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1. 发明授权

US09995703B2 Device similar to electrochemical camera and method for producing device 有权
公开(公告)号：US09995703B2
公开(公告)日：2018-06-12
申请号：US13262578
申请日：2010-03-02
申请人： Alexander Frey , Walter Gumbrecht , Peter Paulicka , Meinrad Schienle , Manfred Stanzel
发明人： Alexander Frey , Walter Gumbrecht , Peter Paulicka , Meinrad Schienle , Manfred Stanzel
IPC分类号： C40B60/00 , C40B60/12 , G01N27/327 , G01N33/543 , C40B30/04 , C40B50/18
CPC分类号： G01N27/3277 , G01N33/5438
摘要： A device for detecting chemical or biochemical substances in fluids for use in an electrochemical camera. The device includes a first carrier having a sensor array with a plurality of electrochemical sensors. A second carrier includes a porous layer having at least one functional region, in which specifically binding capturing molecules are immobilized. The at least one functional region is arranged directly adjacent to at least one non-functionalized region. Assigned to the at least one functional region and the at least one non-functionalized region are several sensors of the sensor array, for use as the electrochemical camera.

2. 发明授权

US08916035B2 Arrangement and method using microsensors for measuring cell vitalities 有权
标题翻译：微传感器用于测量细胞活力的布置和方法
公开(公告)号：US08916035B2
公开(公告)日：2014-12-23
申请号：US13499376
申请日：2010-09-29
申请人： Alexander Frey , Walter Gumbrecht , Peter Paulicka , Meinrad Schienle , Daniel Sickert , Manfred Stanzel
发明人： Alexander Frey , Walter Gumbrecht , Peter Paulicka , Meinrad Schienle , Daniel Sickert , Manfred Stanzel
IPC分类号： G01N21/41 , C12M1/34 , G01N27/42 , G01N27/416 , G01N27/404
CPC分类号： G01N27/416 , C12M41/38 , C12M41/46 , G01N27/404 , G01N27/423 , G01N33/48735
摘要： An arrangement and a method measures cell vitalities with a sensor array. The sensor array is formed on a surface of a semiconductor chip. The semiconductor chip has integrated circuits and an integrated circuit is associated with each sensor of the sensor array, for processing the measurement signals of the respective sensor. The integrated circuits are formed in the semiconductor chip spatially in each case below the associated sensor and neighboring sensors of the sensor array have a center-to-center in the range of micrometers. The pH and/or pO2 can be measured in the environment of a living cell.
摘要翻译：一种安排和方法用传感器阵列测量细胞活力。传感器阵列形成在半导体芯片的表面上。半导体芯片具有集成电路，并且集成电路与传感器阵列的每个传感器相关联，用于处理相应传感器的测量信号。集成电路在空间上形成在半导体芯片中，在每个情况下在相关传感器下方，并且传感器阵列的相邻传感器具有在微米范围内的中心到中心。 pH和/或pO2可以在活细胞的环境中测量。

3. 发明申请

US20120252055A1 ARRANGEMENT AND METHOD USING MICROSENSORS FOR MEASURING CELL VITALITIES 有权
标题翻译：使用微型传感器测量细胞毒素的装置和方法
公开(公告)号：US20120252055A1
公开(公告)日：2012-10-04
申请号：US13499376
申请日：2010-09-29
申请人： Alexander Frey , Walter Gumbrecht , Peter Paulicka , Meinrad Schienle , Daniel Sickert , Manfred Stanzel
发明人： Alexander Frey , Walter Gumbrecht , Peter Paulicka , Meinrad Schienle , Daniel Sickert , Manfred Stanzel
IPC分类号： C12M1/34 , G01N27/26
CPC分类号： G01N27/416 , C12M41/38 , C12M41/46 , G01N27/404 , G01N27/423 , G01N33/48735
摘要： An arrangement and a method measures cell vitalities with a sensor array. The sensor array is formed on a surface of a semiconductor chip. The semiconductor chip has integrated circuits and an integrated circuit is associated with each sensor of the sensor array, for processing the measurement signals of the respective sensor. The integrated circuits are formed in the semiconductor chip spatially in each case below the associated sensor and neighboring sensors of the sensor array have a centre-to-centre in the range of micrometers. The pH and/or pO2 can be measured in the environment of a living cell.
摘要翻译：一种安排和方法用传感器阵列测量细胞活力。传感器阵列形成在半导体芯片的表面上。半导体芯片具有集成电路，并且集成电路与传感器阵列的每个传感器相关联，用于处理相应传感器的测量信号。集成电路在空间上形成在半导体芯片中，在每个情况下在相关传感器下方，并且传感器阵列的相邻传感器具有在微米范围内的中心到中心。 pH和/或pO2可以在活细胞的环境中测量。

