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1. 发明授权

US06940065B2 Method for characterizing biomolecules utilizing a result driven strategy 失效
标题翻译：利用结果驱动策略表征生物分子的方法
公开(公告)号：US06940065B2
公开(公告)日：2005-09-06
申请号：US10646371
申请日：2003-08-22
申请人： Armin Graber , Dale H. Patterson , Peter Juhasz , Stephen A. Martin
发明人： Armin Graber , Dale H. Patterson , Peter Juhasz , Stephen A. Martin
IPC分类号： G01N27/62 , B01D59/44 , G01N27/64 , G01N30/84 , G01N33/68 , H01J49/00
CPC分类号： H01J49/004 , G01N33/6803 , G01N2030/8417 , H01J49/0027 , G01N30/7233
摘要： In various embodiments, the methods for analyzing a sample are provided utilizing a result dependent acquisition strategy. In various embodiments, methods for analyzing a sample are provided wherein the sample is first analyzed by MALDI and MS to produce a first result that is then used to determine a second analysis that is used to analyze the sample again by MALDI and MS/MS or MSn to produce a second result.
摘要翻译：在各种实施例中，利用结果依赖获取策略来提供用于分析样本的方法。在各种实施方案中，提供了用于分析样品的方法，其中首先通过MALDI和MS分析样品以产生第一结果，然后将其用于确定用于通过MALDI和MS / MS再次分析样品的第二分析，或 MS ^{n 以产生第二结果。}

2. 发明授权

US5917184A Interface between liquid flow and mass spectrometer 失效
标题翻译：液体流量与质谱仪之间的界面
公开(公告)号：US5917184A
公开(公告)日：1999-06-29
申请号：US797088
申请日：1997-02-07
申请人： William W. Carson , Stephen C. Gabeler , Yin Liang F. Hsieh , Stephen A. Martin , Michael J. Tomany , Anotoli Verentchikov
发明人： William W. Carson , Stephen C. Gabeler , Yin Liang F. Hsieh , Stephen A. Martin , Michael J. Tomany , Anotoli Verentchikov
IPC分类号： H01J49/04 , H01J49/10
CPC分类号： H01J49/044 , H01J49/165
摘要： An interface apparatus for introducing a sample for analysis from a liquid flow into a mass spectrometer as a plurality of charged droplets is disclosed. The interface apparatus includes interface body which defines a spray chamber and an orifice, a spray means defining a liquid-flow inlet channel and an excess-sample-flow exit channel and having an open end disposed inside the spray chamber, and a voltage device for applying a voltage to the sample to form a plurality of charged droplets. The charged droplets pass through the orifice in the interface body and are introduced into a mass spectrometer for analysis. The interface includes a valve for regulating the flow of sample into the sample inlet channel and a device for imposing a pressure gradient on the sample at the open end which induces the sample to flow from the sample inlet channel through the excess sample outlet channel.
摘要翻译：公开了一种用于将用于分析的样品从液体流引入质谱仪作为多个带电液滴的界面装置。接口装置包括限定喷雾室和孔口的界面体，限定液流入口通道的喷射装置和多余样品流出口通道，并且具有设置在喷雾室内部的开口端;以及电压装置，向样品施加电压以形成多个带电液滴。带电液滴通过界面体中的孔口，并引入质谱仪进行分析。该界面包括用于调节样品流入样品入口通道的阀和用于在开口端施加样品上的压力梯度的装置，其引起样品从样品入口通道流过多余的样品出口通道。

3. 发明授权

US5263484A Method of determining which portion of a stress sensor is best positioned for use in determining intra-arterial blood pressure 失效
标题翻译：确定应力传感器的哪个部分最佳定位以用于确定动脉内血压的方法
公开(公告)号：US5263484A
公开(公告)日：1993-11-23
申请号：US835634
申请日：1992-02-13
申请人： Stephen A. Martin , Robert D. Butterfield
发明人： Stephen A. Martin , Robert D. Butterfield
IPC分类号： A61B5/022 , A61B5/021 , A61B5/02
CPC分类号： A61B5/021
摘要： A method, for use in a non-invasive blood pressure monitoring system, of determining which portion of a stress sensitive element of a tissue stress sensor is best located for detecting the stress of tissue overlying an artery of interest. The tissue stress sensor is placed in communication with tissue overlying the artery of interest and a plurality of electrical signals are obtained therefrom representing stress data across the length of the stress sensitive element. Each electrical signal represents stress datum communicated to a predetermined portion of the stress sensitive element. From the stress datum, a centroid of energy is computed and the centroid of energy is used to determine which portion of the stress sensitive element is best located for determining the blood pressure within the artery of interest. A second method is disclosed which uses the centroid of a tissue foundation flexibility function to determine the best location along the stress sensitive element for determining blood pressure.
摘要翻译：一种用于非侵入式血压监测系统的方法，用于确定组织应力传感器的应力敏感元件的哪个部分最适合用于检测覆盖在感兴趣动脉上的组织的应力。将组织应力传感器置于与感兴趣的动脉相邻的组织的连通中，并且获得多个电信号，表示跨过应力敏感元件长度的应力数据。每个电信号表示传递到应力敏感元件的预定部分的应力基准。从应力数据中，计算能量的质心，并且使用能量的质心来确定应力敏感元件的哪个部分最适合于确定感兴趣动脉内的血压。公开了使用组织基础柔性功能的质心来确定沿应力敏感元件的最佳位置以确定血压的第二种方法。

