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1. 发明申请

US20080281412A1 RIGID BODY AORTIC BLOOD PUMP IMPLANT 有权
标题翻译：刚体动物血液泵植入物
公开(公告)号：US20080281412A1
公开(公告)日：2008-11-13
申请号：US12120457
申请日：2008-05-14
申请人： Robert M. Smith , Adrian Kantrowitz , Valluvan Jeevanandam , Allen B. Kantrowitz , Paul S. Freed
发明人： Robert M. Smith , Adrian Kantrowitz , Valluvan Jeevanandam , Allen B. Kantrowitz , Paul S. Freed
IPC分类号： A61M1/12
CPC分类号： A61M1/107 , A61M1/1037 , A61M1/106 , A61M1/1072 , A61M1/122 , A61M1/125 , B33Y80/00
摘要： An implantable aortic blood pump includes a rigid body having wall extending along a long axis and defining an inflation port portion with an inflation aperture therethrough. The aperture is fluid communication with an inner surface of the body and on a fluid supply, the body is preferably independent of an external brace or an external stiffener, yet still has a cantilevered deformation of less than 8 millimeters in response to a 200 gram weight suspended from a front body edge. A deflecting structure of a membrane deflects in response to fluid pressure so as to pump blood when the pump is secured to a subject aorta.
摘要翻译：可植入主动脉血泵包括刚体，其具有沿着长轴延伸的壁，并且限定具有穿过其的充气孔的充气口部分。孔与主体的内表面和流体供应源流体连通，主体优选地独立于外部支架或外部加强件，但是响应于200克重量仍然具有小于8毫米的悬臂变形从前身边缘悬挂。膜的偏转结构响应于流体压力而偏转，以便当泵固定到主体主动脉时泵送血液。

2. 发明授权

US08721515B2 Rigid body aortic blood pump implant 有权
标题翻译：刚体主动脉血泵植入物
公开(公告)号：US08721515B2
公开(公告)日：2014-05-13
申请号：US12120457
申请日：2008-05-14
申请人： Robert M. Smith , Valluvan Jeevanandam , Allen B. Kantrowitz , Paul S. Freed , Jean Kantrowitz
发明人： Robert M. Smith , Adrian Kantrowitz , Valluvan Jeevanandam , Allen B. Kantrowitz , Paul S. Freed
IPC分类号： A61M1/12 , A61M1/10
CPC分类号： A61M1/107 , A61M1/1037 , A61M1/106 , A61M1/1072 , A61M1/122 , A61M1/125 , B33Y80/00
摘要： An implantable aortic blood pump includes a rigid body having wall extending along a long axis and defining an inflation port portion with an inflation aperture therethrough. The aperture is fluid communication with an inner surface of the body and on a fluid supply, the body is preferably independent of an external brace or an external stiffener, yet still has a cantilevered deformation of less than 8 millimeters in response to a 200 gram weight suspended from a front body edge. A deflecting structure of a membrane deflects in response to fluid pressure so as to pump blood when the pump is secured to a subject aorta.
摘要翻译：可植入主动脉血泵包括刚体，其具有沿着长轴延伸的壁，并且限定具有穿过其的充气孔的充气口部分。孔与主体的内表面和流体供应源流体连通，主体优选地独立于外部支架或外部加强件，但是响应于200克重量仍然具有小于8毫米的悬臂变形从前身边缘悬挂。膜的偏转结构响应于流体压力而偏转，以便当泵固定到主体主动脉时泵送血液。

3. 发明授权

US07846083B2 Left ventricle assist device (LVAD) 有权
标题翻译：左心室辅助装置（LVAD）
公开(公告)号：US07846083B2
公开(公告)日：2010-12-07
申请号：US11679487
申请日：2007-02-27
申请人： Robert M. Smith , Roger W. Snyder , Adrian Kantrowitz , Allen B. Kantrowitz
发明人： Robert M. Smith , Roger W. Snyder , Adrian Kantrowitz , Allen B. Kantrowitz
IPC分类号： A61N1/00
CPC分类号： A61M1/1072 , A61M1/1008 , A61M1/1037 , A61M1/106 , A61M1/122 , A61M1/125
摘要： A pump has an elongated shell with a generally elliptical shape, an outer convex surface and an inner concave surface. A peripheral side edge located between the inner and outer surfaces terminates in a bead edge. A flexible airtight membrane has a membrane edge bonded to the outer shell surface adjacent to the bead edge. Preforming the membrane edge looped with a maximum linear span of curvature that is greater than a maximal transverse linear extent of the bead edge, membrane operational wear during inflation and deflation cycles is reduced in the region around the bead edge. A process of forming a blood pump with a membrane preform is also provided.
摘要翻译：泵具有大致椭圆形的细长壳体，外凸面和内凹面。位于内表面和外表面之间的周边侧边缘终止于边缘。柔性密封膜具有与胎圈边缘相邻的外壳表面结合的膜边缘。预先形成最大线性曲率跨度的膜边缘，其大于胎圈边缘的最大横向线性范围，在充气和放气周期期间的膜操作磨损在珠边缘周围的区域减小。还提供了一种形成具有膜预制件的血液泵的过程。

