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1. 发明授权

US3995040A Cyclopenteno-3-carboxyl-4-quinolone derivatives and their bacteriostatic compositions 失效
标题翻译：环戊烯-3-羧基-4-喹诺酮衍生物及其抑菌组合物
公开(公告)号：US3995040A
公开(公告)日：1976-11-30
申请号：US595929
申请日：1975-07-14
申请人： Alfred Rhomberg , Herbert Berger , Kurt Stach , Wolfgang Vomel , Winfriede Sauer
发明人： Alfred Rhomberg , Herbert Berger , Kurt Stach , Wolfgang Vomel , Winfriede Sauer
IPC分类号： C07D221/16 , C07D215/56
CPC分类号： C07D221/16
摘要： New cyclopenteno-quinolone derivatives of the formula ##SPC1##WhereinR is a saturated or unsaturated aliphatic hydrocarbyl, e.g., alkyl and alkenyl,X is hydrogen or alkyl, andY is halogen, azido, alkylthio, alkyl-sulfonyl, or nitrile or unsubstituted or substituted (e.g., alkyl mono or di-substituted) amino;And the pharmacologically compatible salts thereof; are outstandingly effective as bacteriostats in mammals.
摘要翻译：式WHEREIN R的新的环戊烯 - 喹诺酮衍生物是饱和或不饱和的脂族烃基，例如烷基和烯基，X是氢或烷基，Y是卤素，叠氮基，烷硫基，烷基磺酰基或腈或未取代或取代的（例如烷基单取代或二取代的）氨基; 及其药理学兼容性; 作为母体中的细菌具有非常有效的作用。

2. 发明授权

US4049811A Compositions using cycloalkano-quinolone derivatives and their method of use 失效
标题翻译：使用环烷 - 喹诺酮衍生物的组合物及其使用方法
公开(公告)号：US4049811A
公开(公告)日：1977-09-20
申请号：US676269
申请日：1976-04-12
申请人： Herbert Berger , Alfred Rhomberg , Kurt Stach , Wolfgang Vomel , Winfriede Sauer
发明人： Herbert Berger , Alfred Rhomberg , Kurt Stach , Wolfgang Vomel , Winfriede Sauer
IPC分类号： C07D221/08 , C07D221/10 , C07D221/16 , A61K31/47
CPC分类号： C07D221/08 , C07D221/10 , C07D221/16
摘要： Cycloalkano-quinolone derivatives having anti-microbial activity characterized by the formula: ##STR1##wherein one of R.sub.1 and R.sub.2 designates hydrogen, halogen, nitro, amino, hydroxyl, acylamino, acyloxy, alkoxy or aryloxy and the other taken together with R.sub.3 forms an alkylene bridge containing 2 to 6 carbon atoms, X is hydrogen, lower alkyl, which may be substituted by a member of the group consisting of halogen, hydroxyl, acyloxy, alkoxy, aryloxy, aralkyloxy, mercapto, alkylmercapto, arylmercapto, arylsulfonyl, and alkylsulfonyl, or X is unsubstituted alkenyl including alkadienyl, or alkynyl and Y is hydroxyl, amino or lower alkoxy, and the pharmaceutically acceptable salts thereof.
摘要翻译：具有以下结构式表征的抗微生物活性的环烷醇 - 喹诺酮衍生物：其中R 1和R 2之一表示氢，卤素，硝基，氨基，羟基，酰氨基，酰氧基，烷氧基或芳氧基，另一个与R 3一起形成含有2至6个碳原子的亚烷基桥，X是氢，可以被卤素，羟基，酰氧基，烷氧基，芳氧基，芳烷氧基，巯基，烷基巯基，芳基巯基，芳基磺酰基和烷基磺酰基中的成员所取代的低级烷基或X为未取代的烯基，包括链二烯基或炔基，Y为羟基，氨基或低级烷氧基，及其药学上可接受的盐。

