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1. 发明授权

US5917184A Interface between liquid flow and mass spectrometer 失效
标题翻译：液体流量与质谱仪之间的界面
公开(公告)号：US5917184A
公开(公告)日：1999-06-29
申请号：US797088
申请日：1997-02-07
申请人： William W. Carson , Stephen C. Gabeler , Yin Liang F. Hsieh , Stephen A. Martin , Michael J. Tomany , Anotoli Verentchikov
发明人： William W. Carson , Stephen C. Gabeler , Yin Liang F. Hsieh , Stephen A. Martin , Michael J. Tomany , Anotoli Verentchikov
IPC分类号： H01J49/04 , H01J49/10
CPC分类号： H01J49/044 , H01J49/165
摘要： An interface apparatus for introducing a sample for analysis from a liquid flow into a mass spectrometer as a plurality of charged droplets is disclosed. The interface apparatus includes interface body which defines a spray chamber and an orifice, a spray means defining a liquid-flow inlet channel and an excess-sample-flow exit channel and having an open end disposed inside the spray chamber, and a voltage device for applying a voltage to the sample to form a plurality of charged droplets. The charged droplets pass through the orifice in the interface body and are introduced into a mass spectrometer for analysis. The interface includes a valve for regulating the flow of sample into the sample inlet channel and a device for imposing a pressure gradient on the sample at the open end which induces the sample to flow from the sample inlet channel through the excess sample outlet channel.
摘要翻译：公开了一种用于将用于分析的样品从液体流引入质谱仪作为多个带电液滴的界面装置。接口装置包括限定喷雾室和孔口的界面体，限定液流入口通道的喷射装置和多余样品流出口通道，并且具有设置在喷雾室内部的开口端;以及电压装置，向样品施加电压以形成多个带电液滴。带电液滴通过界面体中的孔口，并引入质谱仪进行分析。该界面包括用于调节样品流入样品入口通道的阀和用于在开口端施加样品上的压力梯度的装置，其引起样品从样品入口通道流过多余的样品出口通道。

2. 发明申请

US20100148057A1 Device And Method For Analyzing A Sample 有权
标题翻译：用于分析样品的装置和方法
公开(公告)号：US20100148057A1
公开(公告)日：2010-06-17
申请号：US12524620
申请日：2008-02-01
申请人： Joseph A. Jarrell , Michael J. Tomany
发明人： Joseph A. Jarrell , Michael J. Tomany
IPC分类号： H01J49/04 , H01J49/26 , H01J49/02
CPC分类号： H01J49/0463
摘要： Embodiments of the invention relate to a device for analysing a sample surface Comprising an outlet and a frame. The outlet is for forming a jet of gas, the jet forming a sampling region for receiving one or more sample surfaces, and the frame holding the outlet and being adapted to receive a detector means. The detector means has an inlet. In use, the jet produces desorbed sample from sample surfaces received in the sample area. At least a portion of the desorbed sample is ionized to produce one or more sample ions. The frame holds the outlet with respect to the sample ions and produce a signal indicative of the composition of the sample ions.
摘要翻译：本发明的实施例涉及一种用于分析包括出口和框架的样品表面的装置。出口用于形成气体射流，喷射形成用于接收一个或多个样品表面的采样区域，并且保持出口的框架适于接收检测器装置。检测器装置具有入口。在使用中，喷射器从样品区域中接收的样品表面产生解吸样品。解吸的样品的至少一部分被离子化以产生一个或多个样品离子。框架相对于样品离子保持出口，并产生指示样品离子的组成的信号。

3. 发明授权

US06558744B2 Enhanced resolution matrix-laser desorption and ionization TOF-MS sample surface 有权
公开(公告)号：US06558744B2
公开(公告)日：2003-05-06
申请号：US09552453
申请日：2000-04-18
申请人： Joseph A. Jarrell , Michael J. Tomany , Craig A. Dorschel
发明人： Joseph A. Jarrell , Michael J. Tomany , Craig A. Dorschel
IPC分类号： B05D302
CPC分类号： G01N1/2813 , G01N2001/2826 , H01J49/0418 , Y10T428/24355 , Y10T428/264 , Y10T428/265
摘要： A thin layer for sample analysis by matrix-assisted laser desorption mass spectrometry, comprising a matrix material in a supported dispersion wherein the support is a solid or is formed from a solid. The invention is also directed to a method of making a thin layer for sample analysis by matrix-assisted laser desorption mass spectrometry, the layer comprising a matrix-solid composition disposed upon a substrate, comprising the step of depositing a solution containing matrix, solid and solvent upon a spinning substrate at a deposition rate sufficient to allow evaporation of the solvent, thereby interspersing the matrix and support on the substrate in a thin layer. Enhanced mass resolution is described.