4. 发明申请

US20120108456A1 DEVICE SIMILAR TO AN ELECTROMECHANICAL CAMERA AND METHOD FOR THE PRODUCTION AND USE OF THE DEVICE 有权
标题翻译：类似于机电相机的装置及其制造和使用的方法
公开(公告)号：US20120108456A1
公开(公告)日：2012-05-03
申请号：US13262578
申请日：2010-03-02
申请人： Alexander Frey , Walter Gumbrecht , Peter Paulicka , Meinrad Schienle , Manfred Stanzel
发明人： Alexander Frey , Walter Gumbrecht , Peter Paulicka , Meinrad Schienle , Manfred Stanzel
IPC分类号： C40B30/04 , C40B50/18 , C40B60/12
CPC分类号： G01N27/3277 , G01N33/5438
摘要： A device for detecting chemical or biochemical substances in fluids includes a first carrier having a sensor array with a plurality of electrochemical sensors. A second carrier includes a porous layer having at least one functional region, in which specifically binding capturing molecules are immobilized. The at least one functional region is arranged directly adjacent to at least one non-functionalized region. Assigned to the at least one functional region and the at least one non-functionalized region are several sensors of the sensor array, for use as an electrochemical camera.
摘要翻译：用于检测流体中的化学或生化物质的装置包括具有传感器阵列的多个电化学传感器的第一载体。第二载体包括具有至少一个功能区的多孔层，其中固定有特异性结合的捕获分子。所述至少一个功能区域直接邻近至少一个非功能化区域布置。分配给至少一个功能区域和至少一个非功能化区域是传感器阵列的几个传感器，用作电化学照相机。

5. 发明申请

US20080151088A1 Switching Circuit Arrangement 审中-公开
标题翻译：开关电路布置
公开(公告)号：US20080151088A1
公开(公告)日：2008-06-26
申请号：US11596005
申请日：2005-05-12
申请人： Alexander Frey , Meinrad Schienle , Roland Thewes
发明人： Alexander Frey , Meinrad Schienle , Roland Thewes
IPC分类号： H04N5/335 , H04N3/14
CPC分类号： G01N27/3275 , G01N33/4836 , G09G2310/0297
摘要： A switching circuit arrangement is disclosed. The arrangement includes a substrate, a plurality of functional units arranged on the substrate, a plurality of selection line groups including selection lines, a plurality of signal line groups including signal lines, a buffer unit for each signal line group, a selection unit which is coupled to the selection line groups, and a signal unit which is coupled to the signal lines.
摘要翻译：公开了一种开关电路装置。该布置包括基板，布置在基板上的多个功能单元，包括选择线的多个选择线组，包括信号线的多个信号线组，每个信号线组的缓冲单元，选择单元耦合到选择线组，以及耦合到信号线的信号单元。

6. 发明授权

US07123029B2 Circuit arrangement, electrochemical sensor, sensor arrangement, and method for processing a current signal provided via a sensor electrode 有权
标题翻译：电路布置，电化学传感器，传感器布置和用于处理经由传感器电极提供的电流信号的方法
公开(公告)号：US07123029B2
公开(公告)日：2006-10-17
申请号：US10913706
申请日：2004-08-05
申请人： Alexander Frey , Christian Paulus , Meinrad Schienle , Roland Thewes
发明人： Alexander Frey , Christian Paulus , Meinrad Schienle , Roland Thewes
IPC分类号： G01R27/26 , G01N27/26
CPC分类号： G01N27/3276
摘要： Circuit arrangement having a sensor electrode, a first circuit unit, which is electrically coupled to the sensor electrode, and a second circuit unit, which has a first capacitor. The first circuit unit holds an electrical potential of the sensor electrode in a predetermined first reference range around a predetermined electrical desired potential by coupling the first capacitor and the sensor electrode such that there is a matching of their electrical potentials. If the second circuit unit detects the electrical potential of the first capacitor being outside a second reference range, the second circuit unit brings the first capacitor to a first electrical reference potential.
摘要翻译：具有传感器电极，电耦合到传感器电极的第一电路单元和具有第一电容器的第二电路单元的电路装置。第一电路单元通过将第一电容器和传感器电极耦合使得存在与它们的电位相匹配的方式，将传感器电极的电位保持在预定的电气期望电位周围的预定的第一参考范围内。如果第二电路单元检测到第一电容器的电位在第二参考范围之外，则第二电路单元将第一电容器引入第一电参考电位。