3. 发明授权

US3966743A Ortho fused cycloalkano-4-quinolone-3-carboxylic acid derivatives 失效
标题翻译：正交稠环亚烷基-4-喹诺酮-3-羧酸衍生物
公开(公告)号：US3966743A
公开(公告)日：1976-06-29
申请号：US504589
申请日：1974-09-09
申请人： Herbert Berger , Alfred Rhomberg , Kurt Stach , Wolfgang Vomel , Winfriede Sauer
发明人： Herbert Berger , Alfred Rhomberg , Kurt Stach , Wolfgang Vomel , Winfriede Sauer
IPC分类号： C07D221/08 , C07D221/10 , C07D221/16 , C07D215/56
CPC分类号： C07D221/16 , C07D221/08 , C07D221/10
摘要： Cycloalkano-quinolone derivatives having anti-microbial activity characterized by the formula: ##SPC1##Wherein one of R.sub.1 and R.sub.2 designates hydrogen, halogen, nitro, amino, hydroxyl, acylamino, acyloxy, alkoxy or aryloxy and the other taken together with R.sub.3 forms an akylene bridge containing 2 to 6 carbon atoms, X is hydrogen, lower alkyl, which may be substituted by a member of the group consisting of halogen, hydroxyl, acyloxy, alkoxy, aryloxy, aralkyloxy, mercapto, alkylmercapto, arylmercapto, arylsulfonyl, and alkylsulfonyl, or X is unsubstituted alkenyl including alkadienyl, or alkynyl and Y is hydroxyl, amino or lower alkoxy, and the pharmaceutically acceptable salts thereof.
摘要翻译：具有抗细菌活性的环烷醇 - 喹诺酮衍生物，其特征在于下式：

4. 发明授权

US3957766A Novel nitrofuran compounds and pharmaceutical compositions 失效
标题翻译：新型硝基化合物和药物组合物
公开(公告)号：US3957766A
公开(公告)日：1976-05-18
申请号：US290682
申请日：1972-09-20
申请人： Herbert Berger , Rudi Gall , Hartmut Merdes , Kurt Stach , Winfriede Sauer , Wolfgang Vomel
发明人： Herbert Berger , Rudi Gall , Hartmut Merdes , Kurt Stach , Winfriede Sauer , Wolfgang Vomel
IPC分类号： C07D487/04 , C07D295/06 , C07D295/12 , C07D471/04
CPC分类号： C07D487/04
摘要： Certain novel nitrofuran compounds of the formula: ##SPC1##WhereinHet is an aromatic heterocylic linkage;B is a bond or vinylene;Y is O or S;m is 0 or 1;X is hydrogen, lower alkyl or alkanoyl; andThe R's are variously defined;Are outstandingly effective bacteriostats and bactericides.

5. 发明授权

US4006141A Nitroimidazolyl-triazolo-pyridazine compounds 失效
标题翻译：硝基咪唑基 - 三唑并 - 哒嗪化合物
公开(公告)号：US4006141A
公开(公告)日：1977-02-01
申请号：US601116
申请日：1975-07-31
申请人： Herbert Berger , Rudi Gall , Kurt Stach , Wolfgang Vomel , Rita Hoffmann
发明人： Herbert Berger , Rudi Gall , Kurt Stach , Wolfgang Vomel , Rita Hoffmann
IPC分类号： C07D487/04
CPC分类号： C07D487/04
摘要： Nitroimidazolyl-s-triazolo[4,3-b]pyridazines of the formula: ##STR1## wherein R is hydrogen or lower alkyl optionally substituted in the 2-position by hydroxyl or by lower acyloxy or lower alkoxy;A is hydrogen, halogen, azido, cyano; lower alkyl alkoxy, alkylthio, alkylsulfonyl, carboxyl; lower alkoxycarbonyl, lower alkoxycarbonimidoyl; or hydrazino, carbamoyl, amidino or a carboximidohydrazide group optionally substituted by one or two lower acyl, alkyl or cycloalkyl radicals; orA is a radical of the formula: ##STR2## wherein R.sub.1 and R.sub.2 are, individually, hydrogen or a number of organic radicals or, taken together, can be an alkylene bridge; andR.sub.3 is hydrogen or lower alkyl; or, together with R.sub.2, R.sub.3 can form an alkylene bridge;n is 0 or 1;And the pharmaceutically compatible thereof, possess high in vivo effectiveness as antimicrobials.
摘要翻译：具有下式的硝基咪唑基-s-三唑并[4,3-b]哒嗪：其中R是氢或在2-位被羟基或低级酰氧基或低级烷氧基任选取代的低级烷基; A是氢，卤素，叠氮基，氰基; 低级烷基烷氧基，烷硫基，烷基磺酰基，羧基; 低级烷氧基羰基，低级烷氧羰基亚氨基; 或肼基，氨基甲酰基，脒基或任选被一个或两个低级酰基，烷基或环烷基取代的碳代酰肼基; 或者A是下式的基团：其中R 1和R 2分别是氢或多个有机基团，或者一起可以是亚烷基桥; 并且R 3是氢或低级烷基; 或者与R 2一起形成亚烷基桥; N IS 0或1; 并且与药物相容，作为抗病毒药物具有高度的生物有效性。