4. 发明授权

US07513864B2 Synchronization system between aortic valve and cardiac assist device 有权
标题翻译：主动脉瓣与心脏辅助装置之间的同步系统
公开(公告)号：US07513864B2
公开(公告)日：2009-04-07
申请号：US11178969
申请日：2005-07-11
申请人： Allen B. Kantrowitz , Adrian Kantrowitz
发明人： Allen B. Kantrowitz , Adrian Kantrowitz
IPC分类号： A61M1/12
CPC分类号： A61M1/122 , A61M1/106 , A61M1/1067 , A61M1/1072 , A61M1/1086 , A61M1/12 , A61M1/127 , A61M2205/33 , A61M2205/3303
摘要： A cardiac assist device synchronization system includes a cardiac assist device and an acoustic or accelerometer sensor that provides a signal input to the cardiac assist device indicative of aortic valve closure. The cardiac assist device is coupled to a mammalian aorta and includes an inflatable chamber and a fluid pump. A fluid conduit is in communication between the chamber and the pump to provide for selective inflation of the chamber. A pump controller triggers the pump in counter-pulsation to a mammalian heart upstream from the aorta. A process for synchronizing a cardiac assist device in counter-pulsation with a left ventricle includes locating an acoustic or accelerometer sensor within a thoracic cavity of a mammal having the assist device coupled to the aorta of the mammal. Through the measurement of an acoustic or acceleration property of an aortic valve of the mammal, and the transmission of aortic valve closure measurement through a controller for the cardiac assist device, counter-pulsatile synchronization for the cardiac assist device is achieved.
摘要翻译：心脏辅助装置同步系统包括心脏辅助装置和声学或加速度计传感器，其向心脏辅助装置提供指示主动脉瓣闭合的信号输入。心脏辅助装置耦合到哺乳动物主动脉并且包括可充气室和流体泵。流体导管在腔室和泵之间连通以提供腔室的选择性充气。泵控制器触发泵与主动脉上游的哺乳动物心脏反搏。将逆向脉动中的心脏辅助装置与左心室同步的过程包括将声学或加速度计传感器定位在哺乳动物的胸腔内，该辅助装置与哺乳动物的主动脉联接。通过测量哺乳动物的主动脉瓣的声学或加速特性，以及通过用于心脏辅助装置的控制器传播主动脉瓣闭合测量，实现了心脏辅助装置的反脉动同步。

5. 发明授权

US4634422A Percutaneous access device and method for implanting same 失效
标题翻译：经皮进入装置及其植入方法
公开(公告)号：US4634422A
公开(公告)日：1987-01-06
申请号：US615883
申请日：1984-05-31
申请人： Adrian Kantrowitz , Paul S. Freed , Frizell L. Vaughan , Isadore A. Bernstein , Robert H. Gray
发明人： Adrian Kantrowitz , Paul S. Freed , Frizell L. Vaughan , Isadore A. Bernstein , Robert H. Gray
IPC分类号： A61F2/02 , A61M1/00 , A61M31/00 , A61M5/32 , C12N5/02
CPC分类号： A61M39/0247 , A61M2039/0291 , Y10S623/901
摘要： A percutaneous access device (PAD) is provided with a sleeve or separable member which may be detached from the device to enable the culturing of a multilayer fibroblast coating on the member in a stable and undisturbed environment. The member is constructed so that when it is assembled into the device and the device is implanted in a patient, the cultured coating of the member is exposed to the patient's dermis whose fibroblasts will, after a relatively short healing period, merge with the fibroblasts of the coating to form a barrier layer interlocked with the member to prevent epidermal ingrowth or marsupialization of the implanted device.Implantation techniques for further facilitating the formation of the dermal barrier are also disclosed.
摘要翻译：经皮进入装置（PAD）设置有套筒或可分离构件，其可以与装置分离，以便能够在稳定且不受干扰的环境中在构件上培养多层成纤维细胞涂层。构件被构造成使得当其组装到装置中并且将装置植入患者体内时，将该构件的培养包被暴露于患者的真皮，其成纤维细胞在相当短的愈合期后将与成纤维细胞所述涂层形成与所述构件互锁的阻挡层，以防止所述植入装置的表皮向内生长或有囊动作。还公开了用于进一步促进真皮屏障形成的植入技术。

