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1. 发明申请

US20070225497A1 Chiral Tertiary Aminoalkylnaphthols 失效
标题翻译：手性三氨基烷基萘酚
公开(公告)号：US20070225497A1
公开(公告)日：2007-09-27
申请号：US11578708
申请日：2005-05-11
申请人： Albert Chan , Gang Chen , Rongwei Guo , Jing Wu
发明人： Albert Chan , Gang Chen , Rongwei Guo , Jing Wu
IPC分类号： C07F9/6512 , B01J31/12 , C07D233/96
CPC分类号： B01J31/2409 , B01J2231/44 , B01J2531/16 , B01J2531/821 , B01J2531/822 , B01J2531/824 , B01J2531/827 , B01J2531/828 , B01J2531/847 , C07F9/6512 , C07F15/0066
摘要： The present invention provides bipyrimidinyl diphosphine compounds of the formula wherein R is optionally substituted alkyl, cycloalkyl, aryl or heteroaryl; R′ and R″ are independently optionally substituted alkyl, cycloalkyl, aryl or heteroaryl; or an enantiomer thereof; or an enantiomeric mixture thereof. The compounds of the formula (I) are chiral atropisomeric bipyrimidinyl diphosphine compounds and, thus, may be employed as ligands to generate chiral transition metal catalysts which may be applied in a variety of asymmetric reactions, e.g., in palladium catalyzed asymmetric allylic substitution reactions. The compounds of the present invention are easily accessible in high enantiomeric purity according to the methods disclosed herein.
摘要翻译：本发明提供下式的二嘧啶基二膦化合物其中R是任选取代的烷基，环烷基，芳基或杂芳基; R'和R“独立地是任选取代的烷基，环烷基，芳基或杂芳基; 或其对映体; 或其对映体混合物。式（I）的化合物是手性的不对称双嘧啶基二膦化合物，因此可以用作配体以产生手性过渡金属催化剂，其可以用于各种不对称反应，例如钯催化的不对称烯丙基取代反应。根据本文公开的方法，本发明的化合物可以以高对映体纯度容易地获得。

2. 发明授权

US07713900B2 Chiral tertiary aminoalkylnaphthols 失效
公开(公告)号：US07713900B2
公开(公告)日：2010-05-11
申请号：US12133551
申请日：2008-06-05
申请人： Albert S Chan , Gang Chen , Rongwei Guo , Jing Wu
发明人： Albert S Chan , Gang Chen , Rongwei Guo , Jing Wu
IPC分类号： C07F9/32 , C07F15/04 , C07F15/00 , B01J31/12
CPC分类号： B01J31/2409 , B01J2231/44 , B01J2531/16 , B01J2531/821 , B01J2531/822 , B01J2531/824 , B01J2531/827 , B01J2531/828 , B01J2531/847 , C07F9/6512 , C07F15/0066
摘要： The present invention provides bipyrimidinyl diphosphine compounds of the formula wherein R is optionally substituted alkyl, cycloalkyl, aryl or heteroaryl; R′ and R″ are independently optionally substituted alkyl, cycloalkyl, aryl or heteroaryl; or an enantiomer thereof; or an enantiomeric mixture thereof. The compounds of the formula (I) are chiral atropisomeric bipyrimidinyl diphosphine compounds and, thus, may be employed as ligands to generate chiral transition metal catalysts which may be applied in a variety of asymmetric reactions, e.g., in palladium catalyzed asymmetric allylic substitution reactions. The compounds of the present invention are easily accessible in high enantiomeric purity according to the methods disclosed herein.