4. 发明授权

US06290650B1 Tonometry system for monitoring blood pressure 有权
标题翻译：用于监测血压的血压计系统
公开(公告)号：US06290650B1
公开(公告)日：2001-09-18
申请号：US09321907
申请日：1999-05-28
申请人： Robert D. Butterfield , Kenneth J. Pytel , Charles R. Holdaway , Stephen A. Martin
发明人： Robert D. Butterfield , Kenneth J. Pytel , Charles R. Holdaway , Stephen A. Martin
IPC分类号： A61B502
CPC分类号： A61B5/021
摘要： A system for noninvasively continuously monitoring arterial blood pressure includes a tissue stress sensor that has a continuous diaphragm for sensing stress within tissue adjacent a preselected artery caused by arterial pulsations within that artery. The stress sensitive diaphragm is coupled with electromechanical means for producing electrical signals that represent the stress within the tissue that is communicated to the sensor. These signals are then processed electronically in order to yield an output that is indicative of the arterial blood pressure of the preselected artery. The disclosed system includes methods of operation for determining blood pressure while maintaining a preselected artery in an optimum applanation state and an off-optimum applanation state.
摘要翻译：用于非侵入性连续监测动脉血压的系统包括组织应力传感器，其具有用于感测由该动脉内的动脉脉动引起的预选动脉附近的组织内的应力的连续膜片。应力敏感隔膜与机电装置相结合，用于产生表示组织内传递到传感器的应力的电信号。然后电子地处理这些信号，以产生指示预选动脉的动脉血压的输出。所公开的系统包括用于确定血压的操作的方法，同时保持预选动脉处于最佳压扁状态和不合适的压扁状态。

5. 发明授权

US5617867A Tonometer mounting device 失效
标题翻译：眼压计安装装置
公开(公告)号：US5617867A
公开(公告)日：1997-04-08
申请号：US344252
申请日：1994-11-23
申请人： Robert D. Butterfield , Charles R. Holdaway , Stephen A. Martin , Stanley J. Boyer , Christine A. Giurdanella-Renzi
发明人： Robert D. Butterfield , Charles R. Holdaway , Stephen A. Martin , Stanley J. Boyer , Christine A. Giurdanella-Renzi
IPC分类号： A61B5/021 , A61B5/00
CPC分类号： A61B5/021
摘要： A device for mounting a tonometry sensor upon a patient's wrist includes a base portion that is specifically adapted to generally conform to the patient's wrist while providing a stable placement of the tonometry sensor relative to a preselected artery. A sensor housing is movably mounted upon the base portion and configured such that the mounting device has an essentially equal thickness at each end of the device. A strap member is provided for releasably securing the mounting device to a patient's wrist. The mounting device facilitates more accurate, non-invasive blood pressure measurement by providing a stable placement of the tonometry sensor relative to the tissue overlying a preselected artery at a measurement location and, further, limits undesirable movement by the patient to thereby reduce undesirable error in the blood pressure measurement.
摘要翻译：用于将眼压测量传感器安装在患者腕部上的装置包括基部，该基部特别地适于大体上符合患者的手腕，同时提供相对于预选动脉的眼压测量传感器的稳定放置。传感器壳体可移动地安装在基座部分上并且构造成使得安装装置在装置的每个端部具有基本相等的厚度。提供带构件用于将安装装置可释放地固定到患者的手腕上。安装装置通过提供眼压计传感器相对于在测量位置处覆盖预选动脉的组织的稳定放置来促进更准确的无创血压测量，并且还限制了患者的不期望的运动，从而减少不期望的误差血压测量。

