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1. 发明授权

US09492084B2 Systems and methods for monitoring subjects in potential physiological distress 有权
标题翻译：用于监测潜在生理困扰的受试者的系统和方法
公开(公告)号：US09492084B2
公开(公告)日：2016-11-15
申请号：US11503350
申请日：2006-08-10
申请人： Andrew Behar , Jeff Cobb , Alex Derchak , Barry Keenan , Dave Darnall
发明人： Andrew Behar , Jeff Cobb , Alex Derchak , Barry Keenan , Dave Darnall
IPC分类号： A61B5/00 , G06F19/00
CPC分类号： A61B5/0002 , A61B5/4866 , A61B5/4884 , A61B5/6804 , A61B5/7264 , A61B2560/0431 , G06F19/3418 , G16H80/00
摘要： The present invention provides systems and methods for monitoring in real time the physiological status of one or more subjects, especially subject engaged in potentially hazardous or dangerous activities. Systems include wearable items with one or more physiological sensors and a local data unit (LDU) operatively coupled to the sensors. The LDUs digitize and filter sensor data, extract physiological parameters, determine abnormal or not acceptable physiological conditions, and communicate to external monitoring facilities. The external facilities display status and data concerning monitored subjects. In preferred embodiments, communication between the LDUs and the external monitoring facilities dynamically adjusts to the condition of the subjects and to system changes such as subjects and external facilities entering and leaving and/or moving from place to place. The invention also provides program products for performing this invention's methods.
摘要翻译：本发明提供用于实时监测一个或多个受试者，特别是从事潜在危险或危险活动的受试者的生理状况的系统和方法。系统包括具有一个或多个生理传感器的可穿戴物品和可操作地耦合到传感器的本地数据单元（LDU）。 LDU数字化和过滤传感器数据，提取生理参数，确定异常或不可接受的生理条件，并与外部监测设施进行通信。外部设施显示有关受监控对象的状态和数据。在优选实施例中，LDU和外部监视设备之间的通信根据被摄体的状态以及诸如被摄体和外部设备进入和离开和/或从一个地方移动到另一个地方的系统变化动态地调整。本发明还提供了用于执行本发明方法的程序产品。

2. 发明申请

US20100274100A1 Systems and methods for monitoring subjects in potential physiological distress 有权
标题翻译：用于监测潜在生理困扰的受试者的系统和方法
公开(公告)号：US20100274100A1
公开(公告)日：2010-10-28
申请号：US11503350
申请日：2006-08-10
申请人： Andrew Behar , Jeff Cobb , Alex Derchak , Barry Keenan , Dave Darnall
发明人： Andrew Behar , Jeff Cobb , Alex Derchak , Barry Keenan , Dave Darnall
IPC分类号： A61B5/00
CPC分类号： A61B5/0002 , A61B5/4866 , A61B5/4884 , A61B5/6804 , A61B5/7264 , A61B2560/0431 , G06F19/3418 , G16H80/00
摘要： The present invention provides systems and methods for monitoring in real time the physiological status of one or more subjects, especially subject engaged in potentially hazardous or dangerous activities. Systems include wearable items with one or more physiological sensors and a local data unit (LDU) operatively coupled to the sensors. The LDUs digitize and filter sensor data, extract physiological parameters, determine abnormal or not acceptable physiological conditions, and communicate to external monitoring facilities. The external facilities display status and data concerning monitored subjects. In preferred embodiments, communication between the LDUs and the external monitoring facilities dynamically adjusts to the condition of the subjects and to system changes such as subjects and external facilities entering and leaving and/or moving from place to place. The invention also provides program products for performing this invention's methods.
摘要翻译：本发明提供用于实时监测一个或多个受试者，特别是从事潜在危险或危险活动的受试者的生理状况的系统和方法。系统包括具有一个或多个生理传感器的可穿戴物品和可操作地耦合到传感器的本地数据单元（LDU）。 LDU数字化和过滤传感器数据，提取生理参数，确定异常或不可接受的生理条件，并与外部监测设施进行通信。外部设施显示有关受监控对象的状态和数据。在优选实施例中，LDU和外部监视设备之间的通信根据被摄体的状况以及诸如主体和外部设备进入和离开和/或从一个地方移动到另一个地方的系统变化动态地调整。本发明还提供了用于执行本发明方法的程序产品。

