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1. 发明授权

US09089292B2 Calibration of glucose monitoring sensor and/or insulin delivery system 有权
标题翻译：葡萄糖监测传感器和/或胰岛素输送系统的校准
公开(公告)号：US09089292B2
公开(公告)日：2015-07-28
申请号：US12748341
申请日：2010-03-26
申请人： Anirban Roy , Barry Keenan , Michael Kremliovsky
发明人： Anirban Roy , Barry Keenan , Michael Kremliovsky
IPC分类号： A61B5/00 , A61B5/145 , A61B5/1486 , A61B5/1495
CPC分类号： A61B5/1495 , A61B5/1451 , A61B5/14532 , A61B5/14865 , A61B5/4839 , A61B5/6849 , A61B5/7203 , A61B5/7221 , A61B5/725 , A61B5/7275 , A61B2560/0223 , A61M5/1723 , A61M2005/1726
摘要： Disclosed are methods, apparatuses, etc. for calibrating glucose monitoring sensors and/or insulin delivery systems. In certain example embodiments, blood glucose reference samples may be correlated with sensor measurements with regard to a delay associated with the sensor measurements. In certain other example embodiments, one or more parameters of a probability model may be estimated based on blood glucose reference sample-sensor measurement pairs. Based on such information, function(s) for estimating a blood-glucose concentration in a patient may be determined.
摘要翻译：公开了用于校准葡萄糖监测传感器和/或胰岛素递送系统的方法，装置等。在某些示例性实施例中，血糖参考样本可以与关于与传感器测量相关联的延迟的传感器测量值相关。在某些其他示例实施例中，可以基于血糖参考样本 - 传感器测量对来估计概率模型的一个或多个参数。基于这样的信息，可以确定用于估计患者血糖浓度的功能。

2. 发明申请

US20110237917A1 CALIBRATION OF GLUCOSE MONITORING SENSOR AND/OR INSULIN DELIVERY SYSTEM 有权
标题翻译：葡萄糖监测传感器和/或胰岛素输送系统的校准
公开(公告)号：US20110237917A1
公开(公告)日：2011-09-29
申请号：US12748341
申请日：2010-03-26
申请人： Anirban Roy , Barry Keenan , Michael Kremliovsky
发明人： Anirban Roy , Barry Keenan , Michael Kremliovsky
IPC分类号： A61B5/145 , G06F19/00 , G01N33/48
CPC分类号： A61B5/1495 , A61B5/1451 , A61B5/14532 , A61B5/14865 , A61B5/4839 , A61B5/6849 , A61B5/7203 , A61B5/7221 , A61B5/725 , A61B5/7275 , A61B2560/0223 , A61M5/1723 , A61M2005/1726
摘要： Disclosed are methods, apparatuses, etc. for calibrating glucose monitoring sensors and/or insulin delivery systems. In certain example embodiments, blood glucose reference samples may be correlated with sensor measurements with regard to a delay associated with the sensor measurements. In certain other example embodiments, one or more parameters of a probability model may be estimated based on blood glucose reference sample-sensor measurement pairs. Based on such information, function(s) for estimating a blood-glucose concentration in a patient may be determined.
摘要翻译：公开了用于校准葡萄糖监测传感器和/或胰岛素递送系统的方法，装置等。在某些示例性实施例中，血糖参考样本可以与关于与传感器测量相关联的延迟的传感器测量值相关。在某些其他示例实施例中，可以基于血糖参考样本 - 传感器测量对来估计概率模型的一个或多个参数。基于这样的信息，可以确定用于估计患者血糖浓度的功能。