6. 发明授权

US5169379A In-series ventricular assist system and method of controlling same 失效
标题翻译：一系列静态辅助系统及其控制方法
公开(公告)号：US5169379A
公开(公告)日：1992-12-08
申请号：US365817
申请日：1989-06-14
申请人： Paul S. Freed , Kevin P. Gage , Adrian Kantrowitz
发明人： Paul S. Freed , Kevin P. Gage , Adrian Kantrowitz
IPC分类号： A61M1/12 , A61F2/958 , A61M1/10
CPC分类号： A61M1/106 , A61M1/1072 , A61M2025/102 , A61M2025/1022
摘要： An in-series ventricular assist system for assisting the circulation of blood in a patient is disclosed. A pumping bladder is disposed in the thoractic aorta of the patient and selected physiologic events relating to each heart beat are monitored by appropriate sensors. A gas handling subsystem inflates and deflates the pumping bladder in accordance with the detected physiologic events and a predetermined set of assist system parameters. A microprocessor evaluates the effects of inflation and deflation of the pumping bladder and the corresponding assistance on the patient for each heart beat. The microprocessor is operable to alter or adjust the assist system parameters for each subsequent heart beat in accordance with the effects of assistance of the pumping bladder on the patient. In the preferred embodiment, the assist system parameters which are set by the microprocessor for inflating and deflating the pumping bladder during the immediately preceding heart beat are used as the base line for making small adjustments in those parameters for the present heart beat. Alternatively, the microprocessor may be made operable to store the assist system parameters associated within an immediately preceding predetermined number of prior heart beats to compare the detected physiologic events from each of the stored preceding heart beats with those of the current heart beat.

7. 发明授权

US5833655A Percutaneous access device having removable turret assembly 失效
标题翻译：具有可拆卸转塔组件的经皮进入装置
公开(公告)号：US5833655A
公开(公告)日：1998-11-10
申请号：US856905
申请日：1997-05-15
申请人： Paul S. Freed , George Taro , Adrian Kantrowitz
发明人： Paul S. Freed , George Taro , Adrian Kantrowitz
IPC分类号： A61M37/00 , A61M1/00 , A61N1/378 , A61M11/00
CPC分类号： A61M39/0247 , A61M2039/0267 , A61M2039/0282 , A61M2039/0294
摘要： A percutaneous access device implantable beneath the skin of a patient which includes a housing having a flange positionable beneath the skin and neck projecting outward through the skin. The percutaneous access device includes electrical communication through the flange and fluid access through the flange. The components providing fluid access and electrical communication are removable through the neck portion of the implant for testing and service as required without the need for further surgery on the patient. A turret body is received within the hollow interior of the neck having a fluid channel extending therethrough and containing current limiting devices securely disposed within the turret body.
摘要翻译：可植入患者皮肤下面的经皮进入装置，其包括壳体，所述壳体具有可定位在皮肤和颈部下方的凸缘，其向外突出穿过皮肤。经皮进入装置包括通过凸缘的电连通和通过凸缘的流体通路。提供流体通路和电气连通的部件可通过植入物的颈部部分移除，以便根据需要进行测试和服务，而无需对患者进一步手术。转塔体容纳在颈部的中空内部，具有延伸穿过其中的流体通道并且包含牢固地设置在转台体内的限流装置。

