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1. 发明申请

US20080281412A1 RIGID BODY AORTIC BLOOD PUMP IMPLANT 有权
标题翻译：刚体动物血液泵植入物
公开(公告)号：US20080281412A1
公开(公告)日：2008-11-13
申请号：US12120457
申请日：2008-05-14
申请人： Robert M. Smith , Adrian Kantrowitz , Valluvan Jeevanandam , Allen B. Kantrowitz , Paul S. Freed
发明人： Robert M. Smith , Adrian Kantrowitz , Valluvan Jeevanandam , Allen B. Kantrowitz , Paul S. Freed
IPC分类号： A61M1/12
CPC分类号： A61M1/107 , A61M1/1037 , A61M1/106 , A61M1/1072 , A61M1/122 , A61M1/125 , B33Y80/00
摘要： An implantable aortic blood pump includes a rigid body having wall extending along a long axis and defining an inflation port portion with an inflation aperture therethrough. The aperture is fluid communication with an inner surface of the body and on a fluid supply, the body is preferably independent of an external brace or an external stiffener, yet still has a cantilevered deformation of less than 8 millimeters in response to a 200 gram weight suspended from a front body edge. A deflecting structure of a membrane deflects in response to fluid pressure so as to pump blood when the pump is secured to a subject aorta.
摘要翻译：可植入主动脉血泵包括刚体，其具有沿着长轴延伸的壁，并且限定具有穿过其的充气孔的充气口部分。孔与主体的内表面和流体供应源流体连通，主体优选地独立于外部支架或外部加强件，但是响应于200克重量仍然具有小于8毫米的悬臂变形从前身边缘悬挂。膜的偏转结构响应于流体压力而偏转，以便当泵固定到主体主动脉时泵送血液。

2. 发明授权

US07513864B2 Synchronization system between aortic valve and cardiac assist device 有权
标题翻译：主动脉瓣与心脏辅助装置之间的同步系统
公开(公告)号：US07513864B2
公开(公告)日：2009-04-07
申请号：US11178969
申请日：2005-07-11
申请人： Allen B. Kantrowitz , Adrian Kantrowitz
发明人： Allen B. Kantrowitz , Adrian Kantrowitz
IPC分类号： A61M1/12
CPC分类号： A61M1/122 , A61M1/106 , A61M1/1067 , A61M1/1072 , A61M1/1086 , A61M1/12 , A61M1/127 , A61M2205/33 , A61M2205/3303
摘要： A cardiac assist device synchronization system includes a cardiac assist device and an acoustic or accelerometer sensor that provides a signal input to the cardiac assist device indicative of aortic valve closure. The cardiac assist device is coupled to a mammalian aorta and includes an inflatable chamber and a fluid pump. A fluid conduit is in communication between the chamber and the pump to provide for selective inflation of the chamber. A pump controller triggers the pump in counter-pulsation to a mammalian heart upstream from the aorta. A process for synchronizing a cardiac assist device in counter-pulsation with a left ventricle includes locating an acoustic or accelerometer sensor within a thoracic cavity of a mammal having the assist device coupled to the aorta of the mammal. Through the measurement of an acoustic or acceleration property of an aortic valve of the mammal, and the transmission of aortic valve closure measurement through a controller for the cardiac assist device, counter-pulsatile synchronization for the cardiac assist device is achieved.
摘要翻译：心脏辅助装置同步系统包括心脏辅助装置和声学或加速度计传感器，其向心脏辅助装置提供指示主动脉瓣闭合的信号输入。心脏辅助装置耦合到哺乳动物主动脉并且包括可充气室和流体泵。流体导管在腔室和泵之间连通以提供腔室的选择性充气。泵控制器触发泵与主动脉上游的哺乳动物心脏反搏。将逆向脉动中的心脏辅助装置与左心室同步的过程包括将声学或加速度计传感器定位在哺乳动物的胸腔内，该辅助装置与哺乳动物的主动脉联接。通过测量哺乳动物的主动脉瓣的声学或加速特性，以及通过用于心脏辅助装置的控制器传播主动脉瓣闭合测量，实现了心脏辅助装置的反脉动同步。

