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1. 发明申请

WO2007024680A1 PYRAZOLOPYRIDINE AND PYRAZOLOPYRIMIDINE COMPOUNDS USEFUL AS KINASE ENZYMES MODULATORS 审中-公开
标题翻译：用作激酶酶调节剂的吡唑并吡啶和吡唑并嘧啶化合物有用
公开(公告)号：WO2007024680A1
公开(公告)日：2007-03-01
申请号：PCT/US2006/032314
申请日：2006-08-18
申请人： AMGEN INC. , BUCHANAN, John L. , BUCKNER, William H. , CARDOZO, Mario G. , DIMAURO, Erin F. , FU, Jiasheng , HAO, Xiaolin , JIAO, XianYun , KAYSER, Frank , KOPECKY, David J. , MASSE, Craig E. , TOMLINSON, Susan A. , WHITE, Ryan , ZHU, Xiaotian
发明人： BUCHANAN, John L. , BUCKNER, William H. , CARDOZO, Mario G. , DIMAURO, Erin F. , FU, Jiasheng , HAO, Xiaolin , JIAO, XianYun , KAYSER, Frank , KOPECKY, David J. , MASSE, Craig E. , TOMLINSON, Susan A. , WHITE, Ryan , ZHU, Xiaotian
IPC分类号： C07D487/04 , C07D231/56 , C07D403/06 , C07D405/06 , C07D401/14 , A61K31/519 , A61K31/416 , A61P19/00 , A61P17/00 , A61P35/00
CPC分类号： C07D403/06 , C07D231/56 , C07D401/14 , C07D405/06 , C07D487/04
摘要： The present invention relates to compounds of Formula (I) or a stereomer, a tautomer, a solvate, a pharmaceutically acceptable salt, or a prodrug thereof, pharmaceutical formulations containing the compounds, methods of treatments using the compounds, for example, protein tyrosine kinase-associated disorders such as immunologic and oncologic disorders and methods of preparing medicaments comprising the compounds.
摘要翻译：本发明涉及式（I）的化合物或立体异构体，互变异构体，溶剂化物，药学上可接受的盐或其前药，含有该化合物的药物制剂，使用该化合物的治疗方法，例如蛋白酪氨酸激酶 - 相关疾病如免疫学和肿瘤学疾病以及制备包含该化合物的药物的方法。

2. 发明申请

WO2010045258A2 SPIROCYCLIC GPR40 MODULATORS 审中-公开
标题翻译：螺旋GPR40调制器
公开(公告)号：WO2010045258A2
公开(公告)日：2010-04-22
申请号：PCT/US2009/060549
申请日：2009-10-13
申请人： AMGEN INC. , BROWN, Sean P. , DRANSFIELD, Paul , DU, Xiaohui , FU, Zice , HOUZE, Jonathan , JIAO, XianYun , LAI, SuJen , LI, An-Rong , LIU, Jiwen , MA, Zhihua , MEDINA, Julio C. , PATTAROPONG, Vatee , SHEN, Wang , VIMOLRATANA, Marc , WANG, Yingcai , WANG, Zhongyu , YU, Ming , ZHU, Liusheng
发明人： BROWN, Sean P. , DRANSFIELD, Paul , DU, Xiaohui , FU, Zice , HOUZE, Jonathan , JIAO, XianYun , LAI, SuJen , LI, An-Rong , LIU, Jiwen , MA, Zhihua , MEDINA, Julio C. , PATTAROPONG, Vatee , SHEN, Wang , VIMOLRATANA, Marc , WANG, Yingcai , WANG, Zhongyu , YU, Ming , ZHU, Liusheng
IPC分类号： C07C62/34 , C07D249/00 , C07D277/00 , C07D311/00 , C07D231/00 , C07D271/00 , C07D221/00
CPC分类号： C07C62/34 , C07C2601/02 , C07C2601/04 , C07C2601/08 , C07C2601/10 , C07C2601/14 , C07D213/643 , C07D217/24 , C07D253/065 , C07D277/22 , C07D311/04 , C07D401/12
摘要： The present invention provides compounds useful, for example, for treating metabolic disorders in a subject. Such compounds have the general formula IA, IB, I'A or I'B, where the definitions of the variables are provided herein. The present invention also provides compositions that include, and methods for using, the compounds in preparing medicaments and for treating metabolic disorders such as, for example, type II diabetes.
摘要翻译：本发明提供了可用于例如治疗受试者的代谢紊乱的化合物。这些化合物具有通式IA，IB，I'A或I'B，其中本文提供变量的定义。本发明还提供了组合物，其包括化合物在制备药物和用于治疗代谢性疾病例如II型糖尿病中的使用方法。