7. 发明申请

US20050247559A1 Biosensors array and method for operating a biosensor array 有权
标题翻译：用于操作生物传感器阵列的生物传感器阵列和方法
公开(公告)号：US20050247559A1
公开(公告)日：2005-11-10
申请号：US11019948
申请日：2004-12-21
申请人： Alexander Frey , Franz Hofmann , Birgit Holzapfl , Christian Paulus , Meinrad Schienle , Roland Thewes
发明人： Alexander Frey , Franz Hofmann , Birgit Holzapfl , Christian Paulus , Meinrad Schienle , Roland Thewes
IPC分类号： G01N33/53 , G01N27/02 , G01N27/327 , G01N27/403 , G01N27/416 , G01N33/487 , G01N37/00 , G01N27/26
CPC分类号： G01N27/3276
摘要： A biosensor array having a substrate, a plurality of biosensor zones arranged on the substrate, each of which has a first terminal and a second terminal, at least one drive line and at least one detection line, the at least one drive line being electrically insulated from the at least one detection line. In each case the first terminal of each biosensor zone is coupled to precisely one of the at least one drive line and the second terminal of each biosensor zone is coupled to precisely one of the at least one detection line, and at least one of the at least one drive line and at least one of the at least one detection line is coupled to at least two of the biosensor zones. The biosensor array also has a drive unit for providing an electrical drive signal, a detection unit for detecting an electrical detection signal resulting from the electrical drive signal, and a selection unit that couples the drive unit to the drive line of a biosensor zone to be selected and the detection unit to the detection line of the biosensor zone to be selected, whereby the biosensor zone is selected.
摘要翻译：一种具有衬底的生物传感器阵列，布置在所述衬底上的多个生物传感器区域，每个生物传感器区域具有第一端子和第二端子，至少一条驱动线路和至少一条检测线路，所述至少一条驱动线路电绝缘从所述至少一个检测线。在每种情况下，每个生物传感器区域的第一端子被精确地耦合到至少一条驱动线路中的一条，并且每个生物传感器区域的第二端口精确地耦合到至少一条检测线路中的至少一条，至少一个驱动线和所述至少一个检测线中的至少一个耦合到所述生物传感器区域中的至少两个。生物传感器阵列还具有用于提供电驱动信号的驱动单元，用于检测由电驱动信号产生的电检测信号的检测单元，以及将驱动单元与生物传感器区域的驱动线连接的选择单元，将选择的检测单元和生物传感器区域的检测线进行选择，从而选择生物传感器区域。

8. 发明申请

US20050194250A1 Sensor arrangement and method for operating a sensor arrangement 有权
标题翻译：用于操作传感器装置的传感器布置和方法
公开(公告)号：US20050194250A1
公开(公告)日：2005-09-08
申请号：US11002736
申请日：2004-12-02
申请人： Alexander Frey , Christian Paulus , Meinrad Schienle , Roland Thewes
发明人： Alexander Frey , Christian Paulus , Meinrad Schienle , Roland Thewes
IPC分类号： C12M1/00 , C12Q1/68 , G01N1/00 , G01N27/02
CPC分类号： C12M1/00 , C12Q1/6837 , G01N1/00 , G01N27/3276 , C12Q2565/607
摘要： Sensor arrangement, set up as an integrated circuit, having a substrate, at least three sensor electrodes arranged on the substrate such that, in an operating state in which an electrically conductive substance is introduced into the sensor arrangement, the sensor electrodes are coupled to one another by means of the electrically conductive substance, capture molecules immobilized on at least a portion of the sensor electrodes, wherein molecules to be detected can hybridize with the capture molecules, a control circuit for applying a first electrical signal to a selected sensor electrode and simultaneously applying a second electrical signal to at least two of the other sensor electrodes, the first electrical signal being a first temporally variable electrical signal and/or the second electrical signal being a second temporally variable electrical signal, a detection device, which is set up such that, in a first operating state, in which a reference liquid is introduced into the sensor arrangement, a reference value of a third temporally variable electrical signal resulting from the first temporally variable electrical signal and/or from the second temporally variable electrical signal is detected at the selected sensor electrode, and in a second operating state, in which an analyte possibly having molecules to be detected is introduced into the sensor arrangement, a sensor value of the third temporally variable electrical signal resulting from the first temporally variable electrical signal and/or from the second temporally variable electrical signal is detected at the selected sensor electrode, and an evaluation circuit, which, on the basis of the reference value and the sensor value, determines whether a hybridization event has taken place at the selected sensor electrode.
摘要翻译：设置为集成电路的传感器布置，具有衬底，布置在衬底上的至少三个传感器电极，使得在将导电物质引入传感器装置的操作状态下，传感器电极耦合到一个另一个通过导电物质捕获固定在传感器电极的至少一部分上的分子，其中待检测的分子可与捕获分子杂交;控制电路，用于将第一电信号施加到所选择的传感器电极，同时将第二电信号施加到至少两个其它传感器电极，所述第一电信号是第一时间可变电信号和/或所述第二电信号是第二时间可变电信号，所述检测装置被设置为在第一操作状态下，将参考液体引入到传感器中在所选择的传感器电极处检测由第一时间可变电信号和/或来自第二时间可变电信号产生的第三时间可变电信号的参考值，并且在第二操作状态中，分析物可能将要检测的分子引入传感器装置中，在所选择的传感器电极处检测由第一时间可变电信号和/或来自第二时间可变电信号产生的第三时间可变电信号的传感器值，评估电路，其基于参考值和传感器值确定在所选择的传感器电极处是否发生杂交事件。