3. 发明授权

US07729753B2 Automated analysis of a cardiac signal based on dynamical characteristics of the cardiac signal 有权
标题翻译：基于心脏信号的动力学特征自动分析心脏信号
公开(公告)号：US07729753B2
公开(公告)日：2010-06-01
申请号：US11376603
申请日：2006-03-14
申请人： Michael Kremliovsky , Lev Korzinov
发明人： Michael Kremliovsky , Lev Korzinov
IPC分类号： A61B5/046
CPC分类号： A61B5/0452 , A61B5/046 , A61B5/7239
摘要： Systems and techniques relating to locating cardiac wave forms in a cardiac signal, and to detecting a physiological condition, such as ventricular fibrillation. In general, in one aspect, a machine-implemented method includes obtaining a sensed cardiac signal of an organism, the sensed cardiac signal comprising a time series x(t); applying a Hilbert (H) transform to the time series x(t) to obtain H(x(t)), wherein x(t) and H(x(t)) together forming a partial state space trajectory; determining a speed of trajectory, for the sensed cardiac signal, from the partial state space trajectory; and identifying physiological information concerning the organism based on a combination of first and second signal elements, the first signal element including a phase property or an amplitude property of the speed of trajectory, and the second signal element including an amplitude property of the partial state space trajectory.
摘要翻译：涉及将心脏波形定位在心脏信号中以及检测诸如心室颤动之类的生理状态的系统和技术。通常，在一个方面，机器实现的方法包括获得生物体的感测的心脏信号，所感测的心脏信号包括时间序列x（t）; 将希尔伯特（H）变换应用于时间序列x（t）以获得H（x（t）），其中x（t）和H（x（t））一起形成部分状态空间轨迹; 从所述部分状态空间轨迹确定所感测的心脏信号的轨迹速度; 以及基于第一和第二信号元素的组合识别关于生物体的生理信息，所述第一信号元素包括轨迹速度的相位特性或振幅特性，并且所述第二信号元素包括部分状态空间的振幅特性弹道。

4. 发明授权

US07996075B2 Monitoring physiological activity using partial state space reconstruction 有权
标题翻译：使用部分状态空间重建监测生理活动
公开(公告)号：US07996075B2
公开(公告)日：2011-08-09
申请号：US11081401
申请日：2005-03-15
申请人： Lev Korzinov , Michael Kremliovsky
发明人： Lev Korzinov , Michael Kremliovsky
IPC分类号： A61B5/0452
CPC分类号： A61B5/0472 , G06K9/00557
摘要： Systems and techniques relating to monitoring physiological activity using partial state space reconstruction. In general, in one aspect, a partial state space is produced using an orthogonal, frequency-independent transform, such as Hilbert transform. The partial state space can then be analyzed using state space techniques to identify physiological information for the biological system. The described techniques can be implemented in a distributed cardiac activity monitoring system, including a cardiac monitoring apparatus, and a QRS detector thereof.
摘要翻译：使用部分状态空间重建监测生理活动的系统和技术。通常，在一个方面，使用正交频率无关变换（例如希尔伯特变换）产生部分状态空间。然后可以使用状态空间技术来分析部分状态空间，以识别生物系统的生理信息。所描述的技术可以在包括心脏监测装置和其QRS检测器的分布式心脏活动监测系统中实现。