3. 发明申请

WO2008030520A1 HETEROCYCLIC GPR40 MODULATORS 审中-公开
标题翻译：杂环GPR40调制器
公开(公告)号：WO2008030520A1
公开(公告)日：2008-03-13
申请号：PCT/US2007/019454
申请日：2007-09-06
申请人： AMGEN INC. , BECK, Hilary , DRANSFIELD, Paul , FU, Zice , HOUZE, Jonathan , JIAO, XianYun , KOHN, Todd, J. , LAI, SuJen , LIU, Jinqian , LIU, Jiwen , MA, Zhihua , SCHMITT, Michael, J. , SHARMA, Rajiv , SHEN, Wang , VIMOLRATANA, Marc , WANG, Yingcai , WANG, Zhongyu
发明人： BECK, Hilary , DRANSFIELD, Paul , FU, Zice , HOUZE, Jonathan , JIAO, XianYun , KOHN, Todd, J. , LAI, SuJen , LIU, Jinqian , LIU, Jiwen , MA, Zhihua , SCHMITT, Michael, J. , SHARMA, Rajiv , SHEN, Wang , VIMOLRATANA, Marc , WANG, Yingcai , WANG, Zhongyu
IPC分类号： C07D261/08 , C07D409/12 , C07D413/06 , C07D413/12 , C07D417/12 , A61K31/42 , A61K31/422 , A61P3/10 , A61P3/04 , A61P9/00 , A61P9/10
CPC分类号： C07D261/08 , C07D409/12 , C07D413/06 , C07D413/12 , C07D417/12
摘要： The present invention provides compounds useful, for example, for treating metabolic disorders in a subject. Such compounds have the general formula I: where the definitions of the variables are provided herein. The present invention also provides compositions that include, and methods for using, the compounds in preparing medicaments and for treating metabolic disorders such as, for example, type II diabetes.
摘要翻译：本发明提供了可用于例如治疗受试者的代谢紊乱的化合物。这些化合物具有通式I：其中本文提供变量的定义。本发明还提供了组合物，其包括化合物在制备药物和用于治疗代谢性疾病例如II型糖尿病中的使用方法。

4. 发明申请

WO2006130160A2 FURANOPYRIDINE DERIVATIVES AND METHODS OF USE 审中-公开
标题翻译：呋喃并吡啶衍生物及其使用方法
公开(公告)号：WO2006130160A2
公开(公告)日：2006-12-07
申请号：PCT/US2005/025725
申请日：2005-07-19
申请人： AMGEN INC. , NUNES, Joseph, J. , MARTIN, Matthew, W. , WHITE, Ryan , MCGOWAN, David , BEMIS, Jean, E. , KAYSER, Frank , FU, Jiasheng , LIU, Jinqian , JIAO, XianYun
发明人： NUNES, Joseph, J. , MARTIN, Matthew, W. , WHITE, Ryan , MCGOWAN, David , BEMIS, Jean, E. , KAYSER, Frank , FU, Jiasheng , LIU, Jinqian , JIAO, XianYun
CPC分类号： C07D491/04 , C07D491/14
摘要： The present invention relates to furanopyridine compounds having the general Formula I (I) and stereoisomers, tautomers, solvates, pharmaceutically acceptable salts and derivatives, and prodrugs thereof. The invention also includes pharmaceutical compositions comprising a compound of Formula I, methods of modulating Lck and ACK-1 enzymes and of treating various related diseases and conditions, including inflammation, inhibition of T cell activation, proliferation, arthritis, organ transplant, ischemic or reperfusion injury, myocardial infarction, stroke, multiple sclerosis, inflammatory bowel disease, Crohn's disease, lupus, hypersensitivity, type 1 diabetes, psoriasis, dermatitis, Hashimoto's thyroiditis, Sjogren's syndrome, autoimmune hyperthyroidism, Addison's disease, autoimmune diseases, glomerulonephritis, allergic diseases, asthma, hayfever, eczema, cancer, colon carcinoma, thymoma, just to name a few, in a mammal, comprising administering to the mammal a therapeutically effective amount a compound of Formula I, as described above, and methods of manufacturing medicaments comprising the compound of Formula I.
摘要翻译：本发明涉及具有通式I（I）的呋喃并吡啶化合物及其立体异构体，互变异构体，溶剂合物，药学上可接受的盐和衍生物及其前药。本发明还包括药物组合物，其包含式I化合物，调节Lck和ACK-1酶的方法以及治疗各种相关疾病和病症，包括炎症，T细胞活化抑制，增殖，关节炎，器官移植，缺血或再灌注损伤，心肌梗塞，中风，多发性硬化，炎性肠病，克罗恩病，狼疮，超敏反应，1型糖尿病，牛皮癣，皮炎，桥本氏甲状腺炎，干燥综合征，自身免疫性甲状腺功能亢进，艾迪生病，自身免疫性疾病，肾小球肾炎，过敏性疾病，哮喘，干草组织，湿疹，癌症，结肠癌，胸腺瘤，仅举几个例子，在哺乳动物中，包括向哺乳动物施用治疗有效量的如上所述的式I化合物和制备包含以下化合物的药物的方法：一级方程式

