΑ, Β, R1, R1a, R2, R3, R4, R5, R6 και R7 έχουντιςέννοιεςπουδίδονταιστηνπροδιαγραφή, είναιαναστολείςυποδοχέατυροσίνηςχρήσιμοιστηθεραπείαασθενειώνκαιδιαταραχώνπουσυνδυάζονταιμεανοσοκύτταρο, όπωςφλεγμονωδώνκαιαυτοάνοσωνδιαταραχών.

5. 发明专利

SMT201400154B 未知
公开(公告)号：SMT201400154B
公开(公告)日：2015-01-15
申请号：SM201400154
申请日：2014-10-21
申请人： ARRAY BIOPHARMA INC
发明人： DELISLE ROBERT KIRK , MUNSON MARK C , RAST BRYSON , TOPALOV GEORGE T , ZHAO QIAN , ALLEN SHELLEY , CELESTE LAURA L , DAVIS GREGG T , GRESCHUK JULIE MARIE , GROSS STEFAN D , HICKEN ERIK JAMES , JACKSON LEILA J , LYSSIKATOS JOSEPH P , KALLAN NICHOLAS C , MARMSATER FREDRIK P , PHENEGER JED , ROBINSON JOHN E , SCHLACHTER STEPHEN T , WRIGHT DALE A
摘要： Compounds of Formula (I), in which A, B, R1, R1a, R2, R3, R4, R5, R6, and R7 have the meanings given in the specification, are receptor tyrosine inhibitors useful in the treatment of immune cell-associated diseases and disorders, such as inflammatory and autoimmune diseases.

8. 发明专利

ES2494590T3 Compuestos de N-(1H-Indazol-4-il)imidazo[1,2-a]piridin-3-carboxamida sustituida como inhibidores de cFMS 未知
公开(公告)号：ES2494590T3
公开(公告)日：2014-09-15
申请号：ES10798683
申请日：2010-12-20
申请人： ARRAY BIOPHARMA INC
发明人： BOYS MARK LAURENCE , BRADLEY MICHAEL F , DELISLE ROBERT KIRK , HENNINGS D DAVID , KENNEDY APRIL L , MARMSATER FREDRIK P , MEDINA MATTHEW DAVID , MUNSON MARK C , RAST BRYSON , RIZZI JAMES P , RODRIGUEZ MARTHA E , TOPALOV GEORGE T , ZHAO QIAN
IPC分类号： C07D471/04 , A61K31/437 , A61K31/4985 , A61P9/00 , A61P19/08 , A61P29/00 , A61P35/00 , C07D519/00
摘要： Compuesto que tiene la fórmula general I o una sal farmacéuticamente aceptable del mismo, en el que: R1 es hetAr1CH2-, hetAr2CH2-, (cicloalquilo C3-6)-CH2-, tetrahidropiranilCH2-, bencilo que está opcionalmente sustituido con alcoxi(C1-4), o (N-alquilo C1-3)piridinonil-CH2- que está opcionalmente sustituido con uno o más sustituyentes seleccionados independientemente de alquilo(C1-6); hetAr1 es piridilo opcionalmente sustituido con uno o más sustituyentes seleccionados independientemente de entre alquilo(1-6C), alcoxi(C1-4), halógeno, hetCyc1, hetCyc1-CH2-, aminoalcoxi(C2-4), [di(alquil C1- 3)amino]alcoxi(C2-4), dihidroxialcoxi(C3-4), hetCyc2O-, hetCyc2a15 alcoxi(C1-2) y OH; hetCyc1 es un heterociclo de 6 miembros que tiene 1-2 átomos de N anulares, y opcionalmente sustituido con NH2; hetCyc2 y hetCyc2a 20 son independientemente un heterociclo de 5-6 miembros que tiene 1-2 átomos de N anulares y opcionalmente sustituido con uno o más sustituyentes seleccionados independientemente de alquilo(C1-6), OH, y halógeno; hetAr2 es un anillo heteroarílico de 5 miembros que tiene 2-3 heteroátomos anulares seleccionados independientemente de entre N, S y O en el que al menos uno de dichos heteroátomos es N, en el que dicho anillo está opcionalmente sustituido con uno o más sustituyentes seleccionados independientemente de entre alquilo(C1-6), hidroxialquilo(C2-4), dihidroxialquilo(C3-4), (cicloalquilo C3-6)CH2-, hetCyc3, hetCyc3aalquilo(C1-2), y bencilo opcionalmente sustituido con alcoxi(C1-4); hetCyc3 y hetCyc3a son independientemente un anillo heterocíclico de 6 miembros que tiene 1-2 átomos de N anulares y opcionalmente sustituido con un halógeno; R2 es alquilo(C2-4), ciclopropilo, OMe, I o Br; R3 es H o Cl; R4 es H o CN; R5 es H, halógeno, OH, hetAr3, hetAr4, N-(alquilo C1-3)piridinona, hetAr5, hetCyc4, hetCyc5C(>=O)-, hetCyc6(alquilo C1-4)-, hetCyc7alcoxi(C1-4), (hetCyc8)-O-, hetCyc940 alcoxi(C1-4), (alcoxi C1-3)alcoxi(C1-4), hidroxialcoxi(C1-4), dihidroxialcoxi(C2-4), difluoroaminoalcoxi(C1-4), [di(alquil C1-3)amino]alcoxi(C1-4), [(alcoxi C1-4)carbonilamida]difluoroalcoxi(C1-4), (alquilo C1-4)C(>=O)NHalquiltio(C2-4)-, (alquilo C1-4)OC(>=O)-, (alquilo C1-4)C(>=O)-, hidroxialquilo(C1-4), [hidroxialquil(C2-4))amino]-alquilo(C1-4), [(alcoxi C1-4)(alquilo C1- 4)amino]alquilo(C1-4), [di(alquilo C1-4)amino]alquilo(C1-4), R'R"NC(>=O)-, alquiltio C1-6, benciloxi, [hidroxialcoxi(C1-4)]alcoxi(C1-4), o [(alqueniloxi C2-4)alcoxi(C1-4)]alcoxi(C1-4).

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