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1. 发明授权

US09333147B2 Device for sealing a vessel and method of manufacturing a sealed vessel 有权
标题翻译：用于密封容器的装置和制造密封容器的方法
公开(公告)号：US09333147B2
公开(公告)日：2016-05-10
申请号：US13814915
申请日：2011-08-08
申请人： Andreas Schuetz , Makoto Kakiuchi , Seiji Shimazaki , Teruo Matsuda
发明人： Andreas Schuetz , Makoto Kakiuchi , Seiji Shimazaki , Teruo Matsuda
IPC分类号： A61J1/20 , A61M5/28 , A61J1/06 , B65B7/28 , B65B63/00 , B65B63/08 , B65B3/00 , A61M5/315 , A61M5/31
CPC分类号： A61J1/2096 , A61J1/065 , A61J1/2031 , A61J1/2093 , A61M5/284 , A61M5/31511 , A61M2005/3123 , B65B3/003 , B65B2220/14 , B65B2230/02
摘要： A device for sealing a vessel, in particular a cartridge (7) or a test-tube for accommodating a freeze-dried pharmaceutical product (S), wherein the vessel (1) comprises at its opening end (3) an opening edge (4) and an adjoining longitudinal portion (5) with an evenly formed inner cross section, including a front plunger (2) to be positioned inside the vessel (1) at the longitudinal portion (5), is characterized in that the front plunger (2) is configured to be positioned in the vessel (1) in a sealing state, in which the front plunger (2) is fully inserted in the vessel (1), or in an exchange state, in which the front plunger (2) is inserted partly in the vessel (1) and partly protrudes over the opening edge (4) of the vessel (1), wherein the front plunger (2) comprises sealing means that are configured to seal the inside of the vessel (1) against the outside when the front plunger (2) is positioned in the sealing state, and one or more communicating grooves (2i) that are configured to place the inside and outside of the vessel (1) in communication with each other when the front plunger (2) is positioned in the exchange state. Furthermore, a method of manufacturing a sealed vessel (1) is disclosed.
摘要翻译：一种用于密封容器的装置，特别是用于容纳冷冻干燥药物（S）的药筒（7）或试管，其中容器（1）在其开口端（3）处包括开口边缘（4））和具有均匀形成的内横截面的相邻的纵向部分（5），其包括在纵向部分（5）处定位在容器（1）内部的前柱塞（2），其特征在于，前柱塞（2））构造成在密封状态下定位在容器（1）中，其中前柱塞（2）完全插入容器（1）中，或者处于交换状态，其中前柱塞（2）是部分地插入容器（1）中并部分地突出在容器（1）的开口边缘（4）上，其中前柱塞（2）包括密封装置，其被构造成密封容器（1）的内部当前柱塞（2）位于密封状态时的外部，以及构造的一个或多个连通槽（2i）当前柱塞（2）位于交换状态时，将容器（1）的内部和外部放置在彼此连通。此外，公开了一种制造密封容器（1）的方法。

