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1. 发明授权

US08067249B2 Method for functionalizing biosensor chips 有权
标题翻译：功能化生物传感器芯片的方法
公开(公告)号：US08067249B2
公开(公告)日：2011-11-29
申请号：US11587058
申请日：2005-03-18
申请人： Alexander Frey , Franz Hofmann , Petra Schindler-Bauer
发明人： Alexander Frey , Franz Hofmann , Petra Schindler-Bauer
IPC分类号： H01L21/00
CPC分类号： G01N33/54366 , G01N27/3277
摘要： A method is disclosed for functionalizing biosensors. The biosensors are based on semiconductor chips mounted on a finished processed wafer. They are provided with sensor fields placed thereupon, which are arranged in any array, and, to be precise, for carrying out a functionalization, for example, with organic molecules such as nucleic acids like DNA, RNA and PNA or with their derivatives, proteins, sugar molecules, or antibodies.
摘要翻译：公开了用于使生物传感器功能化的方法。生物传感器基于安装在成品加工晶片上的半导体芯片。它们设置有放置在其上的传感器场，其被布置成任何阵列，并且准确地，用于进行功能化，例如用有机分子例如核酸如DNA，RNA和PNA或其衍生物，蛋白质，糖分子或抗体。

2. 发明申请

US20080199974A1 Method for Functionalizing Biosensor Chips 有权
标题翻译：功能化生物传感器芯片的方法
公开(公告)号：US20080199974A1
公开(公告)日：2008-08-21
申请号：US11587058
申请日：2005-03-18
申请人： Alexander Frey , Franz Hofmann , Petra Schindler-Bauer
发明人： Alexander Frey , Franz Hofmann , Petra Schindler-Bauer
IPC分类号： H01L21/027
CPC分类号： G01N33/54366 , G01N27/3277
摘要： A met4hod is disclosed for functionalizing biosensors. The biosensors are based on semiconductor chips mounted on a finished processed wafer. They are provided with sensor fields placed thereupon, which are arranged in any array, and, to be precise, for carrying out a functionalization, for example, with organic molecules such as nucleic acids like DNA, RNA and PNA or with their derivatives, proteins, sugar molecules, or antibodies.
摘要翻译：公开了用于功能化生物传感器的met4hod。生物传感器基于安装在成品加工晶片上的半导体芯片。它们设置有放置在其上的传感器场，其被布置成任何阵列，并且准确地，用于进行功能化，例如用有机分子例如核酸如DNA，RNA和PNA或其衍生物，蛋白质，糖分子或抗体。

3. 发明申请

US20060252074A1 Immobilization and reaction matrix for biosensors 审中-公开
标题翻译：生物传感器的固定和反应基质
公开(公告)号：US20060252074A1
公开(公告)日：2006-11-09
申请号：US11403867
申请日：2006-04-14
申请人： Melanie Atzesberger , Petra Schindler-Bauer
发明人： Melanie Atzesberger , Petra Schindler-Bauer
IPC分类号： C12Q1/68 , C12M1/34
CPC分类号： G01N33/5438
摘要： An immobilization and reaction matrix based on a polymeric hydrogel for biosensor chips is disclosed, in particular those based on semiconductor chips which are disposed on a completely processed wafer and have, applied thereto, sensor fields which are normally disposed in array format. Such biosensor chips are normally functionalized by employing organic molecules such as, for example nucleic acids such as DNA, RNA, PNA and LNA or derivatives thereof, proteins, sugar molecules or antibodies.
摘要翻译：公开了一种基于用于生物传感器芯片的聚合物水凝胶的固定和反应基质，特别是那些基于半导体芯片的固定化和反应基质，其设置在完全处理的晶片上并具有通常以阵列形式布置的传感器场。这样的生物传感器芯片通常通过使用有机分子例如DNA，RNA，PNA和LNA等核酸或其衍生物，蛋白质，糖分子或抗体来进行官能化。

4. 发明申请

US20050136423A1 Method and biosensors for detecting macromolecular biopolymers 有权
标题翻译：用于检测大分子生物聚合物的方法和生物传感器
公开(公告)号：US20050136423A1
公开(公告)日：2005-06-23
申请号：US10841413
申请日：2004-05-07
申请人： Christian Paulus , Petra Schindler-Bauer
发明人： Christian Paulus , Petra Schindler-Bauer
IPC分类号： C12M1/34 , C12Q1/68 , G01N33/543
CPC分类号： G01N33/5438
摘要： Method for detecting macromolecular biopolymers using a unit for immobilizing macromolecular biopolymers, in which the unit is provided with first molecules serving as capture molecules. The method includes the steps of bringing a sample into contact with the unit, it being possible for the sample to contain the macromolecular biopolymers, and the macromolecular biopolymers or the first molecules having a marking which is used to generate a detectable signal, binding macromolecular biopolymers contained in the sample to the capture molecules, thereby forming complexes comprising capture molecules and macromolecular biopolymers, exciting the emission of a signal by means of the marking, detecting the signal emitted by means of the marking, separating the complexes comprising capture molecules and macromolecular biopolymers, thereby altering the intensity of the emitted signal, and detecting the separation of the complexes comprising capture molecules and macromolecular biopolymers by means of the change in the intensity of the signal.
摘要翻译：使用用于固定大分子生物聚合物的单元检测大分子生物聚合物的方法，其中该单元具有用作捕获分子的第一分子。该方法包括使样品与单元接触的步骤，样品可以含有大分子生物聚合物，大分子生物聚合物或具有用于产生可检测信号的标记的第一分子，结合大分子生物聚合物包含在捕获分子中的样品，从而形成包含捕获分子和大分子生物聚合物的复合物，通过标记激发信号的发射，检测通过标记发射的信号，分离包含捕获分子和大分子生物聚合物的复合物从而改变发射信号的强度，并通过信号强度的变化来检测包含捕获分子和大分子生物聚合物的络合物的分离。

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