6. 发明授权

US3948912A Nitroimidazolyl-triazolo-pyridazine compounds and therapeutic compositions 失效
标题翻译：硝基咪唑基 - 三唑并 - 哒嗪化合物和治疗组合物
公开(公告)号：US3948912A
公开(公告)日：1976-04-06
申请号：US559285
申请日：1975-03-17
申请人： Herbert Berger , Rudi Gall , Kurt Stach , Wolfgang Vomel , Rita Hoffmann
发明人： Herbert Berger , Rudi Gall , Kurt Stach , Wolfgang Vomel , Rita Hoffmann
IPC分类号： C07D403/14 , A61K31/5025 , C07D487/04 , C07D237/26
CPC分类号： C07D487/04
摘要： New nitroimidazolyl-triazolo-pyridazines of the formula: ##SPC1##WhereinZ is methyl or amino which can be substituted by lower alkyl,And the pharmacologically compatible acid-addition salts thereof, exhibit outstanding anti-microbial activity against bacteria and protozoa, and also systemic effectiveness.
摘要翻译：新的具有下式的硝基咪唑基 - 三唑并 - 哒嗪：

7. 发明授权

US3989832A Combating bacteria with nitroimidazolyl-triazolo-pyridiazine compounds 失效
标题翻译：抗菌与硝基咪唑基 - 三唑并 - 嘧啶化合物
公开(公告)号：US3989832A
公开(公告)日：1976-11-02
申请号：US600533
申请日：1975-07-31
申请人： Herbert Berger , Rudi Gall , Kurt Stach , Wolfgang Vomel , Rita Hoffmann
发明人： Herbert Berger , Rudi Gall , Kurt Stach , Wolfgang Vomel , Rita Hoffmann
IPC分类号： C07D487/04 , A01N9/00 , A01N9/22
CPC分类号： C07D487/04
摘要： Nitroimidazolyl-s-triazolo[4,3-b]pyridazines of the formula: ##SPC1##Wherein R is hydrogen or lower alkyl optionally substituted in the 2-position by hydroxyl or by lower acyloxy or lower alkoxy;A is hydrogen, halogen, azido, cyano; lower alkyl, alkoxy, alkylthio, alkylsulfonyl, carboxyl; lower alkoxycarbonyl, lower alkoxycarbonimidoyl; or hydrazino, carbamoyl, amidino or a carboximidohydrazide group optionally substituted by one or two lower acyl, alkyl or cycloalkyl radicals; orA is a radical of the formula: ##EQU1## wherein R.sub.1 and R.sub.2 are, individually, hydrogen or a number of organic radicals or, taken together, can be an alkylene bridge; andR.sub.3 is hydrogen or lower alkyl; or, together with R.sub.2, R.sub.3 can form an alkylene bridge;n is 0 or 1;And the pharmaceutically compatible thereof, possess high in vivo effectiveness as antimicrobials.
摘要翻译：具有下式的硝基咪唑基-s-三唑并[4,3-b]哒嗪

