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1. 发明授权

US06290650B1 Tonometry system for monitoring blood pressure 有权
标题翻译：用于监测血压的血压计系统
公开(公告)号：US06290650B1
公开(公告)日：2001-09-18
申请号：US09321907
申请日：1999-05-28
申请人： Robert D. Butterfield , Kenneth J. Pytel , Charles R. Holdaway , Stephen A. Martin
发明人： Robert D. Butterfield , Kenneth J. Pytel , Charles R. Holdaway , Stephen A. Martin
IPC分类号： A61B502
CPC分类号： A61B5/021
摘要： A system for noninvasively continuously monitoring arterial blood pressure includes a tissue stress sensor that has a continuous diaphragm for sensing stress within tissue adjacent a preselected artery caused by arterial pulsations within that artery. The stress sensitive diaphragm is coupled with electromechanical means for producing electrical signals that represent the stress within the tissue that is communicated to the sensor. These signals are then processed electronically in order to yield an output that is indicative of the arterial blood pressure of the preselected artery. The disclosed system includes methods of operation for determining blood pressure while maintaining a preselected artery in an optimum applanation state and an off-optimum applanation state.
摘要翻译：用于非侵入性连续监测动脉血压的系统包括组织应力传感器，其具有用于感测由该动脉内的动脉脉动引起的预选动脉附近的组织内的应力的连续膜片。应力敏感隔膜与机电装置相结合，用于产生表示组织内传递到传感器的应力的电信号。然后电子地处理这些信号，以产生指示预选动脉的动脉血压的输出。所公开的系统包括用于确定血压的操作的方法，同时保持预选动脉处于最佳压扁状态和不合适的压扁状态。

2. 发明授权

US5284150A Tonometry system for determining blood pressure 失效
标题翻译：用于测定血压的血压计系统
公开(公告)号：US5284150A
公开(公告)日：1994-02-08
申请号：US962364
申请日：1992-10-16
申请人： Robert D. Butterfield , Kenneth J. Pytel , Charles R. Holdaway , Stephen A. Martin
发明人： Robert D. Butterfield , Kenneth J. Pytel , Charles R. Holdaway , Stephen A. Martin
IPC分类号： A61B5/022 , A61B5/0225 , A61B5/024 , G01L7/00 , G01L9/00 , A61B5/021
CPC分类号： A61B5/021 , A61B5/02422 , A61B2560/0252 , A61B2562/0247 , A61B2562/043 , A61B5/7203
摘要： A tissue contact stress sensing system incorporates a semiconductor assembly and a continuous diaphragm to noninvasively determine the intra-arterial blood pressure of a patient. The system comprises a continuous diaphragm placed against a patient's tissue which covers an underlying artery. The semiconductor assembly is placed in close proximity to and spaced apart from the diaphragm for directly irradiating the diaphragm with electromagnetic radiation and receiving a portion of the electromagnetic radiation which is reflected from the continuous diaphragm. The disclosed system also utilizes a technique for minimizing the system errors associated with temperature drift and aging of the sensor.
摘要翻译：组织接触应力感测系统包括半导体组件和连续隔膜以非侵入性地确定患者的动脉内血压。该系统包括一个连续的隔膜，该隔膜相对于覆盖下面动脉的患者组织放置。半导体组件被放置在与隔膜紧密并且间隔开的位置，以便用电磁辐射直接照射隔膜并且接收从连续隔膜反射的电磁辐射的一部分。所公开的系统还利用用于最小化与传感器的温度漂移和老化相关的系统误差的技术。

3. 发明授权

US5908027A Tonometry system for monitoring blood pressure 失效
标题翻译：用于监测血压的血压计系统
公开(公告)号：US5908027A
公开(公告)日：1999-06-01
申请号：US848920
申请日：1997-05-01
申请人： Robert D. Butterfield , Kenneth J. Pytel , Charles R. Holdaway , Stephen A. Martin
发明人： Robert D. Butterfield , Kenneth J. Pytel , Charles R. Holdaway , Stephen A. Martin
IPC分类号： A61B5/021 , A61B5/02
CPC分类号： A61B5/021
摘要： A system for noninvasively continuously monitoring arterial blood pressure includes a tissue stress sensor that has a continuous diaphragm for sensing stress within tissue adjacent a preselected artery caused by arterial pulsations within that artery. The stress sensitive diaphragm is coupled with electromechanical means for producing electrical signals that represent the stress within the tissue that is communicated to the sensor. These signals are then processed electronically in order to yield an output that is indicative of the arterial blood pressure of the preselected artery. The disclosed system includes methods of operation for determining blood pressure while maintaining a preselected artery in an optimum applanation state and an off-optimum applanation state.
摘要翻译：用于非侵入性连续监测动脉血压的系统包括组织应力传感器，其具有用于感测由该动脉内的动脉脉动引起的预选动脉附近的组织内的应力的连续膜片。应力敏感隔膜与机电装置相结合，用于产生表示组织内传递到传感器的应力的电信号。然后电子地处理这些信号，以产生指示预选动脉的动脉血压的输出。所公开的系统包括用于确定血压的操作的方法，同时保持预选动脉处于最佳压扁状态和不合适的压扁状态。