6. 发明授权

US5273046A Method of determining optimum artery applanation 失效
标题翻译：确定最佳动脉压扁的方法
公开(公告)号：US5273046A
公开(公告)日：1993-12-28
申请号：US869553
申请日：1992-04-15
申请人： Robert D. Butterfield , Stephen A. Martin
发明人： Robert D. Butterfield , Stephen A. Martin
IPC分类号： A61B5/022 , A61B5/02
CPC分类号： A61B5/021 , A61B2562/0247
摘要： A method, for use in a non-invasive blood pressure monitoring system, of determining optimum artery applanation. The system uses a stress sensor including a stress sensitive element for detecting stress of tissue overlying an artery of interest. The tissue stress sensor is placed in communication with tissue overlying the artery of interest and at least one electrical signal is obtained therefrom representing stress data across the length of the stress sensitive element. The data represents stress datum communicated to a preselected portion of the stress sensitive element. From the stress datum, various algorithms are used, singly or in combination, to provide the best measure of optimum applanation state. Intra-arterial blood pressure is then calculated using datum collected at the optimum applanation state. In addition, to the optimum applanation methods, a method is disclosed for determining which portion of the stress sensitive element is best suited for estimating intra-arterial blood pressure.
摘要翻译：一种用于非侵入性血压监测系统的方法，用于确定最佳动脉压扁。该系统使用包括应力敏感元件的应力传感器来检测感兴趣的动脉上方的组织的压力。将组织应力传感器置于与感兴趣的动脉相邻的组织的连通中，并且获得至少一个电信号，表示跨过应力敏感元件长度的应力数据。数据表示传递给应力敏感元件的预选部分的应力基准。从应力数据，单独或组合使用各种算法，以提供最佳压平状态的最佳测量。然后使用在最佳压扁状态下收集的数据计算动脉内血压。另外，对于最佳压平方法，公开了一种用于确定应力敏感元件的哪一部分最适合于估计动脉内血压的方法。

7. 发明授权

US5563347A Pressure sensing vessel adapted to be preloaded against a sensor 失效
标题翻译：压力传感容器适于预先装载在传感器上
公开(公告)号：US5563347A
公开(公告)日：1996-10-08
申请号：US305465
申请日：1994-09-12
申请人： Stephen A. Martin , Robert D. Butterfield , Charles E. Clemens
发明人： Stephen A. Martin , Robert D. Butterfield , Charles E. Clemens
IPC分类号： G01L7/08 , G01L7/00 , G01L19/14
CPC分类号： G01L19/14
摘要： A pumping segment for incorporation into a fluid delivery system, the segment having a dome-shaped pressure vessel with an optimal shape for interfacing with a pressure sensing element, and which is capable of uniformly distributing pressure across its interfacing structure and being optimally pre-loaded against the pressure sensing element. The pumping segment including a lateral restraint to inhibit rupture of the unloaded pressure vessel when experiencing high internal pressures.
摘要翻译：用于结合到流体输送系统中的泵送段，所述段具有具有用于与压力感测元件接合的最佳形状的圆顶形压力容器，并且能够均匀地在其界面结构上分配压力并且被最佳预加载抵靠压力传感元件。泵送段包括横向约束，以在经历高内压时抑制无负载的压力容器的破裂。

8. 发明授权

US5284150A Tonometry system for determining blood pressure 失效
标题翻译：用于测定血压的血压计系统
公开(公告)号：US5284150A
公开(公告)日：1994-02-08
申请号：US962364
申请日：1992-10-16
申请人： Robert D. Butterfield , Kenneth J. Pytel , Charles R. Holdaway , Stephen A. Martin
发明人： Robert D. Butterfield , Kenneth J. Pytel , Charles R. Holdaway , Stephen A. Martin
IPC分类号： A61B5/022 , A61B5/0225 , A61B5/024 , G01L7/00 , G01L9/00 , A61B5/021
CPC分类号： A61B5/021 , A61B5/02422 , A61B2560/0252 , A61B2562/0247 , A61B2562/043 , A61B5/7203
摘要： A tissue contact stress sensing system incorporates a semiconductor assembly and a continuous diaphragm to noninvasively determine the intra-arterial blood pressure of a patient. The system comprises a continuous diaphragm placed against a patient's tissue which covers an underlying artery. The semiconductor assembly is placed in close proximity to and spaced apart from the diaphragm for directly irradiating the diaphragm with electromagnetic radiation and receiving a portion of the electromagnetic radiation which is reflected from the continuous diaphragm. The disclosed system also utilizes a technique for minimizing the system errors associated with temperature drift and aging of the sensor.
摘要翻译：组织接触应力感测系统包括半导体组件和连续隔膜以非侵入性地确定患者的动脉内血压。该系统包括一个连续的隔膜，该隔膜相对于覆盖下面动脉的患者组织放置。半导体组件被放置在与隔膜紧密并且间隔开的位置，以便用电磁辐射直接照射隔膜并且接收从连续隔膜反射的电磁辐射的一部分。所公开的系统还利用用于最小化与传感器的温度漂移和老化相关的系统误差的技术。