8. 发明授权

US5242415A Percutaneous access device 失效
标题翻译：经皮进入装置
公开(公告)号：US5242415A
公开(公告)日：1993-09-07
申请号：US929948
申请日：1992-08-14
申请人： Adrian Kantrowitz , Paul S. Freed
发明人： Adrian Kantrowitz , Paul S. Freed
IPC分类号： A61M1/00
CPC分类号： A61M39/0247 , A61M2039/0261
摘要： A percutaneous access device includes a body having a horizontal disc-like base flange and a frusto conical projection extending centrally upwardly from one side of the base flange. An elongate flexible tube extends loosely through a bore through the projection and base flange and is sealingly bonded to the body adjacent the bottom of the bore. A coating of a silicone-polycarbonate is applied to the outer surface of the projection and is formed with a multiplicity of microscopic pores to facilitate the bonding of dermal cells to the device upon implantation. The body is of a relatively soft, flexible, biocompatible material so that the device absorbs forces tending to displace the implanted device.
摘要翻译：经皮进入装置包括具有水平盘状基部凸缘和从基部凸缘的一侧向中心向上延伸的截头圆锥形凸起的本体。细长的柔性管通过突出部和基部凸缘松动地延伸通过孔，并且密封地结合到与孔的底部相邻的主体。将聚硅氧烷聚碳酸酯的涂层施加到突起的外表面，并且形成有多个微孔，以便于在植入时将真皮细胞与装置结合。身体是相对柔软的，柔性的，生物相容的材料，使得该装置吸收倾向于移植植入装置的力。

9. 发明授权

US5139508A Surgical tool 失效
标题翻译：手术工具
公开(公告)号：US5139508A
公开(公告)日：1992-08-18
申请号：US796040
申请日：1991-11-20
申请人： Adrian Kantrowitz , Paul S. Freed
发明人： Adrian Kantrowitz , Paul S. Freed
IPC分类号： A61B17/32
CPC分类号： A61B17/32053
摘要： A surgical tool for forming a circular opening through the skin which is of smaller diameter at the outer skin surface than at the inner surface of the skin employs a trephine having a circular cutting edge. The trephine is inserted into a pocket surgically formed beneath the skin with its cutting surface facing the skin. A rod member is then inserted through the skin and threaded into the trephine. The rod member is attached to a spring biassed plunger within a tool housing which is released from a ready position by withdrawal of a locking pin. Upon release of the plunger, the spring drives the plunger to drive the cutting edge of the trephine outwardly through the skin.
摘要翻译：用于形成通过皮肤的圆形开口的手术工具，其外皮表面的直径小于皮肤的内表面，采用具有圆形切割边缘的环钻。环钻被插入手术形成在皮肤下方的口袋中，其切割表面面向皮肤。然后将杆构件穿过皮肤并穿入环钻。杆构件附接到工具壳体内的弹簧偏压柱塞，该工具壳体通过撤销锁定销而从就绪位置释放。在释放柱塞时，弹簧驱动柱塞以通过皮肤向外驱动环钻的切割边缘。

10. 发明授权

US4630597A Dynamic aortic patch for thoracic or abdominal implantation 失效
标题翻译：用于胸部或腹部植入的动态主动脉瓣
公开(公告)号：US4630597A
公开(公告)日：1986-12-23
申请号：US604944
申请日：1984-04-30
申请人： Adrian Kantrowitz , Paul S. Freed
发明人： Adrian Kantrowitz , Paul S. Freed
IPC分类号： A61B17/12 , A61M1/10 , A61M1/12 , A61F1/24 , A61M1/03
CPC分类号： A61M1/1037 , A61B17/12109 , A61B17/12136 , A61M1/122 , A61M1/106
摘要： An improved dynamic aortic patch is constructed with an elongate semi-rigid shell member having a concave inner surface and a flexible membrane integrally bonded to the outer surface of the shell to define an inflatable and deflatable chamber between the concave inner surface and the membrane. The pumping capacity of the patch is determined by the concavity of the inner surface of the shell member, thus enabling the construction of a patch which may be implanted in the thoracic cavity (small concavity) or in the abdomen (large concavity). A fabric layer bonded to the membrane over the area overlying the outer surface of the shell has a peripheral suture flange projecting freely clear of the membrane, and a temporary shield adapted to overlie the fabric layer may be employed to assure that sutures placed to attach the patch within an opening in the aorta are not inadvertently passed through the membrane.
摘要翻译：改进的动态主动脉贴片由具有凹形内表面的细长半刚性壳构件和与外壳的外表面整体结合的柔性膜构成，以在凹内表面和膜之间限定可充气和可放气的腔室。贴片的抽吸能力由壳体内表面的凹度确定，从而能够构建可植入胸腔（小凹陷）或腹部（大凹陷）的贴片。在覆盖壳的外表面的区域上结合到膜上的织物层具有自由地远离膜突出的外围缝合线凸缘，并且可以采用适于覆盖在织物层上的临时护罩，以确保将缝合线主动脉开口内的斑块不会无意中通过膜。

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