3. 发明授权

US07674900B2 Chiral tertiary aminoalkylnaphthols 失效
标题翻译：手性叔氨基烷基萘酚
公开(公告)号：US07674900B2
公开(公告)日：2010-03-09
申请号：US11578708
申请日：2005-05-11
申请人： Albert Sun-Chi Chan , Gang Chen , Rongwei Guo , Jing Wu
发明人： Albert Sun-Chi Chan , Gang Chen , Rongwei Guo , Jing Wu
IPC分类号： C07F9/6544
CPC分类号： B01J31/2409 , B01J2231/44 , B01J2531/16 , B01J2531/821 , B01J2531/822 , B01J2531/824 , B01J2531/827 , B01J2531/828 , B01J2531/847 , C07F9/6512 , C07F15/0066
摘要： The present invention provides bipyrimidinyl diphosphine compounds of the formula wherein R is optionally substituted alkyl, cycloalkyl, aryl or heteroaryl; R′ and R″ are independently optionally substituted alkyl, cycloalkyl, aryl or heteroaryl; or an enantiomer thereof; or an enantiomeric mixture thereof. The compounds of the formula (I) are chiral atropisomeric bipyrimidinyl diphosphine compounds and, thus, may be employed as ligands to generate chiral transition metal catalysts which may be applied in a variety of asymmetric reactions, e.g., in palladium catalyzed asymmetric allylic substitution reactions. The compounds of the present invention are easily accessible in high enantiomeric purity according to the methods disclosed herein.
摘要翻译：本发明提供下式的二嘧啶基二膦化合物其中R是任选取代的烷基，环烷基，芳基或杂芳基; R'和R“独立地是任选取代的烷基，环烷基，芳基或杂芳基; 或其对映体; 或其对映体混合物。式（I）的化合物是手性的不对称双嘧啶基二膦化合物，因此可以用作配体以产生手性过渡金属催化剂，其可以用于各种不对称反应，例如钯催化的不对称烯丙基取代反应。根据本文公开的方法，本发明的化合物可以以高对映体纯度容易地获得。

4. 发明申请

US20080255356A1 CHIRAL TERTIARY AMINOALKYLNAPHTHOLS 失效
公开(公告)号：US20080255356A1
公开(公告)日：2008-10-16
申请号：US12133551
申请日：2008-06-05
申请人： Albert Sun-Chi Chan , Gang Chen , Rongwei Guo , Jing Wu
发明人： Albert Sun-Chi Chan , Gang Chen , Rongwei Guo , Jing Wu
IPC分类号： C07F15/00 , C07F9/6512
CPC分类号： B01J31/2409 , B01J2231/44 , B01J2531/16 , B01J2531/821 , B01J2531/822 , B01J2531/824 , B01J2531/827 , B01J2531/828 , B01J2531/847 , C07F9/6512 , C07F15/0066
摘要： The present invention provides bipyrimidinyl diphosphine compounds of the formula wherein R is optionally substituted alkyl, cycloalkyl, aryl or heteroaryl; R′ and R″ are independently optionally substituted alkyl, cycloalkyl, aryl or heteroaryl; or an enantiomer thereof; or an enantiomeric mixture thereof. The compounds of the formula (I) are chiral atropisomeric bipyrimidinyl diphosphine compounds and, thus, may be employed as ligands to generate chiral transition metal catalysts which may be applied in a variety of asymmetric reactions, e.g., in palladium catalyzed asymmetric allylic substitution reactions. The compounds of the present invention are easily accessible in high enantiomeric purity according to the methods disclosed herein.
摘要翻译：本发明提供下式的二嘧啶基二膦化合物其中R是任选取代的烷基，环烷基，芳基或杂芳基; R'和R“独立地是任选取代的烷基，环烷基，芳基或杂芳基; 或其对映体; 或其对映体混合物。式（I）的化合物是手性的不对称双嘧啶基二膦化合物，因此可以用作配体以产生手性过渡金属催化剂，其可以用于各种不对称反应，例如钯催化的不对称烯丙基取代反应。根据本文公开的方法，本发明的化合物可以以高对映体纯度容易地获得。

5. 发明授权

US11773383B2 Methods for promoting extracellular expression of proteins in 有权
公开(公告)号：US11773383B2
公开(公告)日：2023-10-03
申请号：US17349933
申请日：2021-06-17
申请人： Jing Wu , Lingqia Su , Yan Huang
发明人： Jing Wu , Lingqia Su , Yan Huang
IPC分类号： C12N9/92 , C12N9/18 , C12N9/10 , C12N15/75
CPC分类号： C12N9/18 , C12N9/1051 , C12N9/92 , C12N15/75 , C12Y204/01245 , C12Y301/01074 , C12Y503/01005
摘要： Disclosed is a method for promoting extracellular expression of proteins in B. subtilis using cutinase, which belongs to the technical fields of genetic engineering, enzyme engineering and microbial engineering. It teaches co-expressing a cutinase mutant and a target protein in B. subtilis to promote extracellular expression of the target protein which is naturally located inside cells. The target protein includes xylose isomerase, 4,6-α-glucosyltransferase, 4-α-glucosyltransferase, trehalose synthase, branching enzyme and the like. The invention can achieve extracellular expression of intracellularly localized target protein, improve the production efficiency, reduce the production cost and simplify the subsequent extraction process.