2. 发明申请

US20130197467A1 DEVICE FOR SEALING A VESSEL AND METHOD OF MANUFACTURING A SEALED VESSEL 有权
标题翻译：用于密封船舶的装置和制造密封船的方法
公开(公告)号：US20130197467A1
公开(公告)日：2013-08-01
申请号：US13814915
申请日：2011-08-08
申请人： Andreas Schuetz , Makoto Kakiuchi , Seiji Shimazaki , Teruo Matsuda
发明人： Andreas Schuetz , Makoto Kakiuchi , Seiji Shimazaki , Teruo Matsuda
IPC分类号： A61J1/20 , B65B63/08 , B65B63/00 , B65B7/28 , A61J1/06
CPC分类号： A61J1/2096 , A61J1/065 , A61J1/2031 , A61J1/2093 , A61M5/284 , A61M5/31511 , A61M2005/3123 , B65B3/003 , B65B2220/14 , B65B2230/02
摘要： A device for sealing a vessel, in particular a cartridge (7) or a test-tube for accommodating a freeze-dried pharmaceutical product (S), wherein the vessel (1) comprises at its opening end (3) an opening edge (4) and an adjoining longitudinal portion (5) with an evenly formed inner cross section, including a front plunger (2) to be positioned inside the vessel (1) at the longitudinal portion (5), is characterized in that the front plunger (2) is configured to be positioned in the vessel (1) in a sealing state, in which the front plunger (2) is fully inserted in the vessel (1), or in an exchange state, in which the front plunger (2) is inserted partly in the vessel (1) and partly protrudes over the opening edge (4) of the vessel (1), wherein the front plunger (2) comprises sealing means that are configured to seal the inside of the vessel (1) against the outside when the front plunger (2) is positioned in the sealing state, and one or more communicating grooves (2i) that are configured to place the inside and outside of the vessel (1) in communication with each other when the front plunger (2) is positioned in the exchange state. Furthermore, a method of manufacturing a sealed vessel (1) is disclosed.
摘要翻译：一种用于密封容器的装置，特别是用于容纳冷冻干燥药物（S）的药筒（7）或试管，其中容器（1）在其开口端（3）处包括开口边缘（4））和具有均匀形成的内横截面的相邻的纵向部分（5），其包括在纵向部分（5）处定位在容器（1）内部的前柱塞（2），其特征在于，前柱塞（2））构造成在密封状态下定位在容器（1）中，其中前柱塞（2）完全插入容器（1）中，或者处于交换状态，其中前柱塞（2）是部分地插入容器（1）中并部分地突出在容器（1）的开口边缘（4）上，其中前柱塞（2）包括密封装置，其被构造成密封容器（1）的内部当前柱塞（2）位于密封状态时的外部，以及构造的一个或多个连通槽（2i）当前柱塞（2）位于交换状态时，将容器（1）的内部和外部放置在彼此连通。此外，公开了一种制造密封容器（1）的方法。

3. 发明授权

US08517983B2 Dual chamber combined container-syringe 有权
标题翻译：双室组合容器注射器
公开(公告)号：US08517983B2
公开(公告)日：2013-08-27
申请号：US13276273
申请日：2011-10-18
申请人： Makoto Kakiuchi , Seiji Shimazaki , Teruo Matsuda
发明人： Makoto Kakiuchi , Seiji Shimazaki , Teruo Matsuda
IPC分类号： A61M37/00
CPC分类号： A61M5/284 , A61M5/31505 , A61M5/31515 , A61M5/31583 , A61M5/347 , A61M2005/3132 , A61M2005/31508
摘要： A dual chamber combined container-syringe includes: an outer casing having a bypass portion; a hub lure lock; a front stopper; a middle stopper that seals a pharmaceutical preparation together with the front stopper; an end stopper that seals a liquid medicine together with the middle stopper; a finger grip; and a plunger rod that is connected to the end stopper from the rear end side, wherein a female screw portion twisted around an axis is formed on an inner peripheral surface of the finger grip, and a first male screw portion, a tip of which comes into contact with a rear end of the female screw portion and can be screwed into the female portion, and a first guide plate are formed on an outer peripheral surface of the plunger rod when a part of the middle stopper enters the bypass portion.
摘要翻译：双室组合容器 - 注射器包括：具有旁路部分的外壳; 枢纽诱惑锁; 前挡块中间塞子，与前止动器一起密封药物制剂; 止血塞，其与中间塞子一起密封药液; 手指握力以及柱塞杆，其从后端侧连接到端部止动器，其中在手指的内周面上形成有围绕轴线扭转的阴螺纹部分，并且其顶端的第一阳螺纹部分与内螺纹部分的后端接触，并且可以拧入阴部，当中间止挡件的一部分进入旁路部分时，在柱塞杆的外周面上形成有第一引导板。