4. 发明授权

US06071610A Enhanced resolution matrix-laser desorption and ionization TOF-MS sample surface 失效
公开(公告)号：US06071610A
公开(公告)日：2000-06-06
申请号：US853205
申请日：1997-05-09
申请人： Joseph A. Jarrell , Michael J. Tomany , Craig A. Dorschel
发明人： Joseph A. Jarrell , Michael J. Tomany , Craig A. Dorschel
IPC分类号： B01D59/28 , B05D3/00 , B05D3/02 , B05D3/06 , B32B5/16
CPC分类号： G01N1/2813 , H01J49/0418 , G01N2001/2826 , Y10T428/24355 , Y10T428/264 , Y10T428/265
摘要： A thin layer for sample analysis by matrix-assisted laser desorption mass spectrometry, comprising a matrix material in a supported dispersion wherein the support is a solid or is formed from a solid. The invention is also directed to a method of making a thin layer for sample analysis by matrix-assisted laser desorption mass spectrometry, the layer comprising a matrix-solid composition disposed upon a substrate, comprising the step of depositing a solution containing matrix, solid and solvent upon a spinning substrate at a deposition rate sufficient to allow evaporation of the solvent, thereby interspersing the matrix and support on the substrate in a thin layer. Enhanced mass resolution is described.

5. 发明授权

US5828062A Ionization electrospray apparatus for mass spectrometry 失效
标题翻译：用于质谱的电离电喷雾装置
公开(公告)号：US5828062A
公开(公告)日：1998-10-27
申请号：US807993
申请日：1997-03-03
申请人： Joseph A. Jarrell , Michael J. Tomany
发明人： Joseph A. Jarrell , Michael J. Tomany
IPC分类号： H01J49/04 , B01D59/44 , H01J49/00
CPC分类号： H01J49/145 , H01J49/165
摘要： An electrospray (ES) apparatus provides efficient reagent addition and improved ionization of an analyte aerosol at high flow rates by combining an ionized reagent aerosol with the analyte aerosol, thereby producing a superior ionized analyte aerosol for mass spectronomy (MS) implementations. The ES apparatus separately receives a reagent and a flow stream comprising analyte. The ES apparatus nebulizes the reagent and flow stream into aerosols, ionizes the reagent aerosol, combines the aerosols into an ionized analyte aerosol, and outputs the ionized analyte aerosol towards a mass spectrometer. The ionized analyte aerosol is formed at high flow rates and with effective reagent mixing, thereby minimizing flow stream aberrations and substantially improving signal sensitivity and selectivity in the mass spectrometer. Contact, mixing, and charge transfer between analyte and reagent particles is positively impacted in an aerosol format, thereby improving reagent mixing efficiency and producing a suitably ionized analyte aerosol at high flow rate. A plurality of nebulizers are used to provide the analyte and ionized reagent aerosols at high flow rate.
摘要翻译：电喷雾（ES）装置通过将离子化试剂气溶胶与分析物气溶胶组合而提供高效的试剂加入和改进的高流速下的分析物气溶胶的离子化，由此产生用于质谱分析（MS）实施的优异的电离分析物气溶胶。 ES装置分别接收试剂和包含分析物的流动流。 ES装置将试剂和流动物雾化成气溶胶，将试剂气溶胶离子化，将气溶胶结合成电离的分析物气溶胶，并将离子化的分析物气溶胶输出到质谱仪。电离的分析物气溶胶以高流速和有效的试剂混合形成，从而最小化流速像差并且在质谱仪中显着提高信号的灵敏度和选择性。分析物和试剂颗粒之间的接触，混合和电荷转移以气溶胶形式受到积极影响，从而提高试剂混合效率，并以高流速产生合适电离的分析物气溶胶。使用多个喷雾器以高流速提供分析物和离子化试剂气溶胶。