9. 发明授权

US5195522A Tonometry sensor calibration apparatus 失效
标题翻译：眼压计传感器校准装置
公开(公告)号：US5195522A
公开(公告)日：1993-03-23
申请号：US717224
申请日：1991-06-18
申请人： Kenneth J. Pytel , Stephen A. Martin , Robert D. Butterfield
发明人： Kenneth J. Pytel , Stephen A. Martin , Robert D. Butterfield
IPC分类号： A61B5/021 , A61B5/022 , A61B5/0225 , A61B5/024
CPC分类号： A61B5/02422 , A61B5/021 , A61B5/02241 , A61B2560/0223
摘要： A calibration apparatus for use in calibrating a tissue stress sensor used in a blood pressure monitoring system. The calibration apparatus includes a calibration head which is adapted to be retained in close proximity to a tissue stress sensor. The calibration head includes means for heating the tissue stress sensor. A calibration system is also disclosed for calibrating a blood pressure monitoring system, the blood pressure monitoring system employing a stress sensor for generating an electric output signal representative of tissue stress data. The calibration system comprises a tissue stress sensor having a displaceable diaphragm and a sealed chamber. The chamber has a continuous wall defining an inner volume and an outer volume. The displaceable diaphragm comprises a portion of the continuous wall, whereby the displaceable diaphragm is responsive to a pressure differential between the inner chamber volume and the outer chamber volume. The vacuum means is fluidly coupled to the inner volume of the sealed chamber for applying a controlled vacuum to the inner volume of the chamber whereby the diaphragm is displaced in response to the application of the vacuum. Calibration means is provided for detecting the sensors response to heating and displacing of the sensor diaphragm and for generating corrective data for use in correcting the effects of sensor temperture on the data generated by the sensor.
摘要翻译：一种用于校准在血压监测系统中使用的组织应力传感器的校准装置。校准装置包括校准头，其适于保持紧靠组织应力传感器。校准头包括用于加热组织应力传感器的装置。还公开了一种用于校准血压监测系统的校准系统，所述血压监测系统采用应力传感器来产生代表组织应力数据的电输出信号。校准系统包括具有可移动隔膜和密封室的组织应力传感器。该室具有限定内容积和外容积的连续壁。可移动隔膜包括连续壁的一部分，由此可移动隔膜响应于内室容积和外室体积之间的压力差。真空装置流体耦合到密封室的内部容积，用于将受控制的真空施加到室的内部容积，由此隔膜响应于真空的应用而移位。提供了校准装置，用于检测传感器对传感器隔膜的加热和移位的响应，并产生用于校正传感器温度对传感器产生的数据的影响的校正数据。

10. 发明授权

US4668216A System for mounting a drop sensor to a drip chamber 失效
标题翻译：将滴液传感器安装到滴水室的系统
公开(公告)号：US4668216A
公开(公告)日：1987-05-26
申请号：US710044
申请日：1985-03-11
申请人： Stephen A. Martin , Terry L. Landis , Richard A. Bizzigotti
发明人： Stephen A. Martin , Terry L. Landis , Richard A. Bizzigotti
IPC分类号： A61M5/168 , A61M1/00
CPC分类号： A61M5/1689 , A61M2205/6045
摘要： The invention is directed to an improved system for mounting a drop sensor onto a drip chamber having laterally projecting wing-like or flange-like extensions. A pair of mounting members, one fixed, one laterally movable, are provided on the drop sensor housing. The mounting members have inclined guiding surfaces which cradle both ends of the lateral extensions on the drip chamber during the initial stages of mounting the drop sensor to the drip chamber and guide drop sensor movement with respect to the drip chamber to its final mounted position thereon. The mounting system is particularly adapted to dedicated IV set and drop sensor combinations.
摘要翻译：本发明涉及一种用于将液滴传感器安装到具有侧向突出的翼状或凸缘状延伸部的滴水室上的改进系统。在液滴传感器壳体上设有一对安装构件，一个固定的，一个横向可移动的。安装构件具有倾斜的引导表面，其在将滴液传感器安装到滴水室的初始阶段期间，将滴液传感器相对于滴水室的运动引导到其最终安装位置，从而将滴液室上的侧向延伸部的两端支撑起来。安装系统特别适用于专用的IV设定和落下传感器组合。

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