6. 发明授权

US10988550B2 Method for preparing resistant dextrin by using a starch branching enzyme and a cyclodextrin glycosyltransferase 有权
公开(公告)号：US10988550B2
公开(公告)日：2021-04-27
申请号：US16196768
申请日：2018-11-20
申请人： Jing Wu , Sheng Chen , Jun Liu
发明人： Jing Wu , Sheng Chen , Jun Liu
IPC分类号： C08B30/18 , A23L29/269 , C12P19/04 , C08L3/02 , C08B31/00
摘要： Disclosed is a method for preparing a resistant dextrin product by using compound enzyme treatment. Starch is first subjected to high-temperature acidolysis to obtain pyrodextrin which is used as the substrate for the enzyme treatment. A compound enzyme reaction system including a starch branching enzyme and a CGTase is used for preparing the resistant dextrin product. The starch branching enzyme and the CGTase are added simultaneously or sequentially to treat the pyrodextrin to further increase the content of the resistant component in the product. The content of the resistant component of the enzyme treated product reaches up to 65.3%, a 21.3% increase from that of the pyrodextrin before the enzyme treatment.

7. 发明申请

US20190032062A1 Recombinant Escherichia coli for high efficiency production of fructosylated chondroitin and method for making thereof 审中-公开
公开(公告)号：US20190032062A1
公开(公告)日：2019-01-31
申请号：US15891564
申请日：2018-02-08
申请人： Jing Wu , Quan Zhang , Liming Liu , Xiulai Chen , Jia Liu , Qiuling Luo
发明人： Jing Wu , Quan Zhang , Liming Liu , Xiulai Chen , Jia Liu , Qiuling Luo
IPC分类号： C12N15/70 , C12P19/26 , C12N9/90 , C12N9/10 , C12P19/24
CPC分类号： C12N15/70 , C12N9/1096 , C12N9/90 , C12P19/24 , C12P19/26 , C12Y504/0201
摘要： The present invention relates to the field of biotechnology engineering. It provides a recombinant Escherichia coli that can produce fructosylated chondroitin with high yields and the method for constructing the recombinant strain. The present invention discloses a method for constructing an expression plasmid pETM6R1-RBS-glmM-GGGS-glmS that contains a glmM and a glmS gene under regulation of ribosome binding sites. The recombinant plasmid was transformed into E. coli K4 to obtain a recombinant E. coli strain ZQ33 that can produce fructosylated chondroitin up to 3.99 g·L−1 by fed-batch fermentation in a 5-L fermentor, which was increased by 108.90% compared to that of the wild type strain.

8. 发明申请

US20170117614A1 ANTENNA SYSTEM WITH FULL METAL BACK COVER 审中-公开
公开(公告)号：US20170117614A1
公开(公告)日：2017-04-27
申请号：US15283530
申请日：2016-10-03
申请人： Jing Wu , Jianchun Mai , Chao Wang
发明人： Jing Wu , Jianchun Mai , Chao Wang
IPC分类号： H01Q1/24 , H01Q1/38 , H01Q1/48 , H01Q1/22 , H01Q1/36
CPC分类号： H01Q1/243 , H01Q1/2291 , H01Q5/328 , H01Q9/42 , H01Q21/28 , H01Q21/30
摘要： An antenna system with a full metal back cover is provided in the present disclosure. The antenna system includes a metal back cover with a main body, a first sidewall and a second sidewall opposite to each other, a circuit board with a main ground point, a first antenna module and a second antenna module electrically connected to the circuit board. A first gap is formed between the first sidewall and the main body, and a second gap is formed between the second sidewall and the main body; the metal back cover is divided into a first metal portion including the first sidewall and a second metal portion including the second sidewall. The first metal portion includes a top slit penetrating through an edge of the first sidewall, and the second metal portion includes a bottom slit penetrating through an edge of the second sidewall.