6. 发明申请

US20140208836A1 ANALYSIS OF DRIED BLOOD SPOT SAMPLES IN A MICROFLUIDIC SYSTEM WITH DILUTION OF EXTRACTED SAMPLES 审中-公开
标题翻译：在具有稀释样品的微流控系统中的干燥血液样品样品的分析
公开(公告)号：US20140208836A1
公开(公告)日：2014-07-31
申请号：US14238653
申请日：2012-08-22
申请人： James P. Murphy , Michael J. Tomany , Joseph D. Michienzi , Paul Rainville , Robert S. Plumb , Geoff C. Gerhardt , Moon Chul Jung
发明人： James P. Murphy , Michael J. Tomany , Joseph D. Michienzi , Paul Rainville , Robert S. Plumb , Geoff C. Gerhardt , Moon Chul Jung
IPC分类号： G01N30/06
CPC分类号： G01N30/06 , B01L3/502715 , B01L2300/0816 , B01L2300/0874 , B01L2300/0887 , B01L2300/1827 , G01N30/16 , G01N30/6095 , G01N30/88 , G01N33/49 , G01N2001/383 , G01N2030/009 , G01N2030/062
摘要： An apparatus for use in a chromatography system includes a microfluidic substrate having a fluidic channel configured as an analytical chromatographic column and a fluidic port on one side of the microfluidic substrate. The fluidic port opens at a head end of the analytical chromatographic column. A dried blood spot (DBS) collection device holds one or more dried biological samples. The DBS collection device is directly coupled to the microfluidic substrate whereby one of the biological samples is placed into fluidic communication with the fluidic channel of the microfluidic substrate and an extraction of that biological sample flows toward the head end of the analytical chromatographic column. A diluent source fluidically coupled to the fluidic port supplies a solvent to the head end of the analytical column to dilute the extracted biological sample before the biological sample flows into the analytical chromatographic column.
摘要翻译：用于色谱系统的装置包括具有配置为分析色谱柱的流体通道和在微流体衬底的一侧上的流体端口的微流体衬底。流体端口在分析色谱柱的头端打开。干血斑（DBS）收集装置容纳一个或多个干燥的生物样品。 DBS收集装置直接耦合到微流体底物，其中一个生物样品被放置成与微流体底物的流体通道流体连通，并且该生物样品的提取流向分析色谱柱的头端。流体耦合到流体端口的稀释剂源将溶剂提供到分析柱的头端，以在生物样品流入分析色谱柱之前稀释提取的生物样品。

7. 发明申请

US20130056631A1 TECHNIQUES FOR AUTOMATED PARAMETER ADJUSTMENT USING ION SIGNAL INTENSITY FEEDBACK 有权
标题翻译：使用离子信号强度反馈进行自动参数调整的技术
公开(公告)号：US20130056631A1
公开(公告)日：2013-03-07
申请号：US13698336
申请日：2011-05-09
申请人： Michael J. Tomany , James P. Murphy , Paul Rainville
发明人： Michael J. Tomany , James P. Murphy , Paul Rainville
IPC分类号： H01J49/04 , H01J49/26
CPC分类号： H01J49/167 , G01N30/7266 , H01J49/168
摘要： Described are techniques for tuning parameters of a system. For one or more values of a distance, mass spectral analysis of a liquid analyte stream is performed. A corresponding ion signal intensity of a selected ion is obtained. The distance is measured from a first end of a first tube to a second end of a second tube which surrounds said first tube. Using a computing device, a current value of the distance is automatically adjusted in accordance with corresponding ion signal intensities obtained for the selected ion. Using a computing device, a desired value for the distance is automatically determined using the corresponding ion signal intensities. The desired value results in an ion signal intensity for the selected ion which is any of more than a threshold intensity and a maximum of ion signal intensities obtained by performing mass spectral analysis using different values for the distance.
摘要翻译：描述了用于调整系统参数的技术。对于一个或多个距离的值，进行液体分析物流的质谱分析。获得所选离子的相应离子信号强度。距离是从第一管的第一端到围绕所述第一管的第二管的第二端测量的。使用计算设备，根据为所选择的离子获得的对应的离子信号强度，自动调整距离的当前值。使用计算设备，使用相应的离子信号强度自动确定距离的期望值。期望的值导致所选择的离子的离子信号强度，其通过使用不同的距离值进行质谱分析而获得的超过阈值强度和离子信号强度的最大值中的任何一个。