3. 发明授权

US08249683B2 Real-time self-calibrating sensor system and method 有权
标题翻译：实时自校准传感器系统及方法
公开(公告)号：US08249683B2
公开(公告)日：2012-08-21
申请号：US12826497
申请日：2010-06-29
申请人： Lu Wang , Rajiv Shah , Wayne A. Morgan , Barry Keenan
发明人： Lu Wang , Rajiv Shah , Wayne A. Morgan , Barry Keenan
IPC分类号： A61B5/05 , A61B5/00
CPC分类号： A61B5/1495 , A61B5/0031 , A61B5/14532 , A61B5/1468 , A61B5/1473 , A61B5/14865 , A61B2560/0223 , A61M2005/1726
摘要： A system and method for calibrating a sensor of a characteristic monitoring system in real time utilizes a self-calibration module for periodic determination of, and compensation for, the IR drop across unwanted resistances in a cell. A current-interrupt switch is used to open the self-calibration module circuit and either measure the IR drop using a high-frequency (MHz) ADC module, or estimate it through linear regression of acquired samples of the voltage across the sensor's working and reference electrodes (Vmeasured) over time. The IR drop is then subtracted from the closed-circuit value of Vmeasured to calculate the overpotential that exists in the cell (Vimportant). Vimportant may be further optimized by subtracting the value of the open-circuit voltage (Voc) across the sensor's working and reference electrodes. The values of Vmeasured and Vimportant are then controlled by respective first and second control units to compensate for the IR drop.
摘要翻译：用于校准特征监测系统的传感器的系统和方法实时地利用自校准模块来周期性地确定和补偿细胞中不需要的电阻的IR降。使用电流中断开关来打开自校准模块电路，并使用高频（MHz）ADC模块测量IR降压，或通过传感器工作和参考电压的采集样本的线性回归进行估计电极（Vmeasured）随着时间的推移。然后从Vmeasured的闭路电流值中减去IR降，以计算存在于电池（Vimportant）中的超电势。可以通过减去传感器的工作参考电极和参考电极之间的开路电压（Voc）的值来进一步优化V重量。然后由相应的第一和第二控制单元控制V测量和V重量的值以补偿IR下降。

4. 发明授权

US07774038B2 Real-time self-calibrating sensor system and method 有权
标题翻译：实时自校准传感器系统及方法
公开(公告)号：US07774038B2
公开(公告)日：2010-08-10
申请号：US11323216
申请日：2005-12-30
申请人： Lu Wang , Rajiv Shah , Wayne A. Morgan , Barry Keenan
发明人： Lu Wang , Rajiv Shah , Wayne A. Morgan , Barry Keenan
IPC分类号： A61B5/05 , A61B5/00 , G01N33/50 , G01N33/487
CPC分类号： A61B5/1495 , A61B5/0031 , A61B5/14532 , A61B5/1468 , A61B5/1473 , A61B5/14865 , A61B2560/0223 , A61M2005/1726
摘要： A system and method for calibrating a sensor of a characteristic monitoring system in real time utilizes a self-calibration module for periodic determination of, and compensation for, the IR drop across unwanted resistances in a cell. A current-interrupt switch is used to open the self-calibration module circuit and either measure the IR drop using a high-frequency (MHz) ADC module, or estimate it through linear regression of acquired samples of the voltage across the sensor's working and reference electrodes (Vmeasured) over time. The IR drop is then subtracted from the closed-circuit value of Vmeasured to calculate the overpotential that exists in the cell (Vimportant). Vimportant may be further optimized by subtracting the value of the open-circuit voltage (Voc) across the sensor's working and reference electrodes. The values of Vmeasured and Vimportant are then controlled by respective first and second control units to compensate for the IR drop.
摘要翻译：用于校准特征监测系统的传感器的系统和方法实时地利用自校准模块来周期性地确定和补偿细胞中不需要的电阻的IR降。使用电流中断开关来打开自校准模块电路，并使用高频（MHz）ADC模块测量IR降压，或通过传感器工作和参考电压的采集样本的线性回归进行估计电极（Vmeasured）随着时间的推移。然后从Vmeasured的闭路电流值中减去IR降，以计算存在于电池（Vimportant）中的超电势。可以通过减去传感器的工作参考电极和参考电极之间的开路电压（Voc）的值来进一步优化V重量。然后由相应的第一和第二控制单元控制V测量和V重量的值以补偿IR下降。