4. 发明授权

US07727203B2 Combined container-syringe 有权
标题翻译：组合式集装箱注射器
公开(公告)号：US07727203B2
公开(公告)日：2010-06-01
申请号：US11337056
申请日：2006-01-19
申请人： Seiji Shimazaki , Makoto Kakiuchi
发明人： Seiji Shimazaki , Makoto Kakiuchi
IPC分类号： A61M5/00
CPC分类号： A61M5/3134 , A61M5/3129 , A61M2005/14264 , A61M2005/3139
摘要： This combined container-syringe comprising a glass cylinder which can be pre-filled with a drug, an cylindrical tip provided at an exterior portion of an anterior end of the syringe, and a finger grip provided at an exterior portion of an posterior end of the syringe, and a drug is pre-filled therein and sealed by a stopper. Furthermore, an impact absorption part is provided around the exterior portion of the cylindrical tip and a diameter of the impact absorption part is greater than an outer diameter of a fitting part to the cylinder of the cylindrical tip.
摘要翻译：这种组合的容器 - 注射器包括可以预先填充药物的玻璃圆筒，设置在注射器的前端的外部的圆柱形尖端，以及设置在该后端的外部的手指注射器和药物预先填充在其中并通过塞子密封。此外，在圆筒形末端的外部周围设置有冲击吸收部，并且冲击吸收部的直径大于与圆筒形末端的圆筒的配合部的外径。

5. 发明申请

US20080091148A1 Combined container-syringe 审中-公开
标题翻译：组合式集装箱注射器
公开(公告)号：US20080091148A1
公开(公告)日：2008-04-17
申请号：US11974969
申请日：2007-10-16
申请人： Seiji Shimazaki , Makoto Kakiuchi
发明人： Seiji Shimazaki , Makoto Kakiuchi
IPC分类号： A61M5/19
CPC分类号： A61M5/284 , A61M5/3129
摘要： A combined container-syringe is provided. A bypass chamber and front chamber is provided at a cylindrical tip. The bypass chamber has an inner diameter greater than the outer diameters of front and rear stoppers. The front stopper is inserted into the bypass chamber. The front chamber has an inner diameter equal to the inner diameter of a cylinder or not greater than the outer diameters of the front and rear stoppers and has a volume greater than the volume of a drug solution. A bypass groove is formed in the inner wall of the bypass chamber and allows the cylinder to communicate with the front chamber while bypassing the front stopper. Accordingly, it is possible to provide a combined container-syringe enabling observation of the condition of a drug solution filled therein before making an injection and thus to make an injection in a secure manner.
摘要翻译：提供组合的容器注射器。旁路室和前室设置在圆柱形尖端处。旁通室的内径大于前挡块和后挡块的外径。前挡块插入旁路室。前室具有等于圆筒内径或不大于前挡块和后挡块的外径的内径，并且具有大于药液体积的体积。在旁路室的内壁中形成有旁通槽，并且允许气缸在旁路前挡块的同时与前室连通。因此，可以提供一种组合的容器 - 注射器，其能够在进行注射之前观察填充在其中的药液的状态，从而可靠地进行注射。

6. 发明申请

US20110174647A1 COMBINED CONTAINER-SYRINGE 审中-公开
标题翻译：组合容器 - SYRINGE
公开(公告)号：US20110174647A1
公开(公告)日：2011-07-21
申请号：US12918482
申请日：2009-02-19
申请人： Seiji Shimazaki , Makoto Kakiuchi
发明人： Seiji Shimazaki , Makoto Kakiuchi
IPC分类号： A61B19/02
CPC分类号： A61M5/3134 , A61M5/28 , A61M5/31505 , A61M2005/3104 , A61M2005/3106 , A61M2005/3139
摘要： In a combined container-syringe, a rubber packing that covers the distal end opening of a cylinder at a fitting hole of a cylindrical tip in an air tight and liquid tight manner, and in which is formed a through hole that brings a communication hole formed in a lure tip and the inside of the cylinder into communication, and a rubber member that is inserted from the distal end side of the communication hole and blocks the through hole are provided, and the rubber packing is formed with an elastic body that is corrosion resistant to the liquid medicament. With this combined container-syringe, in addition to being able to store it for a long period without deteriorating the liquid medicament, it is possible to observe well the liquid medicament or blood that flows to the cylindrical tip, and moreover preventing leftover liquid medicament after injection becomes possible.
摘要翻译：在组合的容器注射器中，橡胶密封件以气密和液密的方式覆盖圆柱形末端的装配孔处的圆筒的远端开口，并且其中形成有形成有连通孔的通孔在引诱尖端和气缸内部连通，并且设置从连通孔的远端侧插入并堵塞通孔的橡胶构件，并且橡胶衬垫形成有腐蚀性的弹性体耐液体药物。使用这种组合的容器 - 注射器，除了能够长期储存而不使液体药物变质，可以很好地观察流到圆柱形尖端的液体药物或血液，并且还防止剩余的液体药物经过注射成为可能。