8. 发明授权

US08232521B2 Device and method for analyzing a sample 有权
标题翻译：用于分析样品的装置和方法
公开(公告)号：US08232521B2
公开(公告)日：2012-07-31
申请号：US12524620
申请日：2008-02-01
申请人： Joseph A. Jarrell , Michael J. Tomany
发明人： Joseph A. Jarrell , Michael J. Tomany
IPC分类号： H01J49/00
CPC分类号： H01J49/0463
摘要： Embodiments of the invention relate to a device for analyzing a sample surface Comprising an outlet and a frame. The outlet is for forming a jet of gas, the jet forming a sampling region for receiving one or more sample surfaces, and the frame holding the outlet and being adapted to receive a detector means. The detector means has an inlet. In use, the jet produces desorbed sample from sample surfaces received in the sample area. At least a portion of the desorbed sample is ionized to produce one or more sample ions. The frame holds the outlet with respect to the sample ions and produce a signal indicative of the composition of the sample ions.
摘要翻译：本发明的实施例涉及一种用于分析包括出口和框架的样品表面的装置。出口用于形成气体射流，喷射形成用于接收一个或多个样品表面的采样区域，并且保持出口的框架适于接收检测器装置。检测器装置具有入口。在使用中，喷射器从样品区域中接收的样品表面产生解吸样品。解吸的样品的至少一部分被离子化以产生一个或多个样品离子。框架相对于样品离子保持出口，并产生指示样品离子的组成的信号。

9. 发明申请

US20100133431A1 Device, Apparatus And Methods For Mass Spectrometry 有权
标题翻译：用于质谱的装置，装置和方法
公开(公告)号：US20100133431A1
公开(公告)日：2010-06-03
申请号：US12593313
申请日：2008-03-19
申请人： Michael J. Tomany , Joseph A. Jarrell , Stanislaw Koziol , Wade P. Leveille
发明人： Michael J. Tomany , Joseph A. Jarrell , Stanislaw Koziol , Wade P. Leveille
IPC分类号： H01J49/04 , H01J49/34 , H01J49/40 , F16L41/00 , B23P6/00
CPC分类号： G01N30/724 , H01J49/0445 , Y10T29/49718 , Y10T137/85938
摘要： The invention comprises apparatus for use with atmospheric pressure ionization sources in which an aerosol is formed from a solution of a sample. The aerosol is received in a hollow member and discharged outside the chamber of the ionization source in order to reduce contamination of the ionization source itself by involatile material in the solution and by previously analysed samples. The hollow member is easily removable from the ionization source to facilitate cleaning and replacement. Ionization sources, mass spectrometers, and ion mobility spectrometers comprising the apparatus are also described.
摘要翻译：本发明包括与大气压电离源一起使用的装置，其中气溶胶由样品溶液形成。气溶胶被容纳在中空构件中并且排出到电离源的室外，以便通过溶液中的非挥发性材料和先前分析的样品来减少电离源本身的污染。中空构件容易从电离源移除，以便于清洁和更换。还描述了包括该装置的电离源，质谱仪和离子迁移谱仪。

10. 发明授权

US06376044B1 Enhanced resolution matrix-laser desorption and ionization TOF-MS sample surface 有权
标题翻译：增强分辨率矩阵激光解吸和电离TOF-MS样品表面
公开(公告)号：US06376044B1
公开(公告)日：2002-04-23
申请号：US09583264
申请日：2000-05-31
申请人： Joseph A. Jarrell , Michael J. Tomany , Craig A. Dorschel
发明人： Joseph A. Jarrell , Michael J. Tomany , Craig A. Dorschel
IPC分类号： B32B516
CPC分类号： G01N1/2813 , G01N2001/2826 , H01J49/0418 , Y10T428/24355 , Y10T428/264 , Y10T428/265
摘要： A thin layer for sample analysis by matrix-assisted laser desorption mass spectrometry, comprising a matrix material in a supported dispersion wherein the support is a solid or is formed from a solid. The invention is also directed to a method of making a thin layer for sample analysis by matrix-assisted laser desorption mass spectrometry, the layer comprising a matrix-solid composition disposed upon a substrate, comprising the step of depositing a solution containing matrix, solid and solvent upon a spinning substrate at a deposition rate sufficient to allow evaporation of the solvent, thereby interspersing the matrix and support on the substrate in a thin layer. Enhanced mass resolution is described.
摘要翻译：用于通过基质辅助激光解吸质谱进行样品分析的薄层，其包括在支持的分散体中的基质材料，其中载体是固体或由固体形成。本发明还涉及通过基质辅助激光解吸质谱法制备用于样品分析的薄层的方法，所述层包含置于基材上的基质 - 固体组合物，该方法包括以下步骤：沉积含有基质，固体和溶剂在旋转衬底上，以足以允许溶剂蒸发的沉积速率，从而将基体和支撑物分散在薄层上的衬底上。描述了增强的质量分辨率。

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