5. 发明申请

US20110237917A1 CALIBRATION OF GLUCOSE MONITORING SENSOR AND/OR INSULIN DELIVERY SYSTEM 有权
标题翻译：葡萄糖监测传感器和/或胰岛素输送系统的校准
公开(公告)号：US20110237917A1
公开(公告)日：2011-09-29
申请号：US12748341
申请日：2010-03-26
申请人： Anirban Roy , Barry Keenan , Michael Kremliovsky
发明人： Anirban Roy , Barry Keenan , Michael Kremliovsky
IPC分类号： A61B5/145 , G06F19/00 , G01N33/48
CPC分类号： A61B5/1495 , A61B5/1451 , A61B5/14532 , A61B5/14865 , A61B5/4839 , A61B5/6849 , A61B5/7203 , A61B5/7221 , A61B5/725 , A61B5/7275 , A61B2560/0223 , A61M5/1723 , A61M2005/1726
摘要： Disclosed are methods, apparatuses, etc. for calibrating glucose monitoring sensors and/or insulin delivery systems. In certain example embodiments, blood glucose reference samples may be correlated with sensor measurements with regard to a delay associated with the sensor measurements. In certain other example embodiments, one or more parameters of a probability model may be estimated based on blood glucose reference sample-sensor measurement pairs. Based on such information, function(s) for estimating a blood-glucose concentration in a patient may be determined.
摘要翻译：公开了用于校准葡萄糖监测传感器和/或胰岛素递送系统的方法，装置等。在某些示例性实施例中，血糖参考样本可以与关于与传感器测量相关联的延迟的传感器测量值相关。在某些其他示例实施例中，可以基于血糖参考样本 - 传感器测量对来估计概率模型的一个或多个参数。基于这样的信息，可以确定用于估计患者血糖浓度的功能。

6. 发明申请

US20070163894A1 Real-time self-calibrating sensor system and method 有权
标题翻译：实时自校准传感器系统及方法
公开(公告)号：US20070163894A1
公开(公告)日：2007-07-19
申请号：US11323216
申请日：2005-12-30
申请人： Lu Wang , Rajiv Shah , Wayne Morgan , Barry Keenan
发明人： Lu Wang , Rajiv Shah , Wayne Morgan , Barry Keenan
IPC分类号： G01F1/64 , A61B5/05 , G01N17/00 , G01N31/00 , C12N9/00 , C25B11/00
CPC分类号： A61B5/1495 , A61B5/0031 , A61B5/14532 , A61B5/1468 , A61B5/1473 , A61B5/14865 , A61B2560/0223 , A61M2005/1726
摘要： A system and method for calibrating a sensor of a characteristic monitoring system in real time utilizes a self-calibration module for periodic determination of, and compensation for, the IR drop across unwanted resistances in a cell. A current-interrupt switch is used to open the self-calibration module circuit and either measure the IR drop using a high-frequency (MHz) ADC module, or estimate it through linear regression of acquired samples of the voltage across the sensor's working and reference electrodes (Vmeasured) over time. The IR drop is then subtracted from the closed-circuit value of Vmeasured to calculate the overpotential that exists in the cell (Vimportant). Vimportant may be further optimized by subtracting the value of the open-circuit voltage (Voc) across the sensor's working and reference electrodes. The values of Vmeasured and Vimportant are then controlled by respective first and second control units to compensate for the IR drop.
摘要翻译：用于校准特征监测系统的传感器的系统和方法实时地利用自校准模块来周期性地确定和补偿细胞中不需要的电阻的IR降。使用电流中断开关来打开自校准模块电路，并使用高频（MHz）ADC模块测量IR降压，或通过传感器工作和参考电压的采集样本的线性回归进行估计电极（Vmeasured）随着时间的推移。然后从Vmeasured的闭路电流值中减去IR降，以计算存在于电池（Vimportant）中的超电势。可以通过减去传感器的工作参考电极和参考电极之间的开路电压（Voc）的值来进一步优化V重量。然后由相应的第一和第二控制单元控制V测量和V重量的值以补偿IR下降。