3. 发明授权

US07846083B2 Left ventricle assist device (LVAD) 有权
标题翻译：左心室辅助装置（LVAD）
公开(公告)号：US07846083B2
公开(公告)日：2010-12-07
申请号：US11679487
申请日：2007-02-27
申请人： Robert M. Smith , Roger W. Snyder , Adrian Kantrowitz , Allen B. Kantrowitz
发明人： Robert M. Smith , Roger W. Snyder , Adrian Kantrowitz , Allen B. Kantrowitz
IPC分类号： A61N1/00
CPC分类号： A61M1/1072 , A61M1/1008 , A61M1/1037 , A61M1/106 , A61M1/122 , A61M1/125
摘要： A pump has an elongated shell with a generally elliptical shape, an outer convex surface and an inner concave surface. A peripheral side edge located between the inner and outer surfaces terminates in a bead edge. A flexible airtight membrane has a membrane edge bonded to the outer shell surface adjacent to the bead edge. Preforming the membrane edge looped with a maximum linear span of curvature that is greater than a maximal transverse linear extent of the bead edge, membrane operational wear during inflation and deflation cycles is reduced in the region around the bead edge. A process of forming a blood pump with a membrane preform is also provided.
摘要翻译：泵具有大致椭圆形的细长壳体，外凸面和内凹面。位于内表面和外表面之间的周边侧边缘终止于边缘。柔性密封膜具有与胎圈边缘相邻的外壳表面结合的膜边缘。预先形成最大线性曲率跨度的膜边缘，其大于胎圈边缘的最大横向线性范围，在充气和放气周期期间的膜操作磨损在珠边缘周围的区域减小。还提供了一种形成具有膜预制件的血液泵的过程。

4. 发明申请

US20100143577A1 PERCUTANEOUS ACCESS DEVICE SYSTEM FACILITATING CELL GROWTH THEREON 审中-公开
公开(公告)号：US20100143577A1
公开(公告)日：2010-06-10
申请号：US12701784
申请日：2010-02-08
申请人： Allen B. Kantrowitz
发明人： Allen B. Kantrowitz
IPC分类号： B05D3/10
CPC分类号： A61F2/022
摘要： A biocompatible implantable portal is provided that has a wall defining a communicative passage through an interior bore. The exterior of the portal has a neck region adapted to promote autologous cell growth on the neck region. A series of channels are provided on the exterior neck region to facilitate autologous cell growth while disfavoring fluid pooling and bacterial growth. Typical channel widths are from 20 to 300 microns, with adjacent channels being separated by plateaus having a width of between 0 and 600 microns. Providing the portal exterior neck region with a texture varying on a nanometer length scale facilitates autologous cell growth. Applying a coating such as a tissue scaffolding matrix to the neck region prior to implantation also facilitates cell growth. A coupling or a manifold encompassing the neck region facilitates the draw of vacuum and/or mechanical protection for the growing cells.
摘要翻译：提供了一种生物兼容的可植入入口，其具有限定通过内孔的连通通道的壁。门户的外部具有适于促进颈部区域的自体细胞生长的颈部区域。在外颈部提供一系列通道，以促进自体细胞生长，同时不利于液体汇集和细菌生长。典型的通道宽度为20至300微米，相邻通道由0至600微米之间的宽度隔开。提供具有以纳米长度尺度变化的纹理的门静脉外颈部区域促进自体细胞生长。在植入之前将诸如组织支架基质的涂层施用于颈部区域也有助于细胞生长。包围颈部区域的联接器或歧管有助于生长细胞的抽真空和/或机械保护。

5. 发明申请

US20090131741A1 Methods of making aortic counter pulsation cardiac assist devices with three dimensional tortuous shape 有权
标题翻译：主动脉逆脉搏心脏辅助装置三维曲折形状的方法
公开(公告)号：US20090131741A1
公开(公告)日：2009-05-21
申请号：US12154048
申请日：2008-05-20
申请人： Allen B. Kantrowitz
发明人： Allen B. Kantrowitz
IPC分类号： A61M1/10
CPC分类号： A61M1/1072 , A61M1/1008 , A61M1/106 , A61M1/107 , A61M1/125 , A61M1/127 , A61M2230/04
摘要： Disclosed herein are methods of making aortic counter pulsation cardiac assist devices for assisting cardiac function of a patient. The methods can comprise performing at least one medical imaging procedure on an aorta of the patient, selecting at least one active segment of the aortic counter pulsation cardiac assist device based on anatomic information resulting from the at least one medical imaging procedure, and assembling the at least one active segment to accommodate the anatomic information prior to surgical implantation. The methods can further comprise designing individual custom active segment modules to custom fit a patient, providing a series of different individual, pre-manufactured active segment modules that are assembled to custom fit the patient, or providing a range of stock segment configurations manufactured based on previously determined common configurations and selecting one for a particular patient.
摘要翻译：本文公开了制备用于辅助患者的心脏功能的主动脉旁路脉动心脏辅助装置的方法。所述方法可以包括对患者的主动脉进行至少一个医学成像过程，基于从至少一个医学成像程序得到的解剖信息，选择主动脉旁路脉动心脏辅助装置的至少一个活动段，至少一个活动段以在手术植入之前适应解剖信息。该方法还可以包括设计各个定制活动段模块以定制适合患者，提供一系列不同的单独的，预先制造的活动区段模块，其被组装以定制适合患者，或提供基于先前确定的常见配置并为特定患者选择一种。

