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1. 发明申请

US20080041398A1 Tongue Stabilization Device and Methods of Using the Same 有权
标题翻译：舌稳定装置及其使用方法
公开(公告)号：US20080041398A1
公开(公告)日：2008-02-21
申请号：US11847271
申请日：2007-08-29
申请人： Anant Hegde , Kasey Li , Nikhil Bhat , Christopher Bagley , Casidy Hallsten , George Choi , Doyeon Kim
发明人： Anant Hegde , Kasey Li , Nikhil Bhat , Christopher Bagley , Casidy Hallsten , George Choi , Doyeon Kim
IPC分类号： A61F5/56
CPC分类号： A61F5/56 , A61B2017/248 , A61F5/566 , A61F2210/0038 , Y10S602/902
摘要： An airway implant device for maintaining and/or creating an opening in air passageways is disclosed. Methods of using the device are also disclosed. The implant is an implant for stabilizing the tongue, the implant having an anchoring portion for securing a first end of the implant with the mandibula; a control portion connected with the anchoring portion, configured for selectively activating the implant; a flexible portion connected at its proximal end with the control portion, where the flexible portion has three-dimensional flexibility in a first state and where the flexible portion has a lesser three-dimensional flexibility in a second state, and where the flexible portion is selectively switchable between the first and second state by the control portion; an anchoring portion for connecting the implant with the base of the tongue connected with the flexible portion, and a latch mechanism coupled with the control portion and configured to maintain the flexible portion in either of the first and second states. Methods of treating airway disorders such as sleep apnea and snoring with the airway implant device are disclosed herein.
摘要翻译：公开了一种用于在空气通道中保持和/或形成开口的气道植入装置。还公开了使用该装置的方法。植入物是用于稳定舌头的植入物，所述植入物具有用于固定植入物的第一端与下颌骨的锚定部分; 与所述锚定部分连接的控制部分，被配置为选择性地启动所述植入物; 其柔性部分在其近端连接有控制部分，其中柔性部分在第一状态下具有三维柔性，并且柔性部分在第二状态下具有较小的三维柔性，并且其中柔性部分是选择性的通过控制部在第一状态和第二状态之间切换; 用于将植入物与与柔性部分连接的舌片的基部连接的锚定部分，以及与控制部分联接并被配置为将柔性部分保持在第一状态和第二状态中的任一状态的闩锁机构。本文公开了用气道植入装置处理呼吸道疾病如睡眠呼吸暂停和打鼾的方法。

2. 发明授权

US07909038B2 Tongue stabilization device and methods of using the same 有权
标题翻译：舌稳定装置及其使用方法
公开(公告)号：US07909038B2
公开(公告)日：2011-03-22
申请号：US11847271
申请日：2007-08-29
申请人： Anant V. Hegde , Kasey Kai-Chi Li , Nikhil D. Bhat , Christopher Bagley , Casidy Hallsten , George Y. Choi , Doyeon Kim
发明人： Anant V. Hegde , Kasey Kai-Chi Li , Nikhil D. Bhat , Christopher Bagley , Casidy Hallsten , George Y. Choi , Doyeon Kim
IPC分类号： A61F5/56 , F16F1/00 , F16F9/00 , A61J7/00 , A61M31/00 , A61M37/00 , A61M5/20
CPC分类号： A61F5/56 , A61B2017/248 , A61F5/566 , A61F2210/0038 , Y10S602/902
摘要： An airway implant device for maintaining and/or creating an opening in air passageways is disclosed. Methods of using the device are also disclosed. The implant is an implant for stabilizing the tongue, the implant having an anchoring portion for securing a first end of the implant with the mandibula; a control portion connected with the anchoring portion, configured for selectively activating the implant; a flexible portion connected at its proximal end with the control portion, where the flexible portion has three-dimensional flexibility in a first state and where the flexible portion has a lesser three-dimensional flexibility in a second state, and where the flexible portion is selectively switchable between the first and second state by the control portion; an anchoring portion for connecting the implant with the base of the tongue connected with the flexible portion, and a latch mechanism coupled with the control portion and configured to maintain the flexible portion in either of the first and second states. Methods of treating airway disorders such as sleep apnea and snoring with the airway implant device are disclosed herein.
摘要翻译：公开了一种用于在空气通道中保持和/或形成开口的气道植入装置。还公开了使用该装置的方法。植入物是用于稳定舌头的植入物，所述植入物具有用于固定植入物的第一端与下颌骨的锚定部分; 与所述锚定部分连接的控制部分，被配置为选择性地启动所述植入物; 其柔性部分在其近端连接有控制部分，其中柔性部分在第一状态下具有三维柔性，并且柔性部分在第二状态下具有较小的三维柔性，并且其中柔性部分是选择性的通过控制部在第一状态和第二状态之间切换; 用于将植入物与与柔性部分连接的舌片的基部连接的锚定部分，以及与控制部分联接并被配置为将柔性部分保持在第一状态和第二状态中的任一状态的闩锁机构。本文公开了用气道植入装置处理呼吸道疾病如睡眠呼吸暂停和打鼾的方法。

