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    • 3. 发明授权
    • Micromachined synthetic jet actuators and applications thereof
    • 微加工合成射流致动器及其应用
    • US06457654B1
    • 2002-10-01
    • US08969589
    • 1997-11-13
    • Ari GlezerMark G. Allen
    • Ari GlezerMark G. Allen
    • B05B1704
    • B64C21/08B64C2230/04B64C2230/06B64C2230/14B64C2230/16B64C2230/18B64G1/26B64G1/40B64G1/401F01D5/148F02K1/28F15C1/14F15C5/00F15D1/009F15D1/08F15D1/12F16K99/0001F16K99/0007F16K99/0034F16K99/0048F16K2099/0094F16K2099/0098F21V29/677F21V29/70F21V29/83F23R3/24F28F13/02H01L23/4336H01L2924/0002H01L2924/3011H05K7/20172Y02T50/166Y02T50/672Y02T50/673H01L2924/00
    • The present invention involves micromachined synthetic jet actuators, or “microjet” actuators. These fluidic control devices may be fabricated using standard silicon micromachining techniques and comprise an orifice situated atop an actuator cavity which is bounded at least partially by a flexible membrane. Alternatively, microjets may be formed in more robust substrates, such as metals or ceramics. Vibration of the membrane using either electrostatic or piezoelectric drives results in a turbulent air jet formed normal to the microjet orifice. The jet stream is synthesized by a train of vortex rings. Each vortex is formed by the motion of the diaphragm and is advanced away from the jet under self-induced velocity. Alternatively, the microjet actuator can comprise a “piston in cylinder” to take the functional place of the vibrating diaphragm. This can be accomplished by changing the aspect ratio of the actuator cavity to a deeper, more cylindrical shape. A piston-like actuator can then be realized by using a “bossed” diaphragm. An improvement to microjets is the use of modulators with the jet actuators. Modulators are generally devices to selectively cover and uncover the orifice of a synthetic jet actuator in order to prevent either flow into or out of the jet cavity. Such modulators are fabricated as either vertical drive, lateral drive or constricting modulators.
    • 本发明涉及微机加工的合成射流致动器或“微喷”致动器。 这些流体控制装置可以使用标准硅微加工技术制造,并且包括位于致动器空腔顶部的孔口,致动器空腔至少部分地由柔性膜限定。 或者,微孔可以形成在更坚固的基底中,例如金属或陶瓷。 使用静电或压电驱动的膜的振动导致与微喷嘴孔垂直形成的湍流空气喷射。 喷气流由一系列涡旋环合成。 每个涡流由隔膜的运动形成,并在自身引发的速度下从射流前进。 或者,微型喷墨致动器可以包括“活塞在气缸中”以占据振动膜片的功能位置。 这可以通过将致动器腔的纵横比改变为更深,更圆柱形的形状来实现。 然后可以通过使用“凸起的”隔膜来实现活塞式致动器。 微喷射器的改进是使用具有喷射致动器的调制器。 调制器通常是选择性地覆盖和揭开合成射流致动器的孔口的装置,以防止流入或流出喷射空腔。 这样的调制器被制造为垂直驱动,侧向驱动或收缩调制器。
    • 9. 发明授权
    • Apparatus and methods for high throughput network electrophysiology and cellular analysis
    • 用于高通量网络电生理和细胞分析的装置和方法
    • US09290756B2
    • 2016-03-22
    • US12615778
    • 2009-11-10
    • James RossEdgar A. BrownSwaminathan RajaramanMark G. AllenBruce Wheeler
    • James RossEdgar A. BrownSwaminathan RajaramanMark G. AllenBruce Wheeler
    • G01N33/487C12N13/00C12M1/42G01N33/483
    • C12N13/00B32B2535/00C12M1/42G01N33/4836G01N33/48728G01N33/48735Y10T156/10
    • Provided herein are apparatus and methods relating to the development of instrumentation for high throughput network electrophysiology and cellular analysis. More specifically, provided herein are multiwell microelectrode arrays (MEAs) and methods for the development of such an apparatus in an inexpensive fashion with a flexible, ANSI/SBS-compliant (American National Standards Institute/Society for Biomolecular Screening) format. Microelectrode arrays are a grid of tightly spaced microelectrodes useful for stimulating and sensing electrically active cells, networks and tissue. The techniques described herein relate to the use of microfabrication in combination with certain large-area processes that have been employed to achieve multiwell MEAs in ANSI/SBS-compliant culture well formats, which are also transparent for inverted/backside microscopy compatibility. These multiwell MEAs can be used to investigate two and three-dimensional networks of electrically active cells and tissue such as cardiac, neural, and muscular in a high throughput fashion. Also being ANSI/SBS-compliant, they are compatible with machinery and robotics developed for the pharmaceutical industry for drug screening applications.
    • 本文提供了与开发用于高通量网络电生理学和细胞分析的仪器相关的装置和方法。 更具体地,本文提供了多孔微电极阵列(MEA)和用于以便宜的方式开发这种装置的方法,其具有柔性的符合ANSI / SBS(美国国家标准协会/生物分子筛选学会)的格式。 微电极阵列是用于刺激和感测电活性细胞,网络和组织的紧密间隔的微电极的网格。 本文所述的技术涉及使用微加工与已经用于实现符合ANSI / SBS的培养孔格式的多孔MEA的某些大面积方法的组合,其对于倒置/背面显微镜兼容性也是透明的。 这些多孔MEA可用于以高通量方式研究电活性细胞和组织如心脏,神经和肌肉的两维和三维网络。 同样符合ANSI / SBS标准,它们与制药行业开发用于药物筛选应用的机械和机器人兼容。