7. 发明申请

US20060184138A1 Combined container-syringe 有权
标题翻译：组合式集装箱注射器
公开(公告)号：US20060184138A1
公开(公告)日：2006-08-17
申请号：US11337056
申请日：2006-01-19
申请人： Seiji Shimazaki , Makoto Kakiuchi
发明人： Seiji Shimazaki , Makoto Kakiuchi
IPC分类号： A61M5/31 , A61M5/00
CPC分类号： A61M5/3134 , A61M5/3129 , A61M2005/14264 , A61M2005/3139
摘要： This combined container-syringe comprising a glass cylinder which can be pre-filled with a drug, an cylindrical tip provided at an exterior portion of an anterior end of the syringe, and a finger grip provided at an exterior portion of an posterior end of the syringe, and a drug is pre-filled therein and sealed by a stopper. Furthermore, an impact absorption part is provided around the exterior portion of the cylindrical tip and a diameter of the impact absorption part is greater than an outer diameter of a fitting part to the cylinder of the cylindrical tip.
摘要翻译：这种组合的容器 - 注射器包括可以预先填充药物的玻璃圆筒，设置在注射器的前端的外部的圆柱形尖端，以及设置在该后端的外部的手指注射器和药物预先填充在其中并通过塞子密封。此外，在圆筒形末端的外部周围设置有冲击吸收部，并且冲击吸收部的直径大于与圆筒形末端的圆筒的配合部的外径。

8. 发明申请

US20140048432A1 Combination Container/Syringe 有权
标题翻译：组合容器/注射器
公开(公告)号：US20140048432A1
公开(公告)日：2014-02-20
申请号：US13983298
申请日：2012-02-02
申请人： Makoto Kakiuchi , Seiji Shimazaki
发明人： Makoto Kakiuchi , Seiji Shimazaki
IPC分类号： A61J1/00
CPC分类号： A61M5/286 , A61J1/00 , A61M5/347 , A61M2005/287 , A61M2005/3104 , A61M2005/3123 , A61M2005/3132
摘要： A combination container/syringe (1) provided with an outer cylinder (10) that forms a cylindrical shape centered on an axial line (O); a front stopper that is inserted into a distal end side of the outer cylinder (10); and a cylindrical tip (50) that is fitted to an outer periphery of the distal end of the outer cylinder via a fitting hole (61) at a base end side, and that has a bypass chamber (71) that houses the front stopper at a front side of the fitting hole, in which an inner diameter of the bypass chamber is formed larger than an outer diameter of the front stopper, and a plurality of ribs (74) that protrude toward an inside in a radial direction and extend in the direction of the axial line to make close contact with the outer peripheral surface of the front stopper that has moved to the inside of the bypass chamber are provided spaced apart in a circumferential direction on the inner peripheral surface (73) of the bypass chamber. According to this combination container/syringe, it is possible to effectively eliminate air bubbles in a medicinal solution via a medicinal solution flow-through space that is formed over the circumferential direction between the inner peripheral surface of the bypass chamber and the outer peripheral surface of the front stopper.
摘要翻译：具有形成以轴线（O）为中心的圆筒形的外筒（10）的组合容器/注射器（1）前挡块，其插入所述外筒（10）的前端侧; 以及圆筒形末端（50），其经由基端侧的嵌合孔（61）嵌合在所述外筒的前端的外周，并且具有将前止动器所述安装孔的前侧形成有所述旁路室的内径大于所述前止动件的外径，以及多个肋（74），所述肋（74）向径向内侧突出并在在旁路室的内周面（73）上沿周向间隔设置有与前挡块的外周面紧密接触的轴线方向。根据这种组合容器/注射器，可以通过在旁路室的内周面与外周面之间沿圆周方向形成的药液流通空间有效地消除药液中的气泡，前挡块