8. 发明授权

US3991188A 3-Alkyl-4-sulfamoyl-aniline therapeutic compositions 失效
标题翻译： 3-烷基-4-氨磺酰基 - 苯胺治疗组合物
公开(公告)号：US3991188A
公开(公告)日：1976-11-09
申请号：US593089
申请日：1975-07-03
申请人： Ansgar Lerch , Alfred Popelak , Kurt Stach , Egon Roesch , Klaus Hardebeck
发明人： Ansgar Lerch , Alfred Popelak , Kurt Stach , Egon Roesch , Klaus Hardebeck
IPC分类号： A61K31/63 , A61K31/625
CPC分类号： A61K31/63 , Y10S514/869
摘要： New 3-alkyl-4-sulfamoyl-aniline compounds of the formula ##SPC1##WhereinR.sub.1 is phenyl, furyl or thienyl;R.sub.2 is carboxyl or tetrazolyl-(5)R.sub.4 is a straight-chain or branched alkyl radical of from 2 to 5 carbon atoms; andn is 1 or 2;And the pharmacologically compatible salts thereof; are outstandingly effective saluretic compounds, particularly when administered enterally.
摘要翻译：式WHEREIN R1的新的3-烷基-4-氨磺酰基 - 苯胺化合物是苯基，呋喃基或噻吩基; R2是羧基或四唑基 - （5）R4是2至5个碳原子的直链或支链烷基; 和N IS 1 OR 2; 及其药理学兼容性; 具有非常有效的挥发性化合物，特别是在进行管理时尤其如此。

9. 发明授权

US3959261A Biphenyl compounds 失效
标题翻译：联苯化合物
公开(公告)号：US3959261A
公开(公告)日：1976-05-25
申请号：US482956
申请日：1974-06-25
申请人： Ansgar Lerch , Alfred Popelak , Kurt Stach , Klaus Hardebeck , Wolfgang Schaumann
发明人： Ansgar Lerch , Alfred Popelak , Kurt Stach , Klaus Hardebeck , Wolfgang Schaumann
IPC分类号： C07D333/20 , A61K31/255 , A61K31/34 , A61K31/38 , A61K31/395 , A61K31/41 , A61K31/63 , C07C20060101 , C07C67/00 , C07C301/00 , C07C303/40 , C07C311/39 , C07D20060101 , C07D237/00 , C07D239/00 , C07D241/00 , C07D251/00 , C07D257/02 , C07D257/04 , C07D307/00 , C07D307/52 , C07D307/54 , C07D333/06 , C07D333/10 , C07D333/22 , C07D333/24 , C07D405/10 , C07D407/10
CPC分类号： A61K31/63 , C07C311/39 , C07D307/52 , C07D333/20
摘要： Novel biphenyl derivatives of the formula: ##SPC1##WhereinR.sub.1 is phenyl, furyl or thienyl; andR.sub.2 is carboxyl or tetrazolyl-(5);And the pharmacologically compatible salts thereof display outstanding diuretic and saluretic properties.
摘要翻译：下式的新型联苯衍生物：

10. 发明授权

US3947404A Dihydrodigoxin compounds and therapeutic compositions 失效
标题翻译：二氢二氧磷素化合物和治疗组合物
公开(公告)号：US3947404A
公开(公告)日：1976-03-30
申请号：US367312
申请日：1973-06-05
申请人： Fritz Kaiser , Wolfgang Schaumann , Kurt Stach , Wolfgang Voigtlander
发明人： Fritz Kaiser , Wolfgang Schaumann , Kurt Stach , Wolfgang Voigtlander
IPC分类号： C07J19/00 , A61K20060101 , C07D20060101
摘要： New dihydrodigoxin derivatives of the formula ##SPC1##Wherein one of R.sub.1 and R.sub.2 represents a methyl or ethyl radical and the other represents hydrogen, methyl, ethyl or acetyl (i.e. alkanoyl; and R.sub.3 is hydrogen or an acetyl group; are outstandingly effective for therapy of cardiac insufficiencies, particularly via peroral administration.
摘要翻译：式R 1和R 2的新的二氢二磷杂衍生物代表甲基或乙基，另一个表示氢，甲基，乙基或乙酰基（即烷酰基; R 3是氢或乙酰基）;对治疗心脏功能不全有显着的效果，特别是通过口腔管理。

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