6. 发明申请

US20080281147A1 Long term ambulatory intro-aortic balloon pump with percutaneous access device 有权
标题翻译：具有经皮进入装置的长期动态主动脉内球囊泵
公开(公告)号：US20080281147A1
公开(公告)日：2008-11-13
申请号：US12154091
申请日：2008-05-20
申请人： Allen B. Kantrowitz
发明人： Allen B. Kantrowitz
IPC分类号： A61M1/10
CPC分类号： A61M1/1072 , A61B5/0215 , A61B5/0422 , A61M1/1008 , A61M1/106 , A61M1/107 , A61M1/1086 , A61M1/125 , A61M1/127 , A61M2205/33 , A61M2205/3303 , A61M2230/04 , A61N1/056
摘要： Disclosed herein are embodiments of long-term ambulatory intra-aortic balloon pump systems for providing left ventricular cardiac assistance to a patient. The systems can comprise an external drive system for supplying a compressed fluid, the drive system operating in accordance with a control program stored in memory, an intra-luminal balloon pump having an elongate inflatable chamber positionable to be lying completely within a descending aorta of the patient, and a percutaneous access device. The percutaneous access device can be a biocompatible implantable portal comprising a communicative passage through an interior bore and an exterior having a neck region adapted to promote autologous cell growth thereon in an implantable region, the neck region having a plurality of channels extending about the neck region.
摘要翻译：这里公开了用于向患者提供左心室心脏辅助的长期动态主动脉内球囊泵系统的实施例。所述系统可以包括用于供应压缩流体的外部驱动系统，所述驱动系统根据存储在存储器中的控制程序进行操作，腔内球囊泵具有细长的可充气室，其可完全位于下降的主动脉内患者和经皮进入装置。经皮进入装置可以是生物相容的植入式入口，其包括穿过内孔的交通通道和具有适于在可植入区域中促进其自体细胞生长的颈部区域的外部，所述颈部区域具有围绕颈部区域延伸的多个通道。

7. 发明授权

US09498647B2 Fiducial marker system for subject movement compensation during medical treatment 有权
标题翻译：治疗期间受试者运动补偿的基准标记系统
公开(公告)号：US09498647B2
公开(公告)日：2016-11-22
申请号：US11534759
申请日：2006-09-25
申请人： Allen B. Kantrowitz , In K. Mun
发明人： Allen B. Kantrowitz , In K. Mun
IPC分类号： A61N5/10 , A61B17/00
CPC分类号： A61N5/1049 , A61B34/20 , A61B90/36 , A61B90/39 , A61B90/98 , A61B2017/00694 , A61B2017/00699 , A61B2034/2051 , A61B2090/397 , A61N5/1067
摘要： A system is provided for subject movement compensation during a medical procedure. The system uses passive radiofrequency identification tags associated with a subject, and at least one active RFID reader is positioned to interrogate the position of at least three such passive radiofrequency identification tags so as to triangulate the geometric position of a subject body tissue. The reader generates an output signal corresponding to a distance between said reader and a tag. A microprocessor calculates a displacement of a tag relative to the reader from said output signal to yield a value corresponding to subject movement. A medical device operates in synchronicity with the calculation corresponding to subject movement to compensate for subject movement during a treatment process in essentially real time. A process for subject movement compensation during a medical procedure is also provided.
摘要翻译：在医疗过程中提供用于受试者运动补偿的系统。该系统使用与被摄体相关联的无源射频识别标签，并且至少一个有源RFID读取器被定位成询问至少三个这样的被动射频识别标签的位置，以便对被摄体体组织的几何位置进行三角测量。读取器产生对应于所述读取器和标签之间的距离的输出信号。微处理器从所述输出信号计算标签相对于读取器的位移，以产生对应于被摄体移动的值。医疗装置与对应于运动的计算同步运行，以在实质上实时地处理治疗过程中补偿受试者运动。还提供了在医疗过程中的受试者运动补偿的过程。