5. 发明公开

EP2358656A2 SPIROCYCLIC GPR40 MODULATORS 有权
标题翻译：螺GPR40调节剂
公开(公告)号：EP2358656A2
公开(公告)日：2011-08-24
申请号：EP09741123.5
申请日：2009-10-13
申请人： Amgen, Inc
发明人： BROWN, Sean P. , DRANSFIELD, Paul , DU, Xiaohui , FU, Zice , HOUZE, Jonathan , JIAO, XianYun , LAI, SuJen , LI, An-Rong , LIU, Jiwen , MA, Zhihua , MEDINA, Julio C. , PATTAROPONG, Vatee , SHEN, Wang , VIMOLRATANA, Marc , WANG, Yingcai , WANG, Zhongyu , YU, Ming , ZHU, Liusheng
IPC分类号： C07C62/34 , C07D249/00 , C07D277/00 , C07D311/00 , C07D231/00 , C07D271/00 , C07D221/00
CPC分类号： C07C62/34 , C07C2601/02 , C07C2601/04 , C07C2601/08 , C07C2601/10 , C07C2601/14 , C07D213/643 , C07D217/24 , C07D253/065 , C07D277/22 , C07D311/04 , C07D401/12
摘要： The present invention provides compounds useful, for example, for treating metabolic disorders in a subject. Such compounds have the general formula IA, IB, I'A or I'B, where the definitions of the variables are provided herein. The present invention also provides compositions that include, and methods for using, the compounds in preparing medicaments and for treating metabolic disorders such as, for example, type II diabetes.

6. 发明授权

EP2358656B1 SPIROCYCLIC GPR40 MODULATORS 有权
标题翻译： SPIROCYCLISCHE GPR40-MODULATOREN
公开(公告)号：EP2358656B1
公开(公告)日：2014-01-01
申请号：EP09741123.5
申请日：2009-10-13
申请人： Amgen, Inc
发明人： BROWN, Sean P. , DRANSFIELD, Paul , DU, Xiaohui , FU, Zice , HOUZE, Jonathan , JIAO, XianYun , LAI, SuJen , LI, An-Rong , LIU, Jiwen , MA, Zhihua , MEDINA, Julio C. , PATTAROPONG, Vatee , SHEN, Wang , VIMOLRATANA, Marc , WANG, Yingcai , WANG, Zhongyu , YU, Ming , ZHU, Liusheng
IPC分类号： C07C62/34 , C07D249/00 , C07D277/00 , C07D311/00 , C07D231/00 , C07D271/00 , C07D221/00
CPC分类号： C07C62/34 , C07C2601/02 , C07C2601/04 , C07C2601/08 , C07C2601/10 , C07C2601/14 , C07D213/643 , C07D217/24 , C07D253/065 , C07D277/22 , C07D311/04 , C07D401/12

7. 发明公开

EP2064193A1 HETEROCYCLIC GPR40 MODULATORS 审中-公开
标题翻译：杂环GPR40调节剂
公开(公告)号：EP2064193A1
公开(公告)日：2009-06-03
申请号：EP07837816.3
申请日：2007-09-06
申请人： Amgen, Inc
发明人： BECK, Hilary , DRANSFIELD, Paul , FU, Zice , HOUZE, Jonathan , JIAO, XianYun , KOHN, Todd, J. , LAI, SuJen , LIU, Jinqian , LIU, Jiwen , MA, Zhihua , SCHMITT, Michael, J. , SHARMA, Rajiv , SHEN, Wang , VIMOLRATANA, Marc , WANG, Yingcai , WANG, Zhongyu , MEDINA, Julio, C.
IPC分类号： C07D261/08 , C07D409/12 , C07D413/06 , C07D413/12 , C07D417/12 , A61K31/42 , A61K31/422 , A61P3/10 , A61P3/04 , A61P9/00 , A61P9/10
CPC分类号： C07D261/08 , C07D409/12 , C07D413/06 , C07D413/12 , C07D417/12
摘要： The present invention provides compounds useful, for example, for treating metabolic disorders in a subject. Such compounds have the general formula I: where the definitions of the variables are provided herein. The present invention also provides compositions that include, and methods for using, the compounds in preparing medicaments and for treating metabolic disorders such as, for example, type II diabetes.