3. 发明申请

US20090173351A1 CONTROL SYSTEM FOR A TONGUE STABILIZATION DEVICE 审中-公开
标题翻译：用于稳定稳定装置的控制系统
公开(公告)号：US20090173351A1
公开(公告)日：2009-07-09
申请号：US12250398
申请日：2008-10-13
申请人： Koray Sahin , Anant V. Hegde , Kasey Kai-Chi Li , Nikhil D. Bhat , Christopher Bagley , Casidy Domingo , John M. Farbarik , George Y. Choi , Doyeon Kim
发明人： Koray Sahin , Anant V. Hegde , Kasey Kai-Chi Li , Nikhil D. Bhat , Christopher Bagley , Casidy Domingo , John M. Farbarik , George Y. Choi , Doyeon Kim
IPC分类号： A61F5/56 , G06F19/00
CPC分类号： A61F2/02 , A61B2017/248 , A61F5/56 , A61F5/566 , A61F2210/0038
摘要： A tongue implant control system and methods for stabilizing the tongue are disclosed. The tongue implant control system includes an implant device and a non-implanted control device in wireless communication. The control device provides an inductive power transfer for operating the implant device. The control device also sends commands for changing a state of the implant device. The implant device includes a flexible portion for attachment to the tongue and to one or more actuators. The one or more actuators may include shape memory material. The implant device detects a command from the control device and powers an actuator based on the command. Optionally, the implant device communicates its operating state to the control device and the control device displays information about the implant device at a user interface.
摘要翻译：公开了一种舌植入物控制系统和用于稳定舌头的方法。舌植入物控制系统包括无线通信中的植入装置和非植入式控制装置。控制装置提供用于操作植入装置的感应功率传递。控制装置还发送用于改变植入装置的状态的命令。植入装置包括用于附接到舌头和一个或多个致动器的柔性部分。一个或多个致动器可以包括形状记忆材料。植入装置根据该命令检测来自控制装置的命令并对致动器供电。可选地，植入装置将其操作状态传达到控制装置，并且控制装置在用户界面处显示关于植入装置的信息。

4. 发明授权

US08555891B2 Implant system for controlling airway passage 有权
标题翻译：用于控制气道通道的植入系统
公开(公告)号：US08555891B2
公开(公告)日：2013-10-15
申请号：US12785391
申请日：2010-05-21
申请人： Adam Sharkawy , Koray Sahin , Adrian McVicker , Jon F. Moss , Casidy Domingo , Nikhil D. Bhat , Christopher Bagley , Anant V. Hegde , John M. Farbarik , George Y. Choi , Kasey Kai-Chi Li
发明人： Adam Sharkawy , Koray Sahin , Adrian McVicker , Jon F. Moss , Casidy Domingo , Nikhil D. Bhat , Christopher Bagley , Anant V. Hegde , John M. Farbarik , George Y. Choi , Kasey Kai-Chi Li
IPC分类号： A61F5/56 , A61B1/32
CPC分类号： A61F5/566 , A61F5/56
摘要： Techniques for operating a subcutaneous implant device are disclosed. The implant device can be formed of a non-magnetic material that is compatible with diagnostics such as magnetic resonance imaging (MRI) and can include a rotor element that rotates under the influence of an external magnetic field. The implant device includes a tension relief mechanism for relieving excessive force applied between the implant device and a portion of a patient's tongue. A non-implanted device can include a stator and drive circuitry for generating the external magnetic field. The non-implanted device can receive a user command and can vary the external magnetic field based on the command. When activated by the magnetic field, the implant device can change its operating state to interact with the patient's body.
摘要翻译：公开了用于操作皮下植入装置的技术。植入装置可以由与诸如磁共振成像（MRI）的诊断相兼容的非磁性材料形成，并且可以包括在外部磁场的影响下旋转的转子元件。植入装置包括用于减轻施加在植入装置与患者舌头的一部分之间的过大力的张力释放机构。非植入装置可以包括用于产生外部磁场的定子和驱动电路。非植入装置可以接收用户命令并且可以基于命令改变外部磁场。当由磁场激活时，植入装置可以改变其操作状态以与患者的身体相互作用。