9. 发明授权

US09064102B2 Method, system and device for secured access to protected digital material 有权
标题翻译：用于安全访问受保护数字材料的方法，系统和设备
公开(公告)号：US09064102B2
公开(公告)日：2015-06-23
申请号：US11853555
申请日：2007-09-11
申请人： Jing Wu , James Ronald Flesch
发明人： Jing Wu , James Ronald Flesch
IPC分类号： G06F21/34 , H04L9/32 , H04W12/04 , H04L29/06
CPC分类号： G06F21/34 , H04L9/3226 , H04L65/4084 , H04L2209/60 , H04L2209/80 , H04W12/04
摘要： A method, system and device for providing secure access to multimedia content received by a networked digital storage device, such as a set-top box. A mobile device, such as a mobile telephone, obtains appropriate security binding information and application software when coupled to the networked digital storage device at its end user location. The mobile device uploads the security binding information to a randomly located temporary hosting device at its place-shifted location when coupled thereto and, through a logical binding with the temporary hosting device, enables a secure, remote session. The secure binding and transfer of appropriate keys allow the remote hosting device to securely access premium or protected digital material/services available at the networked digital storage device. After completion of the secure, remote access session, termination occurs and the security binding information and the computing activity residue can be removed from the mobile device and the temporary hosting device.
摘要翻译：一种用于提供对联网的数字存储设备（诸如机顶盒）所接收的多媒体内容的安全访问的方法，系统和设备。诸如移动电话的移动设备在其最终用户位置处耦合到联网数字存储设备时获得适当的安全绑定信息和应用软件。移动设备在耦合到其位置移动位置时将安全绑定信息上传到随机定位的临时托管设备，并且通过与临时托管设备的逻辑绑定来启用安全的远程会话。适当密钥的安全绑定和传输允许远程托管设备安全地访问网络数字存储设备上可用的高级或受保护的数字材料/服务。在完成安全的远程访问会话之后，终止并且可以从移动设备和临时托管设备移除安全绑定信息和计算活动残留。

10. 发明申请

US20130209490A1 Diagnostic BioMarkers for Fibrotic Disorders 审中-公开
标题翻译：诊断生物标志物的纤维性疾病
公开(公告)号：US20130209490A1
公开(公告)日：2013-08-15
申请号：US13852079
申请日：2013-03-28
申请人： Alan Buckler , Chao-Min Chen , Chantale T. Guy , Jeffrey Hewett , Chris Lu , Jing Wu
发明人： Alan Buckler , Chao-Min Chen , Chantale T. Guy , Jeffrey Hewett , Chris Lu , Jing Wu
IPC分类号： A61K38/18 , A61K38/16 , A61K31/7088 , A61K45/06 , A61K39/395 , G01N33/50
CPC分类号： A61K38/1875 , A61K31/7088 , A61K38/16 , A61K39/395 , A61K45/06 , G01N33/5091 , G01N33/74 , G01N2333/495 , G01N2800/7052 , A61K2300/00
摘要： The present invention provides novel methods of inhibiting fibrosis, as well as methods of treating or inhibiting fibrotic disorders, using BMP9 and/or BMP10 antagonists. The present invention also provides methods of assessing whether a subject has or is at risk of developing a fibrotic disorder by detecting levels of BMP9 and/or BMP10. Further provided are methods of assessing the efficacy of a treatment regimen for treating a fibrotic disorder by detecting and comparing pre-treatment levels of BMP9 and BMP10 with post-treatment levels of BMP9 and BMP10.
摘要翻译：本发明提供使用BMP9和/或BMP10拮抗剂抑制纤维化的新方法，以及治疗或抑制纤维化病症的方法。本发明还提供了通过检测BMP9和/或BMP10的水平来评估受试者是否具有发展为纤维化疾病的风险的方法。还提供了通过检测和比较BMP9和BMP10的预处理水平与BMP9和BMP10的后处理水平来评估治疗方案用于治疗纤维化病症的功效的方法。

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