7. 发明申请

US20070038382A1 Method and system for limiting interference in electroencephalographic signals 有权
标题翻译：限制脑电信号干扰的方法和系统
公开(公告)号：US20070038382A1
公开(公告)日：2007-02-15
申请号：US11200674
申请日：2005-08-09
申请人： Barry Keenan
发明人： Barry Keenan
IPC分类号： G06F19/00 , A61B5/04
CPC分类号： A61B5/7203 , A61B5/117 , A61B5/7257 , A61B5/726 , G06K9/0051
摘要： This invention provides methods and systems for removing or limiting interference and artifacts often found in EEG signals and/or EOG signals and/or other physiological signals, and produces output signals that can be of greater use for analytic or diagnostic purposes, such as sleep studies. Interference and artifacts are removed by applying a plurality of filtering methods targeted to the particular time-frequency characteristics of the anticipated interference.
摘要翻译：本发明提供了用于去除或限制经常在EEG信号和/或EOG信号和/或其他生理信号中发现的干扰和伪影的方法和系统，并且产生可用于分析或诊断目的更多使用的输出信号，例如睡眠研究。通过应用针对预期干扰的特定时间 - 频率特性的多个滤波方法来去除干扰和伪影。

8. 发明授权

US09089292B2 Calibration of glucose monitoring sensor and/or insulin delivery system 有权
标题翻译：葡萄糖监测传感器和/或胰岛素输送系统的校准
公开(公告)号：US09089292B2
公开(公告)日：2015-07-28
申请号：US12748341
申请日：2010-03-26
申请人： Anirban Roy , Barry Keenan , Michael Kremliovsky
发明人： Anirban Roy , Barry Keenan , Michael Kremliovsky
IPC分类号： A61B5/00 , A61B5/145 , A61B5/1486 , A61B5/1495
CPC分类号： A61B5/1495 , A61B5/1451 , A61B5/14532 , A61B5/14865 , A61B5/4839 , A61B5/6849 , A61B5/7203 , A61B5/7221 , A61B5/725 , A61B5/7275 , A61B2560/0223 , A61M5/1723 , A61M2005/1726
摘要： Disclosed are methods, apparatuses, etc. for calibrating glucose monitoring sensors and/or insulin delivery systems. In certain example embodiments, blood glucose reference samples may be correlated with sensor measurements with regard to a delay associated with the sensor measurements. In certain other example embodiments, one or more parameters of a probability model may be estimated based on blood glucose reference sample-sensor measurement pairs. Based on such information, function(s) for estimating a blood-glucose concentration in a patient may be determined.
摘要翻译：公开了用于校准葡萄糖监测传感器和/或胰岛素递送系统的方法，装置等。在某些示例性实施例中，血糖参考样本可以与关于与传感器测量相关联的延迟的传感器测量值相关。在某些其他示例实施例中，可以基于血糖参考样本 - 传感器测量对来估计概率模型的一个或多个参数。基于这样的信息，可以确定用于估计患者血糖浓度的功能。

