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    • 1. 发明申请
    • Combination Container/Syringe
    • 组合容器/注射器
    • US20140048432A1
    • 2014-02-20
    • US13983298
    • 2012-02-02
    • Makoto KakiuchiSeiji Shimazaki
    • Makoto KakiuchiSeiji Shimazaki
    • A61J1/00
    • A61M5/286A61J1/00A61M5/347A61M2005/287A61M2005/3104A61M2005/3123A61M2005/3132
    • A combination container/syringe (1) provided with an outer cylinder (10) that forms a cylindrical shape centered on an axial line (O); a front stopper that is inserted into a distal end side of the outer cylinder (10); and a cylindrical tip (50) that is fitted to an outer periphery of the distal end of the outer cylinder via a fitting hole (61) at a base end side, and that has a bypass chamber (71) that houses the front stopper at a front side of the fitting hole, in which an inner diameter of the bypass chamber is formed larger than an outer diameter of the front stopper, and a plurality of ribs (74) that protrude toward an inside in a radial direction and extend in the direction of the axial line to make close contact with the outer peripheral surface of the front stopper that has moved to the inside of the bypass chamber are provided spaced apart in a circumferential direction on the inner peripheral surface (73) of the bypass chamber. According to this combination container/syringe, it is possible to effectively eliminate air bubbles in a medicinal solution via a medicinal solution flow-through space that is formed over the circumferential direction between the inner peripheral surface of the bypass chamber and the outer peripheral surface of the front stopper.
    • 具有形成以轴线(O)为中心的圆筒形的外筒(10)的组合容器/注射器(1) 前挡块,其插入所述外筒(10)的前端侧; 以及圆筒形末端(50),其经由基端侧的嵌合孔(61)嵌合在所述外筒的前端的外周,并且具有将前止动器 所述安装孔的前侧形成有所述旁路室的内径大于所述前止动件的外径,以及多个肋(74),所述肋(74)向径向内侧突出并在 在旁路室的内周面(73)上沿周向间隔设置有与前挡块的外周面紧密接触的轴线方向。 根据这种组合容器/注射器,可以通过在旁路室的内周面与外周面之间沿圆周方向形成的药液流通空间有效地消除药液中的气泡, 前挡块
    • 6. 发明授权
    • Device for sealing a vessel and method of manufacturing a sealed vessel
    • 用于密封容器的装置和制造密封容器的方法
    • US09333147B2
    • 2016-05-10
    • US13814915
    • 2011-08-08
    • Andreas SchuetzMakoto KakiuchiSeiji ShimazakiTeruo Matsuda
    • Andreas SchuetzMakoto KakiuchiSeiji ShimazakiTeruo Matsuda
    • A61J1/20A61M5/28A61J1/06B65B7/28B65B63/00B65B63/08B65B3/00A61M5/315A61M5/31
    • A61J1/2096A61J1/065A61J1/2031A61J1/2093A61M5/284A61M5/31511A61M2005/3123B65B3/003B65B2220/14B65B2230/02
    • A device for sealing a vessel, in particular a cartridge (7) or a test-tube for accommodating a freeze-dried pharmaceutical product (S), wherein the vessel (1) comprises at its opening end (3) an opening edge (4) and an adjoining longitudinal portion (5) with an evenly formed inner cross section, including a front plunger (2) to be positioned inside the vessel (1) at the longitudinal portion (5), is characterized in that the front plunger (2) is configured to be positioned in the vessel (1) in a sealing state, in which the front plunger (2) is fully inserted in the vessel (1), or in an exchange state, in which the front plunger (2) is inserted partly in the vessel (1) and partly protrudes over the opening edge (4) of the vessel (1), wherein the front plunger (2) comprises sealing means that are configured to seal the inside of the vessel (1) against the outside when the front plunger (2) is positioned in the sealing state, and one or more communicating grooves (2i) that are configured to place the inside and outside of the vessel (1) in communication with each other when the front plunger (2) is positioned in the exchange state. Furthermore, a method of manufacturing a sealed vessel (1) is disclosed.