9. 发明授权

US08702921B2 Biosensors array and method for operating a biosensor array 有权
标题翻译：用于操作生物传感器阵列的生物传感器阵列和方法
公开(公告)号：US08702921B2
公开(公告)日：2014-04-22
申请号：US11019948
申请日：2004-12-21
申请人： Alexander Frey , Franz Hofmann , Birgit Holzapfl , Christian Paulus , Meinrad Schienle , Roland Thewes
发明人： Alexander Frey , Franz Hofmann , Birgit Holzapfl , Christian Paulus , Meinrad Schienle , Roland Thewes
IPC分类号： G01N27/26
CPC分类号： G01N27/3276
摘要： A biosensor array having a substrate, a plurality of biosensor zones arranged on the substrate, each of which has a first terminal and a second terminal, at least one drive line and at least one detection line, the at least one drive line being electrically insulated from the at least one detection line. In each case the first terminal of each biosensor zone is coupled to precisely one of the at least one drive line and the second terminal of each biosensor zone is coupled to precisely one of the at least one detection line, and at least one of the at least one drive line and at least one of the at least one detection line is coupled to at least two of the biosensor zones. The biosensor array also has a drive unit for providing an electrical drive signal, a detection unit for detecting an electrical detection signal resulting from the electrical drive signal, and a selection unit that couples the drive unit to the drive line of a biosensor zone to be selected and the detection unit to the detection line of the biosensor zone to be selected, whereby the biosensor zone is selected.
摘要翻译：一种具有衬底的生物传感器阵列，布置在所述衬底上的多个生物传感器区域，每个生物传感器区域具有第一端子和第二端子，至少一条驱动线路和至少一条检测线路，所述至少一条驱动线路电绝缘从所述至少一个检测线。在每种情况下，每个生物传感器区域的第一端子被精确地耦合到至少一条驱动线路中的一条，并且每个生物传感器区域的第二端口精确地耦合到至少一条检测线路中的至少一条，至少一个驱动线和所述至少一个检测线中的至少一个耦合到所述生物传感器区域中的至少两个。生物传感器阵列还具有用于提供电驱动信号的驱动单元，用于检测由电驱动信号产生的电检测信号的检测单元，以及将驱动单元与生物传感器区域的驱动线连接的选择单元，将选择的检测单元和生物传感器区域的检测线进行选择，从而选择生物传感器区域。

10. 发明授权

US07670557B2 Planar sensor arrangement, sensor array and method for the production of a planar-sensor arrangement 有权
标题翻译：平面传感器布置，传感器阵列和生产平面传感器装置的方法
公开(公告)号：US07670557B2
公开(公告)日：2010-03-02
申请号：US11631380
申请日：2005-06-30
申请人： Alexander Frey , Christian Paulus , Meinrad Schienle , Roland Thewes
发明人： Alexander Frey , Christian Paulus , Meinrad Schienle , Roland Thewes
IPC分类号： G01N31/00
CPC分类号： G01N33/5438 , G01N27/02 , G01N27/3276
摘要： A planar-sensor arrangement is disclosed, which is used to detect particles possibly contained in an analyte. The sensor element includes a substrate, a first planar-sensor electrode and a second planar-sensor electrode which are formed on and/or in the substrate and whereon catcher molecules can be immobilized. The first sensor-electrode and the second sensor-electrode are divided, respectively, into a plurality of planar sensor-electrode partial areas. The sensor electrode partial areas of the first sensor electrode and the sensor electrode partial areas of the second sensor electrode are arranged in an alternating manner in two dimensions on the surface plane of the substrate. The sensor element also includes a wiring structure by which at least one part of the sensor electrode partial areas of the first sensor electrode are electrically coupled together, and by which at least one part of the sensor-electrode partial areas of the second sensor electrode are electrically coupled together.
摘要翻译：公开了一种平面传感器装置，其用于检测可能包含在分析物中的颗粒。传感器元件包括衬底，第一平面传感器电极和第二平面传感器电极，其形成在衬底上和/或衬底中，并且捕获剂分子可以被固定。第一传感器电极和第二传感器电极分别分成多个平面传感器电极部分区域。第一传感器电极的传感器电极部分区域和第二传感器电极的传感器电极部分区域在基板的表面上以二维交替排列。传感器元件还包括布线结构，通过该布线结构，传感器电极的至少一部分第一传感器电极的部分区域电耦合在一起，并且第二传感器电极的传感器电极部分区域的至少一部分电耦合在一起。

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