5. 发明申请

US20150317891A1 PATIENT CARE SYSTEM WITH CONDITIONAL ALARM FORWARDING 有权
标题翻译：病人护理系统与条件报警
公开(公告)号：US20150317891A1
公开(公告)日：2015-11-05
申请号：US14700357
申请日：2015-04-30
申请人： William Kenneth Day , Steve Joseph Lindo , Paul John Foryt , Justin Joseph Schmidt , Robert Cousineau , Michael Kremliovsky , Sumant Ramachandra , Anatoly S. Belkin , Gary Mills
发明人： William Kenneth Day , Steve Joseph Lindo , Paul John Foryt , Justin Joseph Schmidt , Robert Cousineau , Michael Kremliovsky , Sumant Ramachandra , Anatoly S. Belkin , Gary Mills
IPC分类号： G08B21/04 , A61M5/142
CPC分类号： A61M5/142 , A61M2205/18 , A61M2205/3553 , A61M2205/3584 , A61M2205/3592 , A61M2205/52 , G06F19/00 , G06F19/30 , G06F19/3468 , G08B21/0461 , G16H40/63
摘要： A patient care system is disclosed that includes a medical device such as an infusion pump. The medical device generates a data message containing information such as the status of the therapy being delivered, operating data or both. An alarm generating system assesses the data message from the pump and generates an alarm message if certain conditions established by a first set of rules are met. The alarm message is assessed according to a second set of rules as to whether to suppress the alarm message. The data message contains a required input for both the first and second algorithms. A dispatching system is adapted to forward the alarm message to an alarm destination according to a third set of rules. The alarm destination expresses an alarm upon receipt of the alarm message.
摘要翻译：公开了包括诸如输液泵的医疗装置的病人护理系统。医疗设备产生包含诸如正在传递的治疗的状态，操作数据或两者的信息的数据消息。报警生成系统从泵抽出数据信息，并且如果满足第一组规则建立的某些条件，则会产生报警信息。根据关于是否抑制报警消息的第二组规则评估报警消息。数据消息包含第一和第二算法所需的输入。调度系统适用于根据第三组规则将报警信息转发到报警目的地。报警目的地在收到报警信息后发出报警。

6. 发明授权

US08543354B2 Glucose sensor signal stability analysis 有权
公开(公告)号：US08543354B2
公开(公告)日：2013-09-24
申请号：US12914969
申请日：2010-10-28
申请人： Ying Luo , Rebecca K. Gottlieb , Meena Ramachandran , Chia-Hung Chiu , Nandita Dangui-Patel , Michael Kremliovsky , Jefferson Rose
发明人： Ying Luo , Rebecca K. Gottlieb , Meena Ramachandran , Chia-Hung Chiu , Nandita Dangui-Patel , Michael Kremliovsky , Jefferson Rose
IPC分类号： G06F17/18
CPC分类号： G01N33/66 , A61B5/0017 , A61B5/002 , A61B5/14532 , A61B5/1486 , A61B5/1495 , A61B5/6849 , A61B5/7207
摘要： Disclosed are methods, apparatuses, etc. for glucose sensor signal stability analysis. In certain example embodiments, a series of samples of at least one sensor signal that is responsive to a blood glucose level of a patient may be obtained. Based at least partly on the series of samples, at least one metric may be determined to assess an underlying trend of a change in responsiveness of the at least one sensor signal to the blood glucose level of the patient over time. A reliability of the at least one sensor signal to respond to the blood glucose level of the patient may be assessed based at least partly on the at least one metric assessing an underlying trend. Other example embodiments are disclosed herein.

7. 发明申请

US20110320166A1 GLUCOSE SENSOR SIGNAL STABILITY ANALYSIS 有权
标题翻译：葡萄糖传感器信号稳定性分析
公开(公告)号：US20110320166A1
公开(公告)日：2011-12-29
申请号：US12914969
申请日：2010-10-28
申请人： Ying Luo , Rebecca K. Gottlieb , Meena Ramachandran , Chia-Hung Chiu , Nandita Dangui-Patel , Michael Kremliovsky , Jefferson Rose
发明人： Ying Luo , Rebecca K. Gottlieb , Meena Ramachandran , Chia-Hung Chiu , Nandita Dangui-Patel , Michael Kremliovsky , Jefferson Rose
IPC分类号： G06F19/00 , G06F17/18
CPC分类号： G01N33/66 , A61B5/0017 , A61B5/002 , A61B5/14532 , A61B5/1486 , A61B5/1495 , A61B5/6849 , A61B5/7207
摘要： Disclosed are methods, apparatuses, etc. for glucose sensor signal stability analysis. In certain example embodiments, a series of samples of at least one sensor signal that is responsive to a blood glucose level of a patient may be obtained. Based at least partly on the series of samples, at least one metric may be determined to assess an underlying trend of a change in responsiveness of the at least one sensor signal to the blood glucose level of the patient over time. A reliability of the at least one sensor signal to respond to the blood glucose level of the patient may be assessed based at least partly on the at least one metric assessing an underlying trend. Other example embodiments are disclosed herein.
摘要翻译：公开了用于葡萄糖传感器信号稳定性分析的方法，装置等。在某些示例性实施例中，可以获得响应于患者的血糖水平的至少一个传感器信号的一系列样本。至少部分地基于一系列样本，可以确定至少一个度量以评估至少一个传感器信号对患者随着时间的血糖水平的响应性的变化的潜在趋势。可以至少部分地基于评估潜在趋势的至少一个度量来评估至少一个传感器信号对患者的血糖水平的响应的可靠性。本文公开了其它示例性实施例。