9. 发明授权

US09636463B2 Combination container/syringe 有权
公开(公告)号：US09636463B2
公开(公告)日：2017-05-02
申请号：US13983298
申请日：2012-02-02
申请人： Makoto Kakiuchi , Harumi Kakiuchi , Seiji Shimazaki
发明人： Makoto Kakiuchi , Seiji Shimazaki
IPC分类号： A61M5/28 , A61J1/00 , A61M5/34 , A61M5/31
CPC分类号： A61M5/286 , A61J1/00 , A61M5/347 , A61M2005/287 , A61M2005/3104 , A61M2005/3123 , A61M2005/3132
摘要： A combination container/syringe (1) provided with an outer cylinder (10) that forms a cylindrical shape centered on an axial line (O); a front stopper that is inserted into a distal end side of the outer cylinder (10); and a cylindrical tip (50) that is fitted to an outer periphery of the distal end of the outer cylinder via a fitting hole (61) at a base end side, and that has a bypass chamber (71) that houses the front stopper at a front side of the fitting hole, in which an inner diameter of the bypass chamber is formed larger than an outer diameter of the front stopper, and a plurality of ribs (74) that protrude toward an inside in a radial direction and extend in the direction of the axial line to make close contact with the outer peripheral surface of the front stopper that has moved to the inside of the bypass chamber are provided spaced apart in a circumferential direction on the inner peripheral surface (73) of the bypass chamber. According to this combination container/syringe, it is possible to effectively eliminate air bubbles in a medicinal solution via a medicinal solution flow-through space that is formed over the circumferential direction between the inner peripheral surface of the bypass chamber and the outer peripheral surface of the front stopper.

10. 发明授权

US08684977B2 Combined container-syringe 有权
标题翻译：组合式集装箱注射器
公开(公告)号：US08684977B2
公开(公告)日：2014-04-01
申请号：US12430849
申请日：2009-04-27
申请人： Makoto Kakiuchi
发明人： Makoto Kakiuchi
IPC分类号： A61M5/32
CPC分类号： A61M5/3257 , A61M5/31511 , A61M5/3245 , A61M2005/3247
摘要： A combined container-syringe includes a body that has an outer tube to be filled with a drug solution. A cylindrical tip is attached to a front end portion of the outer tube and to a front end portion of which an injection needle is attached. A cylindrical safety device is attached on an outer circumferential surface of the outer tube in a freely sliding manner. A first retaining member fixes the safety device in a disengageable manner at a first position where the safety device is separated from the injection needle. A second retaining member fixes the safety device at a second position where the safety device covers the injection needle. A biasing member biases the safety device in the direction from the first position to the second position. A latch releasing member releases the engagement by the first retaining member.
摘要翻译：组合的容器 - 注射器包括具有要填充有药物溶液的外管的主体。圆筒形尖端附接到外管的前端部分和连接注射针的前端部分。圆筒形安全装置以自由滑动的方式安装在外管的外周面上。第一保持构件将安全装置以可分离的方式固定在安全装置与注射针分离的第一位置处。第二保持构件将安全装置固定在安全装置覆盖注射针的第二位置。偏置构件沿着从第一位置到第二位置的方向偏压安全装置。闩锁释放构件释放由第一保持构件的接合。

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