5. 发明申请

US20090084388A1 Methods and Devices for Removal of a Tongue Stabilization Device 有权
标题翻译：用于去除舌头稳定装置的方法和装置
公开(公告)号：US20090084388A1
公开(公告)日：2009-04-02
申请号：US12211082
申请日：2008-09-15
申请人： Christopher Bagley , Casidy Domingo , Anant V. Hegde
发明人： Christopher Bagley , Casidy Domingo , Anant V. Hegde
IPC分类号： A61F5/37 , A61B19/00 , A61F5/56
CPC分类号： A61F5/56 , A61B2017/248 , A61F5/566 , A61F2210/0038
摘要： An airway implant device for maintaining and/or creating an opening in air passageways is disclosed. Methods and devices for removing, the device are also disclosed. Methods of treating airway disorders such as sleep apnea and snoring with the airway implant device are disclosed herein.
摘要翻译：公开了一种用于在空气通道中保持和/或形成开口的气道植入装置。还公开了用于移除的方法和装置，该装置也被公开。本文公开了用气道植入装置处理呼吸道疾病如睡眠呼吸暂停和打鼾的方法。

6. 发明授权

US08256425B2 Methods and devices for removal of a tongue stabilization device 有权
标题翻译：用于去除舌头稳定装置的方法和装置
公开(公告)号：US08256425B2
公开(公告)日：2012-09-04
申请号：US12211082
申请日：2008-09-15
申请人： Christopher Bagley , Casidy Domingo , Anant V. Hegde
发明人： Christopher Bagley , Casidy Domingo , Anant V. Hegde
IPC分类号： A61F5/37 , A61F13/00 , A61F2/06 , A61F2/02 , A61D1/12
CPC分类号： A61F5/56 , A61B2017/248 , A61F5/566 , A61F2210/0038
摘要： An airway implant device for maintaining and/or creating an opening in air passageways is disclosed. Methods and devices for removing, the device are also disclosed. Methods of treating airway disorders such as sleep apnea and snoring with the airway implant device are disclosed herein.
摘要翻译：公开了一种用于在空气通道中保持和/或形成开口的气道植入装置。还公开了用于移除的方法和装置，该装置也被公开。本文公开了用气道植入装置处理呼吸道疾病如睡眠呼吸暂停和打鼾的方法。

7. 发明授权

US06200567B1 Therapeutic agents as cytokine antagonists and agonists 失效
标题翻译：作为细胞因子拮抗剂和激动剂的治疗剂
公开(公告)号：US06200567B1
公开(公告)日：2001-03-13
申请号：US09117399
申请日：1998-07-29
申请人： Angel Lopez , Christopher Bagley , Joanna Woodcock
发明人： Angel Lopez , Christopher Bagley , Joanna Woodcock
IPC分类号： A61K39395
CPC分类号： C07K16/2866 , A61K38/00 , C07K14/70503 , C07K14/715 , C07K14/7153 , C07K14/7155
摘要： A therapeutic agent capable of of binding to the F′-G′ loop of domain 4 of the common c Chain of the receptor for GM-CSF, IL-3, and IL-5. The amino acid Tyr421 which is located in the F′-G′ loop is critical in the high affinity binding and stimulation of function of GM-CSF, IL-3 and IL-5 to the common c chain of the receptors. Other receptors for cytokines also show hydrophobic amino acids in analogous positions and it is probable that they too play a pivotal role in binding of respective cytokines to them and in modulating function. Agents capable of binding to the F′-G′ loops are suggested and should be of therapeutic value.
摘要翻译：能够结合GM-CSF，IL-3和IL-5受体的共同C链的结构域4的F'-G'环的治疗剂。位于F'-G'环中的氨基酸Tyr421对于GM-CSF，IL-3和IL-5对受体的常见c链的功能的高亲和力结合和刺激是至关重要的。细胞因子的其他受体也显示类似位置的疏水性氨基酸，并且它们在结合相应的细胞因子和调节功能中也可能起关键作用。提出能够结合F'-G'环的试剂，应具有治疗价值。