8. 发明公开

EP1926734A1 PYRAZOLOPYRIDINE AND PYRAZOLOPYRIMIDINE COMPOUNDS USEFUL AS KINASE ENZYMES MODULATORS 审中-公开
标题翻译：吡唑并吡啶和吡唑并嘧啶类化合物作为激酶调节剂
公开(公告)号：EP1926734A1
公开(公告)日：2008-06-04
申请号：EP06789860.1
申请日：2006-08-18
申请人： Amgen Inc.
发明人： BUCHANAN, John L. , BUCKNER, William H. , CARDOZO, Mario G. , DIMAURO, Erin F. , FU, Jiasheng , HAO, Xiaolin , JIAO, XianYun , KAYSER, Frank , KOPECKY, David J. , MASSE, Craig E. , TOMLINSON, Susan A. , WHITE, Ryan , ZHU, Xiaotian
IPC分类号： C07D487/04 , C07D231/56 , C07D403/06 , C07D405/06 , C07D401/14 , A61K31/519 , A61K31/416 , A61P19/00 , A61P17/00 , A61P35/00
CPC分类号： C07D403/06 , C07D231/56 , C07D401/14 , C07D405/06 , C07D487/04
摘要： The present invention relates to compounds of Formula (I) or a stereomer, a tautomer, a solvate, a pharmaceutically acceptable salt, or a prodrug thereof, pharmaceutical formulations containing the compounds, methods of treatments using the compounds, for example, protein tyrosine kinase-associated disorders such as immunologic and oncologic disorders and methods of preparing medicaments comprising the compounds.
摘要翻译：本发明涉及式（I）化合物或其立体异构体，互变异构体，溶剂化物，药学上可接受的盐或前药，含有该化合物的药物制剂，使用该化合物的治疗方法，例如蛋白酪氨酸激酶相关疾病如免疫和肿瘤疾病以及制备包含该化合物的药物的方法。

9. 发明公开

EP1791845A2 FURANOPYRIDINE DERIVATIVES AS ACK1 AND LCK MODULATORS 审中-公开
标题翻译：呋喃基吡啶衍生物作为ACK1和LCK调节剂
公开(公告)号：EP1791845A2
公开(公告)日：2007-06-06
申请号：EP05857894.9
申请日：2005-07-19
申请人： AMGEN INC.
发明人： NUNES, Joseph, J. , MARTIN, Matthew, W. , WHITE, Ryan , MCGOWAN, David , BEMIS, Jean, E. , KAYSER, Frank , FU, Jiasheng , LIU, Jinqian , JIAO, XianYun
IPC分类号： C07D491/04
CPC分类号： C07D491/04 , C07D491/14
摘要： The present invention relates to furanopyridine compounds having the general Formula (I) and stereoisomers, tautomers, solvates, pharmaceutically acceptable salts and derivatives, and prodrugs thereof. The invention also includes pharmaceutical compositions comprising a compound of Formula I, methods of modulating Lck and ACK-1 enzymes and of treating various related diseases and conditions, including inflammation, inhibition of T cell activation, proliferation, arthritis, organ transplant, ischemic or reperfusion injury, myocardial infarction, stroke, multiple sclerosis, inflammatory bowel disease, Crohn's disease, lupus, hypersensitivity, type 1 diabetes, psoriasis, dermatitis, Hashimoto's thyroiditis, Sjogren's syndrome, autoimmune hyperthyroidism, Addison's disease, autoimmune diseases, glomerulonephritis, allergic diseases, asthma, hayfever, eczema, cancer, colon carcinoma, thymoma, just to name a few, in a mammal, comprising administering to the mammal a therapeutically effective amount a compound of Formula I, as described above, and methods of manufacturing medicaments comprising the compound of Formula (I).
摘要翻译：本发明涉及具有通式（I）的呋喃并吡啶化合物及其立体异构体，互变异构体，溶剂化物，药学上可接受的盐和衍生物以及前药。本发明还包括含有式I化合物的药物组合物，调节Lck和ACK-1酶以及治疗各种相关疾病和病症（包括炎症，抑制T细胞活化，增殖，关节炎，器官移植，局部缺血或再灌注损伤，心肌梗塞，中风，多发性硬化，炎性肠病，克罗恩氏病，狼疮，超敏反应，1型糖尿病，牛皮癣，皮炎，桥本氏甲状腺炎，干燥综合征，自身免疫性甲亢，艾迪生病，自身免疫性疾病，肾小球肾炎，过敏性疾病，哮喘包括向哺乳动物施用治疗有效量的如上所述的式I化合物的药物组合物，以及制备包含式I化合物的药物的方法，所述药物包含公式（I）。

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