8. 发明授权

US08721515B2 Rigid body aortic blood pump implant 有权
标题翻译：刚体主动脉血泵植入物
公开(公告)号：US08721515B2
公开(公告)日：2014-05-13
申请号：US12120457
申请日：2008-05-14
申请人： Robert M. Smith , Valluvan Jeevanandam , Allen B. Kantrowitz , Paul S. Freed , Jean Kantrowitz
发明人： Robert M. Smith , Adrian Kantrowitz , Valluvan Jeevanandam , Allen B. Kantrowitz , Paul S. Freed
IPC分类号： A61M1/12 , A61M1/10
CPC分类号： A61M1/107 , A61M1/1037 , A61M1/106 , A61M1/1072 , A61M1/122 , A61M1/125 , B33Y80/00
摘要： An implantable aortic blood pump includes a rigid body having wall extending along a long axis and defining an inflation port portion with an inflation aperture therethrough. The aperture is fluid communication with an inner surface of the body and on a fluid supply, the body is preferably independent of an external brace or an external stiffener, yet still has a cantilevered deformation of less than 8 millimeters in response to a 200 gram weight suspended from a front body edge. A deflecting structure of a membrane deflects in response to fluid pressure so as to pump blood when the pump is secured to a subject aorta.
摘要翻译：可植入主动脉血泵包括刚体，其具有沿着长轴延伸的壁，并且限定具有穿过其的充气孔的充气口部分。孔与主体的内表面和流体供应源流体连通，主体优选地独立于外部支架或外部加强件，但是响应于200克重量仍然具有小于8毫米的悬臂变形从前身边缘悬挂。膜的偏转结构响应于流体压力而偏转，以便当泵固定到主体主动脉时泵送血液。

9. 发明申请

US20130131436A1 CARDIAC ASSIST DEVICE, INSTRUMENTS, AND METHODS 有权
标题翻译：心脏辅助装置，仪器和方法
公开(公告)号：US20130131436A1
公开(公告)日：2013-05-23
申请号：US13508923
申请日：2010-11-09
申请人： Allen B. Kantrowitz , Chris Mortis
发明人： Allen B. Kantrowitz , Chris Mortis
IPC分类号： A61M1/10
CPC分类号： A61M1/1072 , A61B17/072 , A61B17/07292 , A61B17/1155 , A61B2017/00778 , A61B2017/07221 , A61B2017/07278 , A61B2017/07285 , A61B2017/320052 , A61M1/1008 , A61M1/1037 , A61M1/106 , A61M1/122 , A61M1/125
摘要： A cardiac assist device is provided that can be deployed in any region of the aorta by minimally invasive techniques by the way of an inventive fastener that affixes the device to the aorta wall at the site of an aortonomy. The devices and methods described herein allow for improved patient outcome.
摘要翻译：提供了一种心脏辅助装置，其可以通过微创技术部署在主动脉的任何区域中，该方法通过将本发明的紧固件固定在主动脉位置处的主动脉壁上。本文描述的装置和方法允许改善患者结果。

10. 发明授权

US08383407B2 Percutaneous access device system facilitating cell growth thereon 有权
标题翻译：经皮进入装置系统促进细胞生长
公开(公告)号：US08383407B2
公开(公告)日：2013-02-26
申请号：US13372025
申请日：2012-02-13
申请人： Allen B. Kantrowitz
发明人： Allen B. Kantrowitz
IPC分类号： C12N5/071
CPC分类号： A61F2/022
摘要： A process to facilitate growing of cells on a nanotextured percutaneous portal is provided that includes the placement of a nanotextured percutaneous portal partially within a subject. A vacuum manifold is secured to the nanotextured percutaneous portal. Upon coupling the vacuum manifold to a vacuum source, the growth of the cells is facilitated.
摘要翻译：提供了一种促进细胞在纳米纹理经皮门户上生长的过程，其包括部分在受试者内放置纳米纹理的经皮入口。真空歧管固定在纳米纹理的经皮入口处。当将真空歧管耦合到真空源时，电池的生长便利。

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