8. 发明申请

US20070219453A1 Automated analysis of a cardiac signal based on dynamical characteristics of the cardiac signal 有权
标题翻译：基于心脏信号的动力学特征自动分析心脏信号
公开(公告)号：US20070219453A1
公开(公告)日：2007-09-20
申请号：US11376603
申请日：2006-03-14
申请人： Michael Kremliovsky , Lev Korzinov
发明人： Michael Kremliovsky , Lev Korzinov
IPC分类号： A61B5/04
CPC分类号： A61B5/0452 , A61B5/046 , A61B5/7239
摘要： Systems and techniques relating to locating cardiac wave forms in a cardiac signal, and to detecting a physiological condition, such as ventricular fibrillation. In general, in one aspect, a machine-implemented method includes obtaining a sensed cardiac signal of an organism, the sensed cardiac signal comprising a time series x(t); applying a Hilbert (H) transform to the time series x(t) to obtain H(x(t)), wherein x(t) and H(x(t)) together forming a partial state space trajectory; determining a speed of trajectory, for the sensed cardiac signal, from the partial state space trajectory; and identifying physiological information concerning the organism based on a combination of first and second signal elements, the first signal element including a phase property or an amplitude property of the speed of trajectory, and the second signal element including an amplitude property of the partial state space trajectory.
摘要翻译：涉及将心脏波形定位在心脏信号中以及检测诸如心室颤动之类的生理状态的系统和技术。通常，在一个方面，机器实现的方法包括获得生物体的感测的心脏信号，所感测的心脏信号包括时间序列x（t）; 将希尔伯特（H）变换应用于时间序列x（t）以获得H（x（t）），其中x（t）和H（x（t））一起形成部分状态空间轨迹; 从所述部分状态空间轨迹确定所感测的心脏信号的轨迹速度; 以及基于第一和第二信号元素的组合识别关于生物体的生理信息，所述第一信号元素包括轨迹速度的相位特性或振幅特性，并且所述第二信号元素包括部分状态空间的振幅特性弹道。

9. 发明申请

US20060084881A1 Monitoring physiological activity using partial state space reconstruction 有权
标题翻译：使用部分状态空间重建监测生理活动
公开(公告)号：US20060084881A1
公开(公告)日：2006-04-20
申请号：US11081401
申请日：2005-03-15
申请人： Lev Korzinov , Michael Kremliovsky
发明人： Lev Korzinov , Michael Kremliovsky
IPC分类号： A61B5/04
CPC分类号： A61B5/0472 , G06K9/00557
摘要： Systems and techniques relating to monitoring physiological activity using partial state space reconstruction. In general, in one aspect, a partial state space is produced using an orthogonal, frequency-independent transform, such as Hilbert transform. The partial state space can then be analyzed using state space techniques to identify physiological information for the biological system. The described techniques can be implemented in a distributed cardiac activity monitoring system, including a cardiac monitoring apparatus, and a QRS detector thereof.
摘要翻译：使用部分状态空间重建监测生理活动的系统和技术。通常，在一个方面，使用正交频率无关变换（例如希尔伯特变换）产生部分状态空间。然后可以使用状态空间技术来分析部分状态空间，以识别生物系统的生理信息。所描述的技术可以在包括心脏监测装置和其QRS检测器的分布式心脏活动监测系统中实现。

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