4. 发明授权

US5158091A Tonometry system for determining blood pressure 失效
标题翻译：用于测定血压的测量系统
公开(公告)号：US5158091A
公开(公告)日：1992-10-27
申请号：US621165
申请日：1990-11-30
申请人： Robert D. Butterfield , Kenneth J. Pytel , Charles R. Holdaway , Stephen A. Martin
发明人： Robert D. Butterfield , Kenneth J. Pytel , Charles R. Holdaway , Stephen A. Martin
IPC分类号： A61B5/022 , A61B5/0225 , A61B5/024 , G01L7/00 , G01L9/00
CPC分类号： A61B5/021 , A61B5/02422 , A61B2560/0252 , A61B2562/0247 , A61B2562/043 , A61B5/7203
摘要： A tissue contact stress sensing system incorporates a semiconductor assembly and a continuous diaphragm to noninvasively determine the intra-arterial blood pressure of a patient. The system comprises a continuous diaphragm placed against a patient's tissue which covers an underlying artery. The semiconductor assembly is placed in close proximity to and spaced apart from the diaphragm for directly irradiating the diaphragm with electromagnetic radiation and receiving a portion of the electromagnetic radiation which is reflected from the continuous diaphragm. The disclosed system also utilizes a technique for minimizing the system errors associated with temperature drift and aging of the sensor.
摘要翻译：组织接触应力感测系统包括半导体组件和连续隔膜以非侵入性地确定患者的动脉内血压。该系统包括一个连续的隔膜，该隔膜相对于覆盖下面动脉的患者组织放置。半导体组件被放置在与隔膜紧密并且间隔开的位置，以便用电磁辐射直接照射隔膜并且接收从连续隔膜反射的电磁辐射的一部分。所公开的系统还利用用于最小化与传感器的温度漂移和老化相关的系统误差的技术。

5. 发明授权

US5240007A Apparatus and method for moving a tissue stress sensor for applanating an artery 失效
标题翻译：用于移动组织应变传感器的装置和方法
公开(公告)号：US5240007A
公开(公告)日：1993-08-31
申请号：US700009
申请日：1991-05-14
申请人： Kenneth J. Pytel , Stephen A. Martin , Robert D. Butterfield , William R. Ewing
发明人： Kenneth J. Pytel , Stephen A. Martin , Robert D. Butterfield , William R. Ewing
IPC分类号： A61B5/022
CPC分类号： A61B5/021 , A61B5/02241
摘要： An artery applanation actuator for use in a system for noninvasively determining the intra-arterial blood pressure of a user incorporates a fluid actuator to effect movement of a sensor. The movement of the sensor is effective for applanating an artery of interest and measuring the stress of the tissue overlaying the artery of interest. Alternative embodiments of the artery applanation actuator are presented wherein an electric motor is used to activate a rotating arm which has a sensor located thereon. The rotation of the arm causes the sensor to contact and press against the tissue overlying the artery of interest. The artery applanation actuator is presented having a protective sheath surrounding the sensor to protect the sensor against inadvertent contact.
摘要翻译：用于非侵入性地确定使用者的动脉内血压的系统中的动脉压平致动器包括流体致动器以实现传感器的移动。传感器的运动对于平坦化感兴趣的动脉和测量覆盖感兴趣的动脉的组织的应力是有效的。提出了动脉压平致动器的替代实施例，其中使用电动机来启动具有位于其上的传感器的旋转臂。臂的旋转导致传感器接触并压靠在感兴趣的动脉上方的组织。动脉挤压致动器具有围绕传感器的保护护套，以保护传感器免于意外接触。

6. 发明授权

US5195522A Tonometry sensor calibration apparatus 失效
标题翻译：眼压计传感器校准装置
公开(公告)号：US5195522A
公开(公告)日：1993-03-23
申请号：US717224
申请日：1991-06-18
申请人： Kenneth J. Pytel , Stephen A. Martin , Robert D. Butterfield
发明人： Kenneth J. Pytel , Stephen A. Martin , Robert D. Butterfield
IPC分类号： A61B5/021 , A61B5/022 , A61B5/0225 , A61B5/024
CPC分类号： A61B5/02422 , A61B5/021 , A61B5/02241 , A61B2560/0223
摘要： A calibration apparatus for use in calibrating a tissue stress sensor used in a blood pressure monitoring system. The calibration apparatus includes a calibration head which is adapted to be retained in close proximity to a tissue stress sensor. The calibration head includes means for heating the tissue stress sensor. A calibration system is also disclosed for calibrating a blood pressure monitoring system, the blood pressure monitoring system employing a stress sensor for generating an electric output signal representative of tissue stress data. The calibration system comprises a tissue stress sensor having a displaceable diaphragm and a sealed chamber. The chamber has a continuous wall defining an inner volume and an outer volume. The displaceable diaphragm comprises a portion of the continuous wall, whereby the displaceable diaphragm is responsive to a pressure differential between the inner chamber volume and the outer chamber volume. The vacuum means is fluidly coupled to the inner volume of the sealed chamber for applying a controlled vacuum to the inner volume of the chamber whereby the diaphragm is displaced in response to the application of the vacuum. Calibration means is provided for detecting the sensors response to heating and displacing of the sensor diaphragm and for generating corrective data for use in correcting the effects of sensor temperture on the data generated by the sensor.
摘要翻译：一种用于校准在血压监测系统中使用的组织应力传感器的校准装置。校准装置包括校准头，其适于保持紧靠组织应力传感器。校准头包括用于加热组织应力传感器的装置。还公开了一种用于校准血压监测系统的校准系统，所述血压监测系统采用应力传感器来产生代表组织应力数据的电输出信号。校准系统包括具有可移动隔膜和密封室的组织应力传感器。该室具有限定内容积和外容积的连续壁。可移动隔膜包括连续壁的一部分，由此可移动隔膜响应于内室容积和外室体积之间的压力差。真空装置流体耦合到密封室的内部容积，用于将受控制的真空施加到室的内部容积，由此隔膜响应于真空的应用而移位。提供了校准装置，用于检测传感器对传感器隔膜的加热和移位的响应，并产生用于校正传感器温度对传感器产生的数据的影响的校正数据。

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