    • 一种用于密封容器的装置,特别是用于容纳冷冻干燥药物(S)的药筒(7)或试管,其中容器(1)在其开口端(3)处包括开口边缘(4) )和具有均匀形成的内横截面的相邻的纵向部分(5),其包括在纵向部分(5)处定位在容器(1)内部的前柱塞(2),其特征在于,前柱塞(2) )构造成在密封状态下定位在容器(1)中,其中前柱塞(2)完全插入容器(1)中,或者处于交换状态,其中前柱塞(2)是 部分地插入容器(1)中并部分地突出在容器(1)的开口边缘(4)上,其中前柱塞(2)包括密封装置,其被构造成密封容器(1)的内部 当前柱塞(2)位于密封状态时的外部,以及构造的一个或多个连通槽(2i) 当前柱塞(2)位于交换状态时,将容器(1)的内部和外部放置在彼此连通。 此外,公开了一种制造密封容器(1)的方法。
    • 7. 发明申请
    • DEVICE FOR SEALING A VESSEL AND METHOD OF MANUFACTURING A SEALED VESSEL
    • 用于密封船舶的装置和制造密封船的方法
    • US20130197467A1
    • 2013-08-01
    • US13814915
    • 2011-08-08
    • Andreas SchuetzMakoto KakiuchiSeiji ShimazakiTeruo Matsuda
    • Andreas SchuetzMakoto KakiuchiSeiji ShimazakiTeruo Matsuda
    • A61J1/20B65B63/08B65B63/00B65B7/28A61J1/06
    • A61J1/2096A61J1/065A61J1/2031A61J1/2093A61M5/284A61M5/31511A61M2005/3123B65B3/003B65B2220/14B65B2230/02
    • A device for sealing a vessel, in particular a cartridge (7) or a test-tube for accommodating a freeze-dried pharmaceutical product (S), wherein the vessel (1) comprises at its opening end (3) an opening edge (4) and an adjoining longitudinal portion (5) with an evenly formed inner cross section, including a front plunger (2) to be positioned inside the vessel (1) at the longitudinal portion (5), is characterized in that the front plunger (2) is configured to be positioned in the vessel (1) in a sealing state, in which the front plunger (2) is fully inserted in the vessel (1), or in an exchange state, in which the front plunger (2) is inserted partly in the vessel (1) and partly protrudes over the opening edge (4) of the vessel (1), wherein the front plunger (2) comprises sealing means that are configured to seal the inside of the vessel (1) against the outside when the front plunger (2) is positioned in the sealing state, and one or more communicating grooves (2i) that are configured to place the inside and outside of the vessel (1) in communication with each other when the front plunger (2) is positioned in the exchange state. Furthermore, a method of manufacturing a sealed vessel (1) is disclosed.
    • 一种用于密封容器的装置,特别是用于容纳冷冻干燥药物(S)的药筒(7)或试管,其中容器(1)在其开口端(3)处包括开口边缘(4) )和具有均匀形成的内横截面的相邻的纵向部分(5),其包括在纵向部分(5)处定位在容器(1)内部的前柱塞(2),其特征在于,前柱塞(2) )构造成在密封状态下定位在容器(1)中,其中前柱塞(2)完全插入容器(1)中,或者处于交换状态,其中前柱塞(2)是 部分地插入容器(1)中并部分地突出在容器(1)的开口边缘(4)上,其中前柱塞(2)包括密封装置,其被构造成密封容器(1)的内部 当前柱塞(2)位于密封状态时的外部,以及构造的一个或多个连通槽(2i) 当前柱塞(2)位于交换状态时,将容器(1)的内部和外部放置在彼此连通。 此外,公开了一种制造密封容器(1)的方法。
    • 10. 发明申请
    • COMBINED CONTAINER-SYRINGE
    • 组合容器 - SYRINGE
    • US20100130928A1
    • 2010-05-27
    • US12513167
    • 2008-04-24
    • Makoto Kakiuchi
    • Makoto Kakiuchi
    • A61M5/50
    • A61M5/3243A61M5/284A61M5/3134A61M5/3271A61M5/34A61M2005/3132A61M2005/3247
    • The combined container-syringe 1 has a cylindrical cylinder 7 that is filled with a drug solution and an injection needle is mounted on the front end thereof; an engagement portion 13 that is provided at the front end side of the cylinder; a finger grip 9 that is provided on the rear end side of the cylinder 7; and a cylindrical-shaped safety device 3 that is mounted in a slidable manner on the outer periphery of the cylinder 7, and covers all the sphere of the injection needle 10 when it has moved in the front end direction. Furthermore, a return prevention stopper 27 which flexes inward in the radial direction by a pressing ring 5 and prevents the movement of the safety device 3 in the rear end direction by engaging with the engagement portion 13, and a slip-out prevention stopper 25 which prevents the movement of the safety device 3 in the front end direction, by engaging with the engagement portion 13.
    • 组合的容器 - 注射器1具有填充药液的圆柱形筒体7,其前端安装有注射针头; 设置在气缸的前端侧的接合部13; 设置在气缸7的后端侧的手指9; 以及圆筒形安全装置3,其以可滑动的方式安装在气缸7的外周上,并且当其沿前端方向移动时覆盖注射针10的所有球体。 另外,通过按压环5沿径向向内弯曲的防止止动件27,通过与卡合部13卡合来防止安全装置3沿后端方向的移动,以及防滑止挡件25, 通过与接合部13卡合来防止安全装置3在前端方向上的移动。