9. 发明授权

US09125607B2 Real-time self-calibrating sensor system and method 有权
标题翻译：实时自校准传感器系统及方法
公开(公告)号：US09125607B2
公开(公告)日：2015-09-08
申请号：US13340562
申请日：2011-12-29
申请人： Lu Wang , Rajiv Shah , Wayne A. Morgan , Barry Keenan
发明人： Lu Wang , Rajiv Shah , Wayne A. Morgan , Barry Keenan
IPC分类号： A61B5/1473 , A61B5/1468 , A61B5/1495 , A61B5/1486 , A61B5/00 , A61B5/145 , A61M5/172
CPC分类号： A61B5/1495 , A61B5/0031 , A61B5/14532 , A61B5/1468 , A61B5/1473 , A61B5/14865 , A61B2560/0223 , A61M2005/1726
摘要： A system and method for calibrating a sensor of a characteristic monitoring system in real time utilizes a self-calibration module for periodic determination of, and compensation for, the IR drop across unwanted resistances in a cell. A current-interrupt switch is used to open the self-calibration module circuit and either measure the IR drop using a high-frequency (MHz) ADC module, or estimate it through linear regression of acquired samples of the voltage across the sensor's working and reference electrodes (Vmeasured) over time. The IR drop is then subtracted from the closed-circuit value of Vmeasured to calculate the overpotential that exists in the cell (Vimportant). Vimportant may be further optimized by subtracting the value of the open-circuit voltage (Voc) across the sensor's working and reference electrodes. The values of Vmeasured and Vimportant are then controlled by respective first and second control units to compensate for the IR drop.
摘要翻译：用于校准特征监测系统的传感器的系统和方法实时地利用自校准模块来周期性地确定和补偿细胞中不需要的电阻的IR降。使用电流中断开关来打开自校准模块电路，并使用高频（MHz）ADC模块测量IR降压，或通过传感器工作和参考电压的采集样本的线性回归进行估计电极（Vmeasured）随着时间的推移。然后从Vmeasured的闭路电流值中减去IR降，以计算存在于电池（Vimportant）中的超电势。可以通过减去传感器的工作参考电极和参考电极之间的开路电压（Voc）的值来进一步优化V重量。然后由相应的第一和第二控制单元控制V测量和V重量的值以补偿IR下降。

10. 发明授权

US08919180B2 Determination and application of glucose sensor reliability indicator and/or metric 有权
标题翻译：葡萄糖传感器可靠性指标和/或度量的测定和应用
公开(公告)号：US08919180B2
公开(公告)日：2014-12-30
申请号：US13282128
申请日：2011-10-26
申请人： Rebecca K. Gottlieb , Ying Luo , Raghavendhar Gautham , Bradley Liang , Anirban Roy , Kenneth W. Cooper , Rajiv Shah , Barry Keenan
发明人： Rebecca K. Gottlieb , Ying Luo , Raghavendhar Gautham , Bradley Liang , Anirban Roy , Kenneth W. Cooper , Rajiv Shah , Barry Keenan
IPC分类号： G01N35/00 , A61B5/145 , A61B5/00 , A61M5/172
CPC分类号： A61B5/7221 , A61B5/14503 , A61B5/14532 , A61B5/1473 , A61B5/1495 , A61B5/4839 , A61B5/6849 , A61B5/7275 , A61B5/743 , A61M5/1723 , A61M2005/1726 , A61M2205/3303 , A61M2230/201
摘要： Disclosed are a system and method for determining a metric and/or indicator of a reliability of a blood glucose sensor in providing glucose measurements. In one aspect, the metric and/or indicator may be computed based, at least in part, on an observed trend associated with signals generated by the blood glucose sensor.
摘要翻译：公开了一种用于在提供葡萄糖测量中确定血糖传感器的可靠性的度量和/或指标的系统和方法。在一个方面，可以至少部分地基于与由血糖传感器产生的信号相关联的观察趋势来计算度量和/或指示符。

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