8. 发明授权

US07994399B2 Methods for the production of stably transformed, fertile Zea mays plants 有权
标题翻译：用于生产稳定转化的，可育的玉米种植植物的方法
公开(公告)号：US07994399B2
公开(公告)日：2011-08-09
申请号：US11922828
申请日：2006-06-22
申请人： Fang-Ming Lai , Penny Mrabet , Kangfeng Mei , Luke Mankin , Hongyi Zhang , Christopher Bagley , Larry Nea , Zhongqi Wang , Bijay Singh , Jianying Peng
发明人： Fang-Ming Lai , Penny Mrabet , Kangfeng Mei , Luke Mankin , Hongyi Zhang , Christopher Bagley , Larry Nea , Zhongqi Wang , Bijay Singh , Jianying Peng
IPC分类号： C12N15/84 , A01H1/00 , A01H5/00 , A01H4/00
CPC分类号： C12N15/8205 , A01H5/10 , C12N15/8274
摘要： The present invention relates to improved methods for the incorporation of DNA into the genome of a Zea mays plant by means of Agrobacterium-mediated transformation. Preferred is the use of the Zea may lines deposited with American Type Culture Collection under the Patent Deposit Designation PTA-6170 and PTA-6171.
摘要翻译：本发明涉及通过农杆菌介导的转化将DNA并入Zea mays植物基因组的改进方法。优选使用保藏在专利保藏号PTA-6170和PTA-6171的美国典型培养物保藏中的玉米线。

9. 发明申请

US20100319710A1 IMPLANT SYSTEM FOR CONTROLLING AIRWAY PASSAGE 有权
标题翻译：用于控制空中通行的植入系统
公开(公告)号：US20100319710A1
公开(公告)日：2010-12-23
申请号：US12785391
申请日：2010-05-21
申请人： Adam Sharkawy , Koray Sahin , Adrian McVicker , Jon F. Moss , Casidy Domingo , Nikhil D. Bhat , Christopher Bagley , Anant V. Hegde , John M. Farbarik , George Y. Choi , Kasey Kai-Chi Li
发明人： Adam Sharkawy , Koray Sahin , Adrian McVicker , Jon F. Moss , Casidy Domingo , Nikhil D. Bhat , Christopher Bagley , Anant V. Hegde , John M. Farbarik , George Y. Choi , Kasey Kai-Chi Li
IPC分类号： A61F5/56
CPC分类号： A61F5/566 , A61F5/56
摘要： Techniques for operating a subcutaneous implant device are disclosed. The implant device can be formed of a non-magnetic material that is compatible with diagnostics such as magnetic resonance imaging (MRI) and can include a rotor element that rotates under the influence of an external magnetic field. The implant device includes a tension relief mechanism for relieving excessive force applied between the implant device and a portion of a patient's tongue. A non-implanted device can include a stator and drive circuitry for generating the external magnetic field. The non-implanted device can receive a user command and can vary the external magnetic field based on the command. When activated by the magnetic field, the implant device can change its operating state to interact with the patient's body.
摘要翻译：公开了用于操作皮下植入装置的技术。植入装置可以由与诸如磁共振成像（MRI）的诊断相兼容的非磁性材料形成，并且可以包括在外部磁场的影响下旋转的转子元件。植入装置包括用于减轻施加在植入装置与患者舌头的一部分之间的过大力的张力释放机构。非植入装置可以包括用于产生外部磁场的定子和驱动电路。非植入装置可以接收用户命令并且可以基于命令改变外部磁场。当由磁场激活时，植入装置可以改变其操作状态以与患者的身体相互作用。

10. 发明申请

US20090249514A1 Improved Methods for the Production of Stably Transformed, Fertile Zea Mays Plants 有权
标题翻译：稳定转化，可育玉米植物的改良方法
公开(公告)号：US20090249514A1
公开(公告)日：2009-10-01
申请号：US11922828
申请日：2006-06-22
申请人： Fang-Ming Lai , Penny Mrabet , Kangfeng Mei , Luke Mankin , Hongyi Zhang , Christopher Bagley , Larry Nea , Zhongqi Wang , Bijay Singh , Jianying Peng
发明人： Fang-Ming Lai , Penny Mrabet , Kangfeng Mei , Luke Mankin , Hongyi Zhang , Christopher Bagley , Larry Nea , Zhongqi Wang , Bijay Singh , Jianying Peng
IPC分类号： C12N15/82 , A01H5/00 , C12N5/10
CPC分类号： C12N15/8205 , A01H5/10 , C12N15/8274
摘要： The present invention relates to improved methods for the incorporation of DNA into the genome of a Zea mays plant by means of Agrobacterium-mediated transformation. Preferred is the use of the Zea may lines deposited with American Type Culture Collection under the Patent Deposit Designation PTA-6170 and PTA-6171.
摘要翻译：本发明涉及通过农杆菌介导的转化将DNA并入Zea mays植物基因组的改进方法。优选使用保藏在专利保藏号PTA-6170和PTA-6171的美国典型